Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0177 | 0.8642 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0177 | 0.8642 | 1 |
Onchocerca volvulus | 0.0196 | 1 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.0126 | 0.4861 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0177 | 0.8642 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0126 | 0.4861 | 1 |
Brugia malayi | thymidylate synthase | 0.0126 | 0.4861 | 0.4861 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0177 | 0.8642 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0196 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0177 | 0.8642 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0177 | 0.8642 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0196 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0126 | 0.4861 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0126 | 0.4861 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0126 | 0.4861 | 0.5 |
Onchocerca volvulus | 0.0174 | 0.8375 | 0.6838 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log IC50 (binding) | < 4 | Inhibitory activity against human erythrocyte acetylcholinesterase | ChEMBL. | 15317459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.