Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0013 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0038 | 0.0038 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0899 | 0.1625 | 0.1625 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.0128 | 0.0717 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0038 | 0.2188 |
Leishmania major | ATP-dependent phosphofructokinase | 0.011 | 0.013 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5323 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5323 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5323 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.5323 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.013 | 0.0781 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5323 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.0191 | 0.0188 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.011 | 0.0107 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.011 | 0.013 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.0191 | 0.0188 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0038 | 0.0035 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0899 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0013 | 0.001 |
Schistosoma mansoni | acetylcholinesterase | 0.0899 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0013 | 0.001 |
Echinococcus multilocularis | neuroligin | 0.0899 | 0.1625 | 0.1623 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0899 | 0.1625 | 0.1625 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.0151 | 0.0859 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0038 | 0.0159 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.013 | 0.0781 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0013 | 0.001 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0899 | 0.1625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Echinococcus granulosus | acetylcholinesterase | 0.5323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.0527 | 0.0525 |
Loa Loa (eye worm) | carboxylesterase | 0.0899 | 0.1625 | 0.1623 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.0374 | 0.2289 |
Echinococcus granulosus | carboxylesterase 5A | 0.5323 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0899 | 0.1625 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0014 | 0.0014 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0013 | 0.001 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0013 | 0.001 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.0151 | 0.0859 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0899 | 0.1625 | 0.1623 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.013 | 1 |
Onchocerca volvulus | 0.0899 | 0.1625 | 1 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.0319 | 0.0317 |
Brugia malayi | Carboxylesterase family protein | 0.5323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5323 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 0.013 | 0.013 |
Onchocerca volvulus | 0.0899 | 0.1625 | 1 | |
Brugia malayi | phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Onchocerca volvulus | 0.0899 | 0.1625 | 1 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 0.013 | 0.013 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.011 | 0.013 | 0.0577 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0899 | 0.1625 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.0373 | 0.0371 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0899 | 0.1625 | 0.1625 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0014 | 0.0011 |
Onchocerca volvulus | 0.0899 | 0.1625 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0155 | 0.0152 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0899 | 0.1625 | 0.1623 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Echinococcus granulosus | 6 phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Brugia malayi | Carboxylesterase family protein | 0.0899 | 0.1625 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Brugia malayi | hypothetical protein | 0.0238 | 0.0373 | 0.0371 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5323 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0038 | 0.0038 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0899 | 0.1625 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0021 | 0.0018 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.013 | 0.0781 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0899 | 0.1625 | 0.1625 |
Onchocerca volvulus | 0.0239 | 0.0374 | 0.2234 | |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.0128 | 0.0717 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.013 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Echinococcus granulosus | neuroligin | 0.0899 | 0.1625 | 0.1623 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.0151 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0899 | 0.1625 | 0.1623 |
Brugia malayi | Carboxylesterase family protein | 0.0899 | 0.1625 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.011 | 0.013 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.011 | 0.013 | 0.0727 |
Echinococcus multilocularis | acetylcholinesterase | 0.5323 | 1 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0099 | 0.0096 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0014 | 0.0011 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.0128 | 0.0717 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.013 | 0.0781 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.0128 | 0.0717 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0038 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.011 | 0.0107 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0038 | 0.0035 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.0151 | 0.0859 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.013 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.0128 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.5323 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.0319 | 0.0317 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0899 | 0.1625 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0099 | 0.0096 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.011 | 0.013 | 0.0695 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.011 | 0.013 | 1 |
Onchocerca volvulus | 0.0899 | 0.1625 | 1 | |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.011 | 0.0107 |
Brugia malayi | Carboxylesterase family protein | 0.0899 | 0.1625 | 0.1623 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.011 | 0.0107 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0013 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0899 | 0.1625 | 0.1623 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.0128 | 0.0717 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0238 | 0.0373 | 0.0371 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0899 | 0.1625 | 1 |
Brugia malayi | hypothetical protein | 0.0899 | 0.1625 | 0.1623 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0013 | 0.001 |
Brugia malayi | 6-phosphofructokinase | 0.011 | 0.013 | 0.0127 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0238 | 0.0373 | 0.0371 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0899 | 0.1625 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0899 | 0.1625 | 0.1623 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0899 | 0.1625 | 0.1623 |
Brugia malayi | Carboxylesterase family protein | 0.0899 | 0.1625 | 0.1623 |
Schistosoma mansoni | gliotactin | 0.0899 | 0.1625 | 0.1625 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0013 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 45.4 uM | Concentration required to inhibit growth of human cervical carcinoma (HeLa) cell line | ChEMBL. | 15317455 |
IC50 (functional) | = 45.4 uM | Concentration required to inhibit growth of human cervical carcinoma (HeLa) cell line | ChEMBL. | 15317455 |
IC50 (functional) | = 48.48 uM | Concentration required to inhibit growth of african green monkey kidney cell line | ChEMBL. | 15317455 |
IC50 (functional) | = 64.42 uM | Concentration required to inhibit growth of human hepatocellular carcinoma (HepG2) cell line | ChEMBL. | 15317455 |
IC50 (functional) | = 64.42 uM | Concentration required to inhibit growth of human hepatocellular carcinoma (HepG2) cell line | ChEMBL. | 15317455 |
IC50 (functional) | = 93.75 uM | Concentration required to inhibit growth of human epidermoid carcinoma (KB) cell line | ChEMBL. | 15317455 |
IC50 (functional) | = 93.7500000000001 uM | Concentration required to inhibit growth of human epidermoid carcinoma (KB) cell line | ChEMBL. | 15317455 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.