Detailed information for compound 327944

Basic information

Technical information
  • TDR Targets ID: 327944
  • Name: N-hydroxy-2,2,3,3-tetramethylcyclopropane-1-c arboxamide
  • MW: 157.21 | Formula: C8H15NO2
  • H donors: 2 H acceptors: 2 LogP: 1.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C1C(C1(C)C)(C)C
  • InChi: 1S/C8H15NO2/c1-7(2)5(6(10)9-11)8(7,3)4/h5,11H,1-4H3,(H,9,10)
  • InChiKey: SKMMNJFFVAHDNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,2,3,3-tetramethylcyclopropanecarbohydroxamic acid
  • N-hydroxy-2,2,3,3-tetramethyl-cyclopropane-1-carboxamide
  • 2,2,3,3-tetramethylcyclopropane-1-carbohydroxamic acid
  • 2,2,3,3-tetramethyl-1-cyclopropanecarbohydroxamic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0318 1 0.5
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0318 1 0.5
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0318 1 0.5
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0318 1 0.5
Echinococcus multilocularis thymidylate synthase 0.0318 1 0.5
Mycobacterium ulcerans thymidylate synthase 0.0318 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0151 0 0.5
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 1 0.5
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0318 1 1
Echinococcus granulosus thymidylate synthase 0.0318 1 0.5
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0318 1 1
Loa Loa (eye worm) thymidylate synthase 0.0318 1 0.5
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 1 0.5
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0318 1 0.5
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 1 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 15 min in rats; - means No protection ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 30 min in rats; -means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 1 hr in rats; -means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 2 hr in rats; - means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 4 hr in rats; -means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 15 min in rats; - means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 30 min in rats; -means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 1 hr in rats; - means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 2 hr in rats; - means No protection ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested ChEMBL. 15294003
Anticonvulsant Activity (functional) - 0 Toxicity of the compound after oral administration of 30 mg/kg dose in rats; - means No toxicity ChEMBL. 15294003
Anticonvulsant Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 4 hr in rats; -means No protection ChEMBL. 15294003
clogP = 1.25 Calculated partition coefficient (clogP) ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 100 mg/kg; 0/8= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 100 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 300 mg/kg; 0/2= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) - 0 Toxicity of the compound after oral administration of 50 mg/kg dose in rats; - means No toxicity ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 30 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 30 mg/kg; 0/2= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 1 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 300 mg/kg; 1/4= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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