Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | choline kinase alpha | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Trypanosoma brucei | choline/ethanolamine kinase | choline kinase alpha | 457 aa | 474 aa | 22.1 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3362 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3362 | 0.3362 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3362 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3362 | 0.3362 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3362 | 0.3362 |
Schistosoma mansoni | lipoxygenase | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.3362 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3362 | 0.3362 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3362 | 0.3362 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3362 | 0.3362 |
Schistosoma mansoni | lipoxygenase | 0.0256 | 0.6387 | 0.6387 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3362 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3362 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3362 | 0.3362 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.3362 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0366 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.399 uM | Inhibition of equine BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 0.4 uM | Inhibitory activity against human choline kinase enzyme | ChEMBL. | 15481981 |
IC50 (binding) | = 0.4 uM | Inhibitory activity against human choline kinase enzyme | ChEMBL. | 15481981 |
IC50 (binding) | = 0.869 uM | Inhibition of bovine AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (functional) | = 2.2 uM | Antiproliferative activity was determined using HT-29 human colon cancer cell line | ChEMBL. | 15481981 |
IC50 (functional) | = 2.2 uM | Antiproliferative activity was determined using HT-29 human colon cancer cell line | ChEMBL. | 15481981 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15481981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.