Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Estrogen receptor alpha | Starlite/ChEMBL | References |
Mus musculus | estrogen receptor 1 (alpha) | Starlite/ChEMBL | References |
Mus musculus | estrogen receptor 2 (beta) | Starlite/ChEMBL | References |
Rattus norvegicus | Estrogen receptor beta | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Estrogen receptor beta | 530 aa | 430 aa | 24.9 % | |
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Schistosoma mansoni | retinoic acid receptor RXR | Estrogen receptor beta | 530 aa | 451 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0049 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0049 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.7 | Effect of combination of compound and PPT on rat vasomotor instability in terms of tail skin temperature change 15 min after naloxone injection | ChEMBL. | 15456246 |
Activity (functional) | = 5.2 | Effect of compound (15 mg/kg) on rat vasomotor instability in terms of tail skin temperature change 15 min after naloxone injection | ChEMBL. | 15456246 |
IC50 (binding) | = 4 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 4 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 4.3 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 4.3 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 6 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 6 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 6 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
IC50 (binding) | = 362 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 362 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 411 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 411 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 423 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 423 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER alpha expressed in E. coli | ChEMBL. | 15456246 |
Selectivity (binding) | = 72 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 89 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 98 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 72 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 89 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 98 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Weight (functional) | = 30.3 mg | Weight of rat uterine when treated with compound at 2 mg dose was determined | ChEMBL. | 15456246 |
Weight (functional) | = 76.6 mg | Weight of rat uterine when treated with combination of compound and Ethynyl estradiol was determined | ChEMBL. | 15456246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.