TDR Targets

Basic information

Technical information

TDR Targets ID: 328176
Name: [1-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]oxym ethyl]cyclobutyl]methyl N-[(3S)-1,2-dioxo-1-[ [(1R)-1-phenylethyl]amino]heptan-3-yl]carbama te
MW: 577.734 | Formula: C32H39N3O5S
H donors: 2 H acceptors: 4 LogP: 7.1 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: CCCC[C@@H](C(=O)C(=O)N[C@@H](c1ccccc1)C)NC(=O)OCC1(CCC1)COc1scc(n1)c1ccc(cc1)C
InChi: 1S/C32H39N3O5S/c1-4-5-12-26(28(36)29(37)33-23(3)24-10-7-6-8-11-24)34-30(38)39-20-32(17-9-18-32)21-40-31-35-27(19-41-31)25-15-13-22(2)14-16-25/h6-8,10-11,13-16,19,23,26H,4-5,9,12,17-18,20-21H2,1-3H3,(H,33,37)(H,34,38)/t23-,26+/m1/s1
InChiKey: LUMLMWFOFBIUCG-BVAGGSTKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[1-[[4-(p-tolyl)thiazol-2-yl]oxymethyl]cyclobutyl]methyl N-[(1S)-1-[2-oxo-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamate
N-[(1S)-1-[1,2-dioxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]carbamic acid [1-[[4-(p-tolyl)-2-thiazolyl]oxymethyl]cyclobutyl]methyl ester
N-[(1S)-1-[2-keto-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamic acid [1-[[4-(p-tolyl)thiazol-2-yl]oxymethyl]cyclobutyl]methyl ester
[1-[[4-(4-methylphenyl)thiazol-2-yl]oxymethyl]cyclobutyl]methyl N-[(1S)-1-[2-oxo-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamate
N-[(1S)-1-[1,2-dioxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]carbamic acid [1-[[4-(4-methylphenyl)-2-thiazolyl]oxymethyl]cyclobutyl]methyl ester
N-[(1S)-1-[2-keto-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamic acid [1-[[4-(4-methylphenyl)thiazol-2-yl]oxymethyl]cyclobutyl]methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	AMP deaminase, putative	0.0178	0.3027	1
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.043	0.0265
Echinococcus multilocularis	orexin receptor type 2	0.0041	0.043	0.0265
Schistosoma mansoni	neuropeptide f receptor 76f	0.0041	0.043	0.043
Brugia malayi	GnHR receptor homolog	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3027	0.3027
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.043	0.043
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0169	0.0169
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Echinococcus granulosus	dro:myosuppressin receptor	0.0041	0.043	0.043
Schistosoma mansoni	amine GPCR	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.043	0.0265
Echinococcus granulosus	fmrfamide receptor	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptide receptor A26	0.0041	0.043	0.0265
Brugia malayi	Dopamine receptor protein 2	0.0041	0.043	0.043
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.043	0.043
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0169	0.0169
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.043	0.043
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0367	0.6631	0.6631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Plasmodium vivax	adenosine/AMP deaminase, putative	0.0178	0.3027	0.2907
Leishmania major	adenine aminohydrolase	0.0545	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Brugia malayi	putative neuropeptide receptor NPR1	0.0041	0.043	0.043
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0169	0.0169
Brugia malayi	AKH receptor	0.0041	0.043	0.043
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0545	1	1
Brugia malayi	larval opioid receptor	0.0041	0.043	0.043
Schistosoma mansoni	opsin-like receptor	0.0041	0.043	0.043
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0041	0.043	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0169	0.0169
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus granulosus	g-protein coupled receptor	0.0041	0.043	0.043
Brugia malayi	Serotonin receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0169	0.0169
Schistosoma mansoni	biogenic amine receptor	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0041	0.043	0.043
Echinococcus granulosus	adenosine deaminase	0.0545	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Schistosoma mansoni	neuropeptide receptor	0.0041	0.043	0.043
Trypanosoma cruzi	AMP deaminase 2, putative	0.0178	0.3027	1
Schistosoma mansoni	neuropeptide receptor	0.0041	0.043	0.043
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0169	0.0559
Plasmodium falciparum	adenosine deaminase	0.0545	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.043	0.043
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0169	0.0559
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.043	0.0265
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.043	0.043
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0041	0.043	0.043
Loa Loa (eye worm)	AMP deaminase	0.0178	0.3027	0.3027
Entamoeba histolytica	adenosine deaminase, putative	0.0545	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0367	0.6631	0.6631
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	dro:myosuppressin receptor	0.0041	0.043	0.0265
Echinococcus multilocularis	serotonin receptor	0.0041	0.043	0.0265
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0041	0.043	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0041	0.043	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0169	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus granulosus	AMP deaminase 2	0.0178	0.3027	0.3027
Echinococcus granulosus	g protein coupled receptor	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0041	0.043	0.0265
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus		0.0027	0.0169	0.0169
Echinococcus granulosus	neuropeptide FF receptor 2	0.0041	0.043	0.043
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0169	0.0169
Trypanosoma brucei	AMP deaminase, putative	0.0178	0.3027	1
Onchocerca volvulus		0.0041	0.043	0.043
Plasmodium falciparum	AMP deaminase, putative	0.0178	0.3027	0.2907
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.043	0.0265
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.043	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0169	0.0169
Schistosoma mansoni	adenosine deaminase	0.0545	1	1
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0041	0.043	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0041	0.043	0.0265
Echinococcus granulosus	neuropeptide receptor	0.0041	0.043	0.043
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0041	0.043	0.043
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0041	0.043	0.043
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0545	1	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0041	0.043	0.043
Echinococcus granulosus	G protein coupled receptor 139	0.0041	0.043	0.043
Echinococcus granulosus	7TM GPCR rhodopsin	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus granulosus	allatostatin A receptor	0.0041	0.043	0.043
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.0178	0.3027	0.2907
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Brugia malayi	Dopamine receptor protein 1	0.0041	0.043	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Onchocerca volvulus		0.0178	0.3027	0.3027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0169	0.0169
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0169	0.0169
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus multilocularis	AMP deaminase 2	0.0178	0.3027	0.2907
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0041	0.043	0.0265
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0041	0.043	0.043
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0041	0.043	0.043
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0041	0.043	0.0265
Loa Loa (eye worm)	melatonin receptor type 1A	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.043	0.0265
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0041	0.043	0.043
Brugia malayi	neuropeptide F receptor	0.0041	0.043	0.043
Echinococcus multilocularis	allatostatin A receptor	0.0041	0.043	0.0265
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	hypothetical protein	0.0041	0.043	0.043
Trypanosoma cruzi	AMP deaminase, putative	0.0178	0.3027	1
Brugia malayi	RE15519p	0.0041	0.043	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Leishmania major	hypothetical protein, conserved	0.0178	0.3027	0.2907
Onchocerca volvulus		0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0169	0.0169
Entamoeba histolytica	AMP deaminase, putative	0.0178	0.3027	0.3027
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.043	0.0265
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.043	0.0265
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0041	0.043	0.043
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0169	0.0559
Schistosoma mansoni	adenoreceptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0367	0.6631	0.6631
Onchocerca volvulus	Adenosine deaminase homolog	0.0545	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus granulosus	somatostatin receptor	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptide s receptor	0.0041	0.043	0.0265
Schistosoma mansoni	neuropeptide receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0545	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.043	0.0265
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Trypanosoma brucei	AMP deaminase, putative	0.0178	0.3027	1
Echinococcus multilocularis	sex peptide receptor	0.0041	0.043	0.0265
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.043	0.043
Entamoeba histolytica	AMP deaminase, putative	0.0178	0.3027	0.3027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus granulosus	serotonin receptor	0.0041	0.043	0.043
Onchocerca volvulus	AMP deaminase 2 homolog	0.0178	0.3027	0.3027
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0041	0.043	0.0265
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	adenosine deaminase, putative	0.0545	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	neuropeptide receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Schistosoma mansoni	amine GPCR	0.0041	0.043	0.043
Schistosoma mansoni	amine GPCR	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Loa Loa (eye worm)	cysteine protease	0.0027	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Brugia malayi	G-protein coupled receptor	0.0041	0.043	0.043
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Onchocerca volvulus		0.0027	0.0169	0.0169
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0041	0.043	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0041	0.043	0.043
Brugia malayi	Melatonin receptor type 1A	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0041	0.043	0.043
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.043	0.0265
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.043	0.0265
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Brugia malayi	ORL1-like opioid receptor	0.0041	0.043	0.043
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.043	0.043
Onchocerca volvulus		0.0027	0.0169	0.0169
Brugia malayi	sulfakinin receptor protein	0.0041	0.043	0.043
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0169	0.0559
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0041	0.043	0.043
Schistosoma mansoni	myosin xvIII	0.0041	0.043	0.043
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0178	0.3027	1
Brugia malayi	G-protein coupled receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	ctsf protein	0.0027	0.0169	0.0169
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0169	0.0169
Trypanosoma cruzi	AMP deaminase, putative	0.0178	0.3027	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Onchocerca volvulus		0.0027	0.0169	0.0169
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0178	0.3027	1
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	fibroinase	0.0027	0.0169	0.0169
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0041	0.043	0.0265
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.043	0.043
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Schistosoma mansoni	AMP deaminase	0.0178	0.3027	0.3027
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0041	0.043	0.043
Brugia malayi	adenosine monophosphate deaminase	0.0178	0.3027	0.3027
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.043	0.043
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0169	0.0169
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.043	0.043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.043	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.043	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.043	0.043
Echinococcus granulosus	g protein coupled receptor	0.0041	0.043	0.043
Echinococcus granulosus	cathepsin l1	0.0027	0.0169	0.0169
Schistosoma mansoni	amine GPCR	0.0041	0.043	0.043
Treponema pallidum	adenosine deaminase	0.0545	1	0.5
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0545	1	0.5
Echinococcus multilocularis	somatostatin receptor	0.0041	0.043	0.0265
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0041	0.043	0.043
Schistosoma mansoni	adenosine deaminase-related	0.0545	1	1
Leishmania major	AMP deaminase, putative	0.0178	0.3027	0.2907
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.043	0.043
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.043	0.043
Echinococcus granulosus	hypothetical protein	0.0041	0.043	0.043
Entamoeba histolytica	adenosine deaminase, putative	0.0545	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0041	0.043	0.0265
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.043	0.043
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.0178	0.3027	0.2907
Echinococcus multilocularis	adenosine deaminase	0.0545	1	1
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0178	0.3027	1
Echinococcus granulosus	orexin receptor type 2	0.0041	0.043	0.043
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.043	0.043
Brugia malayi	Serotonin receptor	0.0041	0.043	0.043
Brugia malayi	neuropeptide F receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0041	0.043	0.043
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.0178	0.3027	0.2907
Brugia malayi	G protein-coupled receptor F59B2.13	0.0041	0.043	0.043
Loa Loa (eye worm)	TYRA-2 protein	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.043	0.0265
Schistosoma mansoni	growth hormone secretagogue receptor	0.0041	0.043	0.043
Echinococcus granulosus	neuropeptide receptor A26	0.0041	0.043	0.043
Echinococcus granulosus	neuropeptide receptor	0.0041	0.043	0.043
Schistosoma mansoni	biogenic amine receptor	0.0041	0.043	0.043
Echinococcus granulosus	7tm_1 domain containing protein	0.0041	0.043	0.043
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.043	0.043
Onchocerca volvulus		0.0027	0.0169	0.0169
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0041	0.043	0.043
Mycobacterium ulcerans	adenosine deaminase	0.0545	1	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.043	0.0265
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.043	0.0265
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0169	0.0169
Echinococcus granulosus	g protein coupled receptor	0.0041	0.043	0.043
Echinococcus granulosus	neuropeptide s receptor	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.043	0.0265
Brugia malayi	G protein-coupled receptor	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Onchocerca volvulus		0.0027	0.0169	0.0169
Schistosoma mansoni	opsin-like receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.043	0.0265
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trypanosoma cruzi	AMP deaminase, putative	0.0178	0.3027	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0041	0.043	0.0265
Onchocerca volvulus		0.0041	0.043	0.043
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Trichomonas vaginalis	adenosine deaminase, putative	0.0545	1	1
Brugia malayi	putative neuropeptide receptor	0.0041	0.043	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Brugia malayi	hypothetical protein	0.0041	0.043	0.043
Plasmodium vivax	adenosine deaminase, putative	0.0545	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0169	0.0169
Trypanosoma brucei	AMP deaminase, putative	0.0178	0.3027	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Schistosoma mansoni	hypothetical protein	0.0041	0.043	0.043
Echinococcus multilocularis	serotonin receptor	0.0041	0.043	0.0265
Schistosoma mansoni	amine GPCR	0.0041	0.043	0.043
Schistosoma mansoni	biogenic amine receptor	0.0041	0.043	0.043
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0041	0.043	0.043
Brugia malayi	Dopamine receptor	0.0041	0.043	0.043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.043	0.0265
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.043	0.043
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0041	0.043	0.043
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0169	0.0169
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0169	0.0169
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0041	0.043	0.043
Toxoplasma gondii	AMP deaminase	0.0178	0.3027	0.2907
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0169	0.0169
Schistosoma mansoni	histamine h1 receptor	0.0041	0.043	0.043
Schistosoma mansoni	opsin-like receptor	0.0041	0.043	0.043
Trypanosoma cruzi	AMP deaminase, putative	0.0178	0.3027	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus		0.0027	0.0169	0.0169
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0545	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.043	0.043
Onchocerca volvulus		0.0041	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0367	0.6631	0.6631
Echinococcus granulosus	sex peptide receptor	0.0041	0.043	0.043
Echinococcus multilocularis	g-protein coupled receptor	0.0041	0.043	0.0265
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.043	0.043

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 150 nM	Inhibitory potency against human Cathepsin K	ChEMBL.	15456249
IC50 (binding)	= 150 nM	Inhibitory potency against human Cathepsin K	ChEMBL.	15456249

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 11330658

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 328176