Detailed information for compound 328347

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 243.215 | Formula: C13H9NO4
  • H donors: 3 H acceptors: 4 LogP: 2.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)O)c1oc2c(n1)cc(cc2)O
  • InChi: 1S/C13H9NO4/c15-7-2-4-12-10(5-7)14-13(18-12)9-3-1-8(16)6-11(9)17/h1-6,15-17H
  • InChiKey: RGXSSCFRVTXICH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0095 0.0558 0.0776
Echinococcus multilocularis serotonin receptor 0.0216 0.1915 0.2664
Onchocerca volvulus 0.082 0.8666 0.8621
Loa Loa (eye worm) hypothetical protein 0.0241 0.2193 0.2193
Echinococcus multilocularis biogenic amine (5HT) receptor 0.047 0.4752 0.6611
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus nischarin 0.021 0.185 0.2244
Brugia malayi Trypsin family protein 0.0119 0.0833 0.0833
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0079 0.0386 0.5688
Loa Loa (eye worm) hypothetical protein 0.0507 0.5172 0.5172
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0369 0.3619 1
Echinococcus multilocularis neurogenic locus notch protein 0.0074 0.0325 0.0453
Brugia malayi hypothetical protein 0.0119 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Echinococcus multilocularis dihydrofolate reductase 0.0091 0.051 0.071
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0194 0.1665 0.1665
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0194 0.1665 0.1665
Echinococcus granulosus thymidylate synthase 0.0222 0.198 0.24
Toxoplasma gondii calcium binding egf domain-containing protein 0.0194 0.1665 0.4603
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0254 0.0353
Echinococcus granulosus g protein coupled receptor 0.0095 0.0558 0.0676
Brugia malayi putative neuropeptide receptor NPR1 0.0095 0.0558 0.0558
Brugia malayi Trypsin family protein 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Brugia malayi Trypsin family protein 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0939 1 1
Giardia lamblia High cysteine protein 0.0074 0.0325 0.0899
Brugia malayi sulfakinin receptor protein 0.0095 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Brugia malayi Fibulin-1 precursor 0.0194 0.1665 0.1665
Echinococcus granulosus notch 0.0074 0.0325 0.0394
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0108 0.0704 0.0854
Onchocerca volvulus 0.0095 0.0558 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0108 0.0704 0.0704
Brugia malayi Muscle positioning protein 4 0.0074 0.0325 0.0325
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0324 0.3117 0.3117
Echinococcus granulosus neurogenic locus notch protein 4 0.0074 0.0325 0.0394
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.0902 0.3014
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0108 0.0704 0.0854
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0369 0.3619 0.4388
Onchocerca volvulus 0.0095 0.0558 0.024
Echinococcus granulosus g protein coupled receptor 0.0095 0.0558 0.0676
Brugia malayi GCC2 and GCC3 family protein 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0216 0.1915 0.1915
Echinococcus granulosus dro:myosuppressin receptor 0.0095 0.0558 0.0676
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Echinococcus multilocularis tissue type plasminogen activator 0.019 0.1624 0.2259
Echinococcus granulosus tm gpcr rhodopsin 0.0095 0.0558 0.0676
Brugia malayi Dopamine receptor protein 1 0.0095 0.0558 0.0558
Echinococcus multilocularis g protein coupled receptor 0.0095 0.0558 0.0776
Brugia malayi Kringle domain containing protein 0.019 0.1624 0.1624
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0902 0.1255
Loa Loa (eye worm) dihydrofolate reductase 0.0091 0.051 0.051
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni high-affinity choline transporter 0.0346 0.3372 0.3372
Brugia malayi G protein-coupled receptor 0.0095 0.0558 0.0558
Brugia malayi RE15519p 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0939 1 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0902 0.3014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis neuropeptide s receptor 0.0095 0.0558 0.0776
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0254 0.0308
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis enteropeptidase 0.0119 0.0833 0.1159
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis sex peptide receptor 0.0095 0.0558 0.0776
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0106 0.0679 0.2269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0095 0.0558 0.024
Echinococcus granulosus glycoprotein Antigen 5 0.0119 0.0833 0.101
Echinococcus multilocularis serotonin transporter 0.0241 0.2193 0.3051
Onchocerca volvulus 0.0095 0.0558 0.024
Brugia malayi Trypsin-like protease protein 5 0.0119 0.0833 0.0833
Echinococcus multilocularis G-protein coupled receptor, putative 0.0095 0.0558 0.0776
Schistosoma mansoni dihydrofolate reductase 0.0091 0.051 0.051
Echinococcus granulosus hypothetical protein 0.0783 0.8247 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0095 0.0558 0.0776
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Echinococcus multilocularis fibrillin 1 0.0194 0.1665 0.2317
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0194 0.1665 0.1665
Schistosoma mansoni biogenic amine (5HT) receptor 0.047 0.4752 0.4752
Echinococcus multilocularis neurogenic locus notch protein 4 0.0074 0.0325 0.0453
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0119 0.0833 0.1159
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0241 0.2193 0.193
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.0902 0.1093
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni laminin gamma-3 chain 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0369 0.3619 0.4388
Echinococcus granulosus neuropeptides capa receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0068 0.0254 0.0254
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0108 0.0704 0.0854
Echinococcus granulosus neurogenic locus notch protein 0.0074 0.0325 0.0394
Echinococcus multilocularis nischarin 0.021 0.185 0.2574
Schistosoma mansoni biogenic amine receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0119 0.0833 0.0833
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0194 0.1665 0.1665
Echinococcus granulosus neuropeptides capa receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0095 0.0558 0.0776
Echinococcus multilocularis laminin 0.0194 0.1665 0.2317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0095 0.0558 0.0558
Schistosoma mansoni growth hormone secretagogue receptor 0.0095 0.0558 0.0558
Echinococcus multilocularis neuropeptide receptor A26 0.0095 0.0558 0.0776
Loa Loa (eye worm) hypothetical protein 0.0194 0.1665 0.1665
Mycobacterium ulcerans thymidylate synthase 0.0222 0.198 0.6397
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0095 0.0558 0.0676
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0296 0.2807 1
Echinococcus granulosus laminin 0.0194 0.1665 0.2019
Onchocerca volvulus 0.0095 0.0558 0.024
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Onchocerca volvulus 0.0095 0.0558 0.024
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0079 0.0386 0.5688
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0095 0.0558 0.0776
Echinococcus granulosus neuropeptide s receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.0902 0.0902
Echinococcus multilocularis thymidylate synthase 0.0222 0.198 0.2754
Brugia malayi follicle stimulating hormone receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Onchocerca volvulus 0.0095 0.0558 0.024
Echinococcus granulosus somatostatin receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0254 0.0254
Brugia malayi hypothetical protein 0.0205 0.1795 0.1795
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0119 0.0833 0.0833
Toxoplasma gondii calcium binding egf domain-containing protein 0.0194 0.1665 0.4603
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0194 0.1665 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Echinococcus granulosus protein jagged 2 0.0074 0.0325 0.0394
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Brugia malayi Serotonin receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0095 0.0558 0.0558
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0194 0.1665 0.1665
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0095 0.0558 0.0558
Schistosoma mansoni neuropeptide receptor 0.0095 0.0558 0.0558
Echinococcus multilocularis somatostatin receptor 0.0095 0.0558 0.0776
Echinococcus granulosus alpha 1A adrenergic receptor 0.0095 0.0558 0.0676
Brugia malayi Dopamine receptor 0.0095 0.0558 0.0558
Schistosoma mansoni neuropeptide F-like receptor 0.0095 0.0558 0.0558
Echinococcus granulosus neurogenic locus protein delta 0.0074 0.0325 0.0394
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0254 0.0254
Echinococcus multilocularis neuropeptide receptor 0.0095 0.0558 0.0776
Onchocerca volvulus Neuropeptide F receptor homolog 0.0095 0.0558 0.024
Giardia lamblia NADPH oxidoreductase, putative 0.0079 0.0386 0.1067
Echinococcus multilocularis transmembrane protease serine 3 0.0119 0.0833 0.1159
Echinococcus granulosus neuropeptide Y receptor 0.0095 0.0558 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Loa Loa (eye worm) hypothetical protein 0.0507 0.5172 0.5172
Echinococcus multilocularis slit 2 protein 0.0074 0.0325 0.0453
Loa Loa (eye worm) hypothetical protein 0.039 0.3853 0.3853
Loa Loa (eye worm) neuropeptide F receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0119 0.0833 0.0525
Echinococcus granulosus biogenic amine 5HT receptor 0.0216 0.1915 0.2322
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0074 0.0325 0.0325
Loa Loa (eye worm) melatonin receptor type 1A 0.0095 0.0558 0.0558
Onchocerca volvulus 0.019 0.1624 0.1342
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Brugia malayi Serotonin/octopamine receptor family protein 7 0.039 0.3853 0.3853
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0312 0.2991 1
Echinococcus multilocularis neuropeptides capa receptor 0.0095 0.0558 0.0776
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Echinococcus granulosus G protein coupled receptor 139 0.0095 0.0558 0.0676
Brugia malayi Calcium binding EGF domain containing protein 0.0074 0.0325 0.0325
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0095 0.0558 0.0558
Onchocerca volvulus Arrow homolog 0.0194 0.1665 0.1385
Loa Loa (eye worm) hypothetical protein 0.0216 0.1915 0.1915
Echinococcus multilocularis neurogenic locus protein delta 0.0074 0.0325 0.0453
Brugia malayi Dopamine receptor protein 2 0.0095 0.0558 0.0558
Echinococcus multilocularis protein jagged 1 0.0074 0.0325 0.0453
Brugia malayi thymidylate synthase 0.0222 0.198 0.198
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) neuropeptide F receptor 0.0095 0.0558 0.0558
Schistosoma mansoni septate junction protein 0.0074 0.0325 0.0325
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0095 0.0558 0.0776
Loa Loa (eye worm) trypsin family protein 0.0119 0.0833 0.0833
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.0902 0.3014
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni cell polarity protein 0.0074 0.0325 0.0325
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0095 0.0558 0.0776
Schistosoma mansoni amine GPCR 0.0095 0.0558 0.0558
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0108 0.0704 0.0704
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0312 0.2991 0.8267
Schistosoma mansoni hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0095 0.0558 0.0558
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0312 0.2991 1
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0095 0.0558 0.0558
Echinococcus granulosus allatostatin A receptor 0.0095 0.0558 0.0676
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0254 0.0353
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0902 0.1255
Echinococcus granulosus protein jagged 1 0.0074 0.0325 0.0394
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis Tolloid protein 1 0.0194 0.1665 0.2317
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0939 1 1
Echinococcus granulosus dihydrofolate reductase 0.0091 0.051 0.0619
Schistosoma mansoni neuropeptide receptor 0.0095 0.0558 0.0558
Echinococcus granulosus delta-like protein 1 0.0074 0.0325 0.0394
Echinococcus multilocularis protein jagged 1 0.0074 0.0325 0.0453
Echinococcus granulosus 7TM GPCR rhodopsin 0.0095 0.0558 0.0676
Schistosoma mansoni amine GPCR 0.0095 0.0558 0.0558
Echinococcus granulosus neurogenic locus notch protein 0.0074 0.0325 0.0394
Echinococcus granulosus Tolloid protein 1 0.0194 0.1665 0.2019
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.039 0.3853 0.3853
Schistosoma mansoni neuropeptide f receptor 76f 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0222 0.198 0.171
Schistosoma mansoni myosin xvIII 0.0095 0.0558 0.0558
Loa Loa (eye worm) solute carrier family 6 member 4 0.0241 0.2193 0.2193
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0095 0.0558 0.0776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Schistosoma mansoni neuropeptide receptor 0.0095 0.0558 0.0558
Brugia malayi Delta serrate ligand family protein 0.0074 0.0325 0.0325
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0095 0.0558 0.0558
Echinococcus multilocularis notch 0.0074 0.0325 0.0453
Schistosoma mansoni biogenic amine receptor 0.0095 0.0558 0.0558
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0254 0.0353
Echinococcus multilocularis g protein coupled receptor 0.0095 0.0558 0.0776
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni biogenic amine (5HT) receptor 0.0216 0.1915 0.1915
Loa Loa (eye worm) G-protein coupled receptor 0.0095 0.0558 0.0558
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.0902 0.1093
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0369 0.3619 0.5034
Echinococcus granulosus protein jagged 1 0.0074 0.0325 0.0394
Brugia malayi Carboxylesterase family protein 0.0068 0.0254 0.0254
Brugia malayi Serotonin receptor 0.0553 0.5684 0.5684
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0095 0.0558 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Echinococcus granulosus serotonin receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) thymidylate synthase 0.0222 0.198 0.198
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0079 0.0386 0.5688
Brugia malayi neuropeptide F receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Onchocerca volvulus 0.0095 0.0558 0.024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0095 0.0558 0.0558
Brugia malayi Calcium binding EGF domain containing protein 0.0194 0.1665 0.1665
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0902 0.3014
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0902 0.1255
Echinococcus granulosus tissue type plasminogen activator 0.019 0.1624 0.1969
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Schistosoma mansoni sodium/chloride dependent transporter 0.0241 0.2193 0.2193
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0119 0.0833 0.101
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Onchocerca volvulus Nischarin homolog 0.0205 0.1795 0.1519
Onchocerca volvulus 0.0095 0.0558 0.024
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0833 0.1159
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0095 0.0558 0.0776
Echinococcus multilocularis g-protein coupled receptor 0.0095 0.0558 0.0776
Brugia malayi putative neuropeptide receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Brugia malayi neuropeptide F receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0346 0.3372 0.3372
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0095 0.0558 0.0558
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0095 0.0558 0.0558
Echinococcus granulosus enteropeptidase 0.0119 0.0833 0.101
Echinococcus granulosus protein jagged 2 0.0074 0.0325 0.0394
Chlamydia trachomatis dihydrofolate reductase 0.0091 0.051 0.5
Brugia malayi G-protein coupled receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0194 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.019 0.1624 0.1624
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0095 0.0558 0.0776
Echinococcus granulosus high affinity choline transporter 1 0.0346 0.3372 0.4088
Echinococcus multilocularis dro:myosuppressin receptor 0.0095 0.0558 0.0776
Echinococcus granulosus neuropeptide receptor 0.0095 0.0558 0.0676
Brugia malayi P38 map kinase family protein 2 0.0126 0.0902 0.0902
Schistosoma mansoni hypothetical protein 0.0119 0.0833 0.0833
Brugia malayi G-protein coupled receptor 0.0095 0.0558 0.0558
Schistosoma mansoni egf-like domain protein 0.0194 0.1665 0.1665
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Echinococcus granulosus neuropeptide receptor A26 0.0095 0.0558 0.0676
Onchocerca volvulus 0.0095 0.0558 0.024
Echinococcus granulosus transmembrane protease serine 3 0.0119 0.0833 0.101
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0324 0.3117 0.4337
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0324 0.3117 0.3117
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Plasmodium vivax cysteine repeat modular protein 1, putative 0.019 0.1624 0.5428
Echinococcus granulosus tm gpcr rhodopsin 0.0095 0.0558 0.0676
Echinococcus multilocularis serotonin receptor 0.0216 0.1915 0.2664
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0108 0.0704 0.0979
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Schistosoma mansoni notch 0.0074 0.0325 0.0325
Giardia lamblia NADPH oxidoreductase, putative 0.0079 0.0386 0.1067
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0108 0.0704 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0679 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Brugia malayi hypothetical protein 0.0106 0.0679 0.0679
Echinococcus multilocularis G protein coupled receptor 139 0.0095 0.0558 0.0776
Toxoplasma gondii EGF family domain-containing protein 0.0074 0.0325 0.0899
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0222 0.198 0.7119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Echinococcus multilocularis protein jagged 2 0.0074 0.0325 0.0453
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0095 0.0558 0.0776
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Brugia malayi Calcium binding EGF domain containing protein 0.0074 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Brugia malayi Tachykinin-like peptides receptor 99D 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0095 0.0558 0.024
Loa Loa (eye worm) TYRA-2 protein 0.0095 0.0558 0.0558
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0074 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Echinococcus granulosus fmrfamide receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0095 0.0558 0.0558
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0369 0.3619 0.5034
Echinococcus multilocularis allatostatin A receptor 0.0095 0.0558 0.0776
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Brugia malayi notch-like transmembrane receptor 0.0074 0.0325 0.0325
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0833 0.0833
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.039 0.3853 0.3853
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Toxoplasma gondii kringle domain-containing protein 0.019 0.1624 0.4488
Brugia malayi Calcium binding EGF domain containing protein 0.0074 0.0325 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0095 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0369 0.3619 0.3619
Schistosoma mansoni notch 0.0074 0.0325 0.0325
Echinococcus granulosus neuropeptide Y receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0164 0.2421
Loa Loa (eye worm) norepinephrine transporter 0.0241 0.2193 0.2193
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Loa Loa (eye worm) Notch2 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0119 0.0833 0.0833
Echinococcus granulosus tm gpcr rhodopsin 0.0095 0.0558 0.0676
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0108 0.0704 0.0979
Loa Loa (eye worm) hypothetical protein 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus tachykinin peptides receptor 99D 0.0095 0.0558 0.0676
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0095 0.0558 0.0676
Echinococcus granulosus serotonin transporter 0.0241 0.2193 0.2659
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0095 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0095 0.0558 0.024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0833 0.0833
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Echinococcus multilocularis neural cadherin 0.0074 0.0325 0.0453
Schistosoma mansoni amine GPCR 0.059 0.6094 0.6094
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0222 0.198 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus neural cadherin 0.0074 0.0325 0.0394
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0939 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Echinococcus multilocularis fat cadherin tumor suppressor 0.0074 0.0325 0.0453
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Echinococcus multilocularis fibropellin Ia 0.0074 0.0325 0.0453
Brugia malayi ORL1-like opioid receptor 0.0095 0.0558 0.0558
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0241 0.2193 0.2193
Echinococcus multilocularis neurogenic locus protein delta 0.0074 0.0325 0.0453
Echinococcus multilocularis high affinity choline transporter 1 0.0346 0.3372 0.4691
Echinococcus granulosus orexin receptor type 2 0.0095 0.0558 0.0676
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Schistosoma mansoni notch 0.0074 0.0325 0.0325
Schistosoma mansoni slit 0.0074 0.0325 0.0325
Echinococcus granulosus g protein coupled receptor 0.0095 0.0558 0.0676
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Onchocerca volvulus 0.0095 0.0558 0.024
Onchocerca volvulus 0.0119 0.0833 0.0525
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0108 0.0704 0.0979
Brugia malayi AKH receptor 0.0095 0.0558 0.0558
Brugia malayi dihydrofolate reductase family protein 0.0091 0.051 0.051
Brugia malayi Cadherin domain containing protein 0.0074 0.0325 0.0325
Schistosoma mansoni amine GPCR 0.0095 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.019 0.1624 0.1624
Schistosoma mansoni adenoreceptor 0.0095 0.0558 0.0558
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0324 0.3117 0.3779
Echinococcus multilocularis glycoprotein Antigen 5 0.0119 0.0833 0.1159
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0312 0.2991 1
Loa Loa (eye worm) G-protein coupled receptor 0.0095 0.0558 0.0558
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0095 0.0558 0.0676
Schistosoma mansoni opsin-like receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) serotonin transporter b 0.0241 0.2193 0.2193
Echinococcus multilocularis neurogenic locus notch protein 0.0074 0.0325 0.0453
Brugia malayi Melatonin receptor type 1A 0.0095 0.0558 0.0558
Loa Loa (eye worm) carboxylesterase 0.0068 0.0254 0.0254
Onchocerca volvulus 0.0119 0.0833 0.0525
Plasmodium falciparum cysteine repeat modular protein 1 0.019 0.1624 0.5428
Loa Loa (eye worm) hypothetical protein 0.0068 0.0254 0.0254
Schistosoma mansoni biogenic amine receptor 0.0095 0.0558 0.0558
Brugia malayi Dihydrofolate reductase 0.0091 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0369 0.3619 0.3619
Brugia malayi GH02984p 0.0346 0.3372 0.3372
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni hypothetical protein 0.0119 0.0833 0.0833
Echinococcus multilocularis neuropeptide Y receptor 0.0095 0.0558 0.0776
Schistosoma mansoni amine GPCR 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0222 0.198 0.198
Echinococcus multilocularis neuropeptide FF receptor 2 0.0095 0.0558 0.0776
Brugia malayi Carboxylesterase family protein 0.0068 0.0254 0.0254
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni alpha-1 adrenergic receptor 0.0095 0.0558 0.0558
Brugia malayi larval opioid receptor 0.0095 0.0558 0.0558
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0312 0.2991 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0939 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0095 0.0558 0.0776
Schistosoma mansoni histamine h1 receptor 0.0095 0.0558 0.0558
Treponema pallidum sodium- and chloride- dependent transporter 0.0241 0.2193 0.5
Onchocerca volvulus 0.0095 0.0558 0.024
Brugia malayi Cadherin domain containing protein 0.0074 0.0325 0.0325
Onchocerca volvulus 0.0095 0.0558 0.024
Echinococcus granulosus acetylcholinesterase 0.0068 0.0254 0.0308
Echinococcus granulosus g-protein coupled receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) TK/ROR protein kinase 0.0191 0.1636 0.1636
Onchocerca volvulus 0.0095 0.0558 0.024
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0095 0.0558 0.0558
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Giardia lamblia NADPH oxidoreductase, putative 0.0079 0.0386 0.1067
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0119 0.0833 0.101
Echinococcus multilocularis neuropeptides capa receptor 0.0095 0.0558 0.0776
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus neuropeptide FF receptor 2 0.0095 0.0558 0.0676
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Echinococcus granulosus fibropellin Ia 0.0074 0.0325 0.0394
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Schistosoma mansoni cercarial elastase (S01 family) 0.0119 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0902 0.1255
Schistosoma mansoni opsin-like receptor 0.0095 0.0558 0.0558
Leishmania major hypothetical protein, conserved 0.019 0.1624 0.5428
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0241 0.2193 0.2193
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0241 0.2193 0.2193
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Echinococcus granulosus neuropeptide receptor 0.0095 0.0558 0.0676
Echinococcus multilocularis neuropeptide Y receptor 0.0095 0.0558 0.0776
Brugia malayi GnHR receptor homolog 0.0095 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Onchocerca volvulus 0.0119 0.0833 0.0525
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Mycobacterium tuberculosis Hypothetical protein 0.0106 0.0679 0.0817
Echinococcus granulosus acetylcholinesterase 0.0068 0.0254 0.0308
Echinococcus multilocularis fmrfamide receptor 0.0095 0.0558 0.0776
Schistosoma mansoni hypothetical protein 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0119 0.0833 0.0833
Onchocerca volvulus 0.0095 0.0558 0.024
Onchocerca volvulus 0.0095 0.0558 0.024
Schistosoma mansoni opsin-like receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) notch protein 0.0074 0.0325 0.0325
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0369 0.3619 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0095 0.0558 0.0676
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0095 0.0558 0.0676
Echinococcus multilocularis neuropeptide receptor 0.0095 0.0558 0.0776
Schistosoma mansoni notch 0.0074 0.0325 0.0325
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0312 0.2991 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0095 0.0558 0.0558
Echinococcus granulosus Mastin 0.0119 0.0833 0.101
Schistosoma mansoni neuropeptide receptor 0.0095 0.0558 0.0558
Echinococcus granulosus biogenic amine 5HT receptor 0.047 0.4752 0.5762
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0095 0.0558 0.0776
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0386 0.5688
Echinococcus granulosus slit 2 protein 0.0074 0.0325 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1624 0.5428
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0275 0.2574 1
Echinococcus multilocularis orexin receptor type 2 0.0095 0.0558 0.0776
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0205 0.1795 0.1795
Loa Loa (eye worm) hypothetical protein 0.0194 0.1665 0.1665
Echinococcus granulosus sex peptide receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0296 0.2807 1
Onchocerca volvulus 0.0119 0.0833 0.0525
Loa Loa (eye worm) hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0095 0.0558 0.0776
Onchocerca volvulus Putative nachr subunit 0.0108 0.0704 0.0391
Brugia malayi EGF-like domain containing protein 0.0074 0.0325 0.0325
Schistosoma mansoni hypothetical protein 0.0074 0.0325 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.0558 0.0776
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0095 0.0558 0.0676
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Echinococcus multilocularis conserved hypothetical protein 0.0688 0.7188 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.1665 0.1665
Echinococcus multilocularis fmrfamide receptor 0.0095 0.0558 0.0776
Mycobacterium ulcerans hypothetical protein 0.0119 0.0833 0.1404
Loa Loa (eye worm) hypothetical protein 0.0119 0.0833 0.0833
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.0558 0.0676
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0095 0.0558 0.0558
Brugia malayi hypothetical protein 0.0095 0.0558 0.0558
Echinococcus multilocularis Mastin 0.0119 0.0833 0.1159
Brugia malayi Protein kinase domain containing protein 0.0191 0.1636 0.1636
Echinococcus multilocularis g protein coupled receptor 0.0095 0.0558 0.0776
Echinococcus granulosus peptide allatostatin:somatostatin 0.0095 0.0558 0.0676
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0095 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0241 0.2193 0.2193
Schistosoma mansoni notch 0.0074 0.0325 0.0325
Schistosoma mansoni notch 0.0074 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0325 0.0325
Schistosoma mansoni neuropeptide F-like receptor 0.0095 0.0558 0.0558

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 25 nM Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
IC50 (binding) = 25 nM Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
IC50 (binding) = 25 nM Binding affinity to ERbeta ChEMBL. 17459530
IC50 (binding) = 190 nM Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
IC50 (binding) = 190 nM Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
Selectivity (binding) = 8 Selectivity fold for estrogen receptor beta over estrogen receptor alpha ChEMBL. 15456246
Selectivity (binding) = 8 Selectivity fold for estrogen receptor beta over estrogen receptor alpha ChEMBL. 15456246

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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