Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus granulosus | semaphorin 1A | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0366 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.071 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0437 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.5876 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0437 | 0.687 |
Brugia malayi | Plexin repeat family protein | 0.0108 | 0.2552 | 0.2552 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0366 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | plexin | 0.0063 | 0.1247 | 0.1247 |
Schistosoma mansoni | semaphorin 5-related | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1247 | 0.1247 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.071 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0637 | 0.0637 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0136 | 0.336 | 0.3056 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.3538 | 0.3538 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0637 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.3538 | 0.3538 |
Schistosoma mansoni | plexin | 0.0108 | 0.2552 | 0.2552 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.3422 | 0.3422 |
Echinococcus granulosus | semaphorin 5B | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Onchocerca volvulus | 0.0108 | 0.2552 | 1 | |
Onchocerca volvulus | 0.0065 | 0.1315 | 0.4148 | |
Loa Loa (eye worm) | sema domain-containing protein | 0.0045 | 0.0733 | 0.0733 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0045 | 0.0733 | 0.0733 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0637 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0136 | 0.336 | 0.3056 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 0.1315 | 0.1315 |
Brugia malayi | Sema domain containing protein | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.071 | 0.071 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.071 | 0.071 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2552 | 0.2552 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0437 | 0.687 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Brugia malayi | plexin A | 0.0128 | 0.3124 | 0.3124 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0637 | 0.0208 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0437 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1247 | 0.1247 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 0.1315 | 0.1315 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.3538 | 0.3538 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 0.1315 | 0.1315 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0366 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0366 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0366 | 1 | 1 |
Leishmania major | 0.0366 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0437 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.071 | 0.071 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0437 | 0.0437 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0136 | 0.336 | 0.3056 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0437 | 0.687 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0437 | 0.0437 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.071 | 0.071 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0437 | 0.0437 |
Echinococcus multilocularis | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.3538 | 0.3538 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0733 | 0.0733 |
Onchocerca volvulus | 0.0045 | 0.0733 | 0.14 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0437 | 0.687 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0025 | 0.0153 | 0.2853 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0437 | 0.0437 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.1315 | 0.1315 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0437 | 0.0437 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0536 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0637 | 0.0208 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0536 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0366 | 1 | 1 |
Echinococcus granulosus | plexin a4 | 0.0128 | 0.3124 | 0.3124 |
Echinococcus multilocularis | semaphorin 5B | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1315 | 0.1315 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 0.1315 | 0.4148 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.071 | 0.071 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0136 | 0.336 | 0.3056 |
Loa Loa (eye worm) | plexin A | 0.0128 | 0.3124 | 0.3124 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.071 | 0.071 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0025 | 0.0153 | 0.2853 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0136 | 0.336 | 0.3056 |
Brugia malayi | Sema domain containing protein | 0.0045 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0536 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0437 | 0.687 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0437 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0437 | 0.0437 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0437 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0437 | 0.0437 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0437 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0437 | 0.687 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.071 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 0.1315 | 0.1315 |
Echinococcus multilocularis | plexin a4 | 0.0128 | 0.3124 | 0.3124 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 0.005 uM | Binding affinity to the BIR3 domain of X-linked IAP | ChEMBL. | 15317454 |
Kd (binding) | = 0.24 uM | Relief of caspase inhibition in reconstituted assay (APAF-1, caspase-9, procaspase-3) with BIR3 domain of XIAP | ChEMBL. | 15317454 |
Kd (binding) | = 0.71 uM | Relief of caspase inhibition in reconstituted assay (APAF-1, caspase-9, procaspase-3) with XIAP | ChEMBL. | 15317454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.