Detailed information for compound 328817

Basic information

Technical information
  • TDR Targets ID: 328817
  • Name: sodium 2-[(2,2,3,3-tetramethylcyclopropanecar bonyl)amino]ethanesulfonate
  • MW: 271.309 | Formula: C10H18NNaO4S
  • H donors: 1 H acceptors: 4 LogP: 0.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1C(C1(C)C)(C)C)NCCS(=O)(=O)[O-].[Na+]
  • InChi: 1S/C10H19NO4S.Na/c1-9(2)7(10(9,3)4)8(12)11-5-6-16(13,14)15;/h7H,5-6H2,1-4H3,(H,11,12)(H,13,14,15);/q;+1/p-1
  • InChiKey: LGKFZMHXVWCWFZ-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • sodium 2-[[oxo-(2,2,3,3-tetramethylcyclopropyl)methyl]amino]ethanesulfonate
  • sodium 2-[(2,2,3,3-tetramethylcyclopropyl)carbonylamino]ethanesulfonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0545 0.0623
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0383 0.0547
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0624 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0241 0.0946
Plasmodium falciparum glutathione reductase 0.0095 0.2551 1
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.2551 1
Leishmania major trypanothione reductase 0.0095 0.2551 1
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.2551 0.3546
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.691 0.8837
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0383 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Brugia malayi Pre-SET motif family protein 0.0212 0.6758 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0241 0.0946
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.2492 0.9735
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.1355 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.7776 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0328 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Schistosoma mansoni hypothetical protein 0.0167 0.5147 0.5028
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.037 0.0199
Giardia lamblia DINP protein human, muc B family 0.0041 0.0624 0.1372
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.1562 0.1355
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.7776 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0328 0.1284
Echinococcus granulosus dna polymerase kappa 0.0062 0.1355 0.2336
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.037 0.0056
Echinococcus multilocularis geminin 0.0167 0.5147 1
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.2551 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.7776 1
Trypanosoma brucei trypanothione reductase 0.0095 0.2551 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.2492 0.3674
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.691 0.8837
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0383 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.1355 0.4623
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1562 0.6123
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.1562 0.2754
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0341 0.1336
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0328 0.1284
Schistosoma mansoni rotamase 0.0034 0.037 0.0133
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0328 0.0179
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0328 0.5
Brugia malayi Thioredoxin reductase 0.0095 0.2551 0.3762
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0383 0.0371
Echinococcus granulosus expressed protein 0.0034 0.037 0.0344
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0341 0.006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0328 0.009
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0341 0.0437
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0328 0.0379
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.1562 0.2295
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.1355 0.1374
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.1562 0.5552
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Trypanosoma brucei unspecified product 0.0055 0.1114 0.4368
Loa Loa (eye worm) glutathione reductase 0.0095 0.2551 0.3546
Brugia malayi polk-prov protein 0.0038 0.0504 0.0726
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.0383 0.1502
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.2551 0.471
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0328 0.1284
Echinococcus multilocularis expressed protein 0.0034 0.037 0.0264
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0383 0.0292
Trypanosoma brucei polo-like protein kinase 0.0093 0.2492 0.9769
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0383 0.0147
Treponema pallidum NADH oxidase 0.0033 0.0328 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0383 0.0075
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.037 0.0527
Trichomonas vaginalis set domain proteins, putative 0.0242 0.7809 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.2492 1
Brugia malayi hypothetical protein 0.0149 0.4498 0.6648
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.2551 0.2985
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0328 0.0379
Giardia lamblia Kinase, PLK 0.0093 0.2492 1
Schistosoma mansoni DNA polymerase eta 0.0034 0.0383 0.0147
Echinococcus multilocularis dna polymerase eta 0.0034 0.0383 0.0292
Onchocerca volvulus 0.0149 0.4498 0.5625
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0328 0.5
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.2492 0.459
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0341 0.006
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.1355 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0328 0.0379
Schistosoma mansoni hypothetical protein 0.0167 0.5147 0.5028
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0504 0.1975
Echinococcus granulosus geminin 0.0167 0.5147 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0804 0.0636
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Loa Loa (eye worm) hypothetical protein 0.0149 0.4498 0.6532
Mycobacterium tuberculosis Probable reductase 0.0217 0.691 0.8837
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.1562 0.5676
Onchocerca volvulus 0.0242 0.7809 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0804 0.0636
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.2492 0.3456
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0241 0.0946
Leishmania major DNA polymerase eta, putative 0.0034 0.0383 0.025
Toxoplasma gondii thioredoxin reductase 0.0095 0.2551 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0383 0.025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.1355 0.4623
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.6758 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0328 0.0379
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.1355 0.1374
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1562 0.5552
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.691 0.8837
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.2551 0.4753
Brugia malayi glutathione reductase 0.0095 0.2551 0.3762
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2492 0.9735
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2492 0.9735
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0383 0.0147
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0383 0.0547
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.024 0.0081
Plasmodium falciparum thioredoxin reductase 0.0095 0.2551 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0624 0.2448
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.691 0.8837
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.2492 0.2976
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0328 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Echinococcus multilocularis dna polymerase kappa 0.0062 0.1355 0.2274
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0545 0.0699
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.1355 0.5313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.1355 0.4623
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.2492 0.4634
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.1562 0.2028
Leishmania major DNA polymerase kappa, putative 0.0041 0.0624 0.1335
Schistosoma mansoni kinase 0.0047 0.0848 0.0623
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.691 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.7776 1
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.1355 0.5313
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.2492 0.2308
Trichomonas vaginalis rotamase, putative 0.0033 0.0341 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0328 0.1284
Plasmodium vivax glutathione reductase, putative 0.0095 0.2551 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0624 0.1335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.1355 0.4623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0504 0.0405
Brugia malayi Pre-SET motif family protein 0.003 0.024 0.0334
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.1562 0.2694
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2492 0.2893
Loa Loa (eye worm) hypothetical protein 0.0034 0.0383 0.022
Trichomonas vaginalis rotamase, putative 0.0034 0.037 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1355 0.5313
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0504 0.1975
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0328 0.0258
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0341 0.006
Echinococcus granulosus dna polymerase eta 0.0034 0.0383 0.0371
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.1114 0.4368
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1562 0.5552

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 30 mg/kg; 0/2= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 15 min in rats; - means No protection ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 30 min in rats; -means No protection ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 1 hr in rats; -means No protection ChEMBL. 15294003
Activity (functional) 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 2 hr in rats; + means 25% of the animals protected ChEMBL. 15294003
Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 4 hr in rats; -means No protection ChEMBL. 15294003
Activity (functional) - 0 Toxicity of the compound after oral administration of 100 mg/kg dose in rats; + means 25% of the animals were protected ChEMBL. 15294003
Activity (functional) 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 30 min in rats; +++ means 75% of the animals protected ChEMBL. 15294003
Activity (functional) 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 1 hr in rats; + means 25% of the animals protected ChEMBL. 15294003
Activity (functional) 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 4 hr in rats; +means 25% of the animals protected ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 30 mg/kg; 0/2= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Activity (functional) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested ChEMBL. 15294003
Anticonvulsant Activity (functional) - 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 15 min in rats; - means No protection ChEMBL. 15294003
Anticonvulsant Activity (functional) 0 Anticonvulsant activity of the compound after oral administration of 100 mg/kg dose after 2 hr in rats;++ means 50% of the animals protected ChEMBL. 15294003
clogP = 0.88 Calculated partition coefficient (clogP) ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 100 mg/kg; 0/8= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 100 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 300 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 300 mg/kg; 0/2= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) - 0 Toxicity of the compound after oral administration of 100 mg/kg dose in rats; - means No toxicity ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 30 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003
Toxicity (ADMET) = 0 Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 30 mg/kg; 0/2= No of animals exhibiting toxicity /No of animals tested ChEMBL. 15294003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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