Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | 3-dehydroquinase | Get druggable targets OG5_132746 | All targets in OG5_132746 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | Get druggable targets OG5_132746 | All targets in OG5_132746 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | Get druggable targets OG5_132746 | All targets in OG5_132746 |
Candida albicans | 3-dehydroquinate dehydratase | Get druggable targets OG5_132746 | All targets in OG5_132746 |
Mycobacterium leprae | 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) | Get druggable targets OG5_132746 | All targets in OG5_132746 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Possible alanine rich transferase | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 147 aa | 148 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0297 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0042 | 0.6513 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0042 | 0.2364 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0179 | 0.6031 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0042 | 0.2364 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0297 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0179 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0297 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0179 | 0.6031 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1429 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0042 | 0.6513 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0065 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0065 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0065 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0065 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0297 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0065 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0065 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0042 | 0.6513 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0065 | 0.3629 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0065 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0042 | 0.1426 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0065 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0065 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0042 | 0.1426 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0065 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1429 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0065 | 0.2189 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0042 | 0.6513 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0042 | 0.1426 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0065 | 0.3629 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0042 | 0.2364 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0065 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0042 | 0.6513 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0042 | 0.2364 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0065 | 0.2189 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0065 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0042 | 0.6513 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0042 | 0.1426 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0065 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2125 nM | Inhibition of Mycobacterium tuberculosis type II dehydroquinase at 25 degree C pH 8.2 | ChEMBL. | 16033267 |
Ki (binding) | = 2125 nM | Inhibition of Mycobacterium tuberculosis type II dehydroquinase at 25 degree C pH 8.2 | ChEMBL. | 16033267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.