Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0073 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0073 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0073 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0073 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0073 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0073 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0073 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0073 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0073 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0073 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0073 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0073 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0036 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0064 | 0.7743 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0073 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0037 | 0.0151 | 0.0151 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0045 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0073 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0045 | 0.2407 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0073 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0064 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0073 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0073 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 32 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
EC50 (functional) | = 32 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.