Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Estrogen receptor alpha | Starlite/ChEMBL | References |
Rattus norvegicus | Estrogen receptor beta | Starlite/ChEMBL | References |
Mus musculus | estrogen receptor 1 (alpha) | Starlite/ChEMBL | References |
Mus musculus | estrogen receptor 2 (beta) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Estrogen receptor beta | 530 aa | 430 aa | 24.9 % | |
Schistosoma mansoni | retinoic acid receptor RXR | Estrogen receptor beta | 530 aa | 451 aa | 25.5 % |
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0049 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.5 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0049 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0049 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0049 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0049 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0049 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0049 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0049 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.9 | Effect of combination of compound and PPT on rat vasomotor instability in terms of tail skin temperature change 15 min after naloxone injection | ChEMBL. | 15456246 |
Activity (functional) | = 5.3 | Effect of compound (15 mg/kg) on rat vasomotor instability in terms of tail skin temperature change 15 min after naloxone injection | ChEMBL. | 15456246 |
Density (functional) | = 287.56 mg/cm3 | Trabecular bone mineral density in ovariectomized rat when treated with compound at 10 mg/kg dose | ChEMBL. | 15456246 |
Density (functional) | = 491.43 mg/cm3 | Trabecular bone mineral density in ovariectomized rat when treated with combination of compound (10 mg/kg) and estradiol (2 ug/rat) | ChEMBL. | 15456246 |
Density (functional) | = 525.51 mg/cm3 | Total bone mineral density in ovariectomized rat when treated with compound at 10 mg/kg dose | ChEMBL. | 15456246 |
Density (functional) | = 682.41 mg/cm3 | Total bone mineral density in ovariectomized rat when treated with combination of compound (10 mg/kg) and estradiol (2 ug/rat) | ChEMBL. | 15456246 |
IC50 (binding) | = 1.2 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 1.2 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 1.4 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
IC50 (binding) | = 1.7 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 1.7 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 2 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 2 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 2 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
IC50 (binding) | = 132 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 132 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 132 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 132 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 155 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 155 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
Selectivity (binding) | = 68 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 78 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 109 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 68 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 78 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 109 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Weight (functional) | = 13.1 mg | Weight of mouse uterine when treated with compound at 50 mg/kg dose was determined | ChEMBL. | 15456246 |
Weight (functional) | = 13.1 mg | Weight of mouse uterine when treated with compound at 50 mg/kg dose was determined | ChEMBL. | 15456246 |
Weight (functional) | = 39.2 mg | Weight of rat uterine when treated with compound at 2 mg dose was determined | ChEMBL. | 15456246 |
Weight (functional) | = 95.9 mg | Weight of rat uterine when treated with combination of compound and Ethynyl estradiol was determined | ChEMBL. | 15456246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.