Detailed information for compound 329256

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.139 | Formula: C15H9BrFNO3
  • H donors: 2 H acceptors: 3 LogP: 3.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Br/C=C\c1cc(O)cc2c1oc(n2)c1ccc(cc1F)O
  • InChi: 1S/C15H9BrFNO3/c16-4-3-8-5-10(20)7-13-14(8)21-15(18-13)11-2-1-9(19)6-12(11)17/h1-7,19-20H/b4-3-
  • InChiKey: XOEIPMPQNNQRFN-ARJAWSKDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0028 0.012 0.0123
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0085 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.018 0.1323
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0123 0.1121 0.1121
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0315 0.315 0.315
Brugia malayi SH2 domain containing protein 0.0027 0.0113 0.0116
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0088 0.0477
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0021 0.005 0.0052
Onchocerca volvulus 0.0021 0.005 0.0155
Mycobacterium leprae Probable adenosine kinase adk 0.0042 0.0266 0.1438
Echinococcus multilocularis expressed conserved protein 0.0103 0.0916 0.0938
Echinococcus multilocularis SHC transforming protein 3 0.0021 0.005 0.0052
Loa Loa (eye worm) hypothetical protein 0.0089 0.0767 0.0992
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0184 0.0627
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0028 0.012 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0021 0.005 0.0065
Echinococcus granulosus c src tyrosine kinase 0.003 0.0148 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0183 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0266 0.0344
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0315 0.315 0.3201
Schistosoma mansoni tyrosine kinase 0.003 0.0148 0.0148
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.012 0.023
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.012 0.023
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0324 0.0332
Echinococcus multilocularis tyrosine protein kinase Src64B 0.003 0.0148 0.0151
Schistosoma mansoni hypothetical protein 0.0045 0.0306 0.0306
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0226 0.0519
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.018 0.5
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.018 0.1306
Schistosoma mansoni suppressor of cytokine signaling 0.0021 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0049 0.0348 0.0348
Echinococcus granulosus SH2 domain containing adapter protein F 0.0021 0.005 0.0052
Giardia lamblia Phosphatidylinositol 4-kinase 0.0028 0.012 0.0183
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0028 0.012 0.023
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0021 0.005 0.0052
Echinococcus granulosus GPCR family 2 0.0028 0.0124 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Trypanosoma cruzi adenosine kinase, putative 0.0042 0.0266 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Brugia malayi Muscleblind-like protein 0.0127 0.1166 0.1195
Echinococcus granulosus tyrosine protein kinase Srms 0.0027 0.0113 0.0116
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0123 0.1121 0.1115
Schistosoma mansoni microsomal glutathione s-transferase 0.0221 0.2158 0.2158
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.012 0.0156
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0161 0.0165
Schistosoma mansoni patched 1 0.0047 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0061 0.047 0.0608
Loa Loa (eye worm) hypothetical protein 0.0061 0.0469 0.0607
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0226 0.0231
Echinococcus granulosus tyrosine protein kinase shark 0.0784 0.8098 0.8295
Echinococcus granulosus tyrosine protein kinase Src42A 0.003 0.0148 0.0151
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.0195
Schistosoma mansoni nck2/grb4 0.0025 0.0085 0.0085
Echinococcus granulosus tensin 0.0021 0.005 0.0052
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0027 0.0113 0.0079
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0148 0.0151
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0021 0.005 0.0052
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.012 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.018 0.0148
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0124 0.0127
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0849 0.0869
Echinococcus multilocularis SH2 motif 0.0021 0.005 0.0052
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0021 0.005 0.0052
Echinococcus multilocularis tensin 0.0021 0.005 0.0052
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0123 0.1121 0.1148
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.0086
Entamoeba histolytica hypothetical protein 0.0028 0.012 0.0086
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0483 0.1224
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0123 0.1121 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0366 0.3689 0.477
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.1135 1
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.012 0.0775
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.1135 0.1468
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.011 0.0986 0.1275
Leishmania major putative PfkB family sugar kinase 0.0042 0.0266 0.063
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0027 0.0113 0.0116
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0123 0.1121 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0148 0.0151
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0028 0.012 0.023
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0123 0.1121 0.1121
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.1135 0.1163
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0042 0.0266 0.0236
Echinococcus granulosus tyrosine kinase 0.0027 0.0113 0.0116
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0941 0.9763 1
Entamoeba histolytica kinase, PfkB family 0.0042 0.0266 0.0236
Echinococcus multilocularis 0.0028 0.012 0.0123
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0088 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0941 0.9763 1
Brugia malayi hypothetical protein 0.0242 0.2385 0.2443
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.003 0.0148 0.0151
Onchocerca volvulus Putative pyridoxal kinase 0.0042 0.0266 0.082
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0941 0.9763 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123
Echinococcus granulosus NCK adaptor protein 0.0025 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0032 0.0161 0.0208
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0028 0.012 0.023
Echinococcus multilocularis tensin 0.0021 0.005 0.0052
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.1484 0.152
Brugia malayi 6-phosphofructokinase 0.0124 0.1135 0.1163
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.018 0.1323
Loa Loa (eye worm) phosphofructokinase 0.0124 0.1135 0.1468
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.1135 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2162 0.2796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0028 0.012 0.012
Schistosoma mansoni tyrosine kinase 0.003 0.0148 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0266 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) SRC-1 0.003 0.0148 0.0191
Onchocerca volvulus 0.0028 0.012 0.037
Leishmania major tagatose-6-phosphate kinase-like protein 0.0042 0.0266 0.063
Brugia malayi N-terminal motif family protein 0.0185 0.1781 0.1824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Entamoeba histolytica protein kinase, putative 0.0021 0.005 0.0014
Schistosoma mansoni hypothetical protein 0.033 0.3308 0.3308
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0021 0.005 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1135 0.113
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0392 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1135 0.113
Schistosoma mansoni ap endonuclease 0.002 0.0036 0.0036
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0392 0.0392
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0483 0.1224
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0941 0.9763 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.047 0.0482
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0028 0.012 0.0086
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0028 0.012 0.023
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0025 0.0085 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Loa Loa (eye worm) hypothetical protein 0.061 0.6262 0.8097
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0021 0.005 0.0155
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0088 0.0477
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0483 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0324 0.0296
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.1135 0.3008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0027 0.0113 0.0116
Onchocerca volvulus 0.0027 0.0113 0.0349
Schistosoma mansoni tensin 0.0021 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0849 0.0849
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0148 0.0151
Echinococcus granulosus signal transduction protein lnk realted 0.0021 0.005 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.0161
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0183 0.0183
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.047 0.0482
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.0146
Brugia malayi Adenosine kinase-like 0.0366 0.3689 0.3778
Onchocerca volvulus Ribokinase homolog 0.0042 0.0266 0.082
Schistosoma mansoni tyrosine kinase 0.003 0.0148 0.0148
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0021 0.005 0.0065
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.2385 0.2443
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.012 0.0765
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0392 0.0401
Loa Loa (eye worm) SH2 domain-containing protein 0.0021 0.005 0.0065
Schistosoma mansoni hypothetical protein 0.0045 0.0306 0.0306
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0045 0.0306 0.0306
Brugia malayi cytokine inducible SH2-containing protein 5 0.0021 0.005 0.0052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0161 0.0342
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123
Echinococcus granulosus SHC transforming protein 3 0.0021 0.005 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0647 0.6651 0.6801
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1135 0.113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0226 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.0767 0.0992
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0123 0.1121 0.1115
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0028 0.012 0.023
Schistosoma mansoni growth factor receptor-bound protein 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0324 0.3249 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0021 0.005 0.0052
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0123 0.1121 0.1148
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0123 0.1121 0.1449
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0021 0.005 0.0052
Echinococcus multilocularis tyrosine protein kinase Src42A 0.003 0.0148 0.0151
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.023
Echinococcus granulosus tyrosine protein kinase ABL1 0.0258 0.2544 0.2606
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0021 0.005 0.0065
Brugia malayi Protein kinase domain containing protein 0.0027 0.0113 0.0116
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.2098 0.2149
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.018 0.0313
Trichomonas vaginalis ribokinase, putative 0.0042 0.0266 0.0236
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.1135 0.1468
Schistosoma mansoni inositol monophosphatase 0.0038 0.0226 0.0226
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0161 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.012 0.0156
Echinococcus granulosus tyrosine kinase 0.0027 0.0113 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0021 0.005 0.0052
Echinococcus multilocularis GPCR, family 2 0.0028 0.0124 0.0127
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0042 0.0266 0.0273
Schistosoma mansoni adapter molecule crk 0.0025 0.0085 0.0085
Schistosoma mansoni tyrosine kinase 0.0784 0.8098 0.8098
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.061 0.6262 0.6414
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0123 0.1121 0.1115
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.1135 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0392 0.0392
Echinococcus granulosus microsomal glutathione S transferase 3 0.0221 0.2158 0.221
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0028 0.012 0.012
Leishmania major adenosine kinase, putative 0.0366 0.3689 1
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.1484 0.152
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0315 0.315 0.3201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.0195
Leishmania major phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0266 0.0236
Onchocerca volvulus 0.0028 0.012 0.037
Onchocerca volvulus 0.0049 0.0348 0.1071
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0148 0.0151
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0221 0.2158 0.221
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.1135 0.1163
Loa Loa (eye worm) hypothetical protein 0.0127 0.1166 0.1508
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Brugia malayi phosphofructokinase 0.0124 0.1135 0.1163
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.1135 0.113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Brugia malayi Protein kinase domain containing protein 0.0027 0.0113 0.0116
Onchocerca volvulus 0.0027 0.0113 0.0349
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0156
Echinococcus multilocularis tyrosine protein kinase Blk 0.0027 0.0113 0.0116
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.003 0.0148 0.0151
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.0775
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.2385 0.2443
Trypanosoma brucei adenosine kinase, putative 0.0366 0.3689 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0849 0.0869
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0849 0.1097
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Schistosoma mansoni ap endonuclease 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0021 0.005 0.0052
Schistosoma mansoni hypothetical protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.1004 0.1004
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0483 0.0483
Trypanosoma cruzi adenosine kinase, putative 0.0366 0.3689 0.3755
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.047 0.0482
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0941 0.9763 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0025 0.0085 0.0087
Schistosoma mansoni inositol monophosphatase 0.0038 0.0226 0.0226
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0123 0.1121 0.2969
Brugia malayi Tyrosine-protein kinase abl-1 0.0119 0.1077 0.1104
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0088 0.009
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0124 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.0767 0.0786
Trichomonas vaginalis set domain proteins, putative 0.0252 0.2485 0.2518
Onchocerca volvulus 0.0027 0.0113 0.0349
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0483 0.4068
Schistosoma mansoni vav2 0.0021 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0021 0.005 0.0052
Schistosoma mansoni tensin-related 0.0021 0.005 0.005
Schistosoma mansoni suppressor of cytokine signaling 0.0021 0.005 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Onchocerca volvulus 0.0021 0.005 0.0155
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0021 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0849 0.0849
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.0086
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.012 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0986 0.101
Onchocerca volvulus 0.0021 0.005 0.0155
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0315 0.315 0.3201
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0088 0.0142
Schistosoma mansoni hypothetical protein 0.0021 0.005 0.005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0028 0.012 0.0123
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0392 0.1206
Onchocerca volvulus 0.0021 0.005 0.0155
Loa Loa (eye worm) TK protein kinase 0.0027 0.0113 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0028 0.012 0.0086
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.018 0.5
Loa Loa (eye worm) hypothetical protein 0.0332 0.3327 0.4302
Schistosoma mansoni hypothetical protein 0.0034 0.0183 0.0183
Brugia malayi hypothetical protein 0.0027 0.0113 0.0116
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0123 0.1121 0.1115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0483 0.4068
Brugia malayi mbt repeat family protein 0.0054 0.0392 0.0401
Schistosoma mansoni hypothetical protein 0.0028 0.0124 0.0124
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.012 0.0775
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.012 0.0156
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0348 0.0357
Schistosoma mansoni survival motor neuron protein 0.0049 0.0348 0.0348
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0036 0.0037
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0028 0.012 0.0086
Entamoeba histolytica SH2 domain containing protein 0.0021 0.005 0.0014
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.0519
Brugia malayi CHE-14 protein 0.0047 0.0324 0.0332
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0028 0.012 0.0123
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0986 0.101
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0021 0.005 0.005
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0258 0.2544 0.2606
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0986 0.101
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0124 0.0127
Loa Loa (eye worm) TK/ABL protein kinase 0.0258 0.2544 0.329
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0028 0.012 0.023
Trichomonas vaginalis ribokinase, putative 0.0042 0.0266 0.0236
Echinococcus granulosus N chimaerin 0.0021 0.005 0.0052
Brugia malayi SRC-1 0.003 0.0148 0.0151
Trypanosoma cruzi ribokinase, putative 0.0042 0.0266 0.0236
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0183 0.0187
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.047 0.0482
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0028 0.012 0.0086
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.018 0.1323
Trypanosoma cruzi adenosine kinase, putative 0.0042 0.0266 0.0236
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0123 0.1121 0.1148
Leishmania major hypothetical protein, unknown function 0.0028 0.012 0.023
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.018 0.0393
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0148 0.0151
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.061 0.6262 0.6414
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0028 0.012 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Echinococcus granulosus tyrosine protein kinase Blk 0.0027 0.0113 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Entamoeba histolytica hypothetical protein 0.0028 0.012 0.0086
Echinococcus multilocularis SH2 motif 0.0021 0.005 0.0052
Echinococcus granulosus suppressor of cytokine signaling 7 0.0021 0.005 0.0052
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.012 0.0123
Onchocerca volvulus 0.0021 0.005 0.0155
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0028 0.012 0.0086
Plasmodium vivax hypothetical protein 0.0028 0.012 0.0775
Echinococcus multilocularis SH2 domain containing protein 7 0.0021 0.005 0.0052
Toxoplasma gondii kinase, pfkB family protein 0.0366 0.3689 1
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.0469 0.0481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0849 0.0869
Loa Loa (eye worm) hypothetical protein 0.0127 0.1166 0.1508
Trypanosoma brucei ribokinase, putative 0.0042 0.0266 0.063
Schistosoma mansoni tensin 0.0021 0.005 0.005
Schistosoma mansoni tyrosine kinase 0.0236 0.232 0.232
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.003 0.0148 0.0151
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0025 0.0085 0.011
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0042 0.0266 0.2093
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0036 0.0037
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0021 0.005 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0315 0.315 0.3201
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.012 0.0123
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0124 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Leishmania major phosphatidylinositol 3-kinase, putative 0.0123 0.1121 0.2969
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0749 0.7733 0.7913
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0028 0.012 0.023
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0324 0.0332
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.012 0.0123
Echinococcus granulosus tyrosine protein kinase Src42A 0.0021 0.005 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.003 0.0148 0.0151
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0088 0.0142
Entamoeba histolytica hypothetical protein 0.0028 0.012 0.0086
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0647 0.6651 0.6801
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.047 0.047
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.023
Schistosoma mansoni ribokinase 0.0042 0.0266 0.0266
Schistosoma mansoni adenosine kinase 0.0366 0.3689 0.3689
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0184 0.1344
Echinococcus granulosus hypothetical protein 0.0021 0.005 0.0052
Echinococcus granulosus SH2 motif 0.0021 0.005 0.0052
Echinococcus multilocularis N chimaerin 0.0021 0.005 0.0052
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0941 0.9763 1
Schistosoma mansoni signal transduction protein lnk-related 0.0021 0.005 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.1121 0.2969
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.2098 0.2149
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Brugia malayi Pre-SET motif family protein 0.0221 0.2162 0.2215
Entamoeba histolytica ribokinase, putative 0.0042 0.0266 0.0236
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.012 0.0156
Mycobacterium tuberculosis Adenosine kinase 0.0042 0.0266 0.2093
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.012 0.0086
Leishmania major hypothetical protein, conserved 0.0028 0.012 0.023
Loa Loa (eye worm) SH2 domain-containing protein 0.0021 0.005 0.0065
Echinococcus granulosus ribokinase 0.0042 0.0266 0.0273
Giardia lamblia Ribokinase 0.0042 0.0266 0.0502
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.012 0.012
Brugia malayi Tensin 0.0021 0.005 0.0052
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0028 0.012 0.012
Schistosoma mansoni adenosine kinase 0.0366 0.3689 0.3689
Trypanosoma brucei adenosine kinase, putative 0.0366 0.3689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus multilocularis tyrosine protein kinase Abl 0.0119 0.1077 0.1104
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.012 0.0086
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.018 0.1323
Trypanosoma cruzi target of rapamycin kinase 3 0.0028 0.012 0.0086
Schistosoma mansoni hypothetical protein 0.0028 0.0124 0.0124
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0242 0.2385 0.3084
Echinococcus multilocularis NCK adaptor protein 0.0025 0.0085 0.0087
Mycobacterium ulcerans fructokinase, PfkB 0.0042 0.0266 0.2093
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0986 0.0977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Onchocerca volvulus 0.0027 0.0113 0.0349
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.018 0.0393
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0226 0.1725
Echinococcus granulosus muscleblind protein 0.0127 0.1166 0.1195
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0417 0.4232 0.4314
Trypanosoma brucei ribokinase, putative 0.0042 0.0266 0.063
Trichomonas vaginalis chaperonin, putative 0.0025 0.0088 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0324 0.0332
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0324 0.0419
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0483 0.0495
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0156
Plasmodium vivax SET domain protein, putative 0.0032 0.0161 0.1153
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.003 0.0148 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0021 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0047 0.0324 0.0419
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0483 0.0483
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0226 0.0195
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0315 0.315 0.8525
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0025 0.0085 0.0085
Brugia malayi mbt repeat family protein 0.0054 0.0392 0.0401
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0028 0.012 0.0123
Echinococcus multilocularis tyrosine protein kinase Fgr 0.003 0.0148 0.0151
Onchocerca volvulus 0.0252 0.2485 0.765
Onchocerca volvulus 0.0032 0.0161 0.0496
Entamoeba histolytica hypothetical protein 0.0034 0.0183 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.061 0.6262 0.6414
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0161 0.0165
Leishmania major adenosine kinase-like protein 0.0042 0.0266 0.063
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0042 0.0266 0.0236
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0315 0.315 0.3201
Schistosoma mansoni tyrosine kinase 0.0762 0.7874 0.7874
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0028 0.012 0.023
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.018 0.0393
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1135 0.113
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.1135 0.1135
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0315 0.315 0.3201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.0767 0.0786
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0124 0.016
Leishmania major tagatose-6-phosphate kinase-like protein 0.0042 0.0266 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0094 0.0818 0.1058
Brugia malayi protein-tyrosine kinase 0.0027 0.0113 0.0116
Loa Loa (eye worm) phosphatidylinositol 3 0.0287 0.2856 0.3693
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0123 0.1121 0.1115
Brugia malayi STAT protein, DNA binding domain containing protein 0.0021 0.005 0.0052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0149 0.0153
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0028 0.012 0.0086
Echinococcus multilocularis muscleblind protein 0.0127 0.1166 0.1195
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.018 0.0148
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0392 0.0401
Echinococcus multilocularis 0.0021 0.005 0.0052
Leishmania major ribokinase, putative 0.0042 0.0266 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0028 0.012 0.0086
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.0519
Echinococcus multilocularis SH2 motif 0.0021 0.005 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0161 0.0161
Echinococcus granulosus serine protein kinase ATM 0.0028 0.012 0.0123
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0028 0.012 0.0123
Entamoeba histolytica hypothetical protein 0.0749 0.7733 0.7913
Brugia malayi Protein kinase domain containing protein 0.0027 0.0113 0.0116
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0148 0.0151
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0156
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.022 0.215 0.461
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0148 0.0151
Schistosoma mansoni tyrosine kinase 0.0027 0.0113 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Mycobacterium tuberculosis Ribokinase RbsK 0.0042 0.0266 0.2093
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0028 0.012 0.023
Schistosoma mansoni hypothetical protein 0.0045 0.0306 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.012 0.0086
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0088 0.0088
Brugia malayi Sex muscle abnormal protein 5 0.0025 0.0085 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Entamoeba histolytica hypothetical protein 0.0034 0.0183 0.015
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.1781 0.5483
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0124 0.016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0028 0.012 0.0086
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.1135 0.113
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0226 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus multilocularis muscleblind protein 1 0.0127 0.1166 0.1195
Loa Loa (eye worm) inositol-1 0.0038 0.0226 0.0292
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.018 0.0148
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0021 0.005 0.0052
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0021 0.005 0.0065
Brugia malayi 6-phosphofructokinase 0.0124 0.1135 0.1163
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0036 0.0037
Trypanosoma cruzi adenosine kinase, putative 0.0366 0.3689 0.3755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0042 0.0266 0.2093
Toxoplasma gondii MAPEG family protein 0.0221 0.2158 0.5808
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0226 0.0195
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.047 0.0482
Entamoeba histolytica fructokinase, putative 0.0042 0.0266 0.0236
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.012 0.0156
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0088 0.0113
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0028 0.012 0.0775
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0027 0.0113 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0185 0.1781 0.2303
Echinococcus multilocularis tyrosine protein kinase Srms 0.0027 0.0113 0.0116
Echinococcus multilocularis signal transduction protein lnk realted 0.0021 0.005 0.0052
Echinococcus granulosus tyrosine protein kinase Lyn 0.003 0.0148 0.0151
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0088 0.0142
Echinococcus multilocularis adenosine kinase 0.0366 0.3689 0.3778
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.012 0.0156
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0148 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Toxoplasma gondii FATC domain-containing protein 0.0028 0.012 0.023
Brugia malayi Pre-SET motif family protein 0.0032 0.0161 0.0165
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0392 0.0401
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.1135 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0142 0.1328 0.136
Leishmania major phosphatidylinositol kinase, putative 0.0028 0.012 0.023
Schistosoma mansoni shc transforming protein 0.0021 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0363 0.3659 0.3659
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0483 0.4068
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.003 0.0148 0.0151
Brugia malayi Ribokinase 0.0042 0.0266 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0085 0.0087
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0088 0.0053
Schistosoma mansoni tyrosine kinase 0.003 0.0148 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0849 0.0869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0088 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123
Schistosoma mansoni growth factor receptor-bound protein 0.0025 0.0085 0.0085
Echinococcus granulosus SH2 motif 0.0021 0.005 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus multilocularis tyrosine protein kinase shark 0.0784 0.8098 0.8295
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.012 0.0086
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0088 0.009
Brugia malayi Variant SH3 domain containing protein 0.0021 0.005 0.0052
Brugia malayi hypothetical protein 0.0021 0.005 0.0052
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0454 0.4621 1
Brugia malayi SH2 domain containing protein 0.0021 0.005 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0849 0.0869
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Schistosoma mansoni tensin 0.0021 0.005 0.005
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0226 0.0231
Schistosoma mansoni hypothetical protein 0.0028 0.012 0.012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0028 0.012 0.0086
Echinococcus granulosus SH2 domain containing protein 7 0.0021 0.005 0.0052
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0021 0.005 0.0052
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0123 0.1121 0.1148
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0021 0.005 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.018 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0028 0.012 0.0775
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0941 0.9763 0.9763
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.1135 0.1135
Echinococcus granulosus geminin 0.0363 0.3659 0.3748
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.011
Echinococcus granulosus expressed conserved protein 0.0021 0.005 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0941 0.9763 1
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.1135 0.113
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0021 0.005 0.0052
Echinococcus granulosus tyrosine protein kinase Src64B 0.003 0.0148 0.0151
Echinococcus multilocularis Zinc finger, PHD finger 0.0123 0.1121 0.1148
Brugia malayi Protein kinase domain containing protein 0.0027 0.0113 0.0116
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0226 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0021 0.005 0.0052
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.1135 0.3008
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0021 0.005 0.0014
Echinococcus multilocularis ribokinase 0.0042 0.0266 0.0273
Onchocerca volvulus 0.0021 0.005 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0315 0.315 0.3227
Onchocerca volvulus 0.0027 0.0113 0.0349
Echinococcus multilocularis protein dispatched 1 0.0054 0.0394 0.0404
Entamoeba histolytica hypothetical protein 0.0028 0.012 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.018 0.0148
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.012 0.023
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0123 0.1121 0.1115
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0028 0.012 0.0086
Brugia malayi hypothetical protein 0.0042 0.0266 0.0273
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.012 0.0123
Schistosoma mansoni GTPase activating protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0392 0.0507
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0941 0.9763 1
Entamoeba histolytica hypothetical protein 0.0034 0.0183 0.015
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.018 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.018 0.0148
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0028 0.012 0.012
Leishmania major phosphatidylinositol 3-kinase, putative 0.0028 0.012 0.023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.1121 0.1115
Leishmania major phosphatidylinositol kinase related protein, putative 0.0028 0.012 0.023
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0392 0.0507
Trichomonas vaginalis ribokinase, putative 0.0042 0.0266 0.0236
Onchocerca volvulus 0.0027 0.0113 0.0349
Brugia malayi Protein kinase domain containing protein 0.0027 0.0113 0.0116
Echinococcus granulosus expressed conserved protein 0.0103 0.0916 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0042 0.0266 0.0273
Schistosoma mansoni tensin-related 0.0021 0.005 0.005
Echinococcus multilocularis geminin 0.0363 0.3659 0.3748
Loa Loa (eye worm) MBCTL1 0.0061 0.047 0.0608
Toxoplasma gondii kinase, pfkB family protein 0.0042 0.0266 0.063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.0161
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.012 0.0123
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0027 0.0113 0.0116
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0028 0.012 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.018 0.0148
Leishmania major adenosine kinase-like protein 0.0042 0.0266 0.063
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0914 0.9469 0.9698
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0028 0.012 0.0086
Schistosoma mansoni hypothetical protein 0.0061 0.0469 0.0469
Onchocerca volvulus 0.0054 0.0392 0.1206
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0483 0.4068
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0123 0.1121 0.2969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0088 0.0053
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0287 0.2856 0.2899
Echinococcus multilocularis tyrosine kinase 0.0027 0.0113 0.0116
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0028 0.012 0.0123
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0392 0.0401
Loa Loa (eye worm) STAT protein 0.0021 0.005 0.0065
Brugia malayi SH2 domain containing protein 0.0027 0.0113 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0124 0.0127
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0028 0.012 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0941 0.9763 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0849 0.0849
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0124 0.0127
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.1135 0.113
Loa Loa (eye worm) phosphatidylinositol 3 0.0749 0.7733 1
Schistosoma mansoni hypothetical protein 0.0363 0.3659 0.3659
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0021 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0028 0.0124 0.0124
Echinococcus multilocularis protein patched 0.0047 0.0324 0.0332
Onchocerca volvulus 0.0042 0.0266 0.082
Giardia lamblia GTOR 0.0028 0.012 0.0183
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0088 0.0088
Brugia malayi Inositol-1 0.0038 0.0226 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0065
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Schistosoma mansoni hypothetical protein 0.0028 0.0124 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) SH2 domain-containing protein 0.0021 0.005 0.0065
Echinococcus granulosus adenosine kinase 0.0366 0.3689 0.3778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0058 0.0436 0.0564
Brugia malayi hypothetical protein 0.0034 0.0183 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0086
Giardia lamblia Hypothetical protein 0.0028 0.012 0.0183
Entamoeba histolytica hypothetical protein 0.0034 0.0183 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123
Schistosoma mansoni SH2A 0.0021 0.005 0.005
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0088 0.0088
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0028 0.012 0.0775
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.1121 0.2969
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.012 0.0123
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.012 0.023
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.012 0.023
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0113 0.0146
Echinococcus granulosus suppressor of cytokine signaling 6 0.0021 0.005 0.0052
Brugia malayi Variant SH3 domain containing protein 0.0021 0.005 0.0052
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0021 0.005 0.0052
Echinococcus granulosus growth factor receptor bound protein 2 0.0025 0.0085 0.0087
Brugia malayi RhoGAP domain containing protein 0.0021 0.005 0.0052
Loa Loa (eye worm) phosphatidylinositol kinase 0.0028 0.012 0.0156
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0036 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0123

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 16 nM Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
IC50 (binding) = 16 nM Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
IC50 (binding) = 196 nM Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
IC50 (binding) = 196 nM Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand ChEMBL. 15456246
Selectivity (binding) = 12 Selectivity fold for estrogen receptor beta over estrogen receptor alpha ChEMBL. 15456246
Selectivity (binding) = 12 Selectivity fold for estrogen receptor beta over estrogen receptor alpha ChEMBL. 15456246

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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