Detailed information for compound 329289

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 189.257 | Formula: C11H15N3
  • H donors: 0 H acceptors: 2 LogP: 0.69 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C2CCC1C(C2)c1ccnnc1
  • InChi: 1S/C11H15N3/c1-14-9-2-3-11(14)10(6-9)8-4-5-12-13-7-8/h4-5,7,9-11H,2-3,6H2,1H3
  • InChiKey: CZOBPXOJOUBLHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0076 0.0076
Echinococcus multilocularis Transglutaminase 0.0071 0.0413 0.0413
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0045 0.0076 0.0121
Brugia malayi beta-lactamase family protein 0.0075 0.0472 0.0761
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0113 0.0966 0.1535
Toxoplasma gondii LsmAD domain-containing protein 0.0164 0.1637 1
Entamoeba histolytica type A flavoprotein, putative 0.0124 0.1108 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0413 0.0082
Brugia malayi flavodoxin family protein 0.0124 0.1108 0.1787
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0469 0.0745
Loa Loa (eye worm) hypothetical protein 0.0306 0.35 0.5645
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0045 0.0076 0.0123
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.2165 0.2165
Loa Loa (eye worm) hypothetical protein 0.0243 0.267 0.4307
Echinococcus multilocularis nAChR subunit 0.0045 0.0076 0.0076
Brugia malayi Thioredoxin family protein 0.0071 0.0413 0.0666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1984 0.3151
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0191
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0045 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0045 0.0076 0.0123
Onchocerca volvulus 0.0071 0.0413 0.0882
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0324 0.3728 1
Brugia malayi hypothetical protein 0.0164 0.1637 0.2641
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Trypanosoma cruzi PAB1-binding protein , putative 0.0164 0.1637 0.4392
Schistosoma mansoni alpha-glucosidase 0.0153 0.1485 0.2358
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0045 0.0076 0.0123
Brugia malayi Cation transporter family protein 0.0045 0.0076 0.0123
Echinococcus granulosus Transglutaminase 0.0071 0.0413 0.0656
Brugia malayi flavodoxin family protein 0.0324 0.3728 0.6013
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0076 0.0121
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0074 0.045 0.045
Loa Loa (eye worm) FAD binding domain-containing protein 0.0324 0.3728 0.6013
Mycobacterium ulcerans lipase LipD 0.0075 0.0472 0.0308
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0755 0.0755
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0045 0.0076 0.0121
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0259 0.0418
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0321 0.051
Loa Loa (eye worm) ACC-1 protein 0.0045 0.0076 0.0123
Schistosoma mansoni hypothetical protein 0.0097 0.0755 0.1199
Loa Loa (eye worm) hypothetical protein 0.0059 0.0259 0.0418
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0321 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0472 0.0749
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0045 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0075 0.0472 0.0761
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.4128 0.6658
Loa Loa (eye worm) hypothetical protein 0.0075 0.0473 0.0762
Loa Loa (eye worm) LGC-31 protein 0.0045 0.0076 0.0123
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.1808 0.2916
Mycobacterium ulcerans hypothetical protein 0.0071 0.0413 0.0132
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0076 0.0076
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0113 0.0966 0.0966
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0076 0.0123
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.0209 0.2229 0.3596
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0076 0.0123
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0368 0.225
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0324 0.3728 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0472 0.0472
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0324 0.3728 0.5921
Brugia malayi mbt repeat family protein 0.0052 0.0165 0.0266
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0165 0.0266
Schistosoma mansoni hypothetical protein 0.0097 0.0755 0.1199
Brugia malayi Muscleblind-like protein 0.0474 0.5692 0.9181
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0324 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.1808 0.2916
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0413 0.0082
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0755 0.1218
Onchocerca volvulus Huntingtin homolog 0.0243 0.267 0.68
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0755 0.1199
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.62 1
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0324 0.3728 1
Onchocerca volvulus 0.0075 0.0472 0.1036
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.62 1
Echinococcus multilocularis muscleblind protein 0.0474 0.5692 0.5692
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0473 0.075
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0076 0.0123
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0045 0.0076 0.0076
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0472 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0266 0.0428
Schistosoma mansoni hypothetical protein 0.0315 0.362 0.5749
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0124 0.1108 0.2971
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1025 0.1653
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0076 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.62 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.02 0.2105 0.3395
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0966 0.1535
Brugia malayi hypothetical protein 0.0106 0.0874 0.141
Mycobacterium tuberculosis Conserved protein 0.0075 0.0472 0.0191
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0075 0.0473 0.0762
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0076 0.0121
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0075 0.0472 0.0761
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0165 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1025 0.1653
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0216 0.2318 0.368
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.1984 0.32
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Leishmania major cytochrome P450 reductase, putative 0.0287 0.3246 0.8706
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0472 0.0308
Trichomonas vaginalis sulfite reductase, putative 0.0324 0.3728 0.6013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0368 0.0368
Schistosoma mansoni hypothetical protein 0.0074 0.045 0.0715
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0259 0.0411
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0165 0.0231
Brugia malayi FAD binding domain containing protein 0.0324 0.3728 0.6013
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0512 0.62 1
Entamoeba histolytica type A flavoprotein, putative 0.0124 0.1108 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0216 0.2318 0.2318
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0215
Trypanosoma cruzi p450 reductase, putative 0.0324 0.3728 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0472 0.1265
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0324 0.3728 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0161 0.159 0.9712
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.1984 0.32
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0472 0.1265
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0124 0.1108 0.1787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1984 0.1984
Toxoplasma gondii ABC1 family protein 0.0075 0.0472 0.2882
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Trypanosoma brucei PAB1-binding protein , putative 0.0164 0.1637 0.4392
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0368 0.0585
Brugia malayi mbt repeat family protein 0.0052 0.0165 0.0266
Brugia malayi Cation transporter family protein 0.0045 0.0076 0.0123
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.2165 0.3439
Plasmodium vivax flavodoxin domain containing protein 0.0287 0.3246 0.8518
Leishmania major p450 reductase, putative 0.0324 0.3728 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0472 0.0761
Entamoeba histolytica type A flavoprotein, putative 0.0124 0.1108 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0472 0.0761
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0413 0.0082
Echinococcus multilocularis muscleblind protein 1 0.0474 0.5692 0.5692
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0076 0.0123
Echinococcus multilocularis glycine receptor subunit beta 0.0045 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0216 0.2318 0.3738
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0076 0.0123
Brugia malayi excitatory GABA receptor EXP-1A 0.0045 0.0076 0.0123
Brugia malayi Cation transporter family protein 0.0045 0.0076 0.0123
Echinococcus multilocularis geminin 0.052 0.6297 0.6297
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0324 0.3728 1
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0472 0.0191
Chlamydia trachomatis sulfite reductase 0.02 0.2105 0.5
Mycobacterium tuberculosis Conserved protein 0.0075 0.0472 0.0191
Toxoplasma gondii flavodoxin domain-containing protein 0.0161 0.159 0.9712
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0076 0.0076
Echinococcus granulosus neuropeptide s receptor 0.0467 0.5611 0.8911
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1808 0.1808
Entamoeba histolytica type A flavoprotein, putative 0.0124 0.1108 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.5793 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0472 0.0761
Loa Loa (eye worm) hypothetical protein 0.0324 0.3728 0.6013
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0045 0.0076 0.0123
Onchocerca volvulus Huntingtin homolog 0.0243 0.267 0.68
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0045 0.0076 0.0076
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0045 0.0076 0.0123
Trichomonas vaginalis peptide N-glycanase, putative 0.0071 0.0413 0.0666
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0076 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.4128 0.6658
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0074 0.045 0.0715
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0321 0.051
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0966 0.1535
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0259 0.0411
Mycobacterium leprae Probable lipase LipE 0.0075 0.0472 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0076 0.0121
Plasmodium falciparum ataxin-2 like protein, putative 0.0164 0.1637 0.2021
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0321 0.0518
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0076 0.0121
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0724 0.1149
Entamoeba histolytica type A flavoprotein, putative 0.0124 0.1108 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0045 0.0076 0.0123
Giardia lamblia Hypothetical protein 0.0287 0.3246 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0045 0.0076 0.0121
Loa Loa (eye worm) hypothetical protein 0.0243 0.267 0.4307
Echinococcus granulosus glycine receptor subunit beta 0.0045 0.0076 0.0121
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0259 0.0411
Leishmania major hypothetical protein, conserved 0.0075 0.0472 0.1265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0472 0.0749
Onchocerca volvulus Glucosylceramidase homolog 0.0336 0.3891 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0321 0.051
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0472 0.0191
Leishmania major hypothetical protein, conserved 0.0164 0.1637 0.4392
Onchocerca volvulus 0.0075 0.0472 0.1036
Echinococcus multilocularis tumor protein p63 0.033 0.3817 0.3817
Loa Loa (eye worm) hypothetical protein 0.0075 0.0472 0.0761
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.1808 0.2872
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0076 0.0121
Onchocerca volvulus 0.0048 0.0119 0.011
Leishmania major hypothetical protein, conserved 0.0124 0.1108 0.2971
Loa Loa (eye worm) flavodoxin family protein 0.0124 0.1108 0.1787
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0368 0.0988
Schistosoma mansoni nAChR subunit 0.0045 0.0076 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0164 0.1637 0.4392
Echinococcus granulosus geminin 0.052 0.6297 1
Brugia malayi Melibiase family protein 0.0075 0.0473 0.0762
Echinococcus granulosus tar DNA binding protein 0.0064 0.0321 0.051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0076 0.0123
Mycobacterium ulcerans hypothetical protein 0.0071 0.0413 0.0132
Echinococcus granulosus jumonji domain containing protein 0.004 0.0011 0.0017
Echinococcus granulosus muscleblind protein 0.0474 0.5692 0.904
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Mycobacterium ulcerans putative transglutaminase-like protein 0.0071 0.0413 0.0132
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1808 0.1808
Schistosoma mansoni NADPH flavin oxidoreductase 0.0163 0.1622 0.2577
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Plasmodium vivax hypothetical protein, conserved 0.0124 0.1108 0.1953
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0045 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0075 0.0472 0.0761
Echinococcus granulosus neuropeptide receptor A26 0.0467 0.5611 0.8911
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0472 0.0191
Mycobacterium ulcerans transglutaminase family protein 0.0071 0.0413 0.0132
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0045 0.0076 0.0123
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0165 0.0262
Plasmodium falciparum ataxin-2 like protein, putative 0.0164 0.1637 0.2021
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.02 0.2105 0.3343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1984 0.3151
Loa Loa (eye worm) ACC-1 protein 0.0045 0.0076 0.0123
Loa Loa (eye worm) hypothetical protein 0.0052 0.0165 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0321 0.051
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0966 0.1535
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0755 0.1218
Echinococcus granulosus GPCR family 2 0.0097 0.0755 0.1199
Echinococcus multilocularis neuropeptide s receptor 0.0467 0.5611 0.5611
Mycobacterium ulcerans hypothetical protein 0.0075 0.0472 0.0308
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0216 0.2318 0.368
Brugia malayi beta-lactamase 0.0075 0.0472 0.0761
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0755 0.1199
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.62 1
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Loa Loa (eye worm) hypothetical protein 0.0474 0.5692 0.9181
Echinococcus multilocularis glycine receptor subunit beta 0.0045 0.0076 0.0076
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0076 0.0121
Loa Loa (eye worm) beta-lactamase 0.0075 0.0472 0.0761
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0124 0.1108 0.1787
Loa Loa (eye worm) hypothetical protein 0.0075 0.0472 0.0761
Brugia malayi hypothetical protein 0.0243 0.267 0.4307
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.62 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0472 0.0749
Onchocerca volvulus 0.0075 0.0472 0.1036
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0324 0.3728 1
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0472 0.0191
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0119 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0755 0.0755
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0472 0.0761
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0472 0.0308
Brugia malayi FAD binding domain containing protein 0.02 0.2105 0.3395
Echinococcus multilocularis GPCR, family 2 0.0097 0.0755 0.0755
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0472 0.0191
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0287 0.3246 0.5235
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0124 0.1108 0.2971
Schistosoma mansoni hypothetical protein 0.052 0.6297 1
Brugia malayi jmjC domain containing protein 0.0095 0.0724 0.1167
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Treponema pallidum flavodoxin 0.0124 0.1108 0.5
Schistosoma mansoni cytochrome P450 reductase 0.0324 0.3728 0.5921
Mycobacterium tuberculosis Hypothetical protein 0.0071 0.0413 0.0082
Mycobacterium ulcerans beta-lactamase 0.0075 0.0472 0.0308
Loa Loa (eye worm) hypothetical protein 0.0164 0.1637 0.2641
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Onchocerca volvulus Putative nachr subunit 0.0216 0.2318 0.5875
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0045 0.0076 0.0121
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0165 0.0262
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0165 0.0262
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0124 0.1108 0.2971
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0216 0.2318 0.3738
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0216 0.2318 0.2318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0306 0.35 0.5645
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0259 0.0259
Echinococcus granulosus nAChR subunit 0.0045 0.0076 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Schistosoma mansoni diflavin oxidoreductase 0.0161 0.159 0.2525
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0124 0.1108 0.2971
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0076 0.0123
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0045 0.0076 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Schistosoma mansoni alpha-glucosidase 0.0153 0.1485 0.2358
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0165 0.0262
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0324 0.3728 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Brugia malayi TAR-binding protein 0.0064 0.0321 0.0518
Loa Loa (eye worm) hypothetical protein 0.0209 0.2229 0.3596
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0321 0.051
Loa Loa (eye worm) RNA binding protein 0.0064 0.0321 0.0518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1984 0.3151
Giardia lamblia Nitric oxide synthase, inducible 0.0287 0.3246 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0324 0.3728 1
Schistosoma mansoni hypothetical protein 0.052 0.6297 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.0472 0.0191
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0045 0.0076 0.0121
Echinococcus multilocularis methionine synthase reductase 0.02 0.2105 0.2105
Schistosoma mansoni hypothetical protein 0.0071 0.0413 0.0656
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0124 0.1108 0.1787
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0324 0.3728 0.5921
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0368 0.0585
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0045 0.0076 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1984 0.3151
Echinococcus granulosus glycine receptor subunit beta 0.0045 0.0076 0.0121
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0472 0.0191
Echinococcus granulosus tumor protein p63 0.033 0.3817 0.6062
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0113 0.0966 0.0966
Schistosoma mansoni hypothetical protein 0.0209 0.2229 0.354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1984 0.3151
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0321 0.0518
Trichomonas vaginalis esterase, putative 0.0075 0.0472 0.0761
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0472 0.0761
Brugia malayi MH2 domain containing protein 0.0117 0.1025 0.1653
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0216 0.2318 0.3738
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0755 0.1218
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0165 0.0165
Brugia malayi RNA binding protein 0.0064 0.0321 0.0518
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.35 0.5645
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0724 0.0724
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0011 0.0011
Toxoplasma gondii melibiase subfamily protein 0.0113 0.0966 0.5902
Mycobacterium tuberculosis Long conserved protein 0.0071 0.0413 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0472 0.0761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1984 0.1984
Loa Loa (eye worm) hypothetical protein 0.0474 0.5692 0.9181
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0124 0.1108 0.1787
Brugia malayi beta-lactamase family protein 0.0075 0.0472 0.0761
Schistosoma mansoni hypothetical protein 0.0097 0.0755 0.1199
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0165 0.0262
Echinococcus granulosus methionine synthase reductase 0.02 0.2105 0.3343
Loa Loa (eye worm) MBCTL1 0.0059 0.0259 0.0418
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0324 0.3728 0.3728
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0512 0.62 1
Echinococcus multilocularis neuropeptide receptor A26 0.0467 0.5611 0.5611
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0045 0.0076 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0472 0.0761
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0966 0.1535
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0324 0.3728 1
Onchocerca volvulus 0.0052 0.0165 0.0231
Loa Loa (eye worm) hypothetical protein 0.0097 0.0755 0.1218
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0216 0.2318 0.368
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0368 0.0585
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0045 0.0076 0.0123
Onchocerca volvulus 0.0103 0.0828 0.1971
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0306 0.35 0.5645
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0472 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0472 0.0761
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.62 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0216 0.2318 0.2318
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Schistosoma mansoni hypothetical protein 0.0097 0.0755 0.1199
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0045 0.0076 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3891 0.6275
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0259 0.0259
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0473 0.075
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0324 0.3728 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0045 0.0076 0.0123
Plasmodium falciparum nitric oxide synthase, putative 0.0324 0.3728 1
Plasmodium vivax ataxin-2 like protein, putative 0.0164 0.1637 0.3579
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0321 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0472 0.1265

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.013 uM Agonistic activity against rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes ChEMBL. 11141087
Activity (functional) = 0.2 uM Agonistic activity against Rat muscle Nicotinic Receptor ChEMBL. 11141087
Activity (functional) = 0.32 uM Agonistic activity against Alpha3 beta4 Nicotinic receptor from Xenopus oocytes expressing recombinant nAChR from rat ChEMBL. 11141087
Activity (functional) = 25 uM Agonistic activity against rat nicotinic acetylcholine receptor alpha7 expressed in Xenopus oocytes ChEMBL. 11141087
EC50 (binding) = 0.013 uM Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 ChEMBL. 16033252
EC50 (binding) = 0.32 uM Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 16033252
EC50 (binding) = 25 uM Effective concentration against Nicotinic acetylcholine receptor alpha 7 ChEMBL. 16033252

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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