Detailed information for compound 329404

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.457 | Formula: C22H28O2
  • H donors: 2 H acceptors: 2 LogP: 4.85 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC#Cc1cc2c(cc1O)CCC1C2CC[C@]2(C1CC[C@@]2(C)O)C
  • InChi: 1S/C22H28O2/c1-4-5-15-12-18-14(13-20(15)23)6-7-17-16(18)8-10-21(2)19(17)9-11-22(21,3)24/h12-13,16-17,19,23-24H,6-11H2,1-3H3/t16?,17?,19?,21-,22-/m0/s1
  • InChiKey: KTOGMYFNRYRKRB-ROKIQVFUSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0082 0.027 0.0268
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0218 0.0824 0.0859
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0082 0.027 0.0282
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0107 0.0371 0.0371
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0281
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0094
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0166 0.0172
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Onchocerca volvulus 0.0082 0.027 0.1598
Plasmodium falciparum ferrodoxin reductase-like protein 0.0218 0.0824 0.0846
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0317 0.1227 0.1267
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0166 0.0172
Trypanosoma cruzi NADH dehydrogenase, putative 0.0218 0.0824 0.0846
Mycobacterium tuberculosis Probable reductase 0.0317 0.1227 0.1267
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0218 0.0824 1
Mycobacterium ulcerans hypothetical protein 0.0218 0.0824 0.1839
Schistosoma mansoni RAR-like nuclear receptor 0.0107 0.0371 0.0371
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0218 0.0824 0.1839
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0218 0.0824 0.1839
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Onchocerca volvulus 0.0082 0.027 0.1598
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Schistosoma mansoni nephrin 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Schistosoma mansoni hypothetical protein 0.0052 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0604 0.2395 0.2496
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3422
Leishmania major hypothetical protein, conserved 0.0218 0.0824 0.0846
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0082 0.027 0.027
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0304 0.0304
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0823 0.3284 0.3412
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Trichomonas vaginalis glutamate synthase, putative 0.0218 0.0824 0.2504
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0425 0.0443
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0141 0.0147
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0823 0.3284 0.3412
Schistosoma mansoni nuclear hormone receptor 0.005 0.0141 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.0824 0.0846
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0107 0.0371 0.0386
Mycobacterium tuberculosis Probable oxidoreductase 0.0922 0.3687 0.3833
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0371 0.0386
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0218 0.0824 0.0859
Brugia malayi RE40412p 0.0028 0.0051 0.0054
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Onchocerca volvulus 0.0201 0.0752 0.5114
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0823 0.3284 0.3412
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0107 0.0371 0.0386
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Trypanosoma cruzi polo-like protein kinase, putative 0.009 0.0304 0.0303
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0218 0.0824 0.1839
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0082 0.027 0.0282
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0218 0.0824 0.2457
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3412
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0141 0.0147
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0218 0.0824 0.0859
Schistosoma mansoni hypothetical protein 0.0205 0.0768 0.0768
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.0371 0.0386
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Schistosoma mansoni retinal dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis ecdysone induced protein 78C 0.0107 0.0371 0.0386
Schistosoma mansoni carbonyl reductase 0.0082 0.027 0.027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0823 0.3284 0.3412
Toxoplasma gondii selenide, water dikinase 0.0218 0.0824 0.0846
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Toxoplasma gondii NADPH-glutathione reductase 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0218 0.0824 0.0859
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Brugia malayi nuclear hormone receptor 0.005 0.0141 0.0147
Brugia malayi Tubulin alpha chain 0.0022 0.0023 0.0024
Toxoplasma gondii carbonyl reductase 1, putative 0.0082 0.027 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0161 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.0371 0.0371
Onchocerca volvulus 0.0365 0.1421 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0107 0.0371 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0161 0.0167
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0082 0.027 0.0268
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0141 0.0147
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0218 0.0824 0.0846
Trypanosoma cruzi polo-like protein kinase, putative 0.009 0.0304 0.0303
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.0201 0.0752 0.0783
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0166 0.0172
Onchocerca volvulus 0.0082 0.027 0.1598
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0922 0.3687 0.3833
Brugia malayi photoreceptor-specific nuclear receptor 0.0107 0.0371 0.0386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0218 0.0824 0.1839
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0141 0.0141
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0082 0.027 0.0268
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.009 0.0094
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus granulosus roundabout 2 0.0019 0.0014 0.0014
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0218 0.0824 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.006 0.0048
Brugia malayi ecdysteroid receptor 0.0107 0.0371 0.0386
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0052 0.0149 0.0155
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0018 0.0008 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0107 0.0371 0.0386
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0082 0.027 0.0282
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0062
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0082 0.027 0.0268
Onchocerca volvulus 0.0082 0.027 0.1598
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0141 0.0147
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0028 0.0051 0.004
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0082 0.027 0.3081
Echinococcus granulosus thioredoxin glutathione reductase 0.2374 0.9597 1
Giardia lamblia Hypothetical protein 0.0082 0.027 0.0757
Brugia malayi Nuclear hormone receptor E75 0.005 0.0141 0.0147
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0922 0.3687 0.3833
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.009 0.0094
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Brugia malayi alpha-tubulin 0.0022 0.0023 0.0024
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0082 0.027 0.0268
Plasmodium vivax ferrodoxin reductase, putative 0.0218 0.0824 0.0846
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0317 0.1227 0.1267
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.009 0.0304 0.0303
Echinococcus granulosus FTZ F1 alpha 0.0107 0.0371 0.0386
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0317 0.1227 0.1267
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0082 0.027 0.0282
Echinococcus multilocularis steroid dehydrogenase 0.0082 0.027 0.0282
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0317 0.1227 0.1267
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.0023 0.0024
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.027 0.0268
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0082 0.027 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0161 0.0167
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0472 0.1855 0.1933
Onchocerca volvulus Sepiapterin reductase homolog 0.0082 0.027 0.1598
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0218 0.0824 0.1622
Schistosoma mansoni carbonyl reductase 0.0082 0.027 0.027
Trypanosoma cruzi trypanothione reductase, putative 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Brugia malayi conserved hypotetical protein 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0054
Schistosoma mansoni cell adhesion molecule 0.0018 0.0008 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0823 0.3284 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Brugia malayi Latrophilin receptor protein 2 0.0038 0.009 0.0094
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0082 0.027 0.3081
Onchocerca volvulus 0.0082 0.027 0.1598
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0013 0.0014
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0823 0.3284 0.3412
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0141 0.0147
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Brugia malayi Thioredoxin reductase 0.2374 0.9597 1
Schistosoma mansoni sulfide quinone reductase 0.0218 0.0824 0.0824
Entamoeba histolytica short chain dehydrogenase family protein 0.0082 0.027 0.3081
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0218 0.0824 0.0859
Brugia malayi RE40412p 0.0028 0.0051 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.0075 0.0242 0.0252
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0218 0.0824 0.0846
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0082 0.027 0.0268
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0218 0.0824 0.1839
Schistosoma mansoni kinase 0.0046 0.0123 0.0123
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0082 0.027 0.0282
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0218 0.0824 0.1839
Giardia lamblia Short-chain dehydrogenase, putative 0.0082 0.027 0.0757
Echinococcus multilocularis neuroglian 0.0017 0.0006 0.0006
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.027 0.3081
Giardia lamblia NADH oxidase lateral transfer candidate 0.0823 0.3284 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0218 0.0824 0.0846
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Trypanosoma brucei oxidoreductase-like protein 0.0082 0.027 0.0268
Mycobacterium ulcerans NADH dehydrogenase 0.0218 0.0824 0.1839
Loa Loa (eye worm) dehydrogenase 0.0082 0.027 0.0282
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0166 0.0166
Schistosoma mansoni nuclear hormone receptor 0.005 0.0141 0.0141
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0107 0.0371 0.0386
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Echinococcus multilocularis GPCR, family 2 0.0038 0.009 0.0094
Onchocerca volvulus 0.0082 0.027 0.1598
Brugia malayi hypothetical protein 0.003 0.006 0.0062
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus multilocularis hypothetical protein 0.0022 0.0023 0.0024
Trypanosoma cruzi NADH dehydrogenase, putative 0.0218 0.0824 0.0846
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Schistosoma mansoni carbonyl reductase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.006 0.0048
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.009 0.0304 0.0316
Echinococcus granulosus tubulin subunit TubB 0.0022 0.0023 0.0024
Toxoplasma gondii oxidoreductase, putative 0.0082 0.027 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Brugia malayi dehydrogenases, short chain protein 2 0.0082 0.027 0.0282
Treponema pallidum NADH oxidase 0.0823 0.3284 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Onchocerca volvulus 0.0082 0.027 0.1598
Echinococcus multilocularis thyroid hormone receptor alpha 0.0107 0.0371 0.0386
Trichomonas vaginalis glutamate synthase, putative 0.0218 0.0824 0.2504
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.05 0.197 0.197
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0823 0.3284 1
Schistosoma mansoni sulfide quinone reductase 0.0218 0.0824 0.0824
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0218 0.0824 0.0859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0201 0.0752 0.0783
Plasmodium falciparum glutathione reductase 0.0823 0.3284 0.3412
Schistosoma mansoni thyroid hormone receptor 0.0107 0.0371 0.0371
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0107 0.0371 0.0386
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.0003 0.0003
Schistosoma mansoni glutamate synthase 0.0218 0.0824 0.0824
Echinococcus multilocularis steroid dehydrogenase 0.0082 0.027 0.0282
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0141 0.0147
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0218 0.0824 0.1622
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0023 0.0023
Leishmania major 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0107 0.0371 0.0386
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Onchocerca volvulus 0.0082 0.027 0.1598
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Brugia malayi tubulin alpha-2 chain 0.0022 0.0023 0.0024
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Brugia malayi hypothetical protein 0.0056 0.0166 0.0172
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Echinococcus granulosus retinol dehydrogenase 11 0.0082 0.027 0.0282
Entamoeba histolytica hypothetical protein 0.0082 0.027 0.3081
Brugia malayi hypothetical protein 0.0056 0.0166 0.0172
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0054
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0218 0.0824 0.0859
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.006 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Leishmania major short chain dehydrogenase, putative 0.0082 0.027 0.0268
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Plasmodium falciparum thioredoxin reductase 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Trypanosoma brucei trypanothione reductase 0.2374 0.9597 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0218 0.0824 0.0846
Echinococcus granulosus glutamate synthase 0.0218 0.0824 0.0859
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.0023 0.0024
Leishmania major short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Brugia malayi hypothetical protein 0.0365 0.1421 0.148
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0023 0.0023
Leishmania major short chain dehydrogenase-like protein 0.0082 0.027 0.0268
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0082 0.027 0.0282
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0218 0.0824 0.1839
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0023 0.0024
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0023 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.009 0.0094
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0218 0.0824 0.2504
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0218 0.0824 0.0859
Brugia malayi nuclear receptor RXR 0.0056 0.0166 0.0172
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0823 0.3284 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0082 0.027 0.0282
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0218 0.0824 0.0859
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Leishmania major short chain dehydrogenase, putative 0.0082 0.027 0.0268
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0141 0.0653
Toxoplasma gondii zinc finger cdgsh type protein 0.0028 0.0051 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0107 0.0371 0.2331
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Echinococcus multilocularis glutamate synthase 0.0218 0.0824 0.0859
Brugia malayi Nuclear hormone receptor E75 0.005 0.0141 0.0147
Brugia malayi nuclear receptor RXR 0.005 0.0141 0.0147
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0082 0.027 0.3081
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0166 0.0172
Brugia malayi nuclear receptor NHR-67 0.005 0.0141 0.0147
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0317 0.1227 0.2802
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0141 0.0147
Brugia malayi nuclear receptor NHR-88 0.005 0.0141 0.0147
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.0023 0.001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3284
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3422
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Echinococcus granulosus geminin 0.0205 0.0768 0.0801
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0218 0.0824 0.0846
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0218 0.0824 0.2504
Onchocerca volvulus 0.005 0.0141 0.0653
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0371 0.0386
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0218 0.0824 0.1839
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Brugia malayi hypothetical protein 0.002 0.0016 0.0016
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0024
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0218 0.0824 0.1839
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0082 0.027 0.0757
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0107 0.0371 0.0371
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Leishmania major pteridine reductase 1 0.0082 0.027 0.0268
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0023 0.0024
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0082 0.027 0.0282
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0218 0.0824 0.0846
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0107 0.0371 0.0386
Echinococcus granulosus ecdysone induced protein 78C 0.0107 0.0371 0.0386
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0082 0.027 0.0268
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Brugia malayi Dehydrogenases, short chain protein 30 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Plasmodium vivax steroid dehydrogenase, putative 0.0082 0.027 0.0268
Mycobacterium ulcerans dehydrogenase 0.0218 0.0824 0.1839
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0013 0.0014
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Schistosoma mansoni transcription factor LCR-F1 0.0052 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0823 0.3284 0.3422
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.027 0.0281
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Brugia malayi isocitrate dehydrogenase 0.0019 0.0013 0.0014
Schistosoma mansoni disulfide oxidoreductase 0.0218 0.0824 0.0824
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0218 0.0824 0.0846
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.036 0.0375
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0218 0.0824 0.0846
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi serine/threonine-protein kinase plk-2 0.009 0.0304 0.0316
Loa Loa (eye worm) programmed cell death 8 0.0218 0.0824 0.0859
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0023 0.001
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0107 0.0371 0.0386
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.006 0.0048
Schistosoma mansoni nuclear receptor 0.005 0.0141 0.0141
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0823 0.3284 1
Entamoeba histolytica thioredoxin reductase, putative 0.0218 0.0824 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0823 0.3284 0.3412
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi hypothetical protein 0.0052 0.0149 0.0155
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0028 0.0051 0.004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0107 0.0371 0.0386
Echinococcus granulosus alpha tubulin 0.0022 0.0023 0.0024
Schistosoma mansoni alpha tubulin 0.0022 0.0023 0.0023
Schistosoma mansoni coup transcription factor 0.0107 0.0371 0.0371
Schistosoma mansoni glutamate synthase 0.0218 0.0824 0.0824
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0141 0.0141
Brugia malayi MH2 domain containing protein 0.0075 0.0242 0.0252
Brugia malayi hypothetical protein 0.005 0.0141 0.0147
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0107 0.0371 0.0386
Leishmania major NADH dehydrogenase, putative 0.0218 0.0824 0.0846
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0218 0.0824 0.0846
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Echinococcus multilocularis oxidoreductase 0.0082 0.027 0.0282
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0082 0.027 0.0815
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0082 0.027 0.0268
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0082 0.027 0.0268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0218 0.0824 0.0859
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0141 0.0653
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0425 0.0443
Trypanosoma cruzi short chain dehydrogenase, putative 0.0082 0.027 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Onchocerca volvulus Tyrosine kinase homolog 0.0088 0.0294 0.1772
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.027 0.0268
Plasmodium vivax thioredoxin reductase, putative 0.2374 0.9597 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0107 0.0371 0.0386
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0218 0.0824 0.0846
Schistosoma mansoni steroid hormone receptor ad4bp 0.0107 0.0371 0.0371
Mycobacterium tuberculosis Probable dehydrogenase 0.0317 0.1227 0.1267
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0107 0.0371 0.0386
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0023 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.0824 0.0846
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0836 0.3339 0.3479
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0218 0.0824 0.0859
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0218 0.0824 0.0859
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Schistosoma mansoni hypothetical protein 0.0082 0.027 0.027
Onchocerca volvulus 0.0082 0.027 0.1598
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Toxoplasma gondii thioredoxin reductase 0.2374 0.9597 1
Mycobacterium ulcerans ferredoxin reductase 0.0218 0.0824 0.1839
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Schistosoma mansoni hypothetical protein 0.0028 0.0051 0.0051
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0107 0.0371 0.0386
Leishmania major hypothetical protein, conserved 0.0218 0.0824 0.0846
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.009 0.0094
Echinococcus multilocularis transient receptor potential cation channel 0.0082 0.027 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0082 0.027 0.0268
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0107 0.0371 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0023 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.009 0.0094
Giardia lamblia Thioredoxin reductase 0.0218 0.0824 0.2457
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0107 0.0371 0.0386
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0823 0.3284 0.3412
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0922 0.3687 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0141 0.0147
Echinococcus multilocularis conserved hypothetical protein 0.0028 0.0051 0.0054
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0823 0.3284 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0218 0.0824 0.0846
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0023 0.0024
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0218 0.0824 0.1839
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0242 0.0252
Brugia malayi dehydrogenases, short chain protein 9 0.0082 0.027 0.0282
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0107 0.0371 0.0371
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0107 0.0371 0.0371
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0472 0.1855 0.1933
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0013 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0166 0.0172
Plasmodium falciparum alpha tubulin 1 0.0022 0.0023 0.001
Brugia malayi nuclear receptor NHR-88 0.0107 0.0371 0.0386
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0082 0.027 0.0268
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0365 0.1421 0.148
Leishmania major trypanothione reductase 0.2374 0.9597 1
Giardia lamblia Kinase, PLK 0.009 0.0304 0.0859
Leishmania major hypothetical protein, conserved 0.0218 0.0824 0.0846
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.006 0.0048
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0218 0.0824 0.0859
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0082 0.027 0.0282
Leishmania major hypothetical protein, conserved 0.003 0.006 0.0048
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0023 0.0062
Echinococcus multilocularis roundabout 2 0.0019 0.0014 0.0014
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0082 0.027 0.3081
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0082 0.027 0.0268
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0013 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0161 0.0167
Onchocerca volvulus Serine\/threonine kinase homolog 0.009 0.0304 0.1842
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0028 0.0051 0.004
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0104 0.036 0.0375
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0082 0.027 0.0268
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0218 0.0824 0.0846
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0141 0.0147
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0082 0.027 0.0815
Brugia malayi glutamate synthase 0.0218 0.0824 0.0859
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0023 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0166 0.0166
Brugia malayi Dehydrogenases, short chain protein 2 0.0082 0.027 0.0282
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.004
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0823 0.3284 0.3412
Trypanosoma brucei NADH dehydrogenase 0.0218 0.0824 0.0846
Schistosoma mansoni nuclear hormone receptor 0.0107 0.0371 0.0371
Trichomonas vaginalis steroid dehydrogenase, putative 0.0082 0.027 0.0815
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus multilocularis conserved hypothetical protein 0.0082 0.027 0.0282
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0218 0.0824 1
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0141 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0013 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Brugia malayi tubulin alpha chain - mouse 0.0022 0.0023 0.0024
Onchocerca volvulus 0.0218 0.0824 0.5645
Onchocerca volvulus 0.0082 0.027 0.1598
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.012 0.0425 0.0443
Plasmodium vivax glutathione reductase, putative 0.2374 0.9597 1
Brugia malayi steroid hormone receptor 0.0107 0.0371 0.0386
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0082 0.027 0.1598
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0823 0.3284 1
Onchocerca volvulus 0.0082 0.027 0.1598
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0118 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.0824 0.0846
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0107 0.0371 0.0371
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0052 0.0149 0.0155
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.2374 0.9597 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0082 0.027 0.1598
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.004
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0218 0.0824 0.0846
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.006 0.0048
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3412
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni glutamate synthase 0.0218 0.0824 0.0824
Echinococcus granulosus twitchin 0.0018 0.0007 0.0007
Plasmodium falciparum steroid dehydrogenase, putative 0.0082 0.027 0.0268
Giardia lamblia Glutamate synthase 0.0218 0.0824 0.2457
Plasmodium falciparum thioredoxin reductase 0.2374 0.9597 1
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.027 0.3081
Schistosoma mansoni thyroid hormone receptor 0.0107 0.0371 0.0371
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0118 0.035
Leishmania major dehydrogenase-like protein 0.0082 0.027 0.0268
Echinococcus granulosus hypothetical protein 0.0082 0.027 0.0282
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Echinococcus multilocularis thioredoxin glutathione reductase 0.2374 0.9597 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0218 0.0824 0.2504
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Loa Loa (eye worm) dehydrogenase 0.0082 0.027 0.0282
Loa Loa (eye worm) steroid hormone receptor 0.0107 0.0371 0.0386
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0141 0.0147
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Trichomonas vaginalis mercuric reductase, putative 0.0823 0.3284 1
Trypanosoma brucei polo-like protein kinase 0.009 0.0304 0.0303
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.027
Brugia malayi hypothetical protein 0.0082 0.027 0.0282
Brugia malayi ecdysone receptor 0.005 0.0141 0.0147
Plasmodium falciparum glutathione reductase 0.2374 0.9597 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Schistosoma mansoni hypothetical protein 0.0205 0.0768 0.0768
Echinococcus granulosus steroid dehydrogenase 0.0082 0.027 0.0282
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0082 0.027 0.0268
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0107 0.0371 0.0386
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0218 0.0824 0.0859
Brugia malayi hypothetical protein 0.0082 0.027 0.0282
Loa Loa (eye worm) DR-78 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Echinococcus multilocularis retinol dehydrogenase 13 0.0082 0.027 0.0282
Mycobacterium ulcerans glutamate synthase subunit beta 0.0218 0.0824 0.1839
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0023 0.0062
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.0161
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Onchocerca volvulus 0.0082 0.027 0.1598
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0218 0.0824 1
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Leishmania major hypothetical protein, unknown function 0.0028 0.0051 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Schistosoma mansoni retinoic acid receptor RXR 0.0107 0.0371 0.0371
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0028 0.0051 0.004
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0141 0.0141
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.0023 0.001
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0082 0.027 0.0268
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0218 0.0824 0.0846
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0823 0.3284 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0107 0.0371 0.2331
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0218 0.0824 0.0846
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.0023 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0161 0.0167
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0082 0.027 0.0282
Echinococcus multilocularis retinol dehydrogenase 11 0.0082 0.027 0.0282
Echinococcus granulosus hypothetical protein 0.0082 0.027 0.0282
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0218 0.0824 0.0859
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.0023 0.001
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Loa Loa (eye worm) glutathione reductase 0.2374 0.9597 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0371 0.0386
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.0023 0.0024
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Leishmania major short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0082 0.027 0.3081
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.0023 0.0062
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.0161
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0218 0.0824 0.0846
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0604 0.2395 0.2496
Schistosoma mansoni alpha tubulin 0.0022 0.0023 0.0023
Plasmodium falciparum alpha tubulin 2 0.0022 0.0023 0.001
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0218 0.0824 0.0846
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0141 0.0147
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0082 0.027 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0218 0.0824 0.0846
Mycobacterium tuberculosis Probable dehydrogenase 0.0082 0.027 0.0268
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0218 0.0824 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0107 0.0371 0.0386
Schistosoma mansoni nuclear receptor 0.005 0.0141 0.0141
Echinococcus multilocularis geminin 0.0205 0.0768 0.0801
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0141 0.0147
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0107 0.0371 0.0386
Giardia lamblia Reductase, putative 0.0082 0.027 0.0757
Echinococcus multilocularis FTZ F1 alpha 0.0107 0.0371 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Mycobacterium ulcerans monoxygenase 0.0218 0.0824 0.1839
Echinococcus granulosus retinol dehydrogenase 11 0.0082 0.027 0.0282
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0023 0.001
Onchocerca volvulus Bile acid receptor homolog 0.0107 0.0371 0.2331
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0823 0.3284 0.3412
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0023 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Echinococcus granulosus conserved hypothetical protein 0.0028 0.0051 0.0054
Brugia malayi Steroid receptor seven-up type 2 0.0107 0.0371 0.0386
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0023 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Echinococcus granulosus WW domain containing oxidoreductase 0.0082 0.027 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0107 0.0371 0.0386
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0218 0.0824 0.0846
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0003 0.0003
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0082 0.027 0.0268
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0823 0.3284 0.3412
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0218 0.0824 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.009 0.0304 0.3498
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0218 0.0824 0.0846
Echinococcus granulosus neuroglian 0.0017 0.0006 0.0006
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0082 0.027 0.0282
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0218 0.0824 0.1622
Loa Loa (eye worm) thioredoxin reductase 0.2374 0.9597 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0082 0.027 0.0268
Brugia malayi nuclear hormone receptor 0.0107 0.0371 0.0386
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0023 0.0024
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0218 0.0824 0.2504
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0082 0.027 0.1598
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0082 0.027 0.0815
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.005 0.0141 0.0147
Toxoplasma gondii oxidoreductase, putative 0.0082 0.027 0.0268
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0823 0.3284 0.3412
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Onchocerca volvulus 0.0107 0.0371 0.2331
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.027 0.0268
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0023 0.0024
Echinococcus granulosus serine:threonine protein kinase PLK1 0.009 0.0304 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0371 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Echinococcus granulosus oxidoreductase 0.0082 0.027 0.0282
Echinococcus granulosus GPCR family 2 0.0038 0.009 0.0094
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0028 0.0051 0.004
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.009 0.0094
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0082 0.027 0.0268
Entamoeba histolytica short chain dehydrogenase family protein 0.0082 0.027 0.3081
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0218 0.0824 0.0859
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0218 0.0824 0.1622
Entamoeba histolytica disulphide oxidoreductase, putative 0.0218 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Trichomonas vaginalis apoptosis inducing factor, putative 0.0218 0.0824 0.2504
Schistosoma mansoni hypothetical protein 0.0218 0.0824 0.0824
Brugia malayi glutathione reductase 0.2374 0.9597 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0161 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0107 0.0371 0.0386
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Brugia malayi oxidoreductase 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0082 0.027 0.0268
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.009 0.0304 0.0316
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0082 0.027 0.0282
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0082 0.027 0.027
Brugia malayi tailless protein 0.005 0.0141 0.0147
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0218 0.0824 0.0846
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0425 0.0443
Brugia malayi Retinol dehydrogenase 12 0.0082 0.027 0.0282
Schistosoma mansoni alpha tubulin 0.0022 0.0023 0.0023
Onchocerca volvulus 0.0082 0.027 0.1598
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Leishmania major oxidoreductase-like protein 0.0082 0.027 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0107 0.0371 0.0386
Schistosoma mansoni hypothetical protein 0.05 0.197 0.197
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0023 0.0024
Onchocerca volvulus 0.005 0.0141 0.0653
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0082 0.027 0.0268
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0023 0.0023
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni zinc finger protein 0.005 0.0141 0.0141
Onchocerca volvulus 0.0085 0.0282 0.1686
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0218 0.0824 0.0846
Trypanosoma cruzi trypanothione reductase, putative 0.2374 0.9597 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 0.3 uM Growth inhibitory concentration required against human breast MDA-MB-435 cancer cell line ChEMBL. 15456256
GI50 (functional) = 1.5 uM Growth inhibitory concentration required against human ovarian OVCAR-3 cancer cell line ChEMBL. 15456256
GI50 (functional) = 2.6 uM Growth inhibitory concentration required against human CNS SF-539 cancer cell line ChEMBL. 15456256
GI50 (functional) = 3.1 uM Growth inhibitory concentration against human lung cancer HOP-62 cell line ChEMBL. 15456256
GI50 (functional) = 3.2 uM Average concentration required for 50% growth inhibition of human cancer cell line (tested) ChEMBL. 15456256
GI50 (functional) = 4 uM Growth inhibitory concentration required against human melanoma UACC-62 cancer cell line ChEMBL. 15456256
GI50 (functional) = 4.1 uM Growth inhibitory concentration required against human prostate DU-145 cancer cell line ChEMBL. 15456256
GI50 (functional) = 4.3 uM Growth inhibitory concentration against human colon cancer HCT-116 cell line ChEMBL. 15456256
GI50 (functional) = 7.4 uM Growth inhibitory concentration required for against human renal SN12C cancer cell line ChEMBL. 15456256
IC50 (functional) = 1.94 uM Inhibitory concentration required against growth of HUVEC cancer cell line ChEMBL. 15456256
IC50 (functional) = 5.99 uM Inhibitory concentration against growth of MDA-MB-231 cancer cell line ChEMBL. 15456256
IC50 (functional) = 11 uM Inhibitory concentration against bovine tubulin polymerization ChEMBL. 15456256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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