Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 3 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, beta 4 (neuronal) | References | |
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 505 aa | 486 aa | 34.6 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 4 (neuronal) | 498 aa | 508 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0222 | 0.0924 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0414 | 0.2126 | 1 |
Brugia malayi | Cation transporter family protein | 0.0131 | 0.0353 | 0.1661 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0414 | 0.2126 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0242 | 0.105 | 0.4938 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0414 | 0.2126 | 0.2037 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0131 | 0.0353 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0353 | 0.0685 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.0471 | 0.1569 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0353 | 0.0685 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0414 | 0.2126 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0131 | 0.0353 | 0.1661 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0414 | 0.2126 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0131 | 0.0353 | 0.1661 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0414 | 0.2126 | 1 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1671 | 1 | 1 |
Brugia malayi | PAS domain containing protein | 0.01 | 0.0163 | 0.0768 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0414 | 0.2126 | 0.5 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0414 | 0.2126 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0289 | 0.1344 | 0.6319 |
Onchocerca volvulus | 0.0131 | 0.0353 | 0.3823 | |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0262 | 0.1174 | 0.5519 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0414 | 0.2126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.1642 | 0.7458 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0131 | 0.0353 | 0.1661 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.031 | 0.1479 | 0.6601 |
Onchocerca volvulus | 0.0131 | 0.0353 | 0.3823 | |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0328 | 0.1591 | 0.7275 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0414 | 0.2126 | 0.5 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0414 | 0.2126 | 0.2126 |
Loa Loa (eye worm) | glutamate receptor | 0.0114 | 0.0247 | 0.0125 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0141 | 0.0417 | 0.1959 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.1761 | 0.8083 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0353 | 0.0685 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0131 | 0.0353 | 0.1661 |
Mycobacterium ulcerans | proteasome PrcA | 0.1671 | 1 | 1 |
Mycobacterium ulcerans | membrane protein ComEA | 0.0092 | 0.0113 | 0.0113 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0141 | 0.0417 | 0.129 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0414 | 0.2126 | 0.5 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0149 | 0.0471 | 0.2217 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0414 | 0.2126 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0131 | 0.0353 | 0.1661 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0131 | 0.0353 | 0.0968 |
Brugia malayi | hypothetical protein | 0.0336 | 0.1642 | 0.7725 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0131 | 0.0353 | 0.1661 |
Onchocerca volvulus | 0.0131 | 0.0353 | 0.3823 | |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0242 | 0.105 | 0.4517 |
Treponema pallidum | nitrogen fixation protein (rnfC) | 0.0092 | 0.0113 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0131 | 0.0353 | 0.0685 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0355 | 0.1761 | 0.8284 |
Brugia malayi | hypoxia-induced factor 1 | 0.031 | 0.1479 | 0.6957 |
Loa Loa (eye worm) | glutamate receptor | 0.0289 | 0.1344 | 0.5888 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0131 | 0.0353 | 0.1661 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0242 | 0.105 | 0.4938 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0414 | 0.2126 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0131 | 0.0353 | 0.3823 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0149 | 0.0471 | 0.0363 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0414 | 0.2126 | 0.5 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0149 | 0.0471 | 0.0471 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0355 | 0.1761 | 0.8284 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (binding) | = 0.96 uM | Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 16033252 |
Concentration (binding) | = 0.96 uM | Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 16033252 |
IC50 (binding) | = 8.5 uM | Inhibitory concentration of the compound against Nicotinic acetylcholine receptor alpha 7 | ChEMBL. | 16033252 |
IC50 (binding) | = 8.5 uM | Inhibitory concentration of the compound against Nicotinic acetylcholine receptor alpha 7 | ChEMBL. | 16033252 |
IC50 (binding) | = 9.2 uM | Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta4 | ChEMBL. | 16033252 |
IC50 (binding) | = 9.2 uM | Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta4 | ChEMBL. | 16033252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.