Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0.1124 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.2531 | 0.2531 |
Brugia malayi | thymidylate synthase | 0.0124 | 0.1124 | 0.1124 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0124 | 0.1124 | 0.1124 |
Brugia malayi | ecdysteroid receptor | 0.0207 | 0.2531 | 0.2531 |
Echinococcus granulosus | dihydrofolate reductase | 0.0647 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.5856 | 1 |
Brugia malayi | hypothetical protein | 0.0059 | 0.0018 | 0.0018 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0.1124 | 0.1108 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.5856 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0124 | 0.1124 | 0.1124 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.1124 | 0.4443 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0647 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0124 | 0.1124 | 0.1124 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0647 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0647 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0647 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0647 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0647 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0647 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 0.2531 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.5856 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0059 | 0.0018 | 0.0031 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.5856 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0.0018 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0647 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.5856 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0403 | 0.5856 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 260 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRbeta (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 260 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRbeta (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 275 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 275 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 1.12 uM | Effective concentration in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay | ChEMBL. | 16107141 |
IC50 (binding) | > 5000 nM | Inhibition of human GSK-3beta | ChEMBL. | 16107141 |
IC50 (binding) | > 5000 nM | Inhibition of human GSK-3beta | ChEMBL. | 16107141 |
RE (binding) | = 0.6 | Relative efficacy for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha compared to GW3965 | ChEMBL. | 16107141 |
RE (binding) | = 0.7 | Relative efficacy in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay compared to GW3965 | ChEMBL. | 16107141 |
RE (binding) | = 0.7 | Relative efficacy for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha compared to GW3965 | ChEMBL. | 16107141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.