Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0615 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0615 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0615 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0615 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0615 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0552 | 0.8615 | 0.8615 |
Entamoeba histolytica | aldose reductase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0392 | 0.5102 | 0.5102 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Onchocerca volvulus | 0.0552 | 0.8615 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Giardia lamblia | Aldose reductase | 0.0552 | 0.8615 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0383 | 0.4903 | 0.5691 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus granulosus | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0615 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0552 | 0.8615 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Onchocerca volvulus | 0.0552 | 0.8615 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0552 | 0.8615 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0552 | 0.8615 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0552 | 0.8615 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0383 | 0.4903 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0392 | 0.5102 | 0.5102 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0383 | 0.4903 | 0.5691 |
Leishmania major | aldo-keto reductase-like protein | 0.0552 | 0.8615 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Schistosoma mansoni | aldo-keto reductase | 0.0552 | 0.8615 | 0.8615 |
Onchocerca volvulus | 0.0552 | 0.8615 | 1 | |
Schistosoma mansoni | pol-related | 0.0552 | 0.8615 | 0.8615 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Schistosoma mansoni | dihydrofolate reductase | 0.0615 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0383 | 0.4903 | 0.5691 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0552 | 0.8615 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0552 | 0.8615 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0552 | 0.8615 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0615 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0383 | 0.4903 | 0.5691 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Loa Loa (eye worm) | oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Leishmania major | prostaglandin f synthase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Entamoeba histolytica | aldose reductase, putative | 0.0552 | 0.8615 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.8615 | 0.8615 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0552 | 0.8615 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus granulosus | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Onchocerca volvulus | 0.0552 | 0.8615 | 1 | |
Onchocerca volvulus | 0.0552 | 0.8615 | 1 | |
Schistosoma mansoni | aldo-keto reductase | 0.0552 | 0.8615 | 0.8615 |
Mycobacterium ulcerans | oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Toxoplasma gondii | aldose reductase, putative | 0.0552 | 0.8615 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0383 | 0.4903 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0552 | 0.8615 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0552 | 0.8615 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Echinococcus granulosus | hypothetical protein | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0552 | 0.8615 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0392 | 0.5102 | 0.5102 |
Echinococcus multilocularis | aldo keto reductase | 0.0552 | 0.8615 | 0.8615 |
Onchocerca volvulus | 0.0552 | 0.8615 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0552 | 0.8615 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0552 | 0.8615 | 0.8615 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0552 | 0.8615 | 0.8615 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 10 % | Inhibition of pregnane X receptor mediated activation of alkaline phosphatase reporter gene at 10 uM | ChEMBL. | 15999993 |
Inhibition (functional) | = 10 % | Inhibition of pregnane X receptor mediated activation of alkaline phosphatase reporter gene at 10 uM | ChEMBL. | 15999993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.