Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1418 | 0.5232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2293 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1418 | 0.5232 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2211 | 0.9552 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2211 | 0.9552 | 0.9552 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1418 | 0.5232 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.2293 | 1 | 0.5 |
Onchocerca volvulus | 0.2293 | 1 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1418 | 0.5232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2293 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.2293 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.2293 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.2293 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2211 | 0.9552 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.2211 | 0.9552 | 0.9552 |
Echinococcus granulosus | dihydrofolate reductase | 0.2211 | 0.9552 | 0.9552 |
Brugia malayi | Dihydrofolate reductase | 0.2211 | 0.9552 | 0.9552 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2211 | 0.9552 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2211 | 0.9552 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1418 | 0.5232 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.2293 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2293 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2211 | 0.9552 | 0.9552 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1418 | 0.5232 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.2293 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.2293 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.2293 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2211 | 0.9552 | 0.9552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | NA 0 nM | Effective concentration for stimulation of [35S]-GTP-gammaS, binding to human metabotropic glutamate receptor 2 incubated at 30 degree C for 1 hr; NA = not active at 10 uM | ChEMBL. | 16005222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.