TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.601 | Formula: C24H32N4O2S
H donors: 0 H acceptors: 2 LogP: 3.36 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CN1CC[C@H](C1)N(C(=O)N1CC[C@@H](C1)N(C(=O)c1ccc(s1)c1ccc(cc1)C)C)C
InChi: 1S/C24H32N4O2S/c1-17-5-7-18(8-6-17)21-9-10-22(31-21)23(29)26(3)20-12-14-28(16-20)24(30)27(4)19-11-13-25(2)15-19/h5-10,19-20H,11-16H2,1-4H3/t19-,20+/m1/s1
InChiKey: WNRXBLJWAZTUIA-UXHICEINSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0397	0.1251
Echinococcus multilocularis	voltage gated potassium channel	0.0042	0.0132	0.0132
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0397	0.1251
Echinococcus granulosus	potassium voltage gated channel protein	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0042	0.0132	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0171	0.0539
Onchocerca volvulus		0.0046	0.0191	0.0643
Plasmodium falciparum	phd finger protein, putative	0.0032	0	0.5
Echinococcus granulosus	transient receptor potential cation channel	0.0042	0.0132	0.0417
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0042	0.0132	0.0417
Onchocerca volvulus		0.0046	0.0191	0.0643
Loa Loa (eye worm)	voltage-gated calcium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0042	0.0132	0.0417
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Onchocerca volvulus		0.0046	0.0191	0.0643
Echinococcus granulosus	short transient receptor potential channel 6	0.0042	0.0132	0.0417
Echinococcus granulosus	transient receptor potential cation channel	0.0042	0.0132	0.0417
Echinococcus granulosus	two pore calcium channel protein 2	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0042	0.0132	0.0417
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	ion channel NompC	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel protein	0.0042	0.0132	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	gliotactin	0.0046	0.0191	0.06
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0088	0.0276
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Schistosoma mansoni	two-pore calcium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0042	0.0132	0.0417
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0042	0.0132	0.0417
Treponema pallidum	fructose-bisphosphate aldolase	0.0317	0.3758	0.5
Schistosoma mansoni	jumonji domain containing protein	0.0082	0.0667	0.21
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0104	0.0947	0.0947
Mycobacterium ulcerans	carboxylesterase, LipT	0.0046	0.0191	0.0526
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0046	0.0191	0.0191
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0046	0.0191	0.06
Schistosoma mansoni	voltage-dependent calcium channel	0.0042	0.0132	0.0417
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0042	0.0132	0.0417
Echinococcus multilocularis	para nitrobenzyl esterase	0.0046	0.0191	0.0191
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.012	0.1157	0.3644
Echinococcus granulosus	transient receptor potential cation channel	0.0042	0.0132	0.0417
Echinococcus granulosus	voltage gated potassium channel	0.0042	0.0132	0.0417
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0171	0.0539
Loa Loa (eye worm)	carboxylesterase	0.0273	0.3176	1
Echinococcus granulosus	voltage gated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Loa Loa (eye worm)	acetylcholinesterase 1	0.0273	0.3176	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0042	0.0132	0.0446
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0042	0.0132	0.0417
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0042	0.0132	0.0132
Echinococcus granulosus	potassium voltage gated channel protein	0.0042	0.0132	0.0417
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0042	0.0132	0.0417
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Brugia malayi	Inositol-1	0.004	0.0111	0.035
Brugia malayi	Carboxylesterase family protein	0.0273	0.3176	1
Onchocerca volvulus		0.0032	0.001	0.0034
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0042	0.0132	0.0417
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0273	0.3176	1
Toxoplasma gondii	hypothetical protein	0.0042	0.0132	1
Plasmodium vivax	SET domain protein, putative	0.0032	0.001	1
Loa Loa (eye worm)	carboxylesterase	0.0046	0.0191	0.06
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0042	0.0132	0.0417
Echinococcus multilocularis	short transient receptor potential channel 6	0.0042	0.0132	0.0132
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel protein	0.0042	0.0132	0.0132
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0397	0.1251
Schistosoma mansoni	BC026374 protein (S09 family)	0.0046	0.0191	0.06
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0397	0.1251
Schistosoma mansoni	vesicular amine transporter	0.0042	0.0132	0.0417
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0046	0.0191	0.0191
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0042	0.0132	0.0417
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0042	0.0132	0.0417
Brugia malayi	hypothetical protein	0.012	0.1157	0.3644
Schistosoma mansoni	transient receptor potential channel	0.0042	0.0132	0.0417
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0088	0.0276
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0397	0.1251
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0171	0.0539
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0042	0.0132	0.0417
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0042	0.0132	0.0417
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0042	0.0132	0.0132
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0042	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.012	0.1157	0.3644
Schistosoma mansoni	60S ribosomal protein L21	0.0042	0.0132	0.0417
Echinococcus granulosus	short transient receptor potential channel 6	0.0042	0.0132	0.0417
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0042	0.0132	0.0446
Onchocerca volvulus		0.0042	0.0132	0.0446
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0042	0.0132	0.0417
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0203	0.064
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0042	0.0132	0.0417
Brugia malayi	Pre-SET motif family protein	0.0032	0.001	0.0031
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0163	0.0513
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0111	0.0111
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.001	0.0031
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0042	0.0132	0.0417
Echinococcus granulosus	hyperpolarization activated cyclic	0.0042	0.0132	0.0417
Echinococcus granulosus	neuroligin	0.0046	0.0191	0.06
Echinococcus multilocularis	neuroligin	0.0046	0.0191	0.0191
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0111	0.5
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0042	0.0132	0.0417
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0046	0.0191	0.086
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Brugia malayi	hypothetical protein	0.0046	0.0191	0.06
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.001	0.0031
Brugia malayi	RNA binding protein	0.0062	0.0397	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0042	0.0132	0.0417
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0042	0.0132	0.0417
Onchocerca volvulus	Huntingtin homolog	0.012	0.1157	0.3901
Echinococcus granulosus	acetylcholinesterase	0.0273	0.3176	1
Echinococcus multilocularis	voltage gated potassium channel	0.0042	0.0132	0.0132
Echinococcus granulosus	potassium large conductance calcium activated	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium voltage gated channel protein	0.0042	0.0132	0.0417
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0397	0.1251
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0042	0.0132	0.0417
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0042	0.0132	0.0132
Echinococcus multilocularis	transient receptor potential cation channel	0.0042	0.0132	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3176	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0042	0.0132	0.0132
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0042	0.0132	0.0132
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0317	0.3758	1
Brugia malayi	jmjC domain containing protein	0.0104	0.0947	0.2983
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0042	0.0132	0.0417
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0088	0.0276
Echinococcus multilocularis	transient receptor potential cation channel	0.0042	0.0132	0.0132
Loa Loa (eye worm)	ryanodine receptor	0.0042	0.0132	0.0417
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.001	0.0031
Brugia malayi	Pre-SET motif family protein	0.0226	0.2556	0.8047
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0111	0.8398
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0042	0.0132	1
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0042	0.0132	0.0417
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0042	0.0132	0.0417
Echinococcus multilocularis	voltage dependent calcium channel	0.0042	0.0132	0.0132
Echinococcus granulosus	potassium voltage gated channel protein	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0042	0.0132	0.0417
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.001	0.0753
Schistosoma mansoni	hypothetical protein	0.0042	0.0132	0.0417
Brugia malayi	TAR-binding protein	0.0062	0.0397	0.1251
Onchocerca volvulus		0.0046	0.0191	0.0643
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.001	0.0031
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0042	0.0132	1
Echinococcus granulosus	acetylcholinesterase	0.0273	0.3176	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0032	0.001	0.0031
Schistosoma mansoni	voltage-gated cation channel	0.0042	0.0132	0.0417
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0171	0.0539
Echinococcus granulosus	transient receptor potential cation channel	0.0042	0.0132	0.0417
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0046	0.0191	0.086
Echinococcus multilocularis	potassium voltage gated channel protein	0.0042	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Leishmania major	hypothetical protein, unknown function	0.0042	0.0132	1
Echinococcus multilocularis	ryanodine receptor 44f	0.0042	0.0132	0.0132
Onchocerca volvulus	Huntingtin homolog	0.012	0.1157	0.3901
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0042	0.0132	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0155	0.1623	1
Schistosoma mansoni	transient receptor potential channel 4	0.0042	0.0132	0.0417
Echinococcus granulosus	transient receptor potential cation channel	0.0042	0.0132	0.0417
Brugia malayi	Carboxylesterase family protein	0.0046	0.0191	0.06
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0042	0.0132	0.0417
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0042	0.0132	0.0132
Echinococcus multilocularis	calcium activated potassium channel	0.0042	0.0132	0.0132
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	hypothetical protein	0.0047	0.0203	0.064
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0042	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Loa Loa (eye worm)	voltage-gated potassium channel	0.0042	0.0132	0.0417
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0042	0.0132	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.2621	0.2621
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0397	0.1251
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0042	0.0132	0.0417
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0042	0.0132	0.0417
Brugia malayi	Carboxylesterase family protein	0.0046	0.0191	0.06
Echinococcus granulosus	shaker cognate	0.0042	0.0132	0.0417
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0042	0.0132	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0046	0.0191	0.0218
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0104	0.0947	0.2983
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0046	0.0191	0.06
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0046	0.0191	0.06
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0042	0.0132	0.0417
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0297	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Giardia lamblia	Fructose-bisphosphate aldolase	0.0317	0.3758	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Schistosoma mansoni	inositol monophosphatase	0.004	0.0111	0.035
Brugia malayi	ion channel NompC	0.0042	0.0132	0.0417
Echinococcus granulosus	para nitrobenzyl esterase	0.0046	0.0191	0.06
Echinococcus multilocularis	potassium large conductance calcium activated	0.0042	0.0132	0.0132
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.001	0.001
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0397	0.1251
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0042	0.0132	0.0417
Schistosoma mansoni	transient receptor potential channel	0.0042	0.0132	0.0417
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0088	0.0276
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0042	0.0132	0.0417
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0443	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0042	0.0132	0.0132
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0111	0.035
Onchocerca volvulus		0.0257	0.2967	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0042	0.0132	0.0417
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.001	0.0031
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0042	0.0132	0.0132
Schistosoma mansoni	calcium-activated potassium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0046	0.0191	0.06
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0042	0.0132	0.0417
Brugia malayi	olfactory channel protein osm-9	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0132	0.0058
Brugia malayi	Carboxylesterase family protein	0.0046	0.0191	0.06
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3176	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0042	0.0132	0.0132
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0042	0.0132	0.0417
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0042	0.0132	0.0417
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0042	0.0132	0.0417
Echinococcus granulosus	two pore calcium channel protein 1	0.0042	0.0132	0.0417
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0397	0.1251
Echinococcus multilocularis	conserved hypothetical protein	0.0042	0.0132	0.0132
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0397	0.1251
Brugia malayi	Transient-receptor-potential like protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	acetylcholinesterase	0.0273	0.3176	0.3176
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Brugia malayi	voltage-dependent calcium channel	0.0042	0.0132	0.0417
Echinococcus granulosus	voltage dependent calcium channel	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel protein	0.0042	0.0132	0.0132
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0042	0.0132	0.0132
Leishmania major	hypothetical protein, conserved	0.0042	0.0132	1
Toxoplasma gondii	transporter, cation channel family protein	0.0042	0.0132	1
Brugia malayi	cation channel family protein	0.0042	0.0132	0.0417
Echinococcus granulosus	carboxylesterase 5A	0.0273	0.3176	1
Echinococcus multilocularis	two pore calcium channel protein 2	0.0042	0.0132	0.0132
Echinococcus granulosus	hyperpolarization activated cyclic	0.0042	0.0132	0.0417
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0171	0.0539
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0042	0.0132	0.0417
Brugia malayi	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	voltage dependent calcium channel	0.0042	0.0132	0.0132
Toxoplasma gondii	transporter, cation channel family protein	0.0042	0.0132	1
Schistosoma mansoni	voltage-gated ion channel	0.0042	0.0132	0.0417
Echinococcus granulosus	calcium activated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	inositol-1	0.004	0.0111	0.035
Echinococcus multilocularis	transient receptor potential gamma protein	0.0042	0.0132	0.0132
Brugia malayi	hypothetical protein	0.0231	0.2621	0.8253
Echinococcus multilocularis	transient receptor potential cation channel	0.0042	0.0132	0.0132
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0171	0.0539
Echinococcus multilocularis	acetylcholinesterase	0.0273	0.3176	0.3176
Loa Loa (eye worm)	voltage-gated potassium channel	0.0042	0.0132	0.0417
Echinococcus granulosus	hypothetical protein	0.0042	0.0132	0.0417
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0132	0.0058
Loa Loa (eye worm)	carboxylesterase	0.0046	0.0191	0.06
Echinococcus granulosus	TRP transient receptor potential channel	0.0042	0.0132	0.0417
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0203	0.064
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0042	0.0132	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0171	0.0171
Echinococcus multilocularis	short transient receptor potential channel 6	0.0042	0.0132	0.0132
Echinococcus granulosus	sodium channel protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0163	0.0163
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0155	0.1623	1
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0042	0.0132	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0042	0.0132	0.0417
Echinococcus granulosus	ryanodine receptor 44f	0.0042	0.0132	0.0417
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.2967	0.783
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Toxoplasma gondii	transporter, cation channel family protein	0.0042	0.0132	1
Echinococcus multilocularis	sodium leak channel non selective protein	0.0042	0.0132	0.0132
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0046	0.0191	0.086
Echinococcus granulosus	voltage dependent calcium channel	0.0042	0.0132	0.0417
Echinococcus multilocularis	two pore calcium channel protein 1	0.0042	0.0132	0.0132
Echinococcus multilocularis	sodium channel protein	0.0042	0.0132	0.0132
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0042	0.0132	0.0132
Echinococcus multilocularis	transient receptor potential cation channel	0.0042	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus granulosus	transient receptor potential cation channel	0.0042	0.0132	0.0417
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0042	0.0132	0.0132
Echinococcus multilocularis	transient receptor potential cation channel	0.0042	0.0132	0.0132
Onchocerca volvulus		0.0047	0.0203	0.0685
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0046	0.0191	0.06
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0042	0.0132	0.0417
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0046	0.0191	0.0218
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	calcium channel	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0088	0.0088
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.2621	0.8253
Echinococcus granulosus	transient receptor potential gamma protein	0.0042	0.0132	0.0417
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0171	0.0539
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0132	0.0417
Toxoplasma gondii	hypothetical protein	0.0042	0.0132	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0155	0.1623	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.2556	0.8047
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0042	0.0132	0.0132
Echinococcus granulosus	potassium voltage gated channel protein	0.0042	0.0132	0.0417
Brugia malayi	jmjC domain containing protein	0.0038	0.0088	0.0276
Schistosoma mansoni	acetylcholinesterase	0.0046	0.0191	0.06
Schistosoma mansoni	inositol monophosphatase	0.004	0.0111	0.035
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0042	0.0132	0.0132
Brugia malayi	cation channel family protein	0.0042	0.0132	0.0417
Schistosoma mansoni	transient receptor potential channel	0.0042	0.0132	0.0417
Onchocerca volvulus		0.0046	0.0191	0.0643
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0171	0.0171
Brugia malayi	Carboxylesterase family protein	0.0046	0.0191	0.06
Echinococcus granulosus	sodium leak channel non selective protein	0.0042	0.0132	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0042	0.0132	0.0417
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0042	0.0132	0.0417
Echinococcus multilocularis	carboxylesterase 5A	0.0273	0.3176	0.3176
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0397	0.0397
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0042	0.0132	0.0132
Echinococcus granulosus	BC026374 protein S09 family	0.0046	0.0191	0.06
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0042	0.0132	0.0417
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.3758	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.0417
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0042	0.0132	0.0132
Schistosoma mansoni	ryanodine receptor related	0.0042	0.0132	0.0417
Brugia malayi	Carboxylesterase family protein	0.0273	0.3176	1
Echinococcus multilocularis	shaker cognate	0.0042	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2621	0.8253
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0317	0.3758	1
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0042	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0191	0.06
Echinococcus multilocularis	transfer RNA-Gly	0.0042	0.0132	0.0132

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 3 nM	Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independent measurements	ChEMBL.	15950467
Ki (binding)	= 3 nM	Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independent measurements	ChEMBL.	15950467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 329915