Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0546 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0546 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0546 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0546 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0546 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0546 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0546 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0546 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0546 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 6200 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
EC50 (functional) | > 6200 ng ml-1 | Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38 | ChEMBL. | 15955697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.