Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | nM | Agonist activity by [Ca2+] uptake in CHO cells expressing rat TRPV1 at 10-30 uM; WE = Weakly effective | ChEMBL. | 16005215 |
EC50 (functional) | 0 nM | Agonist activity by [Ca2+] uptake in CHO cells expressing rat TRPV1 at 10-30 uM; WE = Weakly effective | ChEMBL. | 16005215 |
Ki (functional) | nM | Antagonist activity for rat TRPV1 expressed in CHO cells; Weakly effective | ChEMBL. | 16005215 |
Ki (functional) | 0 nM | Antagonist activity for rat TRPV1 expressed in CHO cells; Weakly effective | ChEMBL. | 16005215 |
Ki (binding) | = 750 nM | In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX | ChEMBL. | 16005215 |
Ki (binding) | = 750 nM | In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX | ChEMBL. | 16005215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.