Detailed information for compound 330183

Basic information

Technical information
  • TDR Targets ID: 330183
  • Name: 4-(2-chloro-5-fluoro-4-methoxyphenyl)-8-[ethy l(propan-2-yl)amino]-6-methyl-1,3-dihydropyri do[2,3-b]pyrazin-2-one
  • MW: 406.882 | Formula: C20H24ClFN4O2
  • H donors: 1 H acceptors: 2 LogP: 4.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1cc(C)nc2c1NC(=O)CN2c1cc(F)c(cc1Cl)OC)C(C)C
  • InChi: 1S/C20H24ClFN4O2/c1-6-25(11(2)3)16-7-12(4)23-20-19(16)24-18(27)10-26(20)15-9-14(22)17(28-5)8-13(15)21/h7-9,11H,6,10H2,1-5H3,(H,24,27)
  • InChiKey: DZXRTFDRCBHMEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-chloro-5-fluoro-4-methoxy-phenyl)-8-[ethyl(isopropyl)amino]-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one
  • 4-(2-chloro-5-fluoro-4-methoxyphenyl)-8-[ethyl(isopropyl)amino]-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one
  • 4-(2-chloro-5-fluoro-4-methoxy-phenyl)-8-[ethyl(propan-2-yl)amino]-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one
  • 4-(2-chloro-5-fluoro-4-methoxyphenyl)-8-(ethyl-propan-2-ylamino)-6-methyl-1,3-dihydropyrido[2,3-e]pyrazin-2-one
  • 4-(2-chloro-5-fluoro-4-methoxy-phenyl)-8-(ethyl-isopropyl-amino)-6-methyl-1,3-dihydropyrido[2,3-e]pyrazin-2-one
  • 4-(2-chloro-5-fluoro-4-methoxyphenyl)-8-(ethyl-isopropylamino)-6-methyl-1,3-dihydropyrido[2,3-e]pyrazin-2-one
  • 4-(2-chloro-5-fluoro-4-methoxy-phenyl)-8-(ethyl-propan-2-yl-amino)-6-methyl-1,3-dihydropyrido[2,3-e]pyrazin-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Corticotropin releasing factor receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Pseudouridine-5 prime-monophosphatase homolog Corticotropin releasing factor receptor 1   415 aa 401 aa 27.2 %
Onchocerca volvulus Corticotropin releasing factor receptor 1   415 aa 401 aa 30.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c Corticotropin releasing factor receptor 1   415 aa 394 aa 27.7 %
Loa Loa (eye worm) hypothetical protein Corticotropin releasing factor receptor 1   415 aa 359 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0023 0.0089 0.0118
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0102 0.1008 0.1182
Loa Loa (eye worm) hypothetical protein 0.0396 0.4425 0.6161
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0413 0.0413
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0551 0.071
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1184 0.1552
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0249 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0375 0.0465
Brugia malayi RNA, U transporter 1 0.0089 0.0849 0.1126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Toxoplasma gondii FATC domain-containing protein 0.0032 0.0188 0.0356
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0582 0.0582
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0025 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0118 0.0194
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0168
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0121 0.0168
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0664 0.7541 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0332 0.3675 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0273 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0648 0.0648
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0337 0.0396
Brugia malayi MAP kinase sur-1 0.0055 0.0459 0.0609
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0089 0.0118
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0085 0.0807 0.1071
Chlamydia trachomatis pyruvate kinase 0.0072 0.0657 0.4625
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0188 0.1193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.039 0.0543
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0283 0.0343
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0018 0.0003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0121 0.0142
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.043
Plasmodium vivax SET domain protein, putative 0.0032 0.0194 0.034
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0071 0.0646 0.1203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0273 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.053 0.0672
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0016 0.0016
Brugia malayi hypothetical protein 0.0255 0.2788 0.3697
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0272 0.0675
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0089 0.0118
Echinococcus granulosus chromobox protein 1 0.0075 0.0694 0.0814
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0648 0.076
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0273 0.033
Schistosoma mansoni nuclear receptor 0.0023 0.0089 0.0104
Brugia malayi jmjC domain containing protein 0.0017 0.0016 0.0022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0133
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0283 0.0355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0118 0.0156
Echinococcus granulosus GPCR family 2 0.0019 0.0041 0.0048
Brugia malayi hypothetical protein 0.0131 0.1348 0.1787
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.039 0.0518
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0025 0.0045
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0018 0.0024
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0067 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0012
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.003 0.0035
Brugia malayi intermediate filament protein 0.0029 0.0158 0.021
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0657 0.0914
Echinococcus multilocularis caspase 3 0.0079 0.0733 0.0733
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0273 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0419 0.0523
Brugia malayi Heterochromatin protein 1 0.0075 0.0694 0.0921
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0026 0.0118 0.0135
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0026 0.0118 0.0135
Schistosoma mansoni coup transcription factor 0.0049 0.039 0.0458
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0513 0.0513
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0054 0.0098
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0018 0.0003
Toxoplasma gondii endonuclease IV APN 0.0083 0.0782 0.1488
Loa Loa (eye worm) hypothetical protein 0.0255 0.2788 0.3882
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0113 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0163
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0299 0.0299
Echinococcus multilocularis RUN 0.0021 0.0067 0.0067
Onchocerca volvulus 0.0053 0.044 0.1127
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0102 0.1008 0.1897
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0102 0.1008 0.1308
Echinococcus multilocularis 0.0026 0.0118 0.0118
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0056 0.0103
Brugia malayi isocitrate dehydrogenase 0.0017 0.0018 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0041 0.0041
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0694 0.0966
Brugia malayi nuclear hormone receptor 0.0023 0.0089 0.0118
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0136 0.0159
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0071 0.0646 0.0646
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0582 0.1525
Schistosoma mansoni chromobox protein 0.0075 0.0694 0.0814
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0596 0.0829
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0026 0.0118 0.0138
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0089 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.048
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.031 0.0379
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0271 0.0359
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.171 0.238
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0025
Trypanosoma brucei trypanothione reductase 0.0051 0.0413 0.0759
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.003 0.0035
Brugia malayi MH2 domain containing protein 0.0129 0.1318 0.1748
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0025 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0194 0.0368
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.039 0.0458
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0136 0.0229
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0283 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0646 0.0825
Trypanosoma brucei pteridine reductase 1 0.021 0.2259 0.4289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0168
Mycobacterium ulcerans endonuclease IV 0.0083 0.0782 0.2073
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.028 0.3076 0.4056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0089 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0025 0.0017
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0072 0.0657 0.1748
Brugia malayi ecdysone receptor 0.0023 0.0089 0.0118
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0279 0.3062 0.406
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0113 0.0117
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0025 0.0017
Onchocerca volvulus 0.0039 0.0272 0.0663
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0664 0.7541 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.1184 0.3086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.039 0.0458
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.1105 0.1296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.003 0.004
Leishmania major trypanothione reductase 0.0051 0.0413 0.0759
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0056 0.0052
Echinococcus granulosus RUN 0.0021 0.0067 0.0079
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1325 0.3476
Loa Loa (eye worm) hypothetical protein 0.0176 0.1868 0.2601
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Leishmania major oxidoreductase-like protein 0.002 0.0054 0.0071
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0413 0.0484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0012
Plasmodium vivax vivapain-2 0.0018 0.003 0.0025
Schistosoma mansoni ran 0.0023 0.0086 0.0101
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0089 0.0104
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0025
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0039
Loa Loa (eye worm) cysteine protease 0.0018 0.003 0.004
Plasmodium falciparum metacaspase 1 0.0048 0.0375 0.0685
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0054 0.0099
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0073 0.0118
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0073 0.0096
Echinococcus granulosus tumor protein p63 0.0365 0.4062 0.4762
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.0002
Echinococcus granulosus single minded 2 0.0039 0.0272 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0089 0.0104
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0002 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0026 0.0118 0.0163
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1325 0.3574
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0102 0.1008 0.1303
Echinococcus multilocularis muscleblind protein 0.0161 0.1695 0.1695
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0026 0.0118 0.0194
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.062 0.0803
Loa Loa (eye worm) fibroinase 0.0018 0.003 0.004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0071 0.0646 0.0836
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.1184 0.2233
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.003 0.0035
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0026 0.0118 0.0194
Loa Loa (eye worm) DR-78 0.0023 0.0089 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Echinococcus granulosus thymidylate synthase 0.0332 0.3675 0.4308
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0582 0.1106
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2061 0.2709
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0558 0.0654
Plasmodium falciparum thioredoxin reductase 0.0018 0.0025 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0646 0.0898
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0136 0.14 0.1641
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0102 0.1008 0.1897
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1184 0.1542
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1174 0.3161
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0188 0.1406
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0067 0.0079
Toxoplasma gondii exonuclease III APE 0.002 0.0056 0.0103
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0182 0.0316
Echinococcus granulosus phd:f box containing protein 0.0017 0.0016 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0025
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0111 0.1105 0.1105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0017
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0026 0.0118 0.0194
Toxoplasma gondii pyruvate kinase PyK1 0.0072 0.0657 0.125
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0056 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.039 0.0518
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0016 0.0019
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0026 0.0118 0.0138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0018 0.0002
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.1184 0.1184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.039 0.039
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0375 0.0685
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0071 0.0646 0.082
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0136 0.0159
Echinococcus multilocularis GPCR, family 2 0.0019 0.0041 0.0041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0188 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0375 0.0465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.039 0.0543
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.039 0.0518
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0018 0.0003
Schistosoma mansoni survival motor neuron protein 0.0052 0.0425 0.0498
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0283 0.0283
Echinococcus granulosus FTZ F1 alpha 0.0049 0.039 0.0458
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0102 0.1008 0.192
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0089 0.0104
Echinococcus multilocularis caspase 2 0.0092 0.0892 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.003 0.0006
Brugia malayi Muscleblind-like protein 0.0161 0.1695 0.2247
Echinococcus multilocularis dihydrofolate reductase 0.0135 0.1391 0.1391
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.039 0.0458
Entamoeba histolytica hypothetical protein 0.0025 0.0113 0.0111
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0026 0.0118 0.0194
Brugia malayi Pyruvate kinase, muscle isozyme 0.0072 0.0657 0.0871
Schistosoma mansoni hypothetical protein 0.0044 0.0337 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0056
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0273 0.0324
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0347 0.0871
Onchocerca volvulus 0.0256 0.2795 0.7587
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.039 0.039
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0086 0.0133
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0054 0.005
Schistosoma mansoni rab6-interacting 0.0021 0.0067 0.0079
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0089 0.0123
Echinococcus multilocularis chromobox protein 1 0.0075 0.0694 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0273 0.0341
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0136 0.0229
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.1105 0.1296
Plasmodium vivax vivapain-2 0.0018 0.003 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0067 0.0079
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0459 0.0577
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0375 0.0465
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0016 0.0016
Trypanosoma cruzi metacaspase, putative 0.0048 0.0375 0.0476
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1184 0.1542
Mycobacterium leprae Probable pyruvate kinase PykA 0.0072 0.0657 0.1623
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0056 0.0075
Loa Loa (eye worm) inositol-1 0.004 0.0283 0.0393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0025 0.0012
Brugia malayi jmjC domain containing protein 0.0064 0.0558 0.074
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0188 0.0217
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0449 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.039 0.0543
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0041 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0188 0.0217
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0016 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0664 0.7541 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0375 0.0712
Echinococcus multilocularis pyruvate kinase 0.0057 0.0481 0.0481
Echinococcus granulosus intermediate filament protein 0.0029 0.0158 0.0185
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.3062 0.404
Onchocerca volvulus 0.0033 0.0204 0.0478
Onchocerca volvulus 0.002 0.0054 0.0066
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0025 0.0033
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0089 0.0123
Trypanosoma cruzi metacaspase, putative 0.0048 0.0375 0.0476
Mycobacterium tuberculosis Probable reductase 0.0116 0.1174 0.3161
Echinococcus granulosus caspase 0.0126 0.1288 0.151
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0459 0.0588
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0188 0.0328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.039 0.0518
Schistosoma mansoni caspase-7 (C14 family) 0.0126 0.1288 0.151
Echinococcus multilocularis snurportin 1 0.0332 0.3684 0.3684
Leishmania major pyruvate kinase 0.0072 0.0657 0.1225
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Plasmodium falciparum thioredoxin reductase 0.0051 0.0413 0.0759
Mycobacterium ulcerans epimerase 0.0022 0.0073 0.013
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.02 0.0278
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.039 0.039
Loa Loa (eye worm) glutathione reductase 0.0051 0.0413 0.0574
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0086 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0025 0.0012
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0621 0.0823
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0032 0.0188 0.0328
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0039
Echinococcus granulosus serine protein kinase ATM 0.0032 0.0188 0.0221
Schistosoma mansoni lamin 0.0029 0.0158 0.0185
Schistosoma mansoni hypothetical protein 0.0183 0.1947 0.2283
Plasmodium vivax pyruvate kinase, putative 0.0072 0.0657 0.1225
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.01
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0337 0.0337
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0061 0.0531 0.0983
Trypanosoma cruzi metacaspase, putative 0.0048 0.0375 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0375 0.0465
Loa Loa (eye worm) phosphatidylinositol 3 0.0633 0.7181 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0025 0.002
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0558 0.0654
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0054 0.0078
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0273 0.038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.031 0.0379
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0092
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.5474 0.7249
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0025
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0039 0.0271 0.0486
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0067 0.0097
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0089 0.0162
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0039 0.0271 0.0317
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.0677 0.0794
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.2357 0.3125
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0016 0.0019
Echinococcus granulosus geminin 0.0183 0.1947 0.2283
Onchocerca volvulus 0.0049 0.039 0.099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0041 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.039 0.0458
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0032 0.0188 0.0211
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0558 0.0558
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.003 0.0018
Trypanosoma brucei metacaspase 5, putative 0.0048 0.0375 0.0685
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0102 0.1008 0.1897
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1653 0.2166
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.1184 0.3189
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0459 0.0847
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.0677 0.0794
Leishmania major phosphatidylinositol kinase related protein, putative 0.0026 0.0118 0.0194
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.039 0.0458
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0089 0.0089
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.2757 0.3839
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Schistosoma mansoni inositol monophosphatase 0.004 0.0283 0.0332
Trichomonas vaginalis ran, putative 0.0023 0.0086 0.0081
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.1105 0.1296
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0026 0.0118 0.0222
Brugia malayi jmjC domain containing protein 0.0017 0.0016 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Schistosoma mansoni alpha glucosidase 0.0039 0.0273 0.0321
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0188 0.0217
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0459 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0558 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.053 0.0672
Loa Loa (eye worm) thymidylate synthase 0.0332 0.3675 0.5117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.039 0.0458
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0513 0.0601
Plasmodium vivax metacaspase 1, putative 0.0048 0.0375 0.0685
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0459 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0415 0.0519
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0025 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0102 0.1008 0.1403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.0479
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0073 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.3062 0.404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Leishmania major pteridine reductase 1 0.0221 0.2389 0.4536
Loa Loa (eye worm) phosphatidylinositol 3 0.0026 0.0118 0.0163
Schistosoma mansoni pyruvate kinase 0.0037 0.0249 0.0292
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0118 0.0126
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0467 0.5247 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0563 0.0716
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0249 0.0446
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0459 0.0577
Loa Loa (eye worm) hypothetical protein 0.0044 0.0337 0.0468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0086 0.0161
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0026 0.0118 0.0138
Loa Loa (eye worm) hypothetical protein 0.0053 0.044 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0118 0.0123
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0048 0.0375 0.0497
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0188 0.0217
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0032 0.0188 0.0228
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0283 0.0343
Giardia lamblia Hypothetical protein 0.0026 0.0118 0.0226
Loa Loa (eye worm) phosphatidylinositol kinase 0.0026 0.0118 0.0163
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0467 0.5247 1
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0188 0.0356
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0016 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0121 0.0142
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.0003
Schistosoma mansoni ap endonuclease 0.002 0.0056 0.0065
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0218 0.2357 0.4475
Schistosoma mansoni lipoxygenase 0.006 0.0513 0.0601
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0459 0.0588
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0025 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0041 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.039 0.0518
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0194 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.039 0.0518
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0089 0.0089
Brugia malayi nuclear receptor NHR-88 0.0023 0.0089 0.0118
Echinococcus granulosus importin subunit beta 1 0.0031 0.0182 0.0213
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0016 0.0016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0136 0.14 0.14
Entamoeba histolytica protein kinase rad3, putative 0.0032 0.0188 0.0211
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0158 0.1653 0.2175
Brugia malayi Pre-SET motif family protein 0.0032 0.0194 0.0258
Trypanosoma brucei metacaspase MCA2 0.0048 0.0375 0.0685
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0026 0.0118 0.0222
Schistosoma mansoni ap endonuclease 0.002 0.0056 0.0065
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0048
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.003 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0249 0.0446
Loa Loa (eye worm) hypothetical protein 0.0268 0.2936 0.4088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.039 0.0543
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.4425 0.5867
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0188 0.0328
Brugia malayi nuclear receptor RXR 0.0026 0.0121 0.0161
Leishmania major phosphatidylinositol 4-kinase, putative 0.0026 0.0118 0.0194
Leishmania major phosphatidylinositol kinase, putative 0.0026 0.0118 0.0194
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0039
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0026 0.0118 0.0135
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0273 0.033
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0188 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.039 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0271 0.0376
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0158 0.021
Plasmodium falciparum glutathione reductase 0.0018 0.0025 0.0017
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0089 0.0104
Brugia malayi nuclear receptor RXR 0.0023 0.0089 0.0118
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0067 0.0079
Echinococcus multilocularis pyruvate kinase 0.0072 0.0657 0.0657
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2061 0.2709
Schistosoma mansoni rab6-interacting 0.0021 0.0067 0.0079
Loa Loa (eye worm) phosphatidylinositol 3 0.0193 0.2059 0.2866
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0168
Toxoplasma gondii cathepsin CPL 0.0018 0.003 0.0054
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0375 0.0712
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.046 0.0578
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0273 0.0518
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0459 0.0459
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.039 0.0543
Brugia malayi hypothetical protein 0.0026 0.0121 0.0161
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0056 0.1178
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0621 0.1631
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0749 0.8529 0.8529
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0089 0.0123
Chlamydia trachomatis endonuclease IV 0.0083 0.0782 0.5538
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0657 0.0914
Trypanosoma brucei pyruvate kinase 1 0.0072 0.0657 0.1225
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0459 0.0873
Brugia malayi hypothetical protein 0.0158 0.1653 0.2192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0219
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1174 0.3161
Loa Loa (eye worm) hypothetical protein 0.0161 0.1695 0.2359
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0283 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0026 0.0118 0.0135
Brugia malayi thymidylate synthase 0.0332 0.3675 0.4872
Entamoeba histolytica hypothetical protein 0.0026 0.0118 0.0117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.039 0.0458
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.0404 0.0561
Giardia lamblia Phosphatidylinositol 4-kinase 0.0026 0.0118 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0271 0.0326
Echinococcus multilocularis chromobox protein 1 0.0075 0.0694 0.0694
Echinococcus multilocularis lamin 0.0029 0.0158 0.0158
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0111 0.1105 0.1105
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0648 0.086
Plasmodium falciparum pyruvate kinase 0.0072 0.0657 0.1225
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0621 0.0728
Mycobacterium tuberculosis Hypothetical protein 0.0158 0.1653 0.4473
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0026 0.0118 0.0194
Brugia malayi Protein kinase domain containing protein 0.0016 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0404 0.0561
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0664 0.7541 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0012
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0039 0.0271 0.0271
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1184 0.2233
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1184 0.1542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.0479
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.1865 0.2473
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0113 0.0128
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0056 0.0034
Brugia malayi Cell death protein 3 precursor 0.0092 0.0892 0.1183
Brugia malayi Doublecortin family protein 0.0021 0.0067 0.0089
Schistosoma mansoni hypothetical protein 0.0052 0.0425 0.0498
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.039 0.0518
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0056 0.0075
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0396 0.4425 0.4425
Entamoeba histolytica hypothetical protein 0.0026 0.0118 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Echinococcus multilocularis pyruvate kinase 0.0037 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0041 0.0298 0.0414
Schistosoma mansoni polycystin 1-related 0.0021 0.0067 0.0079
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0782 0.1463
Giardia lamblia Pyruvate kinase 0.0072 0.0657 0.1541
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.3062 0.404
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0121 0.0142
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0102 0.1008 0.1008
Schistosoma mansoni thyroid hormone receptor 0.0185 0.1971 0.2311
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0582 0.0682
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.002 0.0054 0.0078
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1184 0.1388
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0218 0.2357 0.3102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0228
Echinococcus multilocularis geminin 0.0183 0.1947 0.1947
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0086 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0018 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0413 0.0527
Schistosoma mansoni lipoxygenase 0.0021 0.0067 0.0079
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0016 0.0019
Brugia malayi hypothetical protein 0.0039 0.0271 0.036
Brugia malayi dihydrofolate reductase family protein 0.0135 0.1391 0.1845
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.043 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.039 0.0518
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.003 0.003
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0026 0.0118 0.0138
Echinococcus multilocularis cysteine protease 0.0018 0.003 0.003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0025 0.0017
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0245 0.2672 0.3721
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0071 0.0646 0.082
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.039 0.039
Echinococcus multilocularis musashi 0.0029 0.0158 0.0158
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0782 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0419 0.0523
Echinococcus multilocularis thyroid hormone receptor alpha 0.0185 0.1971 0.1971
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0102 0.1008 0.1182
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Brugia malayi hypoxia-induced factor 1 0.0163 0.171 0.2267
Brugia malayi jmjC domain containing protein 0.0017 0.0016 0.0022
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0061 0.0531 0.0983
Onchocerca volvulus 0.0045 0.0337 0.0844
Trichomonas vaginalis set domain proteins, putative 0.0256 0.2793 0.3683
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.039 0.0458
Loa Loa (eye worm) phosphofructokinase 0.0117 0.1184 0.1648
Loa Loa (eye worm) hypothetical protein 0.0072 0.0657 0.0914
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0102 0.1008 0.1318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0271 0.0326
Brugia malayi hypothetical protein 0.0021 0.0067 0.0089
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0102 0.1008 0.1318
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0039 0.0271 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0118 0.0273
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0332 0.3675 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0016 0.0028
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0102 0.1008 0.1182
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1184 0.1537
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.039 0.039
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0056 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.2788 0.2788
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0089 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.0003
Echinococcus granulosus dihydrofolate reductase 0.0135 0.1391 0.1631
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0283 0.051
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0071 0.0646 0.1203
Echinococcus multilocularis caspase 8 0.0048 0.0375 0.0375
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0188 0.0397
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0032 0.0188 0.0188
Giardia lamblia GTOR 0.0071 0.0646 0.1513
Echinococcus multilocularis lamin dm0 0.0029 0.0158 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.1865 0.2186
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0188 0.0217
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0025 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0582 0.0682
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0048
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0089 0.0118
Leishmania major cathepsin L-like protease 0.0069 0.062 0.1155
Trypanosoma cruzi target of rapamycin kinase 3 0.0061 0.0531 0.0683
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0459 0.0847
Schistosoma mansoni chromobox protein 0.0075 0.0694 0.0814
Echinococcus granulosus pyruvate kinase 0.0037 0.0249 0.0292
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0089 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1318 0.1835
Schistosoma mansoni hypothetical protein 0.0039 0.0271 0.0318
Leishmania major cathepsin L-like protease 0.0069 0.062 0.1155
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.1184 0.1388
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0039 0.0271 0.0338
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.003 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0188 0.0217
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0188 0.1193
Brugia malayi Inositol-1 0.004 0.0283 0.0376
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0283 0.0537
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Onchocerca volvulus 0.0026 0.0118 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.3062 0.404
Echinococcus multilocularis muscleblind protein 1 0.0161 0.1695 0.1695
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0089 0.0089
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0135 0.1391 0.3756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0118 0.0123
Leishmania major importin beta-1 subunit, putative 0.0025 0.0113 0.0185
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0018 0.0031
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0016 0.0019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.003 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0188 0.0328
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0347 0.0428
Schistosoma mansoni caspase-3 (C14 family) 0.0126 0.1288 0.151
Brugia malayi hypothetical protein 0.0023 0.0089 0.0118
Brugia malayi hypothetical protein 0.0027 0.0136 0.018
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0021
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0459 0.0588
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0396 0.4425 0.5188
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Brugia malayi 6-phosphofructokinase 0.0117 0.1184 0.157
Schistosoma mansoni pyruvate kinase 0.0072 0.0657 0.077
Echinococcus multilocularis pyruvate kinase 0.0072 0.0657 0.0657
Echinococcus granulosus caspase 2 0.0092 0.0892 0.1046
Brugia malayi steroid hormone receptor 0.0049 0.039 0.0518
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0071 0.0646 0.0757
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0548 0.6193 0.8205
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0235 0.045
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.003 0.003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.3684 0.513
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0016 0.0028
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0235 0.0593
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.062 0.0803
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0089 0.0104
Brugia malayi hypothetical protein 0.0176 0.1868 0.2478
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0025 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0025 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.053 0.0672
Echinococcus multilocularis Ankyrin 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0677 0.0942
Echinococcus granulosus caspase 3 0.0079 0.0733 0.0859
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0657 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0056 0.0075
Giardia lamblia Pyruvate kinase 0.0037 0.0249 0.0547
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0558 0.0654
Brugia malayi 6-phosphofructokinase 0.0117 0.1184 0.157
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0621 0.1631
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.039 0.099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0118 0.0156
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.0188
Schistosoma mansoni hypothetical protein 0.0026 0.0118 0.0138
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0126 0.1288 0.151
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0043 0.0316 0.0572
Trypanosoma brucei protein kinase, putative 0.0055 0.0459 0.0847
Brugia malayi hypothetical protein 0.0026 0.0121 0.0161
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0273 0.033
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0026 0.0118 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.062 0.0803
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0657 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.053 0.0672
Trypanosoma brucei glucosidase, putative 0.0039 0.0273 0.0491
Toxoplasma gondii thioredoxin reductase 0.0051 0.0413 0.0785
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0089 0.0089
Schistosoma mansoni zinc finger protein 0.0023 0.0089 0.0104
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0188 0.0356
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0048 0.0375 0.044
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0026 0.0118 0.0123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.039 0.0458
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0056 0.0262
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.2788 0.3269
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0413 0.0759
Onchocerca volvulus 0.0023 0.0089 0.0162
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0782 0.2089
Brugia malayi Thioredoxin reductase 0.0051 0.0413 0.0548
Leishmania major hypothetical protein, unknown function 0.0026 0.0118 0.0194
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0018 0.0021
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0182 0.0343
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0459 0.0638
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0102 0.1008 0.192
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0283 0.0707
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0283 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0025 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0459 0.0577
Loa Loa (eye worm) hypothetical protein 0.0083 0.0782 0.1088
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0056 0.0074
Onchocerca volvulus 0.0029 0.0158 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0079
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0272 0.036
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.039 0.0518
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Entamoeba histolytica pyruvate kinase, putative 0.005 0.0404 0.0498
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0657 0.0841
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0158 0.0219
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0039
Brugia malayi Dihydrofolate reductase 0.0135 0.1391 0.1845
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0332 0.3675 0.4308
Loa Loa (eye worm) hypothetical protein 0.0161 0.1695 0.2359
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0694 0.089
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0657 0.1721
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0657 0.1721
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.003 0.0025
Brugia malayi jmjC domain containing protein 0.0064 0.0558 0.074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0073 0.015
Echinococcus multilocularis tumor protein p63 0.0365 0.4062 0.4062
Leishmania major hypothetical protein, conserved 0.0027 0.0136 0.0229
Chlamydia trachomatis dihydrofolate reductase 0.0135 0.1391 1
Echinococcus multilocularis pyruvate kinase 0.0037 0.0249 0.0249
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0299 0.0351
Onchocerca volvulus 0.0023 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0049 0.039 0.0458
Brugia malayi nuclear hormone receptor 0.0049 0.039 0.0518
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0218 0.2357 0.311
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1174 0.3057
Toxoplasma gondii target of rapamycin (TOR), putative 0.0059 0.0501 0.0952
Loa Loa (eye worm) dihydrofolate reductase 0.0135 0.1391 0.1937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.039 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Onchocerca volvulus 0.0021 0.0067 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.039 0.0518
Echinococcus granulosus Ankyrin 0.0016 0.0002 0.0002
Schistosoma mansoni intermediate filament proteins 0.0029 0.0158 0.0185
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0026 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.039 0.0518
Trypanosoma brucei metacaspase 0.0048 0.0375 0.0685
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0648 0.0902
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0089 0.0118
Entamoeba histolytica hypothetical protein 0.0032 0.0188 0.0211
Brugia malayi Pre-SET motif family protein 0.0225 0.2432 0.3225
Brugia malayi jmjC domain containing protein 0.0017 0.0016 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0188 0.0217
Brugia malayi hypothetical protein 0.0044 0.0337 0.0447
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0135 0.1391 0.3744
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0459 0.0577
Entamoeba histolytica hypothetical protein 0.0039 0.0271 0.0321
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0032 0.0188 0.0228
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0054 0.0078
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0467 0.5247 0.695
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0071 0.0646 0.0836
Plasmodium vivax hypothetical protein 0.0026 0.0118 0.0194
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0086 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.039 0.0518
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0121 0.0161
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0467 0.5247 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.003 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.039 0.0543
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.039 0.0458
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0467 0.5247 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0459 0.0538
Echinococcus granulosus caspase 8 0.0048 0.0375 0.044
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0582 0.1081
Leishmania major cysteine peptidase A (CPA) 0.0018 0.003 0.0025
Schistosoma mansoni ran 0.0023 0.0086 0.0101
Echinococcus multilocularis caspase 0.0126 0.1288 0.1288
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0026 0.0118 0.0138
Echinococcus granulosus pyruvate kinase 0.0037 0.0249 0.0292
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0188 0.0249
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0039 0.0271 0.0317
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.031 0.0768
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1184 0.1648
Plasmodium falciparum metacaspase-like protein 0.0048 0.0375 0.0685
Trypanosoma cruzi metacaspase, putative 0.0048 0.0375 0.0476
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0558 0.0558
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0188 0.0356
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0279 0.3062 0.4263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.053 0.0672
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0182 0.0182
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0283 0.0355
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0089 0.0104
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0188 0.0217
Echinococcus granulosus lamin 0.0029 0.0158 0.0185
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0016 0.0019
Leishmania major pyruvate kinase 0.0072 0.0657 0.1225
Brugia malayi follicle stimulating hormone receptor 0.0253 0.2757 0.3656
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0018 0.0031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0413 0.1081
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.003 0.003
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0032 0.0188 0.0221
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0664 0.7541 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.039 0.099
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0039 0.0271 0.0486
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0271 0.0318
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0459 0.1059
Loa Loa (eye worm) hypothetical protein 0.0343 0.3802 0.5295
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0648 0.084
Loa Loa (eye worm) hypothetical protein 0.0032 0.0188 0.0261
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.039 0.0458
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0194 0.0228
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0067 0.0092
Brugia malayi hypothetical protein 0.0018 0.0024 0.0032
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0273 0.033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0182 0.0316
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.039 0.0458
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1184 0.1542
Schistosoma mansoni pyruvate kinase 0.0072 0.0657 0.077
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0026 0.0118 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.039 0.0458
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0194 0.0194
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1174 0.3161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Echinococcus granulosus snurportin 1 0.0332 0.3684 0.4319
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0621 0.0621
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.1865 0.2596
Brugia malayi Pyruvate kinase, M2 isozyme 0.0072 0.0657 0.0871
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0136 0.0229
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Brugia malayi tailless protein 0.0023 0.0089 0.0118
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0694 0.089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0168
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0558 0.0654
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0621 0.1648
Echinococcus granulosus lamin dm0 0.0029 0.0158 0.0185
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0657 0.0851
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.044 0.0516
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0272 0.0272
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0086 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0271 0.0326
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0188 0.0217
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0657 0.0841
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0347 0.0428
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0016 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0467 0.5247 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0102 0.1008 0.1308
Brugia malayi ecdysteroid receptor 0.0049 0.039 0.0518
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0089 0.0118
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.003 0.0025
Schistosoma mansoni loxhd1 0.0021 0.0067 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.018 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.039 0.0518
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0126 0.1288 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0448 0.0562
Echinococcus multilocularis thymidylate synthase 0.0332 0.3675 0.3675
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0273 0.033
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0025 0.0017
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1184 0.1648
Loa Loa (eye worm) hypothetical protein 0.0031 0.0182 0.0252
Loa Loa (eye worm) phosphatidylinositol 3 0.0026 0.0118 0.0163
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.039 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0233 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1865 0.1865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Brugia malayi glutathione reductase 0.0051 0.0413 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1184 0.1388
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0582 0.0682
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Trypanosoma brucei metacaspase MCA3 0.0048 0.0375 0.0685
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.2357 0.3098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0646 0.0825
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0092
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0158 0.0219
Onchocerca volvulus 0.0102 0.1003 0.2669
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0298 0.0395
Onchocerca volvulus 0.0026 0.0118 0.0242
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0033 0.02 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0375 0.0465
Onchocerca volvulus 0.0021 0.0067 0.0102
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0744 0.0872
Mycobacterium ulcerans thymidylate synthase 0.0332 0.3675 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.039 0.0458
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0121 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.004
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0348 0.0634
Schistosoma mansoni alpha-glucosidase 0.0151 0.158 0.1853
Schistosoma mansoni nuclear receptor 0.0023 0.0089 0.0104
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0056 0.0065
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0582 0.1542
Leishmania major hypothetical protein, conserved 0.0026 0.0118 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.039 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.003 0.0006
Trypanosoma cruzi metacaspase 5, putative 0.0048 0.0375 0.0476
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0273 0.0491
Plasmodium vivax glutathione reductase, putative 0.0051 0.0413 0.0759
Plasmodium falciparum importin beta, putative 0.0031 0.0182 0.0316
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0749 0.8529 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0041 0.0298 0.0349
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0067 0.0067
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0519 0.0722
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0193 0.2059 0.2714
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0136 0.0256
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0558 0.0776
Brugia malayi Importin beta-1 subunit 0.0031 0.0182 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0025 0.0017
Leishmania major metacaspase, putative 0.0048 0.0375 0.0685
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0744 0.0744
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0018 0.0024
Brugia malayi PAS domain containing protein 0.0053 0.043 0.0571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Schistosoma mansoni hypothetical protein 0.0136 0.14 0.1641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0228
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0054 0.0078
Trypanosoma cruzi metacaspase 5, putative 0.0048 0.0375 0.0476
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0102 0.1008 0.1182
Entamoeba histolytica hypothetical protein 0.0026 0.0118 0.0117
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0218 0.2357 0.2763
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0056 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0646 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0419 0.0523
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0026 0.0118 0.0118
Onchocerca volvulus 0.0044 0.0337 0.0842
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0089 0.0089
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0026 0.0118 0.0194
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0026 0.0118 0.0194
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0425 0.0564
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0118 0.0135
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0664 0.7541 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0273 0.0273
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0102 0.1008 0.1308
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.02 0.0233
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0071 0.0646 0.0757
Echinococcus multilocularis cysteine protease 0.0018 0.003 0.003
Leishmania major phosphatidylinositol 3-kinase, putative 0.0102 0.1008 0.1897
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0648 0.1208
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0271 0.0318
Loa Loa (eye worm) hypothetical protein 0.0092 0.0892 0.1241
Brugia malayi chromobox protein homolog 3 0.0042 0.031 0.0411
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1865 0.1865
Schistosoma mansoni inositol monophosphatase 0.004 0.0283 0.0332
Mycobacterium ulcerans hypothetical protein 0.0022 0.0073 0.013
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0782 0.1037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0123
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0415 0.0519
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0071 0.0646 0.1203
Schistosoma mansoni hypothetical protein 0.0183 0.1947 0.2283
Schistosoma mansoni lamin 0.0029 0.0158 0.0185
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0135 0.1391 0.3662
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0016 0.0022
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0648 0.1208
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.039 0.099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.2194 0.2194
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.039 0.0518
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1174 0.3161
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.1184 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0016 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.048
Schistosoma mansoni importin beta-1 0.0031 0.0182 0.0213
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1184 0.1537
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.2357 0.3102
Loa Loa (eye worm) phosphatidylinositol 3 0.0026 0.0118 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.039 0.0518
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0026 0.0118 0.0138
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0639 0.7243 0.9603
Brugia malayi hypothetical protein 0.0021 0.0067 0.0089
Entamoeba histolytica hypothetical protein 0.0548 0.6193 0.8205
Plasmodium vivax importin-beta 2, putative 0.0031 0.0182 0.0316
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0102 0.1008 0.1897
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0026 0.0118 0.0222
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0218 0.2357 0.3102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0664 0.7541 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0102 0.1008 0.1337
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.3062 0.404
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.1947 0.526
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0073 0.013
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0413 0.0574
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1184 0.1537
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0782 0.1969
Plasmodium falciparum glutathione reductase 0.0051 0.0413 0.0759
Leishmania major phosphatidylinositol 3-kinase, putative 0.0039 0.0271 0.0486
Schistosoma mansoni dihydrofolate reductase 0.0135 0.1391 0.1631
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0188 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.2672 0.3544
Brugia malayi conserved hypotetical protein 0.0023 0.0089 0.0118
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0056 0.0075
Toxoplasma gondii melibiase subfamily protein 0.0111 0.1105 0.2105
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0646 0.0856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.1184 0.3176
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0543
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.039 0.0543
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1174 0.3161
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.1105 0.1296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0386 0.0479
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.037 0.4125 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0375 0.0465
Echinococcus multilocularis pyruvate kinase 0.0037 0.0249 0.0249
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0039
Loa Loa (eye worm) ctsf protein 0.0018 0.003 0.004
Schistosoma mansoni hypothetical protein 0.0332 0.3684 0.4319
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.039 0.0458
Brugia malayi nuclear receptor NHR-88 0.0049 0.039 0.0518
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0041 0.0048
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0025
Echinococcus granulosus pyruvate kinase 0.0037 0.0249 0.0292
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1325 0.3574
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0459 0.0538
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.2357 0.3098
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0142 0.1466 0.3515
Echinococcus granulosus muscleblind protein 0.0161 0.1695 0.1987
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0273 0.033
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0648 0.0823
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0273 0.033
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0054 0.0071
Entamoeba histolytica Ran family GTPase 0.0023 0.0086 0.0075
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0113 0.0117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0582 0.1525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Echinococcus multilocularis serine protein kinase ATM 0.0032 0.0188 0.0188
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1325 0.3574
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0648 0.076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0269
Loa Loa (eye worm) hypothetical protein 0.0048 0.0375 0.0521
Brugia malayi Melibiase family protein 0.0074 0.0677 0.0898
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0102 0.1008 0.1303
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0749 0.8529 1
Schistosoma mansoni single-minded 0.0053 0.043 0.0504
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0283 0.051
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0136 0.0229
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0621 0.1155
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0025 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0056 0.0052
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0074 0.0677 0.0867
Mycobacterium ulcerans pyruvate kinase 0.0072 0.0657 0.1732
Entamoeba histolytica hypothetical protein 0.0039 0.0271 0.0321
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0025 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0273 0.033
Echinococcus multilocularis Zinc finger, PHD finger 0.0102 0.1008 0.1008
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.3062 0.404
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0648 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0501 0.0633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.039 0.0458
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.5474 0.7249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0271 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0271 0.0326
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1318 0.1835
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0056 0.0056
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0657 0.1721
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0582 0.1525
Schistosoma mansoni fkbp-rapamycin associated protein 0.0032 0.0188 0.0221
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0032 0.0188 0.0221
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0056 0.0074
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0016 0.0016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.0006
Schistosoma mansoni alpha-glucosidase 0.0151 0.158 0.1853
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0016 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.039 0.0458
Brugia malayi nuclear receptor NHR-67 0.0023 0.0089 0.0118
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0273 0.033
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0337 0.0395
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0089 0.0104
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0039 0.0271 0.0486
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0026 0.0118 0.0123
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0459 0.0538
Schistosoma mansoni caspase-7 (C14 family) 0.0092 0.0892 0.1046
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0111 0.1105 0.1296
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0375 0.0465
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0375 0.0712
Leishmania major GTP-binding protein, putative 0.0023 0.0086 0.0133
Echinococcus granulosus pyruvate kinase 0.0072 0.0657 0.077
Onchocerca volvulus 0.0029 0.0158 0.0352
Schistosoma mansoni thyroid hormone receptor 0.0185 0.1971 0.2311
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0016 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0089 0.0162
Trypanosoma brucei pyruvate kinase 1, putative 0.0072 0.0657 0.1225
Onchocerca volvulus 0.0332 0.3675 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0026 0.0118 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.2432 0.3387
Onchocerca volvulus 0.0052 0.0425 0.1085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0118 0.0156
Onchocerca volvulus Cell death protein 3 homolog 0.0092 0.0892 0.2366
Echinococcus granulosus chromobox protein 1 0.0075 0.0694 0.0814
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0273 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.062 0.1155
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1947 0.2557
Echinococcus granulosus cathepsin l1 0.0018 0.003 0.0035
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0519 0.0689
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0621 0.0728
Entamoeba histolytica hypothetical protein 0.0039 0.0271 0.0321
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0022
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0048
Leishmania major cathepsin L-like protease 0.0069 0.062 0.1155
Trypanosoma brucei Metacaspase-4 0.0048 0.0375 0.0685
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0283 1
Echinococcus granulosus pyruvate kinase 0.0072 0.0657 0.077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0459 0.0847
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0188 0.0328
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.2194 0.2572
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0071 0.0646 0.1203
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.062 0.0803
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.039 0.039
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0016 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0056 0.0083
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0089 0.0104
Entamoeba histolytica hypothetical protein 0.0039 0.0271 0.0321
Brugia malayi phosphofructokinase 0.0117 0.1184 0.157

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 nM Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1 ChEMBL. 15509177
IC50 (binding) = 1.5 nM Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1 ChEMBL. 15509177

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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