Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0303 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0303 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0303 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0303 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0303 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0303 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0303 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0303 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0303 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0303 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k cat (binding) | = 0.1 min-1 | Kinetic parameter Kcat of the compound was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Km (binding) | = 300 uM | Kinetic parameter KM of the compound was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Kuncat (binding) | = 0.05 M-1 min-1 | Kinetic parameter Kuncat of the compound was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Molarity (binding) | = 2 M | Kinetic parameter effective molarity of the compound was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Rate acceleration (binding) | = 2 | Rate acceleration. the ratio of Kcat to that of Km to that of Kuncat was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Substrate specificity (binding) | = 3 | Substrate specificity, the ratio of Kcat to that of Km was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Vmax (binding) | = 1 uM min-1 | Kinetic parameter Vmax of the compound was determined against monoclonal antibody 16 G3 | ChEMBL. | 12657273 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.