Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0099 | 0.0309 | 0.0309 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0099 | 0.0309 | 0.0309 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0092 | 0 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0099 | 0.0309 | 0.0309 |
Brugia malayi | nuclear hormone receptor | 0.0262 | 0.6773 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0092 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0269 | 0.7029 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0092 | 0 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0092 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0099 | 0.0309 | 0.0309 |
Leishmania major | ribonuclease H1, putative | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0262 | 0.6773 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0099 | 0.0309 | 0.0309 |
Trypanosoma brucei | RNA helicase, putative | 0.0343 | 1 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0092 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Apoptosis (functional) | = 2 % | Percent level of apoptosis induced by 72 h of exposure with IC80 of the compound in (IGROV-1) human ovarian carcinoma cells | ChEMBL. | 16033272 |
Apoptosis (functional) | = 2 % | Percent level of apoptosis induced by 72 h of exposure with IC80 of the compound in (IGROV-1) human ovarian carcinoma cells | ChEMBL. | 16033272 |
EC50 (binding) | = 1.4 uM | Effective concentration against retinoic acid receptor gamma in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.8-2.4) | ChEMBL. | 16033272 |
EC50 (binding) | = 7.7 uM | Effective concentration against retinoic acid receptor beta in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (6.1-9.8) | ChEMBL. | 16033272 |
EC50 (binding) | = 7.7 uM | Effective concentration against retinoic acid receptor beta in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (6.1-9.8) | ChEMBL. | 16033272 |
EC50 (binding) | = 20.3 uM | Effective concentration against retinoic acid receptor alpha in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (13.9-29.7) | ChEMBL. | 16033272 |
IC50 (functional) | = 2 uM | Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50% | ChEMBL. | 16033272 |
IC50 (functional) | = 2 uM | Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50% | ChEMBL. | 16033272 |
IC50 (functional) | = 6.6 uM | Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50% | ChEMBL. | 16033272 |
IC50 (functional) | = 6.6 uM | Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50% | ChEMBL. | 16033272 |
IC50 (functional) | = 10.5 uM | Concentration of compound required for inhibition of (IGROV-1/Pt1) human cisplatin resistant ovarian carcinoma cell growth by 50% | ChEMBL. | 16033272 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16033272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.