TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.324 | Formula: C14H12F3N3O3S
H donors: 3 H acceptors: 4 LogP: 1.7 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)Cc1csc(n1)NC(=O)Cc1cccc(c1)C(F)(F)F
InChi: 1S/C14H12F3N3O3S/c15-14(16,17)9-3-1-2-8(4-9)5-11(21)19-13-18-10(7-24-13)6-12(22)20-23/h1-4,7,23H,5-6H2,(H,20,22)(H,18,19,21)
InChiKey: IUDFGQJZSXWXMS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 1C, calmodulin-dependent 70kDa		References
Homo sapiens	phosphodiesterase 1B, calmodulin-dependent	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 1A, calmodulin-dependent		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128202	All targets in OG5_128202
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Neospora caninum	hypothetical protein	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium hominis	cGMP phosphodiesterase A4	Get druggable targets OG5_128202	All targets in OG5_128202
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	Get druggable targets OG5_128202	All targets in OG5_128202
Trypanosoma brucei gambiense	3, 5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	phosphodiesterase, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	Get druggable targets OG5_128202	All targets in OG5_128202
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Neospora caninum	hypothetical protein	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	phosphodiesterase, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	Get druggable targets OG5_128202	All targets in OG5_128202
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	Get druggable targets OG5_128202	All targets in OG5_128202
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	Get druggable targets OG5_128202	All targets in OG5_128202
Trypanosoma brucei	cAMP phosphodiesterase A, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	PDE1B protein	Get druggable targets OG5_128202	All targets in OG5_128202
Trypanosoma congolense	3', 5'-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Neospora caninum	3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium parvum	cGMP phosphodiesterase A4	Get druggable targets OG5_128202	All targets in OG5_128202
Leishmania infantum	cAMP phosphodiesterase A	Get druggable targets OG5_128202	All targets in OG5_128202
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128202	All targets in OG5_128202
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	Get druggable targets OG5_128202	All targets in OG5_128202
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	phosphodiesterase 1B, calmodulin-dependent	536 aa	465 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0077	0.0319	0.1901
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0039	0.0068
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.004	0.0086	0.0086
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0081	0.0081
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0036	0.0059	0.0059
Schistosoma mansoni	rotamase	0.0032	0.0035	0.0035
Loa Loa (eye worm)	glutamate receptor 2	0.0039	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0828	0.0828
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0167	0.0885	0.0885
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.0487	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Schistosoma mansoni	hypothetical protein	0.005	0.0146	0.0146
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0245	0.1371	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0046	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.1615	1	1
Brugia malayi	jmjC domain containing protein	0.0057	0.0189	0.0189
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0101	0.0466	0.3255
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0201	0.0427
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.0081	0.0081
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0056	0.0056
Loa Loa (eye worm)	glutamate receptor 1	0.0039	0.0075	0.0075
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0699	0.4234	0.4234
Schistosoma mansoni	gliotactin	0.0273	0.1549	0.1549
Loa Loa (eye worm)	hypothetical protein	0.1615	1	1
Schistosoma mansoni	multidrug resistance protein	0.0033	0.0039	0.0039
Echinococcus multilocularis	nmda type glutamate receptor	0.0084	0.0357	0.0357
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0245	0.1371	0.1371
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0189	0.0189
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Echinococcus multilocularis	expressed protein	0.0361	0.2102	0.2102
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0119	0.0454
Echinococcus granulosus	nmda type glutamate receptor	0.0091	0.0401	0.0401
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Schistosoma mansoni	rab6-interacting	0.0038	0.0071	0.0071
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1615	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.006	0.0207	0.0207
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0245	0.1371	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.006	0.0207	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0238	0.1372
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0059	0.0222
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.0033	0.0039	0.0039
Loa Loa (eye worm)	choline O-acetyltransferase	0.0158	0.0828	0.0828
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0032	0.0035	0.0035
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0056	0.0173
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0036	0.0059	0.0196
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.006	0.0207	0.1168
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0081	0.0081
Echinococcus granulosus	glutamate receptor NMDA	0.0076	0.0311	0.0311
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.006	0.0207	0.1168
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0201	0.0201
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Onchocerca volvulus		0.0038	0.0071	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Plasmodium falciparum	amino acid transporter, putative	0.004	0.0081	0.3621
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0273	0.1549	0.1549
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0234	0.1302	0.1302
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1302	0.1302
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0081	0.0081
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0081	0.0081
Schistosoma mansoni	rab6-interacting	0.0038	0.0071	0.0071
Onchocerca volvulus		0.0234	0.1302	0.8405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0071	0.0071
Plasmodium falciparum	glutathione reductase	0.0046	0.0119	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.0487	0.1441
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0059	0.0059
Brugia malayi	hypothetical protein	0.0273	0.1549	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0059	0.0196
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0245	0.1371	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0081	0.0081
Onchocerca volvulus		0.0273	0.1549	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0059	0.0222
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0225	0.0225
Plasmodium falciparum	protoporphyrinogen oxidase	0.004	0.0086	0.4416
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0039	0.0068
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0039	0.0068
Trypanosoma brucei	MATE efflux family protein, putative	0.0033	0.0039	0.0068
Mycobacterium ulcerans	dehydrogenase	0.004	0.0086	0.0088
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.0487	0.1441
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0273	0.1549	0.1549
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.006	0.0207	0.0207
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0104	0.0487	0.8614
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0201	0.1274
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0273	0.1549	0.4805
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0036	0.0059	0.0196
Echinococcus multilocularis	glutamate receptor 2	0.0032	0.0031	0.0031
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.006	0.0207	0.0207
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0119	0.0274
Plasmodium vivax	amine transporter, putative	0.004	0.0081	0.0164
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Schistosoma mansoni	glutamate receptor kainate	0.0039	0.0075	0.0075
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0574	0.3444	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0036	0.0059	0.0196
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0036	0.0059	0.0059
Onchocerca volvulus		0.004	0.0081	0.0523
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0071	0.0071
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.004	0.0086	0.0088
Loa Loa (eye worm)	carboxylesterase	0.1615	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0119	0.0119
Mycobacterium tuberculosis	Possible oxidoreductase	0.004	0.0086	0.0169
Loa Loa (eye worm)	hypothetical protein	0.004	0.0086	0.0086
Leishmania major	hypothetical protein, conserved	0.0033	0.0039	0.0068
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0101	0.0466	0.3255
Echinococcus multilocularis	expressed protein	0.0032	0.0035	0.0035
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.004	0.0086	0.0418
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.0561	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0081
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0201	0.0427
Schistosoma mansoni	amine oxidase	0.004	0.0086	0.0086
Schistosoma mansoni	polycystin 1-related	0.0038	0.0071	0.0071
Echinococcus multilocularis		0.004	0.0086	0.0086
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0119	0.0665
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0574	0.3444	1
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0189	0.0189
Giardia lamblia	Hypothetical protein	0.0036	0.0059	0.5
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0056	0.0056
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.0033	0.0039	0.0039
Toxoplasma gondii	hypothetical protein	0.004	0.0081	0.0382
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0108	0.051	0.051
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0036	0.0059	0.0196
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0167	0.0885	0.0885
Trypanosoma brucei	membrane transporter protein, putative	0.0033	0.0039	0.0068
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.004	0.0086	0.0086
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0036	0.0059	0.0059
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0046	0.0122	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0238	0.1372
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0101	0.0466	0.2874
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0032	0.0035	0.0035
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0201	0.1274
Echinococcus multilocularis	choline O acetyltransferase	0.0158	0.0828	0.0828
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0699	0.4234	0.4234
Chlamydia trachomatis	protoporphyrinogen oxidase	0.004	0.0086	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0059	0.0222
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0036	0.0059	0.0222
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0101	0.0466	0.2874
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0077	0.0319	0.2153
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0081	0.0081
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0273	0.1549	0.1549
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0046	0.0122	0.0122
Echinococcus multilocularis	RUN	0.0038	0.0071	0.0071
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0533	0.319	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Echinococcus granulosus	carboxylesterase 5A	0.1615	1	1
Onchocerca volvulus		0.0273	0.1549	1
Toxoplasma gondii	histone lysine-specific demethylase	0.004	0.0086	0.0418
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0245	0.1371	1
Echinococcus multilocularis	carboxylesterase 5A	0.1615	1	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0201	0.0201
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0119	0.0119
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Onchocerca volvulus		0.0273	0.1549	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0036	0.0059	0.0196
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0092	0.0411	0.0411
Giardia lamblia	hypothetical protein	0.0036	0.0059	0.5
Echinococcus granulosus	Polycystic kidney disease protein	0.0038	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.004	0.0086	0.0086
Schistosoma mansoni	sodium/chloride dependent transporter	0.0234	0.1302	0.1302
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0119	0.0454
Echinococcus granulosus	glutamate receptor 2	0.0032	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0273	0.1549	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0059	0.0222
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0273	0.1549	0.4805
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0046	0.0122	0.0122
Brugia malayi	Carboxylesterase family protein	0.0273	0.1549	0.1549
Brugia malayi	SWIRM domain containing protein	0.004	0.0086	0.0086
Brugia malayi	Inositol-1	0.0036	0.0056	0.0056
Echinococcus multilocularis	glutamate receptor NMDA	0.0076	0.0311	0.0311
Echinococcus granulosus	RUN	0.0038	0.0071	0.0071
Trypanosoma brucei	membrane transporter protein, putative	0.0033	0.0039	0.0068
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Trichomonas vaginalis	rotamase, putative	0.0032	0.0035	0.0031
Schistosoma mansoni	BC026374 protein (S09 family)	0.0273	0.1549	0.1549
Echinococcus multilocularis	glutamate receptor 2	0.0039	0.0075	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0059	0.0196
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0081	0.0081
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0036	0.0059	0.0059
Echinococcus multilocularis	Polycystic kidney disease protein	0.0038	0.0071	0.0071
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0081	0.0081
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0036	0.0059	0.0059
Loa Loa (eye worm)	norepinephrine transporter	0.0234	0.1302	0.1302
Echinococcus granulosus	lysine specific histone demethylase 1A	0.004	0.0086	0.0086
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0046	0.0122	0.0122
Loa Loa (eye worm)	acetylcholinesterase 1	0.1615	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Brugia malayi	Carboxylesterase family protein	0.0273	0.1549	0.1549
Loa Loa (eye worm)	inositol-1	0.0036	0.0056	0.0056
Loa Loa (eye worm)	carboxylesterase	0.0273	0.1549	0.1549
Echinococcus granulosus	choline O acetyltransferase	0.0158	0.0828	0.0828
Trypanosoma cruzi	UDP-galactopyranose mutase	0.004	0.0086	0.0418
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0081
Echinococcus granulosus	serotonin transporter	0.0234	0.1302	0.1302
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Brugia malayi	jmjC domain containing protein	0.0057	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.004	0.0086	0.0086
Brugia malayi	hypothetical protein	0.0038	0.0071	0.0071
Echinococcus multilocularis	serotonin transporter	0.0234	0.1302	0.1302
Schistosoma mansoni	glutamate receptor NMDA	0.0122	0.0602	0.0602
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0101	0.0466	0.3255
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Brugia malayi	Thioredoxin reductase	0.0046	0.0119	0.0119
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0036	0.0059	0.0059
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.004	0.0086	0.4416
Brugia malayi	Choline O-acetyltransferase	0.0158	0.0828	0.0828
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0056	0.0196
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0273	0.1549	0.1549
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Leishmania major	hypothetical protein, conserved	0.0033	0.0039	0.0068
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.006	0.0207	0.1168
Schistosoma mansoni	ATP-binding cassette transporter	0.0039	0.0075	0.0075
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0273	0.1549	0.1549
Mycobacterium ulcerans	oxidoreductase	0.004	0.0086	0.0088
Trypanosoma cruzi	UDP-galactopyranose mutase	0.004	0.0086	0.0418
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0077	0.0319	0.1901
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Treponema pallidum	sodium- and chloride- dependent transporter	0.0234	0.1302	0.5
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Leishmania major	hypothetical protein, conserved	0.0036	0.0059	0.0222
Loa Loa (eye worm)	hypothetical protein	0.006	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1549	0.1549
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0189	0.0189
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0036	0.0059	0.0059
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0189	0.0189
Leishmania major	UDP-galactopyranose mutase	0.004	0.0086	0.0418
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0086	0.02
Toxoplasma gondii	hypothetical protein	0.0065	0.0238	0.1554
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.003	0.0021	0.0021
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0071	0.0071
Mycobacterium ulcerans	monoamine oxidase	0.004	0.0086	0.0088
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0119	0.0119
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0273	0.1549	0.1549
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0036	0.0059	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1302	0.1302
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0036	0.0059	0.0196
Brugia malayi	hypothetical protein	0.004	0.0086	0.0086
Onchocerca volvulus		0.0038	0.0071	0.0459
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0466	0.2874
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0036	0.0059	0.0059
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.0561	0.1673
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0081	0.0081
Schistosoma mansoni	glutamate receptor AMPA	0.0039	0.0075	0.0075
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0296	0.1692	0.1692
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0189	0.0189
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0245	0.1371	1
Schistosoma mansoni	glutamate receptor NMDA	0.0092	0.0411	0.0411
Plasmodium falciparum	transporter, putative	0.004	0.0081	0.3621
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0081
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.0561	0.1673
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0036	0.0059	0.0222
Echinococcus multilocularis	neuroligin	0.0273	0.1549	0.1549
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0699	0.4234	0.4234
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0238	0.1372
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.0081	0.0081
Schistosoma mansoni	amine oxidase	0.004	0.0086	0.0086
Brugia malayi	Carboxylesterase family protein	0.0273	0.1549	0.1549
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0056	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0039	0.0068
Onchocerca volvulus		0.0273	0.1549	1
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.004	0.0086	0.02
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0036	0.0059	0.0196
Brugia malayi	glutathione reductase	0.0046	0.0119	0.0119
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.004	0.0086	0.4416
Schistosoma mansoni	loxhd1	0.0038	0.0071	0.0071
Leishmania major	trypanothione reductase	0.0046	0.0119	0.0665
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0699	0.4234	0.4234
Echinococcus granulosus	acetylcholinesterase	0.1615	1	1
Echinococcus granulosus	acetylcholinesterase	0.1615	1	1
Echinococcus granulosus	nmda type glutamate receptor	0.0084	0.0357	0.0357
Echinococcus multilocularis	para nitrobenzyl esterase	0.0273	0.1549	0.1549
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0189	0.0189
Echinococcus granulosus	para nitrobenzyl esterase	0.0273	0.1549	0.1549
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0119	0.0665
Echinococcus granulosus	expressed protein	0.0032	0.0035	0.0035
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0059	0.0222
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0081	0.0081
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.0487	0.1441
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0101	0.0466	0.3255
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0189	0.0189
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0056	0.0196
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0056	0.0196
Echinococcus multilocularis	protoporphyrinogen oxidase	0.004	0.0086	0.0086
Brugia malayi	Glutamate receptor 2 precursor	0.0039	0.0075	0.0075
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0071	0.0071
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Brugia malayi	amine oxidase, flavin-containing family protein	0.004	0.0086	0.0086
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.0081	0.0081
Schistosoma mansoni	choline o-acyltransferase	0.0158	0.0828	0.0828
Onchocerca volvulus		0.004	0.0086	0.0553
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0081	0.0081
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0245	0.1371	0.1371
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0234	0.1302	0.1302
Loa Loa (eye worm)	doublecortin family protein	0.0038	0.0071	0.0071
Echinococcus granulosus	BC026374 protein S09 family	0.0273	0.1549	0.1549
Onchocerca volvulus		0.004	0.0081	0.0523
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0071	0.0071
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0036	0.0059	0.0222
Brugia malayi	hypothetical protein	0.004	0.0081	0.0081
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0101	0.0466	0.0466
Mycobacterium tuberculosis	Probable reductase	0.0104	0.0487	0.1441
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0056	0.0173
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0036	0.0059	0.0059
Brugia malayi	hypothetical protein	0.0038	0.0071	0.0071
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Loa Loa (eye worm)	carboxylesterase	0.0273	0.1549	0.1549
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.0081	0.0081
Brugia malayi	Glutamate receptor 1 precursor	0.0039	0.0075	0.0075
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0081	0.0164
Echinococcus multilocularis	nmda type glutamate receptor	0.0091	0.0401	0.0401
Brugia malayi	Carboxylesterase family protein	0.0273	0.1549	0.1549
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0201	0.0533
Loa Loa (eye worm)	hypothetical protein	0.004	0.0086	0.0086
Schistosoma mansoni	glutamate receptor kainate	0.0039	0.0075	0.0075
Brugia malayi	Cytochrome P450 family protein	0.0036	0.0055	0.0055
Loa Loa (eye worm)	serotonin transporter b	0.0234	0.1302	0.1302
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0382
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0059	0.0222
Loa Loa (eye worm)	PDE1B protein	0.0699	0.4234	0.4234
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0086	0.0169
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0201	0.0201
Echinococcus granulosus	glutamate receptor 2	0.0046	0.0122	0.0122
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0101	0.0466	0.0466
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0036	0.0059	0.0059
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0273	0.1549	0.1549
Brugia malayi	follicle stimulating hormone receptor	0.0249	0.1399	0.1399
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0036	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1298	0.1298
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0046	0.0122	0.0122
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0119	1
Onchocerca volvulus		0.0273	0.1549	1
Brugia malayi	Carboxylesterase family protein	0.1615	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0036	0.0059	0.0222
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0036	0.0059	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0035	0.0031
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0056	0.0196
Echinococcus granulosus	lysine specific histone demethylase 1A	0.004	0.0086	0.0086
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0382
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0056	0.0173
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0245	0.1371	1
Schistosoma mansoni	glutamate receptor kainate	0.0039	0.0075	0.0075
Mycobacterium ulcerans	carboxylesterase, LipT	0.0273	0.1549	0.4408
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0783	0.4764	0.4764
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0189	0.0189
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0059	0.0059
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.0561	0.1673
Trypanosoma cruzi	membrane transporter protein, putative	0.0033	0.0039	0.0068
Echinococcus granulosus	expressed protein	0.0361	0.2102	0.2102
Toxoplasma gondii	hypothetical protein	0.004	0.0081	0.0382
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0101	0.0466	0.0466
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0081
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0119	0.0119
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0036	0.0059	0.0059
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.004	0.0086	0.1009
Schistosoma mansoni	lipoxygenase	0.0099	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.004	0.0086	0.0086
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0036	0.0059	0.0059
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.004	0.0086	0.0086
Plasmodium vivax	multidomain scavenger receptor, putative	0.0038	0.0071	0.0089
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0036	0.0059	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1761	0.1761
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0056	0.0056
Onchocerca volvulus		0.004	0.0081	0.0523
Brugia malayi	Doublecortin family protein	0.0038	0.0071	0.0071
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0059	0.0222
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0201	0.0201
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0081	0.0081
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.0081	0.0081
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0201	0.0427
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0081
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0056	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0059	0.0059
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0081	0.0382
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0039	0.0068
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0046	0.0122	0.0122
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0092	0.0411	0.0411
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0101	0.0466	0.3255
Schistosoma mansoni	hypothetical protein	0.0038	0.0071	0.0071
Schistosoma mansoni	lipoxygenase	0.0167	0.0885	0.0885
Plasmodium falciparum	LCCL domain-containing protein	0.0038	0.0071	0.1972
Echinococcus multilocularis	acetylcholinesterase	0.1615	1	1
Echinococcus multilocularis	acetylcholinesterase	0.1615	1	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0273	0.1549	1
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.0081	0.0081
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0036	0.0059	0.0196
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.004	0.0086	0.02
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0086	0.02
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0036	0.0059	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0086	0.0086
Echinococcus granulosus	neuroligin	0.0273	0.1549	0.1549
Trypanosoma brucei	trypanothione reductase	0.0046	0.0119	0.0665
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0249	0.1399	0.1399
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0059	0.0222
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0036	0.0059	0.0059
Brugia malayi	Choline O-acetyltransferase	0.0158	0.0828	0.0828
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0245	0.1371	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0273	0.1549	0.4805
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.006	0.0207	0.0207
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Schistosoma mansoni	acetylcholinesterase	0.0273	0.1549	0.1549
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0081	0.0081
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0234	0.1302	0.1302
Trypanosoma brucei	membrane transporter protein, putative	0.0033	0.0039	0.0068
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0056	0.0056
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0101	0.0466	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1302	0.1302
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0036	0.0059	0.0222
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0036	0.0059	0.0222
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.004	0.0081	0.0081
Loa Loa (eye worm)	cytochrome P450 family protein	0.0036	0.0055	0.0055
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.0487	0.1441
Schistosoma mansoni	glutamate receptor AMPA	0.0039	0.0075	0.0075
Echinococcus multilocularis	glutamate receptor 2	0.0046	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0619	0.0619
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0046	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0118	0.0572	0.0572
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0056	0.5
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0101	0.0466	0.2874

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.07 uM	Inhibitory concentration against Phosphodiesterase type 5	ChEMBL.	16005625
IC50 (binding)	= 2.07 uM	Inhibitory concentration against Phosphodiesterase type 5	ChEMBL.	16005625
IC50 (binding)	> 10 uM	Inhibitory concentration against Phosphodiesterase type 1	ChEMBL.	16005625
IC50 (binding)	> 10 uM	Inhibitory concentration against Phosphodiesterase type 1	ChEMBL.	16005625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL188162

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 330372