Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 260 nM | Inhibition of [125I]-NDP-MSH (radioligand) binding to the hMC4R stably expressed in HEK293 cells | ChEMBL. | 15950470 |
Ki (binding) | = 260 nM | Inhibition of [125I]-NDP-MSH (radioligand) binding to the hMC4R stably expressed in HEK293 cells | ChEMBL. | 15950470 |
Stimulation (functional) | = 12 % | Stimulation of cAMP levels in the HEK293 cell line at 10 uM | ChEMBL. | 15950470 |
Stimulation (functional) | = 12 % | Stimulation of cAMP levels in the HEK293 cell line at 10 uM | ChEMBL. | 15950470 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.