Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0036 | 0.7568 | 0.7568 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0036 | 0.7568 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0036 | 0.7568 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0036 | 0.7568 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0.7568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0036 | 0.7568 | 0.7568 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0036 | 0.7568 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0.7568 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0036 | 0.7568 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0036 | 0.7568 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0036 | 0.7568 | 1 |
Onchocerca volvulus | 0.0036 | 0.7568 | 0.5 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0.7568 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0042 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0036 | 0.7568 | 0.7568 |
Echinococcus granulosus | FTZ F1 alpha | 0.0036 | 0.7568 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0036 | 0.7568 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0036 | 0.7568 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0036 | 0.7568 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0036 | 0.7568 | 0.7568 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0.7568 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0036 | 0.7568 | 0.7568 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0.7568 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0036 | 0.7568 | 0.7568 |
Schistosoma mansoni | coup transcription factor | 0.0036 | 0.7568 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0036 | 0.7568 | 0.7568 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0041 | 0.9836 | 0.978 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0036 | 0.7568 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0.7568 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0036 | 0.7568 | 0.7568 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0036 | 0.7568 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | steroid hormone receptor | 0.0036 | 0.7568 | 0.7568 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0036 | 0.7568 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0.7568 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0036 | 0.7568 | 0.7568 |
Trichomonas vaginalis | AGC family protein kinase | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0042 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0.7568 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0036 | 0.7568 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0036 | 0.7568 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0.7568 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0036 | 0.7568 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0042 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0036 | 0.7568 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0036 | 0.7568 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0036 | 0.7568 | 0.7568 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0036 | 0.7568 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0036 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0036 | 0.7568 | 0.7568 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0.7568 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0036 | 0.7568 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0036 | 0.7568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7568 | 0.7568 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0036 | 0.7568 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0036 | 0.7568 | 0.7568 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0036 | 0.7568 | 0.7568 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibitory concentration against MSK-1 | ChEMBL. | 15955699 |
IC50 (binding) | = 2 nM | Inhibitory concentration against MSK-1 | ChEMBL. | 15955699 |
Inhibition (binding) | = 33 | Ratio of RSK-1 IC50 to MSK-1 IC50 | ChEMBL. | 15955699 |
Ratio (binding) | = 17 | Ratio of GSK-3 IC50 to MSK-1 IC50 | ChEMBL. | 15955699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.