Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0642 | 0.9749 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0642 | 0.9749 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.9524 | 0.977 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibitory activity against HIV-1 mutant strain 188L; ND = not determined | ChEMBL. | 15481987 |
IC50 (functional) | = 1.25 uM | Inhibitory activity against wild type HIV-1 LAI cell line | ChEMBL. | 15481987 |
IC50 (functional) | = 10 uM | Inhibitory activity against HIV-1 mutant strain 103N | ChEMBL. | 15481987 |
IC50 (functional) | = 10 uM | Inhibitory activity against HIV-1 mutant strain 181C | ChEMBL. | 15481987 |
Selectivity index (functional) | = 8 uM | Selectivity index of cytotoxic activity (CC50) to inhibitory activity (IC50) relative to LAI cell line | ChEMBL. | 15481987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.