Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | Inhibitory concentration against Mycobacterium avium DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 1 nM | Inhibitory concentration against Mycobacterium avium DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 1.4 nM | Inhibitory concentration against Pneumocystis carinii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 1.4 nM | Inhibitory concentration against Pneumocystis carinii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 4.3 nM | Inhibitory concentration against Toxoplasma gondii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 4.3 nM | Inhibitory concentration against Toxoplasma gondii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 5.7 nM | Inhibitory concentration of the compound against rat DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 5.7 nM | Inhibitory concentration of the compound against rat DHFR | ChEMBL. | 15974594 |
IC50 (functional) | = 6.1 uM | Concentration of the compound causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 h culture | ChEMBL. | 15974594 |
Selectivity index (binding) | = 1.3 | Selectivity index measured as IC50(Rat)/IC50(T. gondii) | ChEMBL. | 15974594 |
Selectivity index (binding) | = 4.2 | Selectivity index measured as IC50(Rat)/IC50(P. carnii) | ChEMBL. | 15974594 |
Selectivity index (binding) | = 5.6 | Selectivity index measured as IC50(Rat)/IC50(M. avium) | ChEMBL. | 15974594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.