TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.32 | Formula: C13H17N7O
H donors: 1 H acceptors: 4 LogP: -0.12 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCn1c(nc2c1ccnc2)c1nonc1N)C
InChi: 1S/C13H17N7O/c1-19(2)6-3-7-20-10-4-5-15-8-9(10)16-13(20)11-12(14)18-21-17-11/h4-5,8H,3,6-7H2,1-2H3,(H2,14,18)
InChiKey: KFWBJWDHALYVMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ribosomal protein S6 kinase, 90kDa, polypeptide 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	serine/threonine-protein kinase ypk, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Babesia bovis	cAMP-dependent protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	serine/threonine-protein kinase, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0017	0	0.5
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Entamoeba histolytica	protein kinase, putative	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0025	0.3144	0.3144
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	serine/threonine-protein kinase ypk, putative	0.0025	0.3144	0.3144
Trichomonas vaginalis	serine/threonine-protein kinase, putative	0.0025	0.3144	0.3144
Echinococcus granulosus	serine:threonine protein kinase N2	0.0017	0	0.5
Toxoplasma gondii	AGC kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0042	1	1
Echinococcus granulosus	protein kinase c iota type	0.0017	0	0.5
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Echinococcus granulosus	NDR protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Entamoeba histolytica	protein kinase, putative	0.0017	0	0.5
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0042	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0042	1	1
Schistosoma mansoni	serine/threonine kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0042	1	1
Entamoeba histolytica	protein kinase, putative	0.0017	0	0.5
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0017	0	0.5
Echinococcus multilocularis	serine threonine protein kinase	0.0017	0	0.5
Echinococcus granulosus	protein kinase C gamma type	0.0017	0	0.5
Echinococcus granulosus	protein kinase c epsilon type	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	protein kinase c iota type	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Schistosoma mansoni	atypical protein kinase C	0.0017	0	0.5
Trichomonas vaginalis	cAMP-dependent protein kinase catalytic subunit, putative	0.0025	0.3144	0.3144
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0041	0.9849	0.9849
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	protein kinase c epsilon type	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus granulosus	Protein kinase C brain isozyme	0.0017	0	0.5
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0025	0.3144	0.3144
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Entamoeba histolytica	protein kinase, putative	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.3144	0.3144

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= uM	GSK_PKIS: Inhibition of Sea Pansy Luciferase (Data from PubChem: AID 652015) [NIH NCATS]	ChEMBL.	No reference
AC50 (binding)	= uM	GSK_PKIS: Inhibition of Firefly Luciferase (Data from PubChem: AID 652016) [NIH NCATS]	ChEMBL.	No reference
IC50 (binding)	= 617 nM	Inhibitory concentration against MSK-1	ChEMBL.	15955699
IC50 (binding)	= 617 nM	Inhibitory concentration against MSK-1	ChEMBL.	15955699
Inhibition (binding)	= 15	Ratio of RSK-1 IC50 to MSK-1 IC50	ChEMBL.	15955699
Inhibition (binding)	= -21.27 %	GSK_PKIS: KIT (D816V mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -10.04 %	GSK_PKIS: PAK5 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -8.31 %	GSK_PKIS: AXL mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -7.29 %	GSK_PKIS: AXL mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -5.79 %	GSK_PKIS: ARG mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -5.34 %	GSK_PKIS: FLT3 (D835Y mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -5.06 %	GSK_PKIS: PAK5 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -5 %	GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= -4.78 %	GSK_PKIS: CDK6/cyclinD3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -4.44 %	GSK_PKIS: SRPK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -4.3 %	GSK_PKIS: SYK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -4.16 %	GSK_PKIS: SRMS mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -4 %	GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= -3.93 %	GSK_PKIS: TNK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -3.59 %	GSK_PKIS: CDK2/cyclinA mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -2.99 %	GSK_PKIS: TYK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -2.65 %	GSK_PKIS: SRPK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -2.15 %	GSK_PKIS: PAK6 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -2.04 %	GSK_PKIS: TYK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.87 %	GSK_PKIS: FGFR4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.86 %	GSK_PKIS: MSSK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.82 %	GSK_PKIS: MST4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.75 %	GSK_PKIS: MST4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.68 %	GSK_PKIS: JAK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.56 %	GSK_PKIS: CK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.36 %	GSK_PKIS: KIT (V560G mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.23 %	GSK_PKIS: FLT3 (D835Y mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.19 %	GSK_PKIS: KIT (V560G mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -1.05 %	GSK_PKIS: MSSK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.98 %	GSK_PKIS: SRMS mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.97 %	GSK_PKIS: SNF1LK2 (QIK) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.88 %	GSK_PKIS: SPHK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.84 %	GSK_PKIS: CAMK4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.83 %	GSK_PKIS: PASK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.78 %	GSK_PKIS: PIM3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.73 %	GSK_PKIS: CAMK1D mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.71 %	GSK_PKIS: CDK3/cyclinE mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.67 %	GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.59 %	GSK_PKIS: ARK5 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.49 %	GSK_PKIS: HIPK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.43 %	GSK_PKIS: MUSK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.27 %	GSK_PKIS: JAK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.25 %	GSK_PKIS: PRAK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.15 %	GSK_PKIS: TRKB mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.11 %	GSK_PKIS: PASK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.09 %	GSK_PKIS: MNK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.04 %	GSK_PKIS: PIM2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= -0.01 %	GSK_PKIS: TRKC mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0 %	GSK_PKIS: TBK1 % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= 0.01 %	GSK_PKIS: AKT1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.05 %	GSK_PKIS: DCAMKL2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.09 %	GSK_PKIS: SPHK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.12 %	GSK_PKIS: BTK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.2 %	GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.2 %	GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.24 %	GSK_PKIS: PIM2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.27 %	GSK_PKIS: BRSK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.27 %	GSK_PKIS: CAMK1D mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.27 %	GSK_PKIS: EPHA2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.37 %	GSK_PKIS: SYK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.39 %	GSK_PKIS: HIPK4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.4 %	GSK_PKIS: HIPK4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.44 %	GSK_PKIS: YES mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.45 %	GSK_PKIS: TSSK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.54 %	GSK_PKIS: MNK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.54 %	GSK_PKIS: TNK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.57 %	GSK_PKIS: BRSK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.58 %	GSK_PKIS: KIT (T6701 mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.63 %	GSK_PKIS: TTK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.64 %	GSK_PKIS: TSSK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.72 %	GSK_PKIS: BTK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.77 %	GSK_PKIS: DYRK1B mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.77 %	GSK_PKIS: TNK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.79 %	GSK_PKIS: JAK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.8 %	GSK_PKIS: PKC-alpha mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.8 %	GSK_PKIS: NEK6 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.86 %	GSK_PKIS: EPHA2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.92 %	GSK_PKIS: AKT3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.92 %	GSK_PKIS: SPHK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.92 %	GSK_PKIS: TIE2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.92 %	GSK_PKIS: ITK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.95 %	GSK_PKIS: PI4K-beta mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.95 %	GSK_PKIS: Aurora-C mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.96 %	GSK_PKIS: EGFR (L858R mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.96 %	GSK_PKIS: ZAP70 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 0.98 %	GSK_PKIS: PRAK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1 %	GSK_PKIS: TBK1 % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= 1.03 %	GSK_PKIS: HIPK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.03 %	GSK_PKIS: PIM3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.05 %	GSK_PKIS: CLK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.06 %	GSK_PKIS: FMS mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.08 %	GSK_PKIS: TNK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.09 %	GSK_PKIS: FLT1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.11 %	GSK_PKIS: FGFR4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.19 %	GSK_PKIS: BRSK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.22 %	GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.23 %	GSK_PKIS: BRSK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.23 %	GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.24 %	GSK_PKIS: TBK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.25 %	GSK_PKIS: JAK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.29 %	GSK_PKIS: DDR2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.3 %	GSK_PKIS: TRKA mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.3 %	GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.31 %	GSK_PKIS: RON mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.32 %	GSK_PKIS: ZAP70 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.32 %	GSK_PKIS: PKC-theta mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.36 %	GSK_PKIS: CDK5/p35 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.37 %	GSK_PKIS: FGR mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.38 %	GSK_PKIS: AKT1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.4 %	GSK_PKIS: CK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.41 %	GSK_PKIS: MER mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.43 %	GSK_PKIS: ITK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.44 %	GSK_PKIS: BLK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.45 %	GSK_PKIS: RSK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.48 %	GSK_PKIS: PRKX mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.48 %	GSK_PKIS: PAK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.5 %	GSK_PKIS: CK1-g3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.51 %	GSK_PKIS: PDK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.53 %	GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.55 %	GSK_PKIS: PTK5 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.57 %	GSK_PKIS: DDR2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.58 %	GSK_PKIS: CDK1/cyclinB mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.59 %	GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.59 %	GSK_PKIS: TIE2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.6 %	GSK_PKIS: PAR-1Balpha mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.62 %	GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.67 %	GSK_PKIS: CSK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.74 %	GSK_PKIS: TYRO3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.79 %	GSK_PKIS: RSK4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.79 %	GSK_PKIS: CSK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.8 %	GSK_PKIS: FER mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.81 %	GSK_PKIS: CRAF mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.84 %	GSK_PKIS: AKT3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.85 %	GSK_PKIS: AKT2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.85 %	GSK_PKIS: FLT3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.86 %	GSK_PKIS: PKC-beta1 (splice variant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.87 %	GSK_PKIS: MKNK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.87 %	GSK_PKIS: FYN mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.89 %	GSK_PKIS: MRCKA mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.93 %	GSK_PKIS: RET (V804L mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.94 %	GSK_PKIS: MAPKAPK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.95 %	GSK_PKIS: PI3K-delta mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.95 %	GSK_PKIS: CDK6/cyclinD3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.96 %	GSK_PKIS: CLK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.97 %	GSK_PKIS: TYRO3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.98 %	GSK_PKIS: NEK7 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.99 %	GSK_PKIS: CDK5/p35 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 1.99 %	GSK_PKIS: IRAK4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2 %	GSK_PKIS: IKK-epsilon % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= 2.02 %	GSK_PKIS: RET (V804L mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.04 %	GSK_PKIS: LRRK2 (G2019S mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.04 %	GSK_PKIS: AMPKA1 (A1B1G1) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.05 %	GSK_PKIS: MAP4K2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.05 %	GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.05 %	GSK_PKIS: DCAMKL2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.05 %	GSK_PKIS: EPHB3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.08 %	GSK_PKIS: LTK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.09 %	GSK_PKIS: EGFR (T790M mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.1 %	GSK_PKIS: PKA mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.14 %	GSK_PKIS: LRRK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.17 %	GSK_PKIS: MER mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.17 %	GSK_PKIS: PAK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.19 %	GSK_PKIS: CDK1/cyclinB mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.2 %	GSK_PKIS: PKC-theta mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.2 %	GSK_PKIS: PTK5 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.2 %	GSK_PKIS: EPHB4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.21 %	GSK_PKIS: SGK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.21 %	GSK_PKIS: MAPK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.22 %	GSK_PKIS: KIT mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.22 %	GSK_PKIS: FGR mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.22 %	GSK_PKIS: LYN B (splice variant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.24 %	GSK_PKIS: PAR-1Balpha mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.27 %	GSK_PKIS: SGK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.27 %	GSK_PKIS: LCK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.28 %	GSK_PKIS: RSK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.28 %	GSK_PKIS: NEK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.29 %	GSK_PKIS: NEK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.32 %	GSK_PKIS: PKC-beta2 (splice variant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.32 %	GSK_PKIS: MAPK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.33 %	GSK_PKIS: PHKG1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.34 %	GSK_PKIS: FMS mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.34 %	GSK_PKIS: SGK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.39 %	GSK_PKIS: p70s6K1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.39 %	GSK_PKIS: CHEK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.41 %	GSK_PKIS: MARK4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.43 %	GSK_PKIS: PHKG2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.45 %	GSK_PKIS: GSK3A mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.47 %	GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.47 %	GSK_PKIS: RET (Y791F mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.49 %	GSK_PKIS: KIT (T6701 mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.51 %	GSK_PKIS: PRKG2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.51 %	GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.51 %	GSK_PKIS: CLK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.51 %	GSK_PKIS: LRRK2 (G2019S mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.52 %	GSK_PKIS: SPHK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.53 %	GSK_PKIS: CDK2/cyclinA mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.53 %	GSK_PKIS: FLT3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.54 %	GSK_PKIS: MAPKAPK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.59 %	GSK_PKIS: IRR mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.61 %	GSK_PKIS: GRK7 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.62 %	GSK_PKIS: PKC-iota mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.62 %	GSK_PKIS: FYN mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.62 %	GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.64 %	GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.66 %	GSK_PKIS: CLK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.69 %	GSK_PKIS: ABL1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.75 %	GSK_PKIS: DYRK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.77 %	GSK_PKIS: GSK3B mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.77 %	GSK_PKIS: FLT1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.81 %	GSK_PKIS: CAMK2A mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.81 %	GSK_PKIS: PIM1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.82 %	GSK_PKIS: ALK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.84 %	GSK_PKIS: PI3K-alpha mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.86 %	GSK_PKIS: FGFR2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.88 %	GSK_PKIS: PHKG1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.88 %	GSK_PKIS: MAPK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.93 %	GSK_PKIS: AMPKA1 (A1B1G1) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.93 %	GSK_PKIS: FES mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.95 %	GSK_PKIS: FES mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.96 %	GSK_PKIS: SRC mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 2.98 %	GSK_PKIS: SGK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.03 %	GSK_PKIS: EPHB2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.03 %	GSK_PKIS: LYN B (splice variant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.04 %	GSK_PKIS: ARK5 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.05 %	GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.08 %	GSK_PKIS: BMX mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.09 %	GSK_PKIS: LOK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.12 %	GSK_PKIS: CDK4/cyclinD mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.15 %	GSK_PKIS: CK1-g2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.15 %	GSK_PKIS: Aurora-A mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.18 %	GSK_PKIS: MSK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.18 %	GSK_PKIS: PKA mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.18 %	GSK_PKIS: CAMK2A mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.2 %	GSK_PKIS: TRKC mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.21 %	GSK_PKIS: FGFR1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.24 %	GSK_PKIS: SNF1LK (SIK) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.25 %	GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.26 %	GSK_PKIS: CK1-g3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.28 %	GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.29 %	GSK_PKIS: TRKA mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.33 %	GSK_PKIS: CAMK2D mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.33 %	GSK_PKIS: P38gamma mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.34 %	GSK_PKIS: PI4K-beta mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.36 %	GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.38 %	GSK_PKIS: EPHB4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.38 %	GSK_PKIS: SGK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.41 %	GSK_PKIS: PRKD1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.42 %	GSK_PKIS: P38gamma mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.42 %	GSK_PKIS: FGFR1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.44 %	GSK_PKIS: TSSK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.44 %	GSK_PKIS: BLK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.45 %	GSK_PKIS: BMX mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.45 %	GSK_PKIS: MARK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.46 %	GSK_PKIS: MARK4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.5 %	GSK_PKIS: DYRK1A mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.5 %	GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.51 %	GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.53 %	GSK_PKIS: RON mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.54 %	GSK_PKIS: EPHA4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.54 %	GSK_PKIS: FER mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.55 %	GSK_PKIS: GRK6 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.55 %	GSK_PKIS: TRKB mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.56 %	GSK_PKIS: ARG mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.61 %	GSK_PKIS: TXK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.62 %	GSK_PKIS: PKC-alpha mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.63 %	GSK_PKIS: LRRK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.64 %	GSK_PKIS: MARK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.67 %	GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.68 %	GSK_PKIS: PRKG1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.73 %	GSK_PKIS: PLK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.75 %	GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.76 %	GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.77 %	GSK_PKIS: PKC-iota mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.78 %	GSK_PKIS: GRK6 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.78 %	GSK_PKIS: MST2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.79 %	GSK_PKIS: CHEK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.79 %	GSK_PKIS: DYRK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.82 %	GSK_PKIS: AKT2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.86 %	GSK_PKIS: LTK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.87 %	GSK_PKIS: P38beta mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.91 %	GSK_PKIS: KIT mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.93 %	GSK_PKIS: Aurora-B mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.96 %	GSK_PKIS: FGFR3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.97 %	GSK_PKIS: PRKX mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 3.98 %	GSK_PKIS: EGFR (L858R mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4 %	GSK_PKIS: TEC mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.01 %	GSK_PKIS: MUSK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.03 %	GSK_PKIS: MST1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.06 %	GSK_PKIS: TEC mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.09 %	GSK_PKIS: PI3K-delta mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.1 %	GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.12 %	GSK_PKIS: CAMK2D mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.13 %	GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.13 %	GSK_PKIS: CDK4/cyclinD mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.15 %	GSK_PKIS: PRKD2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.15 %	GSK_PKIS: SGK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.15 %	GSK_PKIS: PLK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.16 %	GSK_PKIS: IRR mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.17 %	GSK_PKIS: EPHA3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.17 %	GSK_PKIS: MAPKAPK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.22 %	GSK_PKIS: IRAK4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.23 %	GSK_PKIS: MST1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.24 %	GSK_PKIS: MAPKAPK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.24 %	GSK_PKIS: CDK3/cyclinE mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.25 %	GSK_PKIS: MARK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.25 %	GSK_PKIS: PKC-gamma mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.26 %	GSK_PKIS: IKKB mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.3 %	GSK_PKIS: TXK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.33 %	GSK_PKIS: IKKA mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.34 %	GSK_PKIS: MRCKB mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.37 %	GSK_PKIS: MAP4K2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.37 %	GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.41 %	GSK_PKIS: KDR mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.42 %	GSK_PKIS: PKC-gamma mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.45 %	GSK_PKIS: CK1-g1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.46 %	GSK_PKIS: Aurora-B mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.47 %	GSK_PKIS: RSK4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.48 %	GSK_PKIS: PKC-beta2 (splice variant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.52 %	GSK_PKIS: DYRK1B mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.52 %	GSK_PKIS: MST2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.53 %	GSK_PKIS: CDK2/cyclinE mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.54 %	GSK_PKIS: PHKG2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.54 %	GSK_PKIS: CK1-g2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.55 %	GSK_PKIS: RSK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.55 %	GSK_PKIS: PYK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.57 %	GSK_PKIS: JNK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.6 %	GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.6 %	GSK_PKIS: IKKE mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.6 %	GSK_PKIS: LCK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.61 %	GSK_PKIS: PAK3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.62 %	GSK_PKIS: ROS mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.63 %	GSK_PKIS: ALK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.66 %	GSK_PKIS: KIT (D816V mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.68 %	GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.68 %	GSK_PKIS: EGFR (T790M mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.69 %	GSK_PKIS: JAK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.71 %	GSK_PKIS: ABL1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.73 %	GSK_PKIS: IKKE mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.73 %	GSK_PKIS: ERBB2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.75 %	GSK_PKIS: INSR mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.85 %	GSK_PKIS: EPHA4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.87 %	GSK_PKIS: LYN A (splice variant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.9 %	GSK_PKIS: DAPK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.9 %	GSK_PKIS: MAPK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.93 %	GSK_PKIS: PRKD3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.94 %	GSK_PKIS: CHEK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.99 %	GSK_PKIS: PRKG1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 4.99 %	GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.03 %	GSK_PKIS: CK1a mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.05 %	GSK_PKIS: MAP4K4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.05 %	GSK_PKIS: PDGFRB mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.05 %	GSK_PKIS: PI3K-alpha mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.07 %	GSK_PKIS: GRK7 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.07 %	GSK_PKIS: NEK6 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.09 %	GSK_PKIS: NEK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.18 %	GSK_PKIS: MET mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.23 %	GSK_PKIS: NEK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.23 %	GSK_PKIS: PAK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.3 %	GSK_PKIS: EPHB3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.34 %	GSK_PKIS: CK1-g1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.34 %	GSK_PKIS: BRAF (V599E mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.36 %	GSK_PKIS: JNK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.42 %	GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.42 %	GSK_PKIS: EPHA3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.43 %	GSK_PKIS: HCK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.5 %	GSK_PKIS: MKNK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.51 %	GSK_PKIS: BRAF (V599E mutant) mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.53 %	GSK_PKIS: ROS mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.57 %	GSK_PKIS: IKKA mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.59 %	GSK_PKIS: BRAF mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.63 %	GSK_PKIS: CHEK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.65 %	GSK_PKIS: MINK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.66 %	GSK_PKIS: PRKG2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.68 %	GSK_PKIS: EPHB2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.72 %	GSK_PKIS: ERBB2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.74 %	GSK_PKIS: SNF1LK2 (QIK) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.9 %	GSK_PKIS: DAPK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.93 %	GSK_PKIS: P38alpha mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.95 %	GSK_PKIS: PRKD2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 5.96 %	GSK_PKIS: ROCK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.01 %	GSK_PKIS: FGFR3 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.01 %	GSK_PKIS: Aurora-C mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.07 %	GSK_PKIS: BRAF mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.08 %	GSK_PKIS: TBK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.09 %	GSK_PKIS: Aurora-A mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.1 %	GSK_PKIS: MARK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.11 %	GSK_PKIS: LOK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.13 %	GSK_PKIS: CDK2/cyclinE mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.17 %	GSK_PKIS: JAK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.28 %	GSK_PKIS: NEK7 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.29 %	GSK_PKIS: MINK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.31 %	GSK_PKIS: CK1a mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.36 %	GSK_PKIS: PAK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.36 %	GSK_PKIS: FGFR2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.38 %	GSK_PKIS: PKC-eta mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.47 %	GSK_PKIS: IKKB mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.49 %	GSK_PKIS: HCK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.51 %	GSK_PKIS: LYN A (splice variant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.52 %	GSK_PKIS: MAP4K4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.53 %	GSK_PKIS: MET mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.61 %	GSK_PKIS: RSK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.8 %	GSK_PKIS: SRC mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.89 %	GSK_PKIS: MELK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 6.93 %	GSK_PKIS: PDGFRA mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.05 %	GSK_PKIS: INSR mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.16 %	GSK_PKIS: CRAF mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.25 %	GSK_PKIS: RET mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.35 %	GSK_PKIS: PRKD3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.54 %	GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.58 %	GSK_PKIS: PAK6 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.59 %	GSK_PKIS: PRKD1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 7.78 %	GSK_PKIS: TSSK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8 %	GSK_PKIS: IKK-alpha % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= 8.04 %	GSK_PKIS: RET mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.12 %	GSK_PKIS: TTK mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.22 %	GSK_PKIS: PDGFRA mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.24 %	GSK_PKIS: KDR mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.29 %	GSK_PKIS: MSK1 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.3 %	GSK_PKIS: P38beta mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.31 %	GSK_PKIS: RET (Y791F mutant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.39 %	GSK_PKIS: NEK9 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.57 %	GSK_PKIS: SNF1LK (SIK) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.9 %	GSK_PKIS: DYRK1A mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 8.93 %	GSK_PKIS: PDK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 9.44 %	GSK_PKIS: PYK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 9.52 %	GSK_PKIS: PAK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 9.72 %	GSK_PKIS: EGFR mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 9.74 %	GSK_PKIS: IGF1R mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 10 %	GSK_PKIS: IKK-alpha % inhibition at 1 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= 10.03 %	GSK_PKIS: PKC-eta mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 10.19 %	GSK_PKIS: IGF1R mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 10.62 %	GSK_PKIS: EGFR mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 11.61 %	GSK_PKIS: ROCK2 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 11.61 %	GSK_PKIS: PDGFRB mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 11.82 %	GSK_PKIS: RSK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 12.28 %	GSK_PKIS: NEK9 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 12.35 %	GSK_PKIS: GSK3B mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 12.86 %	GSK_PKIS: P38alpha mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 13.17 %	GSK_PKIS: p70s6K1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 13.87 %	GSK_PKIS: MSK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 14.47 %	GSK_PKIS: PKC-beta1 (splice variant) mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 15.1 %	GSK_PKIS: GSK3A mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 15.31 %	GSK_PKIS: FLT4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 15.44 %	GSK_PKIS: FLT4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 15.51 %	GSK_PKIS: CAMK4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 16.29 %	GSK_PKIS: ERBB4 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 16.35 %	GSK_PKIS: MRCKA mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 16.45 %	GSK_PKIS: RSK3 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 17.3 %	GSK_PKIS: ERBB4 mean inhibition at 0.1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 18.92 %	GSK_PKIS: PIM1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 20.11 %	GSK_PKIS: MELK mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 22.64 %	GSK_PKIS: MRCKB mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 23 %	GSK_PKIS: Mer Kinase % inhibition at 10 uM [UNC Frye lab]	ChEMBL.	No reference
Inhibition (binding)	= 28.72 %	GSK_PKIS: MSK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 32.75 %	GSK_PKIS: ROCK1 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Inhibition (binding)	= 45.27 %	GSK_PKIS: ROCK2 mean inhibition at 1 uM [Nanosyn]	ChEMBL.	No reference
Ratio (binding)	= 6	Ratio of GSK-3 IC50 to MSK-1 IC50	ChEMBL.	15955699

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL191105

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 330873