Detailed information for compound 330936

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 621.164 | Formula: C33H34ClFN4O3S
  • H donors: 2 H acceptors: 2 LogP: 6.01 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)n1nc(Sc2ccc(cc2)Cl)cc(c1=O)CC[C@H](NC(=O)[C@H]1CNCC[C@@H]1c1ccccc1F)C
  • InChi: 1S/C33H34ClFN4O3S/c1-21(37-32(40)29-20-36-18-17-27(29)28-5-3-4-6-30(28)35)7-8-22-19-31(43-26-15-9-23(34)10-16-26)38-39(33(22)41)24-11-13-25(42-2)14-12-24/h3-6,9-16,19,21,27,29,36H,7-8,17-18,20H2,1-2H3,(H,37,40)/t21-,27-,29+/m1/s1
  • InChiKey: UOBJNNBHUVYVRA-NRZUKODWSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans chorismate synthase 0.2182 1 1
Onchocerca volvulus 0.0229 0.1027 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Echinococcus multilocularis acetylcholinesterase 0.0135 0.0593 0.1653
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Echinococcus granulosus dna polymerase kappa 0.0077 0.0328 0.1074
Brugia malayi jmjC domain containing protein 0.0015 0.0043 0.03
Loa Loa (eye worm) hypothetical protein 0.0086 0.0368 0.3097
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0157 0.0697 0.1944
Loa Loa (eye worm) trypsin family protein 0.0006 0.0001 0.001
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0439
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0062 0.0428
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0004 0.0009
Echinococcus granulosus phd:f box containing protein 0.0015 0.0043 0.0138
Schistosoma mansoni hypothetical protein 0.008 0.0342 0.112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0057 0.1164
Schistosoma mansoni Smad4 0.0008 0.001 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0047 0.0935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0057 0.0057
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0051 0.0209 0.0685
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Brugia malayi Trypsin family protein 0.0006 0.0001 0.0008
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0078 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Echinococcus multilocularis muscleblind protein 0.0145 0.0638 0.1779
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0079 0.0078
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0078 0.0253
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0104 0.0104
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0067
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0139
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0028
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0004 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0071 0.0298 0.6498
Echinococcus multilocularis smad 0.0008 0.001 0.0024
Loa Loa (eye worm) apoptosis regulator protein 0.008 0.0342 0.2874
Brugia malayi Trypsin family protein 0.0006 0.0001 0.0008
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0062 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0106 0.0294
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0062 0.0483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0101 0.0329
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0104 0.1092
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0043 0.0138
Schistosoma mansoni hypothetical protein 0.0039 0.0155 0.0504
Schistosoma mansoni smad 0.0008 0.001 0.0028
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0017 0.0283
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0086 0.037 0.3114
Echinococcus granulosus acetylcholinesterase 0.0135 0.0593 0.1945
Trypanosoma brucei unspecified product 0.0035 0.0136 0.2913
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0017 0.0051
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0457 0.553
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.016 0.016
Brugia malayi Smad1 0.0008 0.001 0.0067
Mycobacterium ulcerans DNA polymerase IV 0.0077 0.0328 0.0327
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0161 0.0448
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0079 0.1646
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.001 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.1357
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0044 0.0367
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0104 0.0841
Brugia malayi topoisomerase 0.001 0.0017 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0119
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0457 0.1273
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0812 0.0811
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0051 0.0209 0.0685
Leishmania major DNA polymerase kappa, putative 0.0058 0.0239 0.5181
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0018 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0043 0.0363
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0052 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0004 0.0031
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0599 0.1966
Echinococcus granulosus bloom syndrome protein 0.0019 0.0062 0.0199
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0638 0.1779
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0078 0.0253
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0052 0.0052
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0004 0.0003
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0457 1
Schistosoma mansoni hypothetical protein 0.008 0.0342 0.112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0345
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0062 0.0062
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.06 0.1969
Loa Loa (eye worm) oxidoreductase 0.0007 0.0004 0.0037
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0004 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.0128
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0052 0.0051
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0618 0.4299
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.008 0.0342 0.112
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0017 0.0053
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.001 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.0663
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0057 0.1164
Loa Loa (eye worm) hypothetical protein 0.0135 0.0593 0.4985
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0899 0.756
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0062 0.1264
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.008 0.0342 0.112
Trichomonas vaginalis glutaminase, putative 0.0265 0.1189 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0593 0.1945
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0439
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0128
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0043 0.0117
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0057
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0161 0.0527
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0078 0.0253
Brugia malayi Protein kinase domain containing protein 0.0086 0.037 0.2576
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0043 0.0138
Echinococcus multilocularis alkaline phosphatase 0.0157 0.0697 0.1944
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0017 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0345
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0163 0.1339
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0004 0.0037
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0004 0.0009
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0116 0.0508 0.1025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Loa Loa (eye worm) Smad1 0.0008 0.001 0.0081
Echinococcus granulosus carboxylesterase 5A 0.0135 0.0593 0.1945
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0095 0.0411 0.3459
Loa Loa (eye worm) carboxylesterase 0.0023 0.0078 0.0657
Schistosoma mansoni coup transcription factor 0.001 0.0018 0.0057
Brugia malayi Trypsin family protein 0.0006 0.0001 0.0008
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0062 0.0169
Loa Loa (eye worm) hypothetical protein 0.0086 0.0368 0.3097
Brugia malayi hypothetical protein 0.001 0.0017 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0155
Brugia malayi MH2 domain containing protein 0.0116 0.0504 0.3509
Onchocerca volvulus 0.0006 0.0001 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.0128
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.016 0.3439
Echinococcus granulosus replication factor c subunit 1 0.001 0.0017 0.0053
Echinococcus granulosus muscleblind protein 0.0145 0.0638 0.2093
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0079 0.1646
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0086 0.037 0.8088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0163 0.0163
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0018 0.0128
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0004 0.0004
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0812 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0108
Onchocerca volvulus 0.001 0.0017 0.0168
Mycobacterium ulcerans DNA polymerase IV 0.0077 0.0328 0.0327
Entamoeba histolytica protein kinase, putative 0.0086 0.037 0.8088
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0057
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0057 0.0501
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0047 0.0047
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0062 0.0199
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1027 0.863
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0116 0.0507 0.1664
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0062 0.2002
Chlamydia trachomatis dehyroquinate synthase 0.0116 0.0508 0.0492
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0057
Onchocerca volvulus 0.0007 0.0004 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0128
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0079 0.0078
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.3043 0.8498
Schistosoma mansoni terminal deoxycytidyl transferase 0.0051 0.0209 0.0685
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.001 0.0081
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0057 0.0116
Brugia malayi Pre-SET motif family protein 0.0201 0.0899 0.6254
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0067 0.0283 0.2379
Schistosoma mansoni hypothetical protein 0.0033 0.0125 0.0407
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0457 1
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0457 0.1498
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.001 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3562
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0116 0.0508 0.0507
Schistosoma mansoni hypothetical protein 0.0039 0.0155 0.0504
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0017 0.0283
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0004 0.0009
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0004 0.0003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.001 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0004 0.0003
Leishmania major DNA damage repair protein, putative 0.0016 0.0047 0.0935
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0235 0.0769
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0363
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0018 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0128
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0078 0.0253
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0057 0.1799
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0057
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0057 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0155
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0457 0.1498
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0017 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0043 0.0857
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0812 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0108
Echinococcus multilocularis carboxylesterase 5A 0.0135 0.0593 0.1653
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0062 0.1264
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0599 0.1671
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0022 0.0076 0.0076
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0147 0.5866
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0057 0.0056
Brugia malayi 6-phosphofructokinase 0.0105 0.0457 0.3178
Echinococcus multilocularis protein dispatched 1 0.0047 0.0188 0.0522
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0044 0.0303
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0078 0.0159
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0018 0.0048
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0235 0.0769
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0017 0.0108
Onchocerca volvulus 0.0023 0.0078 0.0761
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0057 0.0156
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0052 0.0035
Brugia malayi ecdysteroid receptor 0.001 0.0018 0.0128
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0018 0.0048
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0028
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0078 0.0159
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0018 0.0179
Echinococcus granulosus dna polymerase eta 0.0076 0.0323 0.1057
Loa Loa (eye worm) carboxylesterase 0.0023 0.0078 0.0657
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0077 0.0328 0.2729
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0079 0.0152
Echinococcus granulosus acetylcholinesterase 0.0135 0.0593 0.1945
Onchocerca volvulus 0.0006 0.0001 0.0011
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0411 0.1349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0155
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0047 0.015
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0135 0.0593 0.4989
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0057 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.0128
Onchocerca volvulus 0.0146 0.0646 0.6286
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0047 0.0935
Brugia malayi jmjC domain containing protein 0.0015 0.0043 0.03
Entamoeba histolytica recQ family DNA helicase 0.001 0.0018 0.0309
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0145
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0004 0.0003
Echinococcus granulosus expressed conserved protein 0.009 0.0385 0.1261
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0457 1
Schistosoma mansoni hypothetical protein 0.0082 0.0349 0.1144
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0018 0.0014
Plasmodium falciparum chorismate synthase 0.2182 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0457 0.3842
Giardia lamblia DINP protein human, muc B family 0.0058 0.0239 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.0128
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.008 0.0342 0.112
Brugia malayi Carboxylesterase family protein 0.0135 0.0593 0.4123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0299 0.1347 0.1332
Brugia malayi Carboxylesterase family protein 0.0023 0.0078 0.0543
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0062 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.037 0.1214
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0078 0.0215
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0239 0.0485
Brugia malayi hypothetical protein 0.001 0.0017 0.012
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0057 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3562
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0004 0.0011
Loa Loa (eye worm) acetyltransferase 0.014 0.0618 0.5197
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0047 0.0935
Brugia malayi jmjC domain containing protein 0.0057 0.0235 0.1635
Brugia malayi Carboxylesterase family protein 0.0023 0.0078 0.0543
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0051 0.0209 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0235 0.0769
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0457 0.3842
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0104 0.0841
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0163 0.0532
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.1051
Echinococcus multilocularis GPCR, family 2 0.0015 0.0044 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0299 0.1347 0.1346
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0457 0.0929
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0145
Echinococcus granulosus Smad4 0.0008 0.001 0.0028
Brugia malayi hypothetical protein 0.0023 0.0078 0.0543
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0017 0.0108
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0043 0.0138
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0104 0.0104
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0004 0.0004
Entamoeba histolytica recQ family helicase, putative 0.0009 0.0017 0.0271
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0439
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.037 0.8088
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0235 0.0653
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0052 0.0106
Brugia malayi hypothetical protein 0.0006 0.0001 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0504 0.4242
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0017 0.0283
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0009 0.0017 0.0017
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0104 0.2202
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0043 0.0363
Mycobacterium ulcerans hypothetical protein 0.0023 0.0079 0.0078
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0235 0.0769
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0018 0.0057
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0062 0.0169
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0062 0.0169
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0457 0.0456
Plasmodium vivax SET domain protein, putative 0.0029 0.0106 0.0106
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0018 0.0179
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.037 0.8088
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0161 0.0527
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0057 0.1164
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.1387
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0079 0.0078
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0051 0.0209 0.1761
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0062 0.0062
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.008 0.0342 0.0952
Entamoeba histolytica hypothetical protein 0.001 0.0017 0.0283
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0078 0.0077
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0018 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0079 0.0152
Onchocerca volvulus 0.0006 0.0001 0.0011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.008 0.0342 0.112
Onchocerca volvulus 0.0006 0.0001 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0079 0.0549
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0078 0.0622
Onchocerca volvulus 0.0007 0.0004 0.0043
Onchocerca volvulus 0.0007 0.0004 0.0043
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0017 0.0108
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0018 0.0309
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Brugia malayi Carboxylesterase family protein 0.0135 0.0593 0.4123
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0047 0.0935
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0004 0.0003
Loa Loa (eye worm) RecQ helicase 0.0019 0.0062 0.0518
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0893
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0018 0.0057
Brugia malayi nuclear hormone receptor 0.001 0.0018 0.0128
Brugia malayi CHE-14 protein 0.0041 0.0161 0.1122
Onchocerca volvulus 0.0006 0.0001 0.0011
Onchocerca volvulus 0.0023 0.0078 0.0761
Trypanosoma brucei DNA polymerase eta, putative 0.0076 0.0323 0.7036
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0018 0.0309
Echinococcus granulosus microtubule associated protein 2 0.0668 0.3043 1
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0043 0.0138
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0135 0.0593 0.4985
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0457 0.3819
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.3549
Trypanosoma brucei unspecified product 0.0071 0.0298 0.6498
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0139
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0411 0.8993
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0239 0.5181
Loa Loa (eye worm) hypothetical protein 0.005 0.0204 0.1712
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0043 0.0138
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0017 0.012
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0043 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0079 0.1646
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Onchocerca volvulus 0.0007 0.0004 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0323 0.2245
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0047 0.0935
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0043 0.0857
Schistosoma mansoni nuclear hormone receptor 0.001 0.0018 0.0057
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0004 0.0004
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0157 0.0697 0.2287
Echinococcus multilocularis neuroligin 0.0023 0.0078 0.0215
Echinococcus multilocularis expressed conserved protein 0.009 0.0385 0.1072
Onchocerca volvulus 0.0023 0.0078 0.0761
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0147 0.3156
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.0128
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.0663
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0235 0.0653
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0004 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.0328 0.7146
Schistosoma mansoni alkaline phosphatase 0.0157 0.0697 0.2287
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0017 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0079 0.1646
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0125 0.087
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.008 0.0342 0.2377
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0209 0.1457
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0079 0.1646
Schistosoma mansoni topbp1 0.001 0.0017 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.001 0.0081
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0017 0.012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0209 0.0426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0018 0.0155
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0062 0.1264
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0104 0.3918
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0457 1
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0017 0.0283
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0139
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0043 0.0363
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0079 0.016
Toxoplasma gondii exonuclease III APE 0.0018 0.0057 0.0057
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0057 0.048
Schistosoma mansoni ap endonuclease 0.0018 0.0057 0.0184
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0104 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0166 0.3562
Schistosoma mansoni DNA helicase recq1 0.0019 0.0062 0.0199
Loa Loa (eye worm) hypothetical protein 0.0145 0.0638 0.5363
Echinococcus granulosus dual specificity 0.0086 0.037 0.1214
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0018 0.0018
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0078 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0086 0.037 0.8088
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0504 0.4242
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0017 0.0283
Plasmodium vivax chorismate synthase 0.2182 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0439
Brugia malayi phosphofructokinase 0.0105 0.0457 0.3178
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0812 0.0796
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.0663
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0079 0.1646
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0195 0.1641
Brugia malayi DKFZp564C0469 protein 0.001 0.0017 0.012
Brugia malayi steroid hormone receptor 0.001 0.0018 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0518
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0062 0.0199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0235 0.0769
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0037
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0004 0.0009
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0104 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.0076 0.0323 0.7036
Entamoeba histolytica protein kinase, putative 0.0086 0.037 0.8088
Brugia malayi hypothetical protein 0.0146 0.0646 0.449
Loa Loa (eye worm) hypothetical protein 0.008 0.0342 0.2874
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0057
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0157 0.0697 0.1944
Schistosoma mansoni apoptosis regulator bax 0.008 0.0342 0.112
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.3549
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0062 0.0483
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Schistosoma mansoni ap endonuclease 0.0018 0.0057 0.0184
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0078 0.0253
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0145
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.358 1
Echinococcus multilocularis dual specificity 0.0086 0.037 0.1032
Entamoeba histolytica deoxycytidyl transferase, putative 0.0051 0.0209 0.4532
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0147 0.0147
Schistosoma mansoni DNA polymerase eta 0.0076 0.0323 0.1057
Echinococcus granulosus alkaline phosphatase 0.0157 0.0697 0.2287
Echinococcus granulosus FTZ F1 alpha 0.001 0.0018 0.0057
Leishmania major DNA polymerase eta, putative 0.0041 0.016 0.3439
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0108
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.1076 0.4918 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0251 0.1127 0.9479
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0145 0.0638 0.5363
Echinococcus multilocularis dna polymerase eta 0.0076 0.0323 0.0899
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0057 0.0397
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0106 0.0294
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0004 0.0037
Echinococcus granulosus intestinal type alkaline phosphatase 0.0157 0.0697 0.2287
Leishmania major DNA polymerase kappa, putative 0.0016 0.0047 0.0935
Leishmania major DNA polymerase eta, putative 0.0076 0.0323 0.7036
Schistosoma mansoni hypothetical protein 0.0039 0.0155 0.0504
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0043 0.0857
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0018 0.0057
Plasmodium vivax JmjC domain containing protein 0.0015 0.0043 0.0043
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0457 0.0921
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0017 0.0026
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0078 0.0215
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0079 0.0549
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0004 0.0011
Leishmania major hypothetical protein, conserved 0.0015 0.0043 0.0857
Entamoeba histolytica hypothetical protein 0.0086 0.037 0.8088
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.3043 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0057 0.0445
Giardia lamblia DNA damage repair protein 0.0016 0.0047 0.133
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0235 0.1976
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0079 0.0078
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0047 0.0935
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0116 0.0508 0.1033
Echinococcus multilocularis dna polymerase kappa 0.0077 0.0328 0.0913
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0163 0.0163
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0163 0.0163
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0057
Echinococcus granulosus GPCR family 2 0.0015 0.0044 0.0139
Trypanosoma brucei unspecified product 0.0035 0.0136 0.2913
Brugia malayi jmjC domain containing protein 0.0015 0.0043 0.03
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0079 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0004 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0018 0.0128
Schistosoma mansoni acetylcholinesterase 0.0023 0.0078 0.0253
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Brugia malayi Carboxylesterase family protein 0.0023 0.0078 0.0543
Echinococcus granulosus neuroligin 0.0023 0.0078 0.0253
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0043 0.0138
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0239 0.5181
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0157 0.0697 0.2287
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0062 0.1264
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0004 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0079 0.0549
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0367
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0078 0.0215
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0411 0.2861
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0078 0.0253
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0146 0.0646 0.5428
Loa Loa (eye worm) hypothetical protein 0.0076 0.0323 0.2714
Brugia malayi Trypsin-like protease protein 5 0.0006 0.0001 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0097
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Schistosoma mansoni patched 1 0.0041 0.0161 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0155
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0104 0.0087
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0157 0.0697 0.1944
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0161 0.1325
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0004 0.0009
Echinococcus multilocularis Smad4 0.0008 0.001 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0097
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0618 0.2028
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0004 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0079 0.016
Brugia malayi Pre-SET motif family protein 0.0029 0.0106 0.0739
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0043 0.0117
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0018 0.0057
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0319 0.1438 1
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0006 0.0003 0.0005
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0047 0.0935
Schistosoma mansoni glutaminase 0.0265 0.1189 0.3906
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0457 0.3819
Onchocerca volvulus 0.0023 0.0078 0.0761
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0116 0.0508 0.1033
Brugia malayi 6-phosphofructokinase 0.0105 0.0457 0.318
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0104 0.0104
Onchocerca volvulus 0.0023 0.0079 0.0768
Loa Loa (eye worm) carboxylesterase 0.0135 0.0593 0.4985
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0106 0.0345
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0106 0.0345
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0363
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.0328 0.7146
Brugia malayi polk-prov protein 0.0042 0.0165 0.1147
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0104 0.0104
Brugia malayi Trypsin family protein 0.0006 0.0001 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0018 0.0057
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0108
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0017 0.0017
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0062 0.0518
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.008 0.0342 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0345
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0097
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0457 0.3842
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0104 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0128
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0043 0.0138
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0018 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0057 0.0445
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0457 0.1498
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0104 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0145
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0079 0.0078
Loa Loa (eye worm) glutaminase 0.0265 0.1189 1
Loa Loa (eye worm) glutaminase 2 0.0265 0.1189 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0043 0.0117
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0078 0.0253
Schistosoma mansoni gliotactin 0.0023 0.0078 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0017 0.0017
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0078 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0004 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0017 0.0284
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0104 0.0841
Echinococcus multilocularis nibrin 0.001 0.0017 0.0045
Brugia malayi Muscleblind-like protein 0.0145 0.0638 0.4436
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0017 0.0108
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0457 1
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0067
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0057 0.1164
Schistosoma mansoni hypothetical protein 0.0039 0.0155 0.0504
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Onchocerca volvulus 0.0029 0.0106 0.1034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0195 0.1357
Echinococcus multilocularis protein patched 0.0041 0.0161 0.0448
Brugia malayi glutaminase DH11.1 0.0265 0.1189 0.8272
Schistosoma mansoni 3-dehydroquinate synthase 0.0116 0.0508 0.1667
Schistosoma mansoni topbp1 0.001 0.0017 0.0053
Echinococcus granulosus nibrin 0.001 0.0017 0.0053
Onchocerca volvulus 0.001 0.0018 0.0179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0018 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0018 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0047 0.0935
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0161 0.1357
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0163 0.1339
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.1076 0.4918 1
Echinococcus granulosus smad 0.0008 0.001 0.0028
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0062 0.0483
Trichomonas vaginalis DNA polymerase eta, putative 0.0077 0.0328 0.2729
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0017 0.0108
Echinococcus multilocularis acetylcholinesterase 0.0135 0.0593 0.1653
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.001 0.0024
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0104 0.0841
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0657
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0618 0.1724
Onchocerca volvulus 0.0006 0.0001 0.0011
Brugia malayi Carboxylesterase family protein 0.0023 0.0078 0.0543
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0155
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0411 0.1146
Brugia malayi jmjC domain containing protein 0.0057 0.0235 0.1635
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0104 0.0841
Schistosoma mansoni DNA helicase recq5 0.0019 0.0062 0.0199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0048
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0299 0.1347 0.1347
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0079 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0457 0.3819
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0018 0.0057
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0004 0.0031
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0418 0.1371
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0018 0.0057
Onchocerca volvulus 0.0023 0.0078 0.0761
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0047 0.0935
Schistosoma mansoni alkaline phosphatase 0.0157 0.0697 0.2287
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0062 0.0428
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0004 0.0031
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0018 0.0048
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.037 0.8088
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0043 0.0117
Brugia malayi jmjC domain containing protein 0.0015 0.0043 0.03
Brugia malayi nuclear receptor NHR-88 0.001 0.0018 0.0128
Loa Loa (eye worm) hypothetical protein 0.0048 0.0195 0.1641
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0057 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0457 0.3819
Toxoplasma gondii chorismate synthase, putative 0.2182 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0104 0.0104
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0062 0.0428
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.0328 0.7146
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.0128
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0018 0.0128
Schistosoma mansoni DNA ligase IV 0.001 0.0017 0.0053
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0004 0.0003
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0299 0.1347 0.2733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0004 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0044 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0195 0.1357
Mycobacterium ulcerans glutaminase 0.0265 0.1189 0.1188
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0018 0.0057
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0043 0.0117
Mycobacterium ulcerans hypothetical protein 0.0016 0.0047 0.0046
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0006 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0097
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0017 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0043 0.0138
Loa Loa (eye worm) acetylcholinesterase 1 0.0135 0.0593 0.4985
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0018 0.0057

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 550 nM Effective concentration at human melanocortin 4 receptor in cAMP release assay ChEMBL. 16005624
EC50 (functional) = 550 nM Effective concentration at human melanocortin 4 receptor in cAMP release assay ChEMBL. 16005624
IC50 (binding) = 13 nM Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cells ChEMBL. 16005624
IC50 (binding) = 13 nM Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cells ChEMBL. 16005624
Max (functional) = 58 % Maximum percentage of cAMP accumulation relative to alpha-MSH at human melanocortin 4 receptor at 10 uM ChEMBL. 16005624
Max (functional) = 58 % Maximum percentage of cAMP accumulation relative to alpha-MSH at human melanocortin 4 receptor at 10 uM ChEMBL. 16005624

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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