Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | nM | Induction of [Ca2+] uptake in CHO cells expressing rat TRPV1 at 10-30 uM relative to 300 nM capsaicin; Not effective | ChEMBL. | 15993063 |
EC50 (functional) | 0 nM | Induction of [Ca2+] uptake in CHO cells expressing rat TRPV1 at 10-30 uM relative to 300 nM capsaicin; Not effective | ChEMBL. | 15993063 |
Ki (functional) | = 225 nM | Antagonist activity towards rat TRPV1 expressed in CHO cells | ChEMBL. | 15993063 |
Ki (functional) | = 225 nM | Antagonist activity towards rat TRPV1 expressed in CHO cells | ChEMBL. | 15993063 |
Ki (binding) | = 2560 nM | In vitro inhibition of [3H]-RTX binding to rat TRPV1 expressed in CHO cells | ChEMBL. | 15993063 |
Ki (binding) | = 2560 nM | In vitro inhibition of [3H]-RTX binding to rat TRPV1 expressed in CHO cells | ChEMBL. | 15993063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.