Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.153705 | 0.922648 | 0.922648 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.111209 | 0.651905 | 0.651905 |
Echinococcus granulosus | Homeodomain | 0.021149 | 0.0781374 | 0.0781374 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Echinococcus multilocularis | Homeodomain | 0.021149 | 0.0781374 | 0.0781374 |
Entamoeba histolytica | hypothetical protein | 0.0264635 | 0.111996 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.165847 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.165847 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.165847 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.165847 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.165847 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.165847 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.111209 | 0.651905 | 0.651905 |
Schistosoma mansoni | hypothetical protein | 0.021149 | 0.0781374 | 0.0781374 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.165847 | 1 | 0.5 |
Schistosoma mansoni | integrin alpha-4 | 0.0447156 | 0.228279 | 0.228279 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.063412 | 0.347393 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.165847 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.153705 | 0.922648 | 0.922648 |
Echinococcus granulosus | dihydrofolate reductase | 0.165847 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.165847 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0416368 | 0.208664 | 0.208664 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | NA 0 | Cytotoxicity against human diploid embryonic lung cell line hMRC-5 was observed at conc. upto 32 uM ;(No cytotoxicity) | ChEMBL. | 15537352 |
IC50 (functional) | = 1.5 uM | Inhibitory concentration against Plasmodium falciparum FcBIR strain | ChEMBL. | 15537352 |
IC50 (functional) | = 1.5 uM | Inhibitory concentration against Plasmodium falciparum FcBIR strain | ChEMBL. | 15537352 |
IC50 (binding) | = 22.7 uM | Inhibitory concentration against human glutathione reductase | ChEMBL. | 15537352 |
IC50 (binding) | = 22.7 uM | Inhibitory concentration against human glutathione reductase | ChEMBL. | 15537352 |
IC50 (binding) | = 57 uM | Inhibitory concentration against Plasmodium falciparum glutathione reductase | ChEMBL. | 15537352 |
IC50 (binding) | = 57 uM | Inhibitory concentration against Plasmodium falciparum glutathione reductase | ChEMBL. | 15537352 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15537352 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.