Detailed information for compound 331015

Basic information

Technical information
  • TDR Targets ID: 331015
  • Name: 4-[[5-[6-(3-chloroanilino)pyrazin-2-yl]pyridi n-3-yl]amino]butan-1-ol
  • MW: 369.848 | Formula: C19H20ClN5O
  • H donors: 3 H acceptors: 4 LogP: 2.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCCNc1cncc(c1)c1cncc(n1)Nc1cccc(c1)Cl
  • InChi: 1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
  • InChiKey: IDNNHUIRPPFJBA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[[5-[6-(3-chloroanilino)pyrazin-2-yl]-3-pyridyl]amino]butan-1-ol
  • 4-[[5-[6-(3-chloroanilino)-2-pyrazinyl]-3-pyridyl]amino]-1-butanol
  • 4-[[5-[6-[(3-chlorophenyl)amino]pyrazin-2-yl]pyridin-3-yl]amino]butan-1-ol
  • 4-[[5-[6-[(3-chlorophenyl)amino]pyrazin-2-yl]-3-pyridyl]amino]butan-1-ol
  • 4-[[5-[6-[(3-chlorophenyl)amino]-2-pyrazinyl]-3-pyridyl]amino]butan-1-ol
  • Pyrazine-Pyridine Biheteroaryl 39

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 2, alpha prime polypeptide References
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References
Homo sapiens calcium/calmodulin-dependent protein kinase II alpha References
Homo sapiens casein kinase 2, beta polypeptide Starlite/ChEMBL References
Homo sapiens cyclin D1 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens casein kinase 1, gamma 2 References
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens casein kinase 2, alpha 1 polypeptide References
Homo sapiens glycogen synthase kinase 3 alpha References
Homo sapiens calcium/calmodulin-dependent protein kinase II beta References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens casein kinase 1, epsilon References
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 4 References
Homo sapiens casein kinase 1, alpha 1 Starlite/ChEMBL References
Homo sapiens casein kinase 1, delta References
Homo sapiens calcium/calmodulin-dependent protein kinase II gamma References
Homo sapiens fibroblast growth factor receptor 2 Starlite/ChEMBL References
Homo sapiens casein kinase 1, gamma 1 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to headcase protein Get druggable targets OG5_128520 All targets in OG5_128520
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CK1 Casein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax unspecified product Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans hypothetical protein Get druggable targets OG5_128520 All targets in OG5_128520
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K08958 casein kinase 1, gamma, putative Get druggable targets OG5_128520 All targets in OG5_128520
Cryptosporidium hominis protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K02218 casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Kinase, CMGC CK2 Get druggable targets OG5_126901 All targets in OG5_126901
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans second casein kinase I-like orf Get druggable targets OG5_128520 All targets in OG5_128520
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to headcase protein Get druggable targets OG5_128520 All targets in OG5_128520
Plasmodium yoelii casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis casein kinase II, alpha chain (CK II) Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii CMGC kinase, CK2 family Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium falciparum casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei Casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) casein kinase Get druggable targets OG5_128520 All targets in OG5_128520
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Casein kinase I isoform delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_128520 All targets in OG5_128520
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128520 All targets in OG5_128520
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum casein kinase 1 Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi casein kinase 1, delta Get druggable targets OG5_126780 All targets in OG5_126780
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum hypothetical protein Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma congolense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K03097 casein kinase 2, alpha polypeptide, putative Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus casein kinase I gamma Get druggable targets OG5_128520 All targets in OG5_128520
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CMGC/CK2 protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis casein kinase I gamma Get druggable targets OG5_128520 All targets in OG5_128520
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_128520 All targets in OG5_128520
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Plasmodium knowlesi casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans casein kinase I-like orf Get druggable targets OG5_128520 All targets in OG5_128520
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Leishmania major casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K08959 casein kinase 1, delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans second casein kinase I-like orf Get druggable targets OG5_128520 All targets in OG5_128520
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania donovani casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum casein kinase II, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) protein kinase domain-containing protein Get druggable targets OG5_128520 All targets in OG5_128520
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Neospora caninum AFL091Wp, related Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha prime polypeptide 350 aa 319 aa 50.2 %
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha 1 polypeptide 391 aa 316 aa 51.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Brugia malayi Protein kinase domain containing protein casein kinase 1, alpha 1 365 aa 307 aa 24.4 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0081 0.0621 0.2663
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0144 0.1267 0.358
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Brugia malayi G-protein coupled receptor 0.0059 0.0388 0.0733
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.1045 0.1045
Echinococcus multilocularis calcium dependent protein kinase 0.0072 0.0528 0.0862
Echinococcus multilocularis allatostatin A receptor 0.0059 0.0388 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0487 0.0794
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Onchocerca volvulus 0.0136 0.119 0.7278
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0059 0.0388 0.0634
Schistosoma mansoni protein kinase 0.0613 0.6126 1
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0487 0.0487
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0388 0.0634
Schistosoma mansoni biogenic amine receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis casein kinase I gamma 0.0152 0.1349 0.2203
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0059 0.0388 0.2375
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.1349 0.2203
Echinococcus granulosus G protein coupled receptor 139 0.0059 0.0388 0.0634
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.1552 0.293
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Entamoeba histolytica casein kinase 1, putative 0.0144 0.1267 0.5432
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0068 0.0487 0.1375
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0059 0.0388 0.0634
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.008 0.0605 0.2866
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Brugia malayi Dopamine receptor 0.0059 0.0388 0.0733
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Echinococcus granulosus neuropeptide receptor 0.0059 0.0388 0.0634
Plasmodium vivax unspecified product 0.0169 0.1525 1
Schistosoma mansoni neuropeptide receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0144 0.1267 0.2391
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Echinococcus granulosus fibroblast growth factor receptor 4 0.0164 0.1473 0.2405
Schistosoma mansoni hypothetical protein 0.0059 0.0388 0.0634
Schistosoma mansoni tyrosine kinase 0.0166 0.1501 0.245
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0388 0.0634
Echinococcus granulosus protein kinase shaggy 0.0122 0.1045 0.1706
Entamoeba histolytica protein kinase, putative 0.0122 0.1045 0.4481
Giardia lamblia Kinase, CMGC GSK 0.0122 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0059 0.0388 0.0634
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.008 0.0605 0.2866
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0544 0.0888
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni adenoreceptor 0.0059 0.0388 0.0634
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0388 0.0634
Echinococcus granulosus serotonin receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis neuropeptide s receptor 0.0059 0.0388 0.0634
Plasmodium falciparum calcium-dependent protein kinase 3 0.008 0.0605 0.397
Brugia malayi Csnk2b protein 0.0044 0.0236 0.0445
Echinococcus multilocularis roundabout 2 0.0023 0.0012 0.0019
Trypanosoma cruzi casein kinase, putative 0.0144 0.1267 0.358
Trichomonas vaginalis conserved hypothetical protein 0.0741 0.7446 0.7446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni amine GPCR 0.0059 0.0388 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Brugia malayi Casein kinase II, alpha chain 0.0169 0.1525 0.2878
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Trypanosoma cruzi casein kinase, putative 0.0144 0.1267 0.358
Plasmodium falciparum casein kinase 2, alpha subunit 0.0169 0.1525 1
Trypanosoma brucei Casein kinase II 0.0169 0.1525 0.4309
Schistosoma mansoni tyrosine kinase 0.0171 0.1552 0.2534
Echinococcus granulosus 7tm_1 domain containing protein 0.0059 0.0388 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0218 0.2039 0.3848
Schistosoma mansoni hypothetical protein 0.0059 0.0388 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Schistosoma mansoni protein kinase 0.0169 0.1525 0.2489
Loa Loa (eye worm) TK protein kinase 0.0171 0.1552 0.293
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0059 0.0388 0.0733
Brugia malayi protein kinase C II. 0.0026 0.0051 0.0097
Echinococcus granulosus neuropeptide s receptor 0.0059 0.0388 0.0634
Brugia malayi putative neuropeptide receptor 0.0059 0.0388 0.0733
Onchocerca volvulus 0.0059 0.0388 0.2375
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis mitogen activated protein kinase 3 0.0068 0.0487 0.0794
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0059 0.0388 0.0634
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis casein kinase I delta 0.0144 0.1267 0.2068
Echinococcus granulosus tachykinin peptides receptor 99D 0.0059 0.0388 0.0634
Schistosoma mansoni growth hormone secretagogue receptor 0.0059 0.0388 0.0634
Trypanosoma brucei protein kinase, putative 0.0068 0.0487 0.1375
Echinococcus multilocularis orexin receptor type 2 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Schistosoma mansoni tyrosine kinase 0.0218 0.2039 0.3328
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.3539 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0059 0.0388 0.0634
Brugia malayi Protein kinase c protein 2 0.0064 0.0439 0.083
Plasmodium vivax calcium-dependent protein kinase, putative 0.008 0.0605 0.2866
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.008 0.0605 0.1711
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis protein kinase shaggy 0.0122 0.1045 0.1706
Echinococcus granulosus calcium dependent protein kinase 0.0072 0.0528 0.0862
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0044 0.0236 0.0667
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0271 0.0442
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0388 0.0634
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.008 0.0605 0.0988
Loa Loa (eye worm) hypothetical protein 0.0363 0.3539 0.6679
Echinococcus granulosus g-protein coupled receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0068 0.0487 0.1375
Trichomonas vaginalis CK1 family protein kinase 0.0144 0.1267 0.1267
Schistosoma mansoni myosin xvIII 0.0059 0.0388 0.0634
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0068 0.0487 0.1375
Echinococcus granulosus insulin receptor 0.0218 0.2039 0.3328
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0059 0.0388 0.0733
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Onchocerca volvulus 0.0059 0.0388 0.2375
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.3539 1
Echinococcus granulosus orexin receptor type 2 0.0059 0.0388 0.0634
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni tyrosine kinase 0.0166 0.1501 0.245
Brugia malayi putative neuropeptide receptor NPR1 0.0059 0.0388 0.0733
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.008 0.0605 0.1143
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Schistosoma mansoni amine GPCR 0.0059 0.0388 0.0634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.008 0.0605 0.0988
Schistosoma mansoni amine GPCR 0.0059 0.0388 0.0634
Plasmodium falciparum calcium-dependent protein kinase 5 0.008 0.0605 0.397
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0247 0.2332 0.2332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0055 0.0347 0.0654
Schistosoma mansoni neuropeptide receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis G-protein coupled receptor, putative 0.0059 0.0388 0.0634
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0057 0.0364 0.0687
Echinococcus granulosus roundabout 2 0.0023 0.0012 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0144 0.1267 0.2391
Schistosoma mansoni atypical protein kinase C 0.0025 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Onchocerca volvulus 0.0144 0.1267 0.7751
Brugia malayi neuropeptide F receptor 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.0236 0.1012
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Echinococcus granulosus g protein coupled receptor 0.0059 0.0388 0.0634
Echinococcus granulosus neuropeptide FF receptor 2 0.0059 0.0388 0.0634
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0169 0.1525 1
Trichomonas vaginalis CK1 family protein kinase 0.0144 0.1267 0.1267
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0271 0.0442
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0068 0.0487 0.1375
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0388 0.0733
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0487 0.0487
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0059 0.0388 0.0634
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni protein kinase 0.0144 0.1267 0.2068
Schistosoma mansoni histamine h1 receptor 0.0059 0.0388 0.0634
Plasmodium falciparum casein kinase 1 0.0144 0.1267 0.8308
Onchocerca volvulus 0.0059 0.0388 0.2375
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Entamoeba histolytica casein kinase, putative 0.0144 0.1267 0.5432
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0388 0.0634
Brugia malayi Protein kinase domain containing protein 0.0152 0.1349 0.2547
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Echinococcus multilocularis 0.0076 0.0569 0.0929
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.0236 0.1444
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis g-protein coupled receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) protein kinase domain-containing protein 0.0152 0.1349 0.2547
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis epidermal growth factor receptor 0.0171 0.1552 0.2534
Trypanosoma cruzi casein kinase II, putative 0.0169 0.1525 0.4309
Leishmania major casein kinase II, putative 0.0169 0.1525 0.4309
Onchocerca volvulus Tyrosine kinase homolog 0.0179 0.1634 1
Entamoeba histolytica protein kinase, putative 0.008 0.0605 0.2596
Onchocerca volvulus 0.0122 0.1045 0.6394
Echinococcus granulosus neuropeptide receptor A26 0.0059 0.0388 0.0634
Brugia malayi casein kinase I 0.0144 0.1267 0.2391
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Echinococcus granulosus protein kinase c iota type 0.0025 0.0035 0.0058
Schistosoma mansoni opsin-like receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Schistosoma mansoni biogenic amine receptor 0.0059 0.0388 0.0634
Brugia malayi casein kinase 1, delta 0.0144 0.1267 0.2391
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0059 0.0388 0.0634
Echinococcus granulosus casein kinase ii subunit alpha 0.0169 0.1525 0.2489
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0247 0.2332 0.2332
Giardia lamblia Kinase, CMGC MAPK 0.0068 0.0487 0.0487
Echinococcus multilocularis casein kinase i 0.0144 0.1267 0.2068
Giardia lamblia NADPH oxidoreductase, putative 0.0988 1 1
Echinococcus granulosus casein kinase I delta 0.0144 0.1267 0.2068
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0544 0.0888
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni amine GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) TYRA-2 protein 0.0059 0.0388 0.0733
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0136 0.119 0.3362
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis protein kinase c iota type 0.0025 0.0035 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Plasmodium falciparum calcium-dependent protein kinase 2 0.008 0.0605 0.397
Brugia malayi follicle stimulating hormone receptor 0.0059 0.0388 0.0733
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0122 0.1045 0.6278
Trypanosoma cruzi casein kinase, putative 0.0144 0.1267 0.358
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0164 0.1473 0.2405
Echinococcus multilocularis casein kinase I alpha 0.0144 0.1267 0.2068
Echinococcus multilocularis casein kinase I alpha 0.0144 0.1267 0.2068
Echinococcus granulosus casein kinase I gamma 0.0152 0.1349 0.2203
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0122 0.1045 0.1706
Giardia lamblia Casein kinase II beta chain 0.0044 0.0236 0.0236
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0068 0.0487 0.0794
Brugia malayi G protein-coupled receptor F59B2.13 0.0059 0.0388 0.0733
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis casein kinase I alpha 0.0144 0.1267 0.2068
Giardia lamblia Kinase, CMGC CK2 0.0169 0.1525 0.1525
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0247 0.2332 0.2332
Onchocerca volvulus Neuropeptide F receptor homolog 0.0059 0.0388 0.2375
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.1709 0.3226
Echinococcus granulosus somatostatin receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Brugia malayi Furin-like cysteine rich region family protein 0.0255 0.2415 0.4558
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0059 0.0388 0.0733
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.0236 0.0385
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0218 0.2039 0.3328
Loa Loa (eye worm) Csnk2b protein 0.0044 0.0236 0.0445
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0122 0.1045 0.1706
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0068 0.0487 0.0918
Onchocerca volvulus 0.0059 0.0388 0.2375
Brugia malayi neuropeptide F receptor 0.0059 0.0388 0.0733
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0059 0.0388 0.0634
Plasmodium falciparum calcium-dependent protein kinase 4 0.008 0.0605 0.397
Brugia malayi Dopamine receptor protein 1 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0186 0.17 0.3209
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0074 0.0544 0.0888
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0388 0.0634
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0487 0.1375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0164 0.1473 0.2405
Echinococcus granulosus protein kinase c epsilon type 0.0026 0.0051 0.0084
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0613 0.6126 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0122 0.1045 0.1972
Schistosoma mansoni hypothetical protein 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Echinococcus multilocularis insulin receptor 0.0218 0.2039 0.3328
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus granulosus allatostatin A receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.0236 0.0385
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.008 0.0605 0.0988
Plasmodium falciparum calcium-dependent protein kinase 1 0.008 0.0605 0.397
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0388 0.0733
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0388 0.0634
Echinococcus granulosus neuropeptide receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis serotonin receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis casein kinase ii subunit alpha 0.0169 0.1525 0.2489
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0388 0.0634
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0388 0.0634
Toxoplasma gondii CMGC kinase, CK2 family 0.0169 0.1525 1
Brugia malayi Serotonin receptor 0.0059 0.0388 0.0733
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.008 0.0605 0.2866
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Onchocerca volvulus 0.0059 0.0388 0.2375
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0487 0.0487
Plasmodium vivax casein kinase 1, putative 0.0144 0.1267 0.7998
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0059 0.0388 0.0733
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.3539 1
Onchocerca volvulus 0.0059 0.0388 0.2375
Entamoeba histolytica hypothetical protein 0.0247 0.2332 1
Schistosoma mansoni protein kinase 0.0613 0.6126 1
Brugia malayi AKH receptor 0.0059 0.0388 0.0733
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Brugia malayi Dopamine receptor protein 2 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.008 0.0605 0.1143
Leishmania major protein kinase, putative 0.008 0.0605 0.1711
Echinococcus granulosus hypothetical protein 0.0059 0.0388 0.0634
Echinococcus multilocularis neuropeptide FF receptor 2 0.0059 0.0388 0.0634
Schistosoma mansoni neuropeptide receptor 0.0059 0.0388 0.0634
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0122 0.1045 0.1706
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni amine GPCR 0.0059 0.0388 0.0634
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0048 0.0271 0.0512
Schistosoma mansoni tyrosine kinase 0.0218 0.2039 0.3328
Echinococcus granulosus 7TM GPCR rhodopsin 0.0059 0.0388 0.0634
Brugia malayi Serotonin receptor 0.0059 0.0388 0.0733
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0388 0.0733
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0988 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0388 0.0634
Trypanosoma brucei casein kinase I, isoform 2 0.0144 0.1267 0.358
Echinococcus granulosus g protein coupled receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis somatostatin receptor 0.0059 0.0388 0.0634
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.0236 0.1012
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0059 0.0388 0.0634
Leishmania major casein kinase, putative 0.0144 0.1267 0.358
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0988 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.067 0.1265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Echinococcus granulosus casein kinase i 0.0144 0.1267 0.2068
Entamoeba histolytica protein kinase domain containing protein 0.0169 0.1525 0.6538
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni neuropeptide f receptor 76f 0.0059 0.0388 0.0634
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.0236 0.0385
Brugia malayi G protein-coupled receptor 0.0059 0.0388 0.0733
Echinococcus granulosus dro:myosuppressin receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Schistosoma mansoni biogenic amine receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0059 0.0388 0.0733
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0388 0.0634
Schistosoma mansoni tyrosine kinase 0.0171 0.1552 0.2534
Schistosoma mansoni protein kinase 0.0613 0.6126 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Brugia malayi sulfakinin receptor protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0026 0.0051 0.0097
Trypanosoma cruzi casein kinase, putative 0.0144 0.1267 0.358
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni tyrosine kinase 0.0255 0.2415 0.3942
Brugia malayi Melatonin receptor type 1A 0.0059 0.0388 0.0733
Giardia lamblia NADPH oxidoreductase, putative 0.0988 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0187 0.1709 0.3226
Echinococcus granulosus casein kinase I alpha 0.0144 0.1267 0.2068
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0533 0.5298 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Onchocerca volvulus 0.0059 0.0388 0.2375
Brugia malayi ORL1-like opioid receptor 0.0059 0.0388 0.0733
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0613 0.6126 1
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.1045 0.4481
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0169 0.1525 0.2878
Brugia malayi GnHR receptor homolog 0.0059 0.0388 0.0733
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Plasmodium falciparum casein kinase II beta chain 0.0044 0.0236 0.1548
Echinococcus granulosus g protein coupled receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0988 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.008 0.0605 0.0988
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.008 0.0605 0.1143
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.008 0.0605 0.0988
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0164 0.1473 0.2405
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.0236 0.0667
Echinococcus granulosus casein kinase I alpha 0.0144 0.1267 0.2068
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.008 0.0605 0.0988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Onchocerca volvulus 0.0059 0.0388 0.2375
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.3539 0.6679
Echinococcus multilocularis mitogen activated protein kinase 0.0068 0.0487 0.0794
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0388 0.0634
Echinococcus granulosus epidermal growth factor receptor 0.0171 0.1552 0.2534
Brugia malayi Tachykinin-like peptides receptor 99D 0.0059 0.0388 0.0733
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0533 0.5298 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0059 0.0388 0.0733
Schistosoma mansoni tyrosine kinase 0.0164 0.1473 0.2405
Echinococcus multilocularis casein kinase I delta 0.0144 0.1267 0.2068
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus multilocularis serotonin receptor 0.0059 0.0388 0.0634
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Schistosoma mansoni tyrosine kinase 0.0166 0.1501 0.245
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0144 0.1267 0.2391
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0487 0.0487
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0388 0.0634
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.008 0.0605 0.2866
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0059 0.0388 0.0634
Echinococcus granulosus twitchin 0.0026 0.0051 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.1045 0.4481
Trichomonas vaginalis CK1 family protein kinase 0.0144 0.1267 0.1267
Giardia lamblia Kinase, CK1 Casein kinase 0.0144 0.1267 0.1267
Echinococcus multilocularis neuropeptide receptor A26 0.0059 0.0388 0.0634
Onchocerca volvulus 0.0059 0.0388 0.2375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Schistosoma mansoni hypothetical protein 0.0059 0.0388 0.0634
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0122 0.1045 0.2953
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0388 0.0634
Giardia lamblia Kinase, CMGC GSK 0.0122 0.1045 0.1045
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0487 0.1375
Brugia malayi Protein kinase domain containing protein 0.0218 0.2039 0.3848
Plasmodium vivax glycogen synthase kinase 3, putative 0.0122 0.1045 0.6278
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.008 0.0605 0.2866
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0388 0.0634
Trypanosoma brucei protein kinase, putative 0.0122 0.1045 0.2953
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0271 0.0442
Echinococcus multilocularis dro:myosuppressin receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis sex peptide receptor 0.0059 0.0388 0.0634
Echinococcus granulosus casein kinase I delta 0.0144 0.1267 0.2068
Echinococcus granulosus fmrfamide receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0388 0.0634
Echinococcus granulosus protein kinase C gamma type 0.0067 0.0468 0.0765
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0171 0.1552 0.2534
Trypanosoma cruzi casein kinase, putative 0.0144 0.1267 0.358
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis epidermal growth factor receptor 0.0255 0.2415 0.3942
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0068 0.0487 0.1944
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.0236 0.1012
Brugia malayi Protein kinase domain containing protein 0.0091 0.0722 0.1363
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.1525 0.1525
Echinococcus granulosus sex peptide receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.008 0.0605 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0218 0.2039 0.3328
Echinococcus granulosus mitogen activated protein kinase 0.0068 0.0487 0.0794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Echinococcus granulosus epidermal growth factor receptor 0.0255 0.2415 0.3942
Echinococcus multilocularis serine threonine protein kinase 0.0067 0.0468 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0059 0.0388 0.0733
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0059 0.0388 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.1267 0.2068
Echinococcus granulosus alpha 1A adrenergic receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0247 0.2332 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0388 0.0634
Toxoplasma gondii casein kinase I 0.0144 0.1267 0.7998
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0388 0.0634
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0605 0.0605
Brugia malayi RE15519p 0.0059 0.0388 0.0733
Brugia malayi intracellular kinase 0.0122 0.1045 0.1972
Entamoeba histolytica casein kinase, putative 0.0169 0.1525 0.6538
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0122 0.1045 0.1972
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Echinococcus granulosus Protein kinase C brain isozyme 0.0074 0.0544 0.0888
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.2332 0.2332
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0122 0.1045 0.2953
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0388 0.0634
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0388 0.0634
Brugia malayi G-protein coupled receptor 0.0059 0.0388 0.0733
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0388 0.0634
Plasmodium falciparum casein kinase II beta chain 0.0044 0.0236 0.1548
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Schistosoma mansoni opsin-like receptor 0.0059 0.0388 0.0634
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0236 0.0236
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0388 0.0634
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0247 0.2332 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) TK/EGFR protein kinase 0.0255 0.2415 0.4558
Schistosoma mansoni alpha-1 adrenergic receptor 0.0059 0.0388 0.0634
Onchocerca volvulus 0.0059 0.0388 0.2375
Plasmodium falciparum glycogen synthase kinase 3 0.0122 0.1045 0.6854
Schistosoma mansoni opsin-like receptor 0.0059 0.0388 0.0634
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0059 0.0388 0.0634
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.008 0.0605 0.2866
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0059 0.0388 0.0733
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0388 0.0634
Brugia malayi hypothetical protein 0.0059 0.0388 0.0733
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.0236 0.0667
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0388 0.0634
Loa Loa (eye worm) melatonin receptor type 1A 0.0059 0.0388 0.0733
Echinococcus granulosus casein kinase I alpha 0.0144 0.1267 0.2068
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0059 0.0388 0.0634
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.0236 0.0667
Onchocerca volvulus 0.0167 0.1503 0.9198
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Brugia malayi Cam kinase protein 1 0.008 0.0605 0.1143
Brugia malayi larval opioid receptor 0.0059 0.0388 0.0733
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0388 0.0634
Brugia malayi MAP kinase sur-1 0.0068 0.0487 0.0918
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0605 0.0988
Trichomonas vaginalis modulator of drug activity B, putative 0.0247 0.2332 0.2332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0059 0.0388 0.0634
Onchocerca volvulus 0.0059 0.0388 0.2375
Loa Loa (eye worm) casein kinase 0.0144 0.1272 0.2401
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0068 0.0487 0.1375
Echinococcus multilocularis protein kinase c epsilon type 0.0026 0.0051 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0988 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.1045 0.1045
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0388 0.0634
Echinococcus granulosus peptide allatostatin:somatostatin 0.0059 0.0388 0.0634
Loa Loa (eye worm) hypothetical protein 0.0059 0.0388 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0051 0.0084
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.0236 0.1444
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0388 0.0634
Schistosoma mansoni neuropeptide receptor 0.0059 0.0388 0.0634

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.2 Inhibitory concentration (experimental) against vascular endothelial growth factor receptor 2 ChEMBL. 16033269
IC50 (functional) = 0.063 uM Concentration of the compound inhibiting VEGF stimulated (2 ng/well) HUVE cell proliferation ChEMBL. 16033269
IC50 (binding) = 0.063 uM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 16033269
IC50 (binding) = 0.063 uM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 16033269
IC50 (functional) = 0.063 uM Concentration of the compound inhibiting VEGF stimulated (2 ng/well) HUVE cell proliferation ChEMBL. 16033269
IC50 (functional) = 1.17 uM Concentration of the compound required to inhibit proliferation of HUVEC ChEMBL. 16033269
IC50 (functional) = 1.17 uM Concentration of the compound required to inhibit proliferation of HUVEC ChEMBL. 16033269
IC50 (binding) = 2.36 uM Inhibitory concentration of the compound against Fibroblast growth factor receptor 2 ChEMBL. 16033269
IC50 (binding) = 2.36 uM Inhibitory concentration of the compound against Fibroblast growth factor receptor 2 ChEMBL. 16033269
IC50 (binding) = 2.8 uM Inhibition of platelet-derived growth factor receptor ChEMBL. 16033269
IC50 (functional) = 3.23 uM Concentration of the compound required to inhibit proliferation of HASMC ChEMBL. 16033269
IC50 (functional) = 3.23 uM Concentration of the compound required to inhibit proliferation of HASMC ChEMBL. 16033269
IC50 (functional) = 3.61 uM Concentration of the compound required to inhibit proliferation of human MRC5 fibroblast cell growth ChEMBL. 16033269
IC50 (functional) = 3.61 uM Concentration of the compound required to inhibit proliferation of human MRC5 fibroblast cell growth ChEMBL. 16033269
IC50 (binding) = 4.02 uM Inhibition of glycogen synthase kinase-3 ChEMBL. 16033269
IC50 (binding) = 4.02 uM Inhibition of glycogen synthase kinase-3 ChEMBL. 16033269
IC50 (functional) = 5.56 uM Concentration of the compound required to inhibit proliferation of HeLa cell growth ChEMBL. 16033269
IC50 (functional) = 5.56 uM Concentration of the compound required to inhibit proliferation of HeLa cell growth ChEMBL. 16033269
IC50 (functional) = 6.08 uM Concentration of the compound required to inhibit proliferation of A375 human amelanotic melanoma cell growth ChEMBL. 16033269
IC50 (functional) = 6.08 uM Concentration of the compound required to inhibit proliferation of A375 human amelanotic melanoma cell growth ChEMBL. 16033269
IC50 (binding) = 7.4 uM Inhibition of epidermal growth factor receptor ChEMBL. 16033269
IC50 (binding) = 7.4 uM Inhibition of epidermal growth factor receptor ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of cyclin-dependent kinase 1 activity ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of insulin Receptor kinase ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibitiion of mitogen-activated protein kinase ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of protein kinase A ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of protein kinase C beta activity ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of protein kinase C gamma ChEMBL. 16033269
IC50 (functional) > 10 uM Concentration of the compound required to inhibit proliferation of human HCT116 colon cancer cell growth ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of calcium/calmodulin-dependent protein kinase type II ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of casein kinase 1 ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of casein kinase 2 ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of cyclin dependent kinase 4-cyclinD1 ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of insulin Receptor kinase ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibitiion of mitogen-activated protein kinase ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of protein kinase C beta activity ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of calcium/calmodulin-dependent protein kinase type II ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of casein kinase 1 ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of casein kinase 2 ChEMBL. 16033269
IC50 (binding) > 10 uM Inhibition of cyclin dependent kinase 4-cyclinD1 ChEMBL. 16033269
IC50 (functional) > 10 uM Concentration of the compound required to inhibit proliferation of human HCT116 colon cancer cell growth ChEMBL. 16033269
Log IC50 (binding) = 6.96 uM Inhibitory concentration (calculated) against vascular endothelial growth factor receptor 2 ChEMBL. 16033269
Log IC50 (binding) = 7.2 uM Inhibitory concentration (experimental) against vascular endothelial growth factor receptor 2 ChEMBL. 16033269
MDS (functional) = 24 The antitumor activity shown by the compound against A375 human melanoma xenografts growing in nude mice (10 mg/kg, i.p.) in terms of mean day of survival ChEMBL. 16033269
MDS (functional) = 29.2 The antitumor activity shown by the compound against A375 human melanoma xenografts growing in nude mice (75 mg/kg, i.p.) in terms of mean day of survival ChEMBL. 16033269

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16033269

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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