Detailed information for compound 33103

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 860.902 | Formula: C44H52N4O14
  • H donors: 8 H acceptors: 9 LogP: 4.04 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(O[C@@H]1C(C)CCC2(C31OC1(C4(C3(O)C([C@]2(C1)C)(O)[C@@H](C4(O)C(C)C)OC(=O)c1[nH]ccc1)C)O)O)CN=C(NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1
  • InChi: 1S/C44H52N4O14/c1-25(2)41(55)33(61-32(50)29-17-12-20-45-29)42(56)37(4)24-40(54)38(41,5)44(42,57)43(62-40)31(26(3)18-19-39(37,43)53)60-30(49)21-46-34(47-35(51)58-22-27-13-8-6-9-14-27)48-36(52)59-23-28-15-10-7-11-16-28/h6-17,20,25-26,31,33,45,53-57H,18-19,21-24H2,1-5H3,(H2,46,47,48,51,52)/t26?,31-,33-,37+,38?,39?,40?,41?,42?,43?,44?/m1/s1
  • InChiKey: NQGUDUOLYOZNBB-UTTPSZOSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Ryanodine receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Brugia malayi Ryanodine Receptor TM 4-6 family protein Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma japonicum ko:K04963 ryanodine receptor 3 (brain), putative Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus granulosus ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) ryanodine receptor Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma japonicum ko:K05327 ryanodine receptor, invertebrate, putative Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus multilocularis ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus multilocularis ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) ryanodine receptor Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma mansoni ryanodine receptor related Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma japonicum Ryanodine receptor 3, putative Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129275 All targets in OG5_129275
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0014 0.0014
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0636 0.2031
Onchocerca volvulus 0.0148 0.1895 1
Onchocerca volvulus 0.0029 0.0124 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0014 0.0014
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0124 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0124 0.0311
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0077 0.0835 0.0835
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0636 0.1598
Schistosoma mansoni hypothetical protein 0.0033 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0124 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Loa Loa (eye worm) proprotein convertase 2 0.0112 0.1362 0.1362
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi Sugar transporter family protein 0.0029 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0066 0.0683 0.2182
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0014 0.0014
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0014 0.0074
Onchocerca volvulus 0.0077 0.0835 0.4407
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0014 0.0014
Schistosoma mansoni inositol transporter 0.0077 0.0835 0.0835
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0014 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0127 0.0406
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi hypothetical protein 0.0029 0.0127 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0423 0.0423
Toxoplasma gondii facilitative glucose transporter GT1 0.0204 0.272 1
Echinococcus multilocularis protein patched 0.0041 0.0313 0.0313
Onchocerca volvulus 0.0029 0.0124 0.0653
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0218 0.0218
Brugia malayi hypothetical protein 0.0035 0.0222 0.0222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0232 0.3131 0.3131
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0127 0.0468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Brugia malayi major facilitator superfamily protein 0.0029 0.0124 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0364 0.0364
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0014 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0636 0.1598
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Schistosoma mansoni ryanodine receptor related 0.0184 0.2429 0.2429
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0014 0.0014
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0014 0.0014
Echinococcus multilocularis solute carrier family 22 0.0029 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0033 0.0194 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.398 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0014 0.0014
Schistosoma mansoni inositol transporter 0.0077 0.0835 0.0835
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0125 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi cation channel family protein 0.0079 0.0866 0.0866
Brugia malayi ecdysteroid receptor 0.0021 0.0014 0.0014
Giardia lamblia High cysteine membrane protein Group 2 0.0177 0.2316 1
Echinococcus multilocularis Furin 1 0.0112 0.1362 0.1362
Loa Loa (eye worm) hypothetical protein 0.0049 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0127
Schistosoma mansoni cpg binding protein 0.0029 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0204 0.272 0.272
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0021 0.0014 0.0014
Echinococcus multilocularis geminin 0.0339 0.4721 0.4721
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0124 0.1812
Schistosoma mansoni hypothetical protein 0.0045 0.0372 0.0372
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0127 0.1862
Echinococcus multilocularis ryanodine receptor 44f 0.0149 0.1909 0.1909
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0124 0.5
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Onchocerca volvulus 0.0029 0.0124 0.0653
Brugia malayi endoprotease bli-4 precursor 0.0476 0.6743 0.6743
Schistosoma mansoni hypothetical protein 0.0339 0.4721 0.4721
Loa Loa (eye worm) sugar transporter 0.0204 0.272 0.272
Echinococcus granulosus cpg binding protein 0.003 0.0149 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0423 0.0423
Echinococcus granulosus dnaJ subfamily B 0.041 0.5769 0.5769
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus granulosus solute carrier family 22 0.0029 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0014 0.0014
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.002 0 0.5
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0636 0.9308
Schistosoma mansoni hypothetical protein 0.0035 0.0222 0.0222
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0124 0.0124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0506 0.1862
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0603 0.0603
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0127 0.0468
Schistosoma mansoni hypothetical protein 0.0092 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0031
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0476 0.6743 0.6743
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0127 0.1862
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Brugia malayi hypothetical protein 0.0029 0.0124 0.0124
Echinococcus multilocularis dnaJ subfamily B 0.041 0.5769 0.5769
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0204 0.272 0.272
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Loa Loa (eye worm) hypothetical protein 0.0116 0.1423 0.1423
Onchocerca volvulus 0.0029 0.0124 0.0653
Onchocerca volvulus 0.0021 0.0014 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.1362 0.3423
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Echinococcus multilocularis General substrate transporter 0.0175 0.2295 0.2295
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0187 0.2462 0.2462
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0112 0.1362 0.1362
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0124 0.0455
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Onchocerca volvulus 0.0029 0.0124 0.0653
Echinococcus multilocularis solute carrier family 5 0.0077 0.0835 0.0835
Giardia lamblia Furin precursor putative serine protease 0.0092 0.1061 0.4277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0014 0.0014
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0124 0.1812
Onchocerca volvulus 0.0029 0.0124 0.0653
Schistosoma mansoni coup transcription factor 0.0021 0.0014 0.0014
Echinococcus granulosus expressed conserved protein 0.0091 0.1043 0.1043
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0066 0.0683 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0124 0.0311
Trichomonas vaginalis hypothetical protein 0.0092 0.1061 0.2667
Onchocerca volvulus 0.0029 0.0124 0.0653
Leishmania major glucose transporter/membrane transporter D2, putative 0.0063 0.0636 1
Echinococcus granulosus geminin 0.0339 0.4721 0.4721
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0014 0.0074
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1152 0.1152
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0211 0.309
Onchocerca volvulus 0.0029 0.0124 0.0653
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0636 0.9308
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Echinococcus granulosus ryanodine receptor 44f 0.0116 0.1423 0.1423
Onchocerca volvulus 0.0029 0.0124 0.0653
Schistosoma mansoni high-affinity choline transporter 0.0696 1 1
Echinococcus granulosus General substrate transporter 0.0175 0.2295 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0014 0.0014
Brugia malayi nuclear hormone receptor 0.0021 0.0014 0.0014
Brugia malayi nuclear receptor NHR-88 0.0021 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.1362 0.3423
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi Sugar transporter family protein 0.0204 0.272 0.272
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0124 0.0455
Brugia malayi hypothetical protein 0.0029 0.0124 0.0124
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0014 0.0014
Echinococcus granulosus sodium:glucose cotransporter 0.0077 0.0835 0.0835
Brugia malayi proprotein convertase 2 0.0299 0.4125 0.4125
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0077 0.0835 0.0835
Brugia malayi hypothetical protein 0.0029 0.0124 0.0124
Echinococcus multilocularis cpg binding protein 0.003 0.0149 0.0149
Echinococcus multilocularis 0.0384 0.538 0.538
Mycobacterium leprae Possible secreted protease 0.002 0 0.5
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0014 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Echinococcus multilocularis solute carrier family 22 0.0029 0.0124 0.0124
Schistosoma mansoni sugar transporter 0.0029 0.0124 0.0124
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0056 0.0534 0.0534
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Onchocerca volvulus 0.0029 0.0124 0.0653
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Onchocerca volvulus 0.0029 0.0124 0.0653
Leishmania major hypothetical protein, conserved 0.0029 0.0124 0.1946
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0014 0.0014
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0289 0.398 0.398
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0014 0.0014
Brugia malayi steroid hormone receptor 0.0021 0.0014 0.0014
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0124 1
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0636 0.1598
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.1362 0.3423
Plasmodium vivax sugar transporter, putative 0.0029 0.0124 0.0455
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1744 0.1744
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0014 0.0014
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0124 0.0124
Echinococcus granulosus sodium:glucose cotransporter 2 0.0077 0.0835 0.0835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0364 0.0364
Schistosoma mansoni sugar transporter 0.0029 0.0124 0.0124
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0077 0.0835 0.0835
Schistosoma mansoni furin-1 (S08 family) 0.0207 0.2763 0.2763
Schistosoma mansoni patched 1 0.0041 0.0313 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus granulosus solute carrier family 22 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Brugia malayi Nuclear hormone receptor-like 1 0.0288 0.3967 0.3967
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0124 0.0124
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0313 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0014 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0124 0.0124
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0077 0.0835 0.307
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0696 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi neuroendocrine convertase 1 precursor 0.0299 0.4125 0.4125
Trypanosoma cruzi hexose transporter 0.0063 0.0636 0.9308
Toxoplasma gondii sugar transporter ST3 0.0029 0.0124 0.0455
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus granulosus solute carrier family 5 0.0077 0.0835 0.0835
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0127 0.0468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Leishmania major glucose transporter, lmgt2 0.0063 0.0636 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Onchocerca volvulus 0.0029 0.0124 0.0653
Schistosoma mansoni sugar transporter 0.0029 0.0124 0.0124
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0124 0.0395
Trypanosoma brucei glucose transporter 2A 0.0063 0.0636 0.2031
Loa Loa (eye worm) hypothetical protein 0.0277 0.38 0.38
Loa Loa (eye worm) hypothetical protein 0.0077 0.0835 0.0835
Schistosoma mansoni sodium/solute symporter 0.0077 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0034 0.0197 0.0197
Echinococcus multilocularis neuroendocrine convertase 2 0.0299 0.4125 0.4125
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0014 0.0014
Brugia malayi Sugar transporter family protein 0.0029 0.0124 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0364 0.0364
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0636 0.1598
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0092 0.1061 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0077 0.0835 0.0835
Toxoplasma gondii sugar transporter ST1 0.0029 0.0124 0.0455
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0222 0.0222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0124 0.0311
Brugia malayi celfurPC protein 0.0384 0.538 0.538
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0124 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.272 0.6835
Schistosoma mansoni cpg binding protein 0.003 0.0149 0.0149
Loa Loa (eye worm) endoprotease bli-4 0.0476 0.6743 0.6743
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0124 0.0311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.1362 0.3423
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0222 0.0222
Leishmania major glucose transporter, lmgt3 0.0063 0.0636 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0423 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.398 1
Brugia malayi Nuclear hormone receptor-like 1 0.0278 0.3818 0.3818
Schistosoma mansoni hypothetical protein 0.041 0.5769 0.5769
Echinococcus multilocularis protein dispatched 1 0.0047 0.04 0.04
Echinococcus granulosus Furin 1 0.0112 0.1362 0.1362
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0194 0.0194
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0092 0.1061 0.2667
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0636 0.2031
Loa Loa (eye worm) ryanodine receptor 0.0043 0.0343 0.0343
Echinococcus granulosus high affinity choline transporter 1 0.0696 1 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0313 0.0313
Echinococcus multilocularis ryanodine receptor 44f 0.0116 0.1423 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0364 0.0364
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0313 0.0786
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0364 0.0364
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0127 0.0468
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0313 0.0313
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0148 0.1895 0.1895
Brugia malayi major facilitator superfamily protein 0.0029 0.0124 0.0124
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.113 0.113
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0124 0.0124
Trypanosoma brucei glucose transporter 1E 0.0063 0.0636 0.2031
Loa Loa (eye worm) ryanodine receptor 0.0069 0.0719 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0124 0.0311
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0278 0.3818 0.3818
Schistosoma mansoni sugar transporter 0.0029 0.0124 0.0124
Onchocerca volvulus 0.0029 0.0124 0.0653
Echinococcus granulosus sodium:myo inositol cotransporter 0.0077 0.0835 0.0835
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Schistosoma mansoni glucose transport protein 0.0204 0.272 0.272
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Trypanosoma brucei RNA helicase, putative 0.0232 0.3131 1
Leishmania major hypothetical protein, conserved 0.0029 0.0127 0.2001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0014 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.113 0.113
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0124 1
Mycobacterium ulcerans sugar transporter 0.0029 0.0124 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0014 0.0014
Trypanosoma brucei glucose transporter, putative 0.0063 0.0636 0.2031
Brugia malayi Nuclear hormone receptor-like 1 0.0278 0.3818 0.3818
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0014 0.0014
Schistosoma mansoni glucose transporter 0.0029 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Onchocerca volvulus 0.0029 0.0125 0.0661
Echinococcus multilocularis high affinity choline transporter 1 0.0696 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.113 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0014 0.0014
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1744 0.1744
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0092 0.1061 0.2667
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0124 0.0124
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0124 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.1043 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0636 0.1598
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0014 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0149 0.0149
Trypanosoma brucei sugar transporter, putative 0.0029 0.0124 0.0395
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0014 0.0014
Echinococcus multilocularis solute carrier family 22 0.0029 0.0124 0.0124
Plasmodium vivax hexose transporter 0.0204 0.272 1
Leishmania major glucose transporter, lmgt1 0.0063 0.0636 1
Schistosoma mansoni glucose transport protein 0.0204 0.272 0.272
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0014 0.0014
Onchocerca volvulus 0.0029 0.0124 0.0653
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Echinococcus multilocularis solute carrier family 22 0.0029 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0045 0.0368 0.5788
Echinococcus granulosus solute carrier family 22 0.0029 0.0124 0.0124
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0364 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0124 0.0311
Brugia malayi hypothetical protein 0.0148 0.1895 0.1895
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0313 0.0313
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.1362 0.3423
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0636 0.9308
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0014 0.0014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0364 0.0364
Onchocerca volvulus 0.0029 0.0124 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0014 0.0014
Echinococcus granulosus solute carrier family 22 0.0029 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0014 0.0014
Loa Loa (eye worm) sugar transporter 0.0029 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0636 0.1598
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0636 0.1598
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1061 0.2667
Schistosoma mansoni hypothetical protein 0.0339 0.4721 0.4721
Brugia malayi CHE-14 protein 0.0041 0.0313 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0364 0.0364
Toxoplasma gondii sugar transporter ST2 0.0029 0.0124 0.0455
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.272 0.272
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0636 0.2031
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0184 0.2429 0.2429
Brugia malayi CXXC zinc finger family protein 0.0029 0.0125 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Echinococcus granulosus neuroendocrine convertase 2 0.0299 0.4125 0.4125
Loa Loa (eye worm) hypothetical protein 0.0476 0.6743 0.6743
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0014 0.0014
Onchocerca volvulus 0.0029 0.0124 0.0653
Echinococcus granulosus ryanodine receptor 44f 0.0149 0.1909 0.1909
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.1362 0.3423
Echinococcus granulosus furin 0.0476 0.6743 0.6743
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0097 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0051 0.0451 0.0451
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0014 0.0014
Plasmodium falciparum hexose transporter 0.0204 0.272 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0124 0.0311
Onchocerca volvulus Putative transporter 0.0029 0.0124 0.0653
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0124 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0022 0.0031 0.0031
Brugia malayi Sodium:solute symporter family protein 0.0077 0.0835 0.0835
Schistosoma mansoni glucose transport protein 0.0204 0.272 0.272
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0364 0.0364
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0124 0.1946
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0289 0.398 0.398
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0124 0.1812
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0014 0.0014

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 135.6 nM Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles ChEMBL. 8388466
IC50 (binding) = 135.6 nM Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles ChEMBL. 8388466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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