Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3273 | 0.9321 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1557 | 0.432 | 0.432 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0075 | 0 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0439 | 0.1061 | 0.1138 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3273 | 0.9321 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3506 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3273 | 0.9321 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0439 | 0.1061 | 0.1138 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3506 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0439 | 0.1061 | 0.1138 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0439 | 0.1061 | 0.1138 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0346 | 0.079 | 0.079 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3506 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.3273 | 0.9321 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0439 | 0.1061 | 0.1138 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3506 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1557 | 0.432 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0439 | 0.1061 | 0.1138 |
Brugia malayi | hypothetical protein | 0.1557 | 0.432 | 0.4635 |
Brugia malayi | Dihydrofolate reductase | 0.0439 | 0.1061 | 0.1138 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0075 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0439 | 0.1061 | 0.1138 |
Onchocerca volvulus | 0.3273 | 0.9321 | 1 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.1557 | 0.432 | 0.4635 |
Echinococcus multilocularis | thymidylate synthase | 0.3273 | 0.9321 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0346 | 0.079 | 0.079 |
Mycobacterium ulcerans | thymidylate synthase | 0.3273 | 0.9321 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3506 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0439 | 0.1061 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0346 | 0.079 | 0.079 |
Giardia lamblia | CDC8 | 0.0075 | 0 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0075 | 0 | 0.5 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0346 | 0.079 | 0.079 |
Brugia malayi | thymidylate synthase | 0.3273 | 0.9321 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0439 | 0.1061 | 0.1138 |
Loa Loa (eye worm) | thymidylate synthase | 0.3273 | 0.9321 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.5 nM | Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells | ChEMBL. | 12657272 |
EC50 (functional) | = 2.5 nM | Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells | ChEMBL. | 12657272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.