Detailed information for compound 331112

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.392 | Formula: C18H21N5O
  • H donors: 3 H acceptors: 1 LogP: 2.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)OC1=NC(NC2CC3CC2CC3)c2c(N1)[nH]cn2
  • InChi: 1S/C18H21N5O/c1-2-4-13(5-3-1)24-18-22-16-15(19-10-20-16)17(23-18)21-14-9-11-6-7-12(14)8-11/h1-5,10-12,14,17,21H,6-9H2,(H,19,20)(H,22,23)
  • InChiKey: UNSNNPGKSUGRSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0076 0.0185
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.0065 0.0898
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0026
Brugia malayi Latrophilin receptor protein 2 0.0012 0.002 0.0065
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.001 0.0003 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0076 0.0076
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.006 0.0193
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0029 0.0147 0.1142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.002 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0065 0.1546
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0031 0.016 0.3926
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0174 0.1224 1
Schistosoma mansoni hypothetical protein 0.0047 0.0277 0.0969
Echinococcus granulosus GPCR family 2 0.0012 0.002 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0104 0.0363
Onchocerca volvulus 0.0016 0.0052 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Brugia malayi Cathepsin L-like precursor 0.0016 0.0052 0.0166
Onchocerca volvulus 0.0016 0.0052 0.0166
Schistosoma mansoni zinc finger protein 0.002 0.0077 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Echinococcus multilocularis GPCR, family 2 0.0012 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.0071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0065 0.1575
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0058 0.0362 0.0362
Schistosoma mansoni aldehyde dehydrogenase 0.0031 0.016 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0052 0.0386
Echinococcus multilocularis tumor protein p63 0.0566 0.4127 0.4127
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0026
Loa Loa (eye worm) matrixin family protein 0.0077 0.0502 0.1618
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0404 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0076 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0076 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.1625 0.3938
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0076 0.0185
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0029 0.0147 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0277 0.0969
Echinococcus granulosus TRP transient receptor potential channel 0.003 0.0157 0.0379
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0008 0.0026
Schistosoma mansoni lozenge 0.0054 0.033 0.1152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0431
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0052 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0374 0.1308
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0048 0.029 0.0704
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0101
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0046 0.0275 0.0962
Schistosoma mansoni hypothetical protein 0.0014 0.0036 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0123 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Brugia malayi Cathepsin L-like precursor 0.0016 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0077 0.0499 0.1607
Brugia malayi ADAMTS-like protease 0.0034 0.0184 0.0592
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0065 0.1575
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.001 0.0003 0.0009
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0404 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0076 0.0185
Brugia malayi cathepsin L-like precursor 0.0011 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.041 0.2973 0.9579
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0052 0.0166
Toxoplasma gondii aldehyde dehydrogenase 0.0031 0.016 0.4626
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0048 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0537
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0027 0.0134 0.0903
Plasmodium vivax vivapain-2 0.0016 0.0052 0.3383
Brugia malayi PHD-finger family protein 0.0024 0.0113 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0076 0.0185
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0052 0.1216
Brugia malayi follicle stimulating hormone receptor 0.0224 0.159 0.5124
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0395 0.2861 1
Echinococcus granulosus cpg binding protein 0.0031 0.0162 0.0393
Leishmania major cathepsin L-like protease 0.0016 0.0052 0.1216
Echinococcus multilocularis protein patched 0.0039 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0228 0.1625 0.5236
Onchocerca volvulus Matrilysin homolog 0.0035 0.0189 0.0606
Brugia malayi DNA polymerase family B containing protein 0.001 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0209
Echinococcus granulosus expressed conserved protein 0.0085 0.0561 0.1358
Schistosoma mansoni hypothetical protein 0.0037 0.0209 0.0729
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0134 0.3264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Loa Loa (eye worm) metalloprotease 0.0015 0.0043 0.0139
Schistosoma mansoni transient receptor potential channel 0.0052 0.0314 0.1099
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0052 0.1216
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0134 0.1037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0076 0.0076
Mycobacterium ulcerans hypothetical protein 0.0027 0.0134 0.4803
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.006 0.0193
Schistosoma mansoni bromodomain containing protein 0.006 0.0374 0.1306
Brugia malayi nuclear receptor NHR-88 0.002 0.0076 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0076 0.0246
Onchocerca volvulus 0.0027 0.0134 0.043
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.001 0.0003 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0134 0.9084
Brugia malayi nuclear receptor RXR 0.001 0.0008 0.0026
Schistosoma mansoni thyroid hormone receptor 0.002 0.0076 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.002 0.002
Brugia malayi DNA polymerase delta catalytic subunit 0.0029 0.0147 0.0474
Loa Loa (eye worm) hypothetical protein 0.009 0.0601 0.1937
Echinococcus multilocularis lamin 0.0032 0.0171 0.0171
Loa Loa (eye worm) fibroinase 0.0016 0.0052 0.0166
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0015 0.0043 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0076 0.0267
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0209
Brugia malayi DNA polymerase alpha catalytic subunit 0.001 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0284 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0076 0.0246
Schistosoma mansoni thyroid hormone receptor 0.002 0.0076 0.0267
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0139
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.009 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Leishmania major hypothetical protein, conserved 0.0014 0.0036 0.082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0076 0.0185
Plasmodium vivax acyl-CoA synthetase, putative 0.0013 0.0031 0.1969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0058 0.0362 0.1165
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0097 0.0234
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0076 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0052 0.0673
Echinococcus granulosus adam 0.0032 0.0167 0.0406
Echinococcus granulosus sodium channel protein 0.0048 0.029 0.0704
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.022 0.0533
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0013 0.0031 0.5
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.001 0.0003 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0031 0.016 0.6047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0404 0.6662
Onchocerca volvulus 0.0011 0.0012 0.0038
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0072 0.0232
Trichomonas vaginalis esterase, putative 0.0027 0.0134 0.1037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0166
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0158 0.1105 0.3561
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0076 0.0246
Mycobacterium tuberculosis Conserved protein 0.0027 0.0134 0.0903
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0291 0.717
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0079 0.0516 0.1803
Schistosoma mansoni cpg binding protein 0.0031 0.0162 0.0567
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0047 0.0114
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0029 0.0147 0.0474
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0026
Brugia malayi hypothetical protein 0.001 0.0008 0.0026
Schistosoma mansoni hypothetical protein 0.0037 0.0209 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0076 0.0185
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0171 0.0551
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0065
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.0065 0.1575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0031 0.016 0.6047
Loa Loa (eye worm) hypothetical protein 0.0428 0.3104 1
Leishmania major cathepsin L-like protease 0.0016 0.0052 0.1216
Brugia malayi beta-lactamase 0.0027 0.0134 0.0431
Echinococcus multilocularis transient receptor potential gamma protein 0.0077 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0038 0.0212 0.0682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0609
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0397
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0031 0.016 0.016
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0349 0.8618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Brugia malayi hypothetical protein 0.0228 0.1625 0.5236
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0219 0.171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0076 0.0246
Loa Loa (eye worm) ctsf protein 0.0016 0.0052 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0058 0.0362 0.1264
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0431
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0052 0.0052
Schistosoma mansoni aldehyde dehydrogenase 0.0031 0.016 0.0561
Mycobacterium ulcerans hypothetical protein 0.0018 0.0065 0.1575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0012 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0076 0.0246
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0404 1
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0015 0.0043 0.0151
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0027 0.0134 0.0903
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0104 0.0104
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0015 0.0043 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0058 0.0362 0.0877
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0015 0.0043 0.0043
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0052 0.0166
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0029 0.0147 0.3593
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0031 0.016 0.1125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0212 0.0682
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0389 0.9605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0058 0.0362 0.1264
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0134 0.1037
Schistosoma mansoni cellular tumor antigen P53 0.0083 0.0546 0.1908
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0076 0.0246
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0404 0.0404
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0134 0.3264
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0389 0.9605
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0504
Onchocerca volvulus 0.0028 0.0137 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0076 0.0246
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0058 0.0362 0.0362
Leishmania major cathepsin L-like protease 0.0016 0.0052 0.1216
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0052 0.1761
Loa Loa (eye worm) angiogenesis inhibito 0.0017 0.006 0.0192
Onchocerca volvulus 0.002 0.0076 0.0245
Schistosoma mansoni coup transcription factor 0.002 0.0076 0.0267
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0046 0.0275 0.0667
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0101
Toxoplasma gondii cathepsin CPL 0.0016 0.0052 0.1433
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0134 0.0431
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0008 0.0029
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0029 0.0147 0.0356
Onchocerca volvulus 0.0016 0.0052 0.0166
Echinococcus multilocularis protein dispatched 1 0.0044 0.026 0.026
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0389 0.9605
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0404 1
Mycobacterium leprae Probable lipase LipE 0.0027 0.0134 0.3832
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0389 0.9605
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0032 0.0167 0.0585
Loa Loa (eye worm) hypothetical protein 0.0025 0.0116 0.0375
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.002 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0065 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Brugia malayi Matrixin family protein 0.0035 0.0189 0.0609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0076 0.0076
Brugia malayi angiogenesis inhibito 0.0034 0.0184 0.0592
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.043 0.3118 1
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0065 0.0209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0058 0.0362 0.0877
Onchocerca volvulus Papilin homolog 0.0035 0.0191 0.0613
Leishmania major cathepsin L-like protease 0.0062 0.0389 0.9605
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0052 0.0125
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2861 0.2861
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.017 0.1194 0.2893
Loa Loa (eye worm) hypothetical protein 0.0037 0.0209 0.0672
Loa Loa (eye worm) reprolysin 0.0015 0.0043 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Leishmania major cathepsin L-like protease 0.0062 0.0389 0.9605
Brugia malayi hypothetical protein 0.0428 0.3104 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0171 0.0551
Schistosoma mansoni transient receptor potential channel 0.0077 0.0499 0.1744
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.1625 0.1625
Echinococcus granulosus intermediate filament protein 0.0032 0.0171 0.0415
Brugia malayi Cathepsin L-like precursor 0.0016 0.0052 0.0166
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0344 1
Onchocerca volvulus 0.0016 0.0052 0.0166
Onchocerca volvulus 0.0035 0.0189 0.0606
Brugia malayi Pre-SET motif family protein 0.0023 0.0104 0.0335
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0277 0.0893
Schistosoma mansoni transient receptor potential channel 0.0052 0.0314 0.1099
Onchocerca volvulus Matrilysin homolog 0.0121 0.0829 0.266
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0052 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Brugia malayi steroid hormone receptor 0.002 0.0076 0.0246
Mycobacterium ulcerans beta-lactamase 0.0027 0.0134 0.4803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.022 0.0768
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0104 0.0363
Mycobacterium ulcerans esterase/lipase LipP 0.0027 0.0134 0.4803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0076 0.0246
Echinococcus multilocularis lamin dm0 0.0032 0.0171 0.0171
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0025 0.012 0.0418
Brugia malayi hypothetical protein 0.001 0.0008 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0076 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0134 0.3264
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Mycobacterium ulcerans lipase LipD 0.0027 0.0134 0.4803
Echinococcus granulosus tumor protein p63 0.0566 0.4127 1
Schistosoma mansoni cpg binding protein 0.0031 0.0162 0.0567
Echinococcus multilocularis sodium channel protein 0.0048 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.018
Brugia malayi intermediate filament protein 0.0032 0.0171 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0052 0.018
Mycobacterium tuberculosis Probable lipase LipE 0.0027 0.0134 0.0903
Echinococcus granulosus Niemann Pick C1 protein 0.0129 0.0888 0.2153
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0065 0.0209
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0029 0.0147 0.2294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0134 0.0468
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0052 0.0166
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0092 0.0611 0.2137
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0176 0.0427
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0048 0.029 0.7162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0039
Leishmania major cathepsin L-like protease 0.0016 0.0052 0.1216
Schistosoma mansoni hypothetical protein 0.0049 0.0296 0.1036
Brugia malayi nuclear hormone receptor 0.002 0.0076 0.0246
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Brugia malayi CHE-14 protein 0.0039 0.0219 0.0706
Brugia malayi CXXC zinc finger family protein 0.0028 0.0137 0.0443
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.017 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0076 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0065 0.1575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0031 0.016 0.6047
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0134 0.0134
Brugia malayi beta-lactamase family protein 0.0027 0.0134 0.0431
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0205 0.0498
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0076 0.0245
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2861 0.6933
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.022 0.022
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0052 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.001 0.0003 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0104 0.2965
Echinococcus multilocularis short transient receptor potential channel 6 0.0052 0.0314 0.0314
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0097 0.0097
Echinococcus granulosus Niemann Pick C1 protein 0.009 0.0601 0.1457
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0076 0.0246
Entamoeba histolytica cysteine protease, putative 0.0016 0.0052 0.0673
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0076 0.0185
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.001 0.0003 0.0003
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0029 0.0147 0.3593
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0404 0.1414
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0052 0.1761
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.001 0.0003 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0171 0.0551
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.022 0.0768
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0052 0.018
Echinococcus multilocularis cpg binding protein 0.0031 0.0162 0.0162
Echinococcus multilocularis zinc finger protein 0.002 0.0077 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0134 0.0468
Echinococcus multilocularis sterol regulatory element binding protein 0.0039 0.0219 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0076 0.0246
Echinococcus multilocularis Protein lozenge 0.0054 0.033 0.033
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0019 0.0072 0.0252
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0076 0.0267
Onchocerca volvulus 0.0027 0.0134 0.043
Onchocerca volvulus 0.0016 0.0052 0.0166
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0065 0.0413 0.1329
Echinococcus multilocularis cysteine protease 0.0016 0.0052 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.002 0.0065
Loa Loa (eye worm) bromodomain containing protein 0.0016 0.0052 0.0167
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0031 0.0045
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0134 0.3832
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0029 0.0147 0.0472
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0056 0.0349 0.0847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Onchocerca volvulus 0.0083 0.0546 0.175
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0029 0.0147 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0076 0.0267
Loa Loa (eye worm) hypothetical protein 0.0079 0.0516 0.1662
Loa Loa (eye worm) beta-lactamase 0.0027 0.0134 0.0431
Brugia malayi beta-lactamase family protein 0.0027 0.0134 0.0431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0101
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0076 0.0076
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0052 0.0673
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0058 0.0362 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0012 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0076 0.0246
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0419 0.3041 0.9799
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0037 0.0209 0.0729
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0706
Brugia malayi hypothetical protein 0.0032 0.0167 0.0539
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0076 0.0246
Leishmania major cathepsin L-like protease 0.0016 0.0052 0.1216
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0065 0.0326
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0029 0.0147 0.0514
Onchocerca volvulus 0.0428 0.3104 0.9955
Onchocerca volvulus 0.0032 0.0171 0.0549
Loa Loa (eye worm) hypothetical protein 0.0083 0.0546 0.1758
Brugia malayi Matrixin family protein 0.0035 0.0189 0.0609
Trypanosoma brucei ISWI complex protein 0.0014 0.0036 0.082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0042 0.0245 0.183
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0134 0.0324
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0404 0.1303
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.0027 0.0134 0.0903
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0012 0.0039
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.001 0.0003 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0027 0.0134 0.4803
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.001 0.0003 0.0007
Plasmodium vivax SET domain protein, putative 0.0023 0.0104 0.7003
Brugia malayi Bromodomain containing protein 0.007 0.0453 0.1461
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0076 0.0267
Echinococcus multilocularis short transient receptor potential channel 6 0.0052 0.0314 0.0314
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0076 0.0267
Onchocerca volvulus DNA polymerase homolog 0.001 0.0003 0.0009
Schistosoma mansoni lamin 0.0032 0.0171 0.0598
Brugia malayi Pre-SET motif family protein 0.0158 0.1105 0.3561
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0052 0.0052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0076 0.0267
Brugia malayi Cathepsin L-like precursor 0.0011 0.0012 0.0039
Brugia malayi Transient-receptor-potential like protein 0.003 0.0157 0.0504
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0026
Echinococcus multilocularis transient receptor potential ion channel A 0.0071 0.0459 0.0459
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0212 0.0682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.0621
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0052 0.0125
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0134 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0076 0.0246
Brugia malayi ADAM-TS Spacer 1 family protein 0.0111 0.0754 0.2429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0539
Onchocerca volvulus 0.0032 0.0171 0.0549
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0037 0.0209 0.0729
Mycobacterium tuberculosis Probable hydrolase 0.0027 0.0134 0.0903
Brugia malayi Cathepsin L-like precursor 0.0011 0.0012 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Onchocerca volvulus 0.0049 0.0296 0.0951
Echinococcus granulosus transient receptor potential gamma protein 0.0077 0.0499 0.1209
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0029 0.0147 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0029 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0046 0.0274 0.0883
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0056 0.0349 0.0349
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0137 0.0443
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0024 0.0108 0.2611
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0076 0.0246
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Schistosoma mansoni nuclear hormone receptor 0.002 0.0076 0.0267
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.0065 0.0326
Schistosoma mansoni cpg binding protein 0.0028 0.0137 0.048
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0039 0.0219 0.0706
Plasmodium vivax vivapain-2 0.0016 0.0052 0.3383
Loa Loa (eye worm) hypothetical protein 0.0041 0.0233 0.0752
Onchocerca volvulus 0.0027 0.0134 0.043
Echinococcus granulosus FTZ F1 alpha 0.002 0.0076 0.0185
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.0071
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.0071
Loa Loa (eye worm) matrix metalloproteinase 0.0035 0.0189 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0076 0.0246
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0026
Schistosoma mansoni transient receptor potential channel 4 0.0077 0.0499 0.1744
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0076 0.0267
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.0065 0.1575
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0138
Mycobacterium tuberculosis Conserved protein 0.0027 0.0134 0.0903
Brugia malayi nuclear hormone receptor 0.0419 0.3041 0.9799
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0404 0.1303
Onchocerca volvulus 0.0016 0.0052 0.0166
Onchocerca volvulus 0.018 0.1267 0.4063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0065 0.1546
Echinococcus granulosus cathepsin l1 0.0011 0.0012 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Echinococcus granulosus transient receptor potential ion channel A 0.0071 0.0459 0.1111
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0008 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Trypanosoma cruzi ISWI complex protein 0.0014 0.0036 0.082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0076 0.0246
Echinococcus multilocularis adam 0.0032 0.0167 0.0167
Schistosoma mansoni patched 1 0.0039 0.0219 0.0765
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0431
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0076 0.0246
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0101
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.001 0.0003 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0065 0.1546
Brugia malayi Matrixin family protein 0.0035 0.0189 0.0609
Loa Loa (eye worm) hypothetical protein 0.0039 0.022 0.0708
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0015 0.0043 0.0151
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0176 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0609
Brugia malayi Matrixin family protein 0.0035 0.0189 0.0609
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0065 0.0209
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0048 0.0167
Leishmania major hypothetical protein, conserved 0.0027 0.0134 0.3264
Echinococcus multilocularis Niemann Pick C1 protein 0.009 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0431
Echinococcus multilocularis expressed conserved protein 0.0085 0.0561 0.0561
Echinococcus granulosus sterol regulatory element binding protein 0.0039 0.0219 0.0531
Brugia malayi ecdysteroid receptor 0.002 0.0076 0.0246
Brugia malayi Cathepsin L-like precursor 0.0016 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0052 0.1761
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0246
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0138
Loa Loa (eye worm) runx1 0.0054 0.033 0.1062
Schistosoma mansoni zinc finger protein 0.0014 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.0428 0.3104 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.002 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0076 0.0267
Mycobacterium tuberculosis Conserved protein 0.0027 0.0134 0.0903
Echinococcus granulosus cathepsin l1 0.0016 0.0052 0.0125
Onchocerca volvulus Matrix metalloproteinase homolog 0.0077 0.0502 0.1611
Onchocerca volvulus 0.0018 0.0065 0.0208
Loa Loa (eye worm) matrixin family protein 0.0128 0.0881 0.2837
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.0071
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0076 0.0185
Leishmania major cathepsin L-like protease 0.0062 0.0389 0.9605
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0134 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0076 0.0246
Brugia malayi Niemann-Pick C1 protein precursor 0.009 0.0601 0.1937
Loa Loa (eye worm) hypothetical protein 0.0111 0.0754 0.2429
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0046 0.0275 0.0275
Echinococcus granulosus short transient receptor potential channel 6 0.0052 0.0314 0.0762
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0027 0.0134 0.0903
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0076 0.0246
Brugia malayi Matrixin family protein 0.0128 0.0881 0.2837
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0097 0.0338
Loa Loa (eye worm) hypothetical protein 0.0042 0.0245 0.0789
Onchocerca volvulus 0.0047 0.0277 0.0889
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.001 0.0003 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0134 0.0431
Brugia malayi Bromodomain containing protein 0.0035 0.0192 0.0619
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0551
Echinococcus granulosus lamin dm0 0.0032 0.0171 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.9605
Schistosoma mansoni lamin 0.0032 0.0171 0.0598
Echinococcus granulosus zinc finger protein 0.002 0.0077 0.0185
Mycobacterium leprae PROBABLE HYDROLASE 0.0042 0.0245 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0052 0.0052
Schistosoma mansoni intermediate filament proteins 0.0032 0.0171 0.0598
Echinococcus multilocularis Niemann Pick C1 protein 0.0129 0.0888 0.0888
Toxoplasma gondii DNA polymerase 0.0029 0.0147 0.4234
Brugia malayi Cathepsin L-like precursor 0.0016 0.0052 0.0166
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0065 0.0898
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0029 0.0147 0.3593
Echinococcus granulosus Protein patched homolog 1 0.0039 0.0219 0.0531
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0031 0.016 0.0389
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0076 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0065 0.1575
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0052 0.0386
Schistosoma mansoni hypothetical protein 0.0026 0.0123 0.043
Brugia malayi Cathepsin L-like precursor 0.0016 0.0052 0.0166
Brugia malayi Hemopexin family protein 0.0049 0.0296 0.0955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0058 0.0362 0.1264
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0076 0.0076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0212 0.0682
Mycobacterium tuberculosis Probable lipase LipD 0.0027 0.0134 0.0903
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0048 0.0167
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0065 0.1575
Trichomonas vaginalis set domain proteins, putative 0.018 0.1267 1
Echinococcus granulosus lamin 0.0032 0.0171 0.0415
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0014 0.0044
Brugia malayi metalloprotease 0.0015 0.0043 0.0139
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0042 0.0245 0.0789
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0431
Echinococcus multilocularis TRP (transient receptor potential) channel 0.003 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0052 0.0386
Loa Loa (eye worm) cysteine protease 0.0016 0.0052 0.0166
Echinococcus granulosus short transient receptor potential channel 6 0.0052 0.0314 0.0762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0052 0.0386
Mycobacterium ulcerans hydrolase 0.0042 0.0245 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.159 0.5124
Toxoplasma gondii ABC1 family protein 0.0027 0.0134 0.3847
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0076 0.0246
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0052 0.0166
Echinococcus multilocularis musashi 0.0032 0.0171 0.0171
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0076 0.0076
Brugia malayi Reprolysin 0.0015 0.0043 0.0139
Onchocerca volvulus 0.0016 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0101
Loa Loa (eye worm) hypothetical protein 0.0035 0.0191 0.0616
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0093 0.0226
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0134 0.1037
Echinococcus multilocularis cysteine protease 0.0016 0.0052 0.0052
Onchocerca volvulus 0.0023 0.0104 0.0333
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0404 0.098
Trypanosoma cruzi ISWI complex protein 0.0014 0.0036 0.082
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.002 0.0065

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 25 % Percent inhibition of [3H]-DPCPX binding to human adenosine A2A receptor expressed in CHO cells at 10 uM ChEMBL. 16033270
Ki (binding) = 0.074 uM Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells ChEMBL. 16033270
Ki (binding) = 1.47 uM Percent inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM ChEMBL. 16033270

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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