Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, beta 2 (neuronal) | References | |
Homo sapiens | cholinergic receptor, nicotinic, alpha 3 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, beta 4 (neuronal) | References | |
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 4 (neuronal) | 498 aa | 508 aa | 31.1 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 2 (neuronal) | 502 aa | 482 aa | 32.4 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 505 aa | 486 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0195 | 0.0396 | 0.5 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.032 | 0.0775 | 0.0606 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0124 | 0.018 | 0.1726 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.036 | 0.5799 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0269 | 0.062 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Toxoplasma gondii | chorismate synthase, putative | 0.3347 | 1 | 1 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.165 | 0.483 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0881 | 0.2487 | 0.2349 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0881 | 0.2487 | 0.2349 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0819 | 0.2298 | 0.4554 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0195 | 0.0396 | 0.022 |
Schistosoma mansoni | CDGSH-type Zn finger-containing protein-like protein | 0.0251 | 0.0567 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0098 | 0.0099 | 0.1597 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0269 | 0.062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0269 | 0.062 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0269 | 0.062 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0269 | 0.062 | 0.8087 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.02 | 0.3222 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0183 | 0.036 | 0.5563 |
Onchocerca volvulus | 0.0183 | 0.036 | 0.5 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0098 | 0.0099 | 0.1597 |
Plasmodium falciparum | chorismate synthase | 0.3347 | 1 | 0.5 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.032 | 0.0775 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0543 | 0.8765 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0269 | 0.062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0269 | 0.062 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0307 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.036 | 0.5799 |
Loa Loa (eye worm) | LGC-31 protein | 0.0098 | 0.0099 | 0.1597 |
Echinococcus granulosus | geminin | 0.0166 | 0.0307 | 0.3996 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.032 | 0.0775 | 0.1279 |
Plasmodium vivax | chorismate synthase | 0.3347 | 1 | 0.5 |
Echinococcus granulosus | cdgsh iron sulfur domain containing protein | 0.0237 | 0.0524 | 0.8152 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0307 | 0.4446 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.165 | 0.483 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0098 | 0.0099 | 0.1597 |
Mycobacterium ulcerans | chorismate synthase | 0.3347 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0222 | 0.358 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Brugia malayi | Cation transporter family protein | 0.0183 | 0.036 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0195 | 0.0396 | 0.022 |
Onchocerca volvulus | 0.0183 | 0.036 | 0.5 | |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0309 | 0.0743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0307 | 0.4446 |
Onchocerca volvulus | 0.0101 | 0.0108 | 0.0175 | |
Onchocerca volvulus | Putative nachr subunit | 0.0269 | 0.062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0108 | 0.1744 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0113 | 0.0144 | 0.097 |
Schistosoma mansoni | hypothetical protein | 0.0251 | 0.0567 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0195 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Brugia malayi | Uncharacterized hematopoietic stem/progenitor cells protein MDS029 | 0.0101 | 0.0108 | 0.0142 |
Onchocerca volvulus | 0.0183 | 0.036 | 0.5 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0269 | 0.062 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0183 | 0.036 | 0.5563 |
Echinococcus multilocularis | cdgsh iron sulfur domain containing protein | 0.0237 | 0.0524 | 0.8152 |
Loa Loa (eye worm) | ACC-1 protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0099 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.062 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 51 % | Percent inhibition of 10 uM nicotine response in human Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 15908213 |
Inhibition (functional) | = 51 % | Percent inhibition of 10 uM nicotine response in human Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 15908213 |
Ki (binding) | 0 nM | Inhibition of [3H]-alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1-beta1-delta-gamma of electroplax; (-)= Not determined | ChEMBL. | 15908213 |
Ki (binding) | = 1.4 nM | Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 in human HEK293 cells using [3H]- nicotine as radioligand | ChEMBL. | 15908213 |
Ki (binding) | = 1.4 nM | Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 in human HEK293 cells using [3H]- nicotine as radioligand | ChEMBL. | 15908213 |
Ki (binding) | = 3.2 nM | Inhibition of [3H]-nicotine binding to nicotinic acetylcholine receptor alpha4-beta2 in rat cortex | ChEMBL. | 15908213 |
Ki (binding) | = 3.2 nM | Inhibition of [3H]-nicotine binding to nicotinic acetylcholine receptor alpha4-beta2 in rat cortex | ChEMBL. | 15908213 |
Ki (binding) | = 810 nM | Inhibition of [3H]-epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells | ChEMBL. | 15908213 |
Ki (binding) | = 810 nM | Inhibition of [3H]-epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells | ChEMBL. | 15908213 |
Ki (binding) | = 2400 nM | Inhibition of [3H]-alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha7 of IMR32 cells | ChEMBL. | 15908213 |
Ki (binding) | = 2400 nM | Inhibition of [3H]-alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha7 of IMR32 cells | ChEMBL. | 15908213 |
Response (functional) | = 30 % | Percent response relative to 10 uM nicotine in human Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 15908213 |
Response (functional) | = 30 % | Percent response relative to 10 uM nicotine in human Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 15908213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.