Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0187 | 0.117 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0708 | 0.4891 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0249 | 0.1218 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.011 | 0.0696 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0284 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0022 | 0.0136 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0298 | 0.2011 | 0.1994 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0028 | 0.0046 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0106 | 0.0047 |
Onchocerca volvulus | 0.0167 | 0.1097 | 1 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0179 | 0.0297 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0044 | 0.0073 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0054 | 0.009 |
Onchocerca volvulus | 0.0061 | 0.0351 | 0.3195 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0022 | 0.0118 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0052 | 0.0284 | 0.047 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0166 | 0.1084 | 0.1796 |
Brugia malayi | Muscleblind-like protein | 0.0166 | 0.1084 | 0.53 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0179 | 0.6003 |
Onchocerca volvulus | 0.0026 | 0.0106 | 0.0965 | |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0182 | 0.1198 | 0.1178 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0015 | 0.0028 | 0.0046 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0106 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1595 | 1 |
Echinococcus multilocularis | sentrin specific protease 7 | 0.0014 | 0.0022 | 0.0036 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.0351 | 0.0581 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0249 | 0.0413 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C48, putative | 0.0014 | 0.0022 | 0.5 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0014 | 0.0022 | 0.0036 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0309 | 0.1939 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0106 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0014 | 0.0022 | 0.0036 |
Toxoplasma gondii | chorismate synthase, putative | 0.1435 | 1 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0052 | 0.0284 | 1 |
Brugia malayi | hypothetical protein | 0.0167 | 0.1097 | 0.5365 |
Schistosoma mansoni | hypothetical protein | 0.0871 | 0.6036 | 1 |
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0052 | 0.0284 | 0.0263 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0052 | 0.0284 | 0.0263 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0052 | 0.0284 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0106 | 0.0664 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0106 | 0.0518 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0116 | 0.0735 | 0.0715 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0106 | 0.0047 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0179 | 0.6003 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0044 | 0.0073 |
Trypanosoma cruzi | hypothetical protein | 0.0014 | 0.0022 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0375 | 0.0622 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0106 | 0.0112 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0249 | 0.0413 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0059 | 0.0016 |
Giardia lamblia | Sentrin specific protease, putative | 0.0014 | 0.0022 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0179 | 0.0297 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0106 | 0.3208 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0014 | 0.0022 | 0.0106 |
Trypanosoma cruzi | SUMO1/Ulp2, putative | 0.0014 | 0.0022 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0106 | 0.3208 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0044 | 0.0277 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0014 | 0.0022 | 0.0036 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0309 | 0.1512 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0014 | 0.0022 | 0.0118 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0044 | 0.0073 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0821 | 0.5144 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0106 | 0.0518 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.0708 | 0.4891 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0106 | 1 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0302 | 0.2045 | 1 |
Plasmodium vivax | chorismate synthase | 0.1435 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0061 | 0.0351 | 0.2198 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.037 | 0.2322 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0249 | 0.0413 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0106 | 0.0047 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0249 | 0.0413 |
Brugia malayi | CXXC zinc finger family protein | 0.0061 | 0.0351 | 0.1714 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0106 | 0.0047 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0106 | 0.0112 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0179 | 0.6003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0249 | 0.0413 |
Mycobacterium ulcerans | chorismate synthase | 0.1435 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0044 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0022 | 0.0136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0249 | 0.0413 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0106 | 0.0518 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0106 | 0.0047 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0052 | 0.0284 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0182 | 0.1198 | 0.5 |
Trichomonas vaginalis | sentrin/sumo-specific protease, senp8, putative | 0.0014 | 0.0022 | 0.0118 |
Echinococcus multilocularis | cpg binding protein | 0.0065 | 0.0375 | 0.0622 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0044 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0044 | 0.0277 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0044 | 0.0073 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0014 | 0.0022 | 0.0106 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.013 | 0.0832 | 0.1378 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0052 | 0.0284 | 0.047 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0179 | 0.0297 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0179 | 0.0297 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0052 | 0.0284 | 0.1388 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0044 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0179 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0059 | 0.0371 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0871 | 0.6036 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0182 | 0.1198 | 0.1145 |
Chlamydia trachomatis | dehyroquinate synthase | 0.0116 | 0.0735 | 0.0715 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0116 | 0.0735 | 0.1411 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0375 | 0.0622 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0014 | 0.0022 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0044 | 0.0073 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0298 | 0.2011 | 0.3981 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0116 | 0.0735 | 0.1217 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Echinococcus granulosus | sentrin specific protease 7 | 0.0014 | 0.0022 | 0.0036 |
Loa Loa (eye worm) | Ulp1 protease | 0.0014 | 0.0022 | 0.0136 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0106 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0106 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0059 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0309 | 0.1939 |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0052 | 0.0284 | 0.0226 |
Echinococcus granulosus | dnaJ subfamily B | 0.0871 | 0.6036 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0187 | 0.0309 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0106 | 1 |
Trypanosoma brucei | SUMO1/Ulp2, putative | 0.0014 | 0.0022 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0298 | 0.2011 | 0.1994 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1084 | 0.6796 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0298 | 0.2011 | 0.1963 |
Loa Loa (eye worm) | Ulp1 protease | 0.0014 | 0.0022 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0106 | 0.0664 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0179 | 0.6003 |
Echinococcus granulosus | muscleblind protein | 0.0166 | 0.1084 | 0.1796 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Echinococcus multilocularis | muscleblind protein | 0.0166 | 0.1084 | 0.1796 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0116 | 0.0735 | 0.1411 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0182 | 0.1198 | 0.5 |
Loa Loa (eye worm) | histone methyltransferase | 0.0019 | 0.0054 | 0.034 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0044 | 0.0073 |
Plasmodium falciparum | chorismate synthase | 0.1435 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0059 | 0.0038 |
Onchocerca volvulus | 0.0014 | 0.0022 | 0.0198 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0044 | 0.0073 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.0052 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0059 | 0.0371 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0309 | 0.1512 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1097 | 0.688 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0014 | 0.0022 | 0.0118 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0044 | 0.0216 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0116 | 0.0735 | 0.068 |
Echinococcus granulosus | cpg binding protein | 0.0065 | 0.0375 | 0.0622 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0044 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0059 | 0.0371 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0052 | 0.0284 | 0.047 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0187 | 0.0912 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0249 | 0.1562 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0028 | 0.0046 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0015 | 0.0028 | 0.0046 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0028 | 0.0046 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0054 | 0.009 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0014 | 0.0022 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0059 | 0.0371 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0116 | 0.0735 | 0.1314 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0059 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1084 | 0.6796 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0106 | 0.0047 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0249 | 0.0413 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0106 | 0.3208 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Apoptotic Activity (functional) | = 42 % | Percent apoptotic activity of compound in human acute myelocytic leukemia HL-60 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Apoptotic Activity (functional) | = 42 % | Percent apoptotic activity of compound in human acute myelocytic leukemia HL-60 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Apoptotic Activity (functional) | = 43 % | Percent apoptotic activity of compound in chronic myelogenous leukaemia K562 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Apoptotic Activity (functional) | = 43 % | Percent apoptotic activity of compound in chronic myelogenous leukaemia K562 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.