Detailed information for compound 331734

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 320.367 | Formula: C14H16N4O3S
  • H donors: 3 H acceptors: 4 LogP: 1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)Cc1csc(n1)NC(=O)c1cccc(c1)N(C)C
  • InChi: 1S/C14H16N4O3S/c1-18(2)11-5-3-4-9(6-11)13(20)16-14-15-10(8-22-14)7-12(19)17-21/h3-6,8,21H,7H2,1-2H3,(H,17,19)(H,15,16,20)
  • InChiKey: ZAKGKHUAPCFFQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 1B, calmodulin-dependent Starlite/ChEMBL References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 1A, calmodulin-dependent References
Homo sapiens phosphodiesterase 1C, calmodulin-dependent 70kDa References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative phosphodiesterase 1B, calmodulin-dependent 536 aa 465 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine receptor 0.1107 1 1
Onchocerca volvulus 0.0048 0.0211 0.0162
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0829 0.7433 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0245 0.203 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.5146
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0245 0.203 1
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.01
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.0222
Echinococcus multilocularis serotonin receptor 0.1107 1 1
Echinococcus multilocularis tumor protein p63 0.0335 0.2864 0.2833
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0036 0.0104 0.0072
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0036 0.0104 0.0513
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.0513
Echinococcus granulosus expressed conserved protein 0.0092 0.0616 0.0586
Schistosoma mansoni lipoxygenase 0.0055 0.0275 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.0513
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0867 0.1053
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.5146
Loa Loa (eye worm) melatonin receptor type 1A 0.1107 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1107 1 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0308 0.0266
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0308 0.0266
Brugia malayi hypothetical protein 0.1107 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1107 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0308 0.0276
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1107 1 1
Brugia malayi Serotonin receptor 0.1107 1 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0036 0.0104 0.5146
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1107 1 1
Schistosoma mansoni amine GPCR 0.1107 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.1107 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0321 0.1558
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Brugia malayi G protein-coupled receptor 0.1107 1 1
Plasmodium vivax SET domain protein, putative 0.003 0.0043 0.021
Echinococcus granulosus fmrfamide receptor 0.1107 1 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0699 0.6231 0.6215
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Brugia malayi putative neuropeptide receptor NPR1 0.1107 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0275 0.0243
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0757 0.0902
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0038 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Loa Loa (eye worm) hypothetical protein 0.0039 0.0127 0.0127
Brugia malayi hypothetical protein 0.0234 0.1935 0.1935
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0765 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0308 0.0266
Echinococcus granulosus orexin receptor type 2 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0765 0.3874
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0245 0.203 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.0513
Onchocerca volvulus 0.1107 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0325 0.0314
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0236 1
Onchocerca volvulus 0.1107 1 1
Brugia malayi CHE-14 protein 0.0042 0.0156 0.0156
Brugia malayi hypothetical protein 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0765 0.3874
Brugia malayi hypothetical protein 0.1107 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1107 1 1
Echinococcus multilocularis orexin receptor type 2 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus S formylglutathione hydrolase 0.0035 0.0095 0.0062
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0765 0.0913
Loa Loa (eye worm) PDE1B protein 0.0699 0.6231 0.6231
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0699 0.6231 0.6218
Loa Loa (eye worm) hypothetical protein 0.0042 0.0156 0.0156
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.7195 0.7183
Echinococcus multilocularis neuropeptides capa receptor 0.1107 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1107 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0236 0.0194
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0036 0.0104 0.0062
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus somatostatin receptor 0.1107 1 1
Schistosoma mansoni neuropeptide receptor 0.1107 1 1
Brugia malayi putative neuropeptide receptor 0.1107 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0077 0.0484 0.2387
Schistosoma mansoni neuropeptide receptor 0.1107 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0202 0.017
Loa Loa (eye worm) G-protein coupled receptor 0.1107 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1107 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Echinococcus multilocularis chromobox protein 1 0.0069 0.0407 0.0366
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.006 0.0321 0.0321
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0035 0.0095 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1107 1 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0321 0.1558
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0366 0.1796
Schistosoma mansoni hypothetical protein 0.0048 0.0211 0.0169
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0765 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0036 0.0104 0.5146
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0366 0.1796
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0236 0.1162
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0426
Echinococcus multilocularis neuropeptide Y receptor 0.1107 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.1107 1 1
Brugia malayi follicle stimulating hormone receptor 0.1107 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0202 0.016
Brugia malayi 6-phosphofructokinase 0.0108 0.0765 0.0765
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1107 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1107 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0765 0.3767
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0325 0.0294
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0236 0.1162
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0765 0.0725
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Schistosoma mansoni neuropeptide receptor 0.1107 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1107 1 1
Onchocerca volvulus 0.0235 0.1938 0.1898
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Leishmania major hypothetical protein, conserved 0.0036 0.0104 0.0513
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Loa Loa (eye worm) TYRA-2 protein 0.1107 1 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0036 0.0104 0.0072
Echinococcus granulosus 7TM GPCR rhodopsin 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.1935 0.1935
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0127 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0036 0.0104 0.0513
Echinococcus multilocularis serotonin receptor 0.1107 1 1
Brugia malayi Serotonin receptor 0.1107 1 1
Brugia malayi Heterochromatin protein 1 0.0069 0.0407 0.0407
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1935 0.1908
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0101 0.0701 0.3544
Schistosoma mansoni hypothetical protein 0.1107 1 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.006 0.0321 0.028
Echinococcus granulosus biogenic amine 5HT receptor 0.1107 1 1
Schistosoma mansoni myosin xvIII 0.1107 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0036 0.0104 0.3336
Brugia malayi jmjC domain containing protein 0.0058 0.0308 0.0308
Brugia malayi hypothetical protein 0.1107 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0701 0.3456
Echinococcus multilocularis g protein coupled receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1107 1 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0038 0.0188
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus neuropeptides capa receptor 0.1107 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Onchocerca volvulus Neuropeptide F receptor homolog 0.1107 1 1
Brugia malayi neuropeptide F receptor 0.1107 1 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.006 0.0321 0.0289
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0325 0.0284
Echinococcus granulosus sex peptide receptor 0.1107 1 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0765 0.0913
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0765 0.3767
Echinococcus multilocularis neuropeptide receptor 0.1107 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0236 0.1162
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0077 0.0484 0.2411
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0236 0.1114
Loa Loa (eye worm) hypothetical protein 0.006 0.0321 0.0321
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1107 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0765 0.0765
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Onchocerca volvulus 0.1107 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1107 1 1
Brugia malayi phosphofructokinase 0.0108 0.0765 0.0765
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1107 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0325 0.0314
Echinococcus multilocularis sex peptide receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0082
Schistosoma mansoni opsin-like receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0308 0.0308
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1107 1 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0211 0.0169
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0513
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0325 0.0314
Schistosoma mansoni biogenic amine (5HT) receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus multilocularis somatostatin receptor 0.1107 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1107 1 1
Echinococcus granulosus g protein coupled receptor 0.1107 1 1
Mycobacterium tuberculosis Probable reductase 0.0107 0.0757 0.0902
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0156 0.0114
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0236 0.1162
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi hypothetical protein 0.1107 1 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0036 0.0104 0.0104
Echinococcus multilocularis expressed conserved protein 0.0092 0.0616 0.0576
Brugia malayi larval opioid receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0101 0.0701 0.0671
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0043
Brugia malayi 6-phosphofructokinase 0.0108 0.0765 0.0765
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0236 0.1162
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0101 0.0701 0.0662
Leishmania major hypothetical protein, conserved 0.0036 0.0104 0.0513
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0308 0.0276
Echinococcus multilocularis neuropeptide FF receptor 2 0.1107 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.01
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0765 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0426
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0275 0.0233
Echinococcus granulosus g protein coupled receptor 0.1107 1 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Brugia malayi hypothetical protein 0.1107 1 1
Echinococcus granulosus neuropeptide s receptor 0.1107 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0757 0.0902
Echinococcus granulosus biogenic amine 5HT receptor 0.1107 1 1
Echinococcus granulosus allatostatin A receptor 0.1107 1 1
Brugia malayi G-protein coupled receptor 0.1107 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0077 0.0484 0.2411
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0245 0.203 1
Schistosoma mansoni amine GPCR 0.1107 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0236 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0082
Echinococcus granulosus neuropeptide receptor 0.1107 1 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0156 0.0124
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0236 0.0204
Schistosoma mansoni amine GPCR 0.1107 1 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0245 0.203 0.2004
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0829 0.7433 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Schistosoma mansoni hypothetical protein 0.1107 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.01
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0867 0.1053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0036 0.0104 0.5146
Echinococcus granulosus neuropeptides capa receptor 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Echinococcus multilocularis g-protein coupled receptor 0.1107 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Echinococcus granulosus neuropeptide receptor A26 0.1107 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1107 1 1
Schistosoma mansoni histamine h1 receptor 0.1107 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0671 0.0631
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0222 0.018
Brugia malayi Tachykinin-like peptides receptor 99D 0.1107 1 1
Brugia malayi hypothetical protein 0.1107 1 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0765 0.3767
Schistosoma mansoni amine GPCR 0.1107 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0202 0.0202
Schistosoma mansoni adenoreceptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0104
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1058 0.1029
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Onchocerca volvulus 0.1107 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0325 0.0284
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0513
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0104
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0036 0.0104 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.0513
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus chromobox protein 1 0.0069 0.0407 0.0376
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0757 0.0902
Schistosoma mansoni chromobox protein 0.0069 0.0407 0.0366
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.006 0.0321 0.028
Onchocerca volvulus 0.1107 1 1
Schistosoma mansoni opsin-like receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi Esterase D 0.0035 0.0095 0.0095
Echinococcus multilocularis neuropeptide receptor 0.1107 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0036 0.0104 0.0072
Loa Loa (eye worm) hypothetical protein 0.0098 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0321 0.1558
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0765 0.0765
Echinococcus granulosus neuropeptide Y receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1107 1 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0671 0.0671
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0043 0.021
Schistosoma mansoni alpha-1 adrenergic receptor 0.1107 1 1
Brugia malayi hypothetical protein 0.0121 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi sulfakinin receptor protein 0.1107 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0325 0.1602
Echinococcus granulosus chromobox protein 1 0.0069 0.0407 0.0376
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0407 0.2008
Echinococcus multilocularis G protein coupled receptor 139 0.1107 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1107 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0236 0.1162
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0765 0.0913
Brugia malayi G protein-coupled receptor F59B2.13 0.1107 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1107 1 1
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0765 0.0735
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1107 1 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1107 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Echinococcus granulosus G protein coupled receptor 139 0.1107 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0701 0.3456
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0325 0.0284
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0765 0.3874
Echinococcus multilocularis allatostatin A receptor 0.1107 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Brugia malayi ORL1-like opioid receptor 0.1107 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.0513
Loa Loa (eye worm) hypothetical protein 0.0314 0.2674 0.2674
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1107 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0036 0.0104 0.0062
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1107 1 1
Brugia malayi hypothetical protein 0.1107 1 1
Onchocerca volvulus 0.0049 0.0222 0.0173
Schistosoma mansoni opsin-like receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0104
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1107 1 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0236 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0104 0.0426
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0236 0.1162
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Onchocerca volvulus 0.1107 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.1107 1 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0154 0.0687
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0211 0.0211
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0426
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0867 0.1053
Loa Loa (eye worm) glutathione reductase 0.0047 0.0202 0.0202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1107 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0104 0.0513
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0407 0.2008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0699 0.6231 0.6215
Leishmania major trypanothione reductase 0.0047 0.0202 0.0996
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0101 0.0701 0.3456
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Brugia malayi Pre-SET motif family protein 0.003 0.0043 0.0043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0036 0.0104 0.0426
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0202 0.0996
Loa Loa (eye worm) hypothetical protein 0.0051 0.0243 0.0243
Echinococcus granulosus serotonin receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0127 0.0127
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0765 0.3874
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.1107 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0236 0.1114
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0036 0.0104 0.0426
Echinococcus granulosus tumor protein p63 0.0335 0.2864 0.284
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0308 0.0266
Plasmodium vivax glutathione reductase, putative 0.0047 0.0202 0.0996
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0513
Echinococcus multilocularis neuropeptide receptor A26 0.1107 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0426
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi Pre-SET motif family protein 0.0206 0.1675 0.1675
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0325 0.1602
Echinococcus multilocularis fmrfamide receptor 0.1107 1 1
Echinococcus granulosus neuropeptide Y receptor 0.1107 1 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0211 0.0169
Trypanosoma brucei protein kinase, putative 0.005 0.0236 0.1162
Onchocerca volvulus 0.1107 1 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0245 0.203 0.1996
Brugia malayi glutathione reductase 0.0047 0.0202 0.0202
Brugia malayi jmjC domain containing protein 0.0058 0.0308 0.0308
Schistosoma mansoni biogenic amine receptor 0.1107 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0038 0.1884
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0038 0.5
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0765 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0036 0.0104 0.0062
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.01
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1107 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0036 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0765 0.0725
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0101 0.0701 0.0662
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1938 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0038 0.0188
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0036 0.0104 0.0426
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1107 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1107 1 1
Schistosoma mansoni amine GPCR 0.1107 1 1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0038 0.0188
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0036 0.0104 0.0072
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.005
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0036 0.0104 0.0062
Echinococcus granulosus peptide allatostatin:somatostatin 0.1107 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1107 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1107 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0366 0.1796
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Schistosoma mansoni biogenic amine receptor 0.1107 1 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0245 0.203 1
Echinococcus multilocularis fmrfamide receptor 0.1107 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1675 0.1675
Brugia malayi Dopamine receptor 0.1107 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0147 0.0105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0757 0.0902
Brugia malayi G-protein coupled receptor 0.1107 1 1
Schistosoma mansoni chromobox protein 0.0069 0.0407 0.0366
Brugia malayi Dopamine receptor protein 2 0.1107 1 1
Plasmodium falciparum glutathione reductase 0.0047 0.0202 1
Brugia malayi neuropeptide F receptor 0.1107 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0101 0.0701 0.3544
Onchocerca volvulus 0.1107 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0757 0.0902
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0036 0.0104 0.5146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Schistosoma mansoni hypothetical protein 0.1107 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1107 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0701 0.3544
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0245 0.203 1
Brugia malayi MAP kinase sur-1 0.005 0.0236 0.0236
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1107 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Trypanosoma brucei trypanothione reductase 0.0047 0.0202 0.0996
Echinococcus multilocularis protein patched 0.0042 0.0156 0.0114
Echinococcus multilocularis neuropeptide s receptor 0.1107 1 1
Brugia malayi hypothetical protein 0.1107 1 1
Schistosoma mansoni patched 1 0.0042 0.0156 0.0114
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0829 0.7433 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Brugia malayi RE15519p 0.1107 1 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0765 0.0725
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0036 0.0104 0.0513
Echinococcus granulosus 7tm_1 domain containing protein 0.1107 1 1
Echinococcus multilocularis S formylglutathione hydrolase 0.0035 0.0095 0.0052
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0236 0.0204
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0038 0.1884
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0156 0.0124
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0036 0.0104 0.0426
Schistosoma mansoni hypothetical protein 0.1107 1 1
Echinococcus granulosus g protein coupled receptor 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0082
Toxoplasma gondii thioredoxin reductase 0.0047 0.0202 0.0996
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0867 0.1053
Toxoplasma gondii hypothetical protein 0.0065 0.0366 0.1806
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1107 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0685 0.0645
Brugia malayi GnHR receptor homolog 0.1107 1 1
Giardia lamblia hypothetical protein 0.0036 0.0104 0.3336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0036 0.0104 0.0062
Schistosoma mansoni growth hormone secretagogue receptor 0.1107 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1107 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0202 0.0996
Echinococcus granulosus neuropeptide FF receptor 2 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Schistosoma mansoni neuropeptide F-like receptor 0.1107 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1935 0.19
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0036 0.0104 0.0426
Brugia malayi Thioredoxin reductase 0.0047 0.0202 0.0202
Echinococcus granulosus alpha 1A adrenergic receptor 0.1107 1 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.0202 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0101 0.0701 0.3456
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0127 0.0545
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0202 0.0146
Giardia lamblia Hypothetical protein 0.0036 0.0104 0.3336
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0671 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.0513
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0757 0.0902
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0236 0.1114
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0236 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0156 0.0698
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1107 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1107 1 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Schistosoma mansoni neuropeptide receptor 0.1107 1 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0154 0.0687
Echinococcus multilocularis g protein coupled receptor 0.1107 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0082
Onchocerca volvulus 0.1107 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1107 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0308 0.0266
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0043 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.1107 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1058 0.102
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0036 0.0104 0.0426
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0765 0.0765
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0038 0.0188
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0036 0.0104 0.0104
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0036 0.0104 0.0062
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0701 0.3456
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0325 0.0314
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0036 0.0104 0.0513
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0156 0.0156
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0407 0.0407
Plasmodium vivax phosphodiesterase gamma, putative 0.0036 0.0104 0.0513
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0407 0.0366
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1107 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1107 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1107 1 1
Brugia malayi Dopamine receptor protein 1 0.1107 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0699 0.6231 0.6231
Brugia malayi Melatonin receptor type 1A 0.1107 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0236 0.1114
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0082
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1107 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1107 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1107 1 1
Brugia malayi AKH receptor 0.1107 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1107 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0104 0.0426
Echinococcus multilocularis dro:myosuppressin receptor 0.1107 1 1
Onchocerca volvulus 0.0041 0.0147 0.0098
Onchocerca volvulus 0.1107 1 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0038 0.0082
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0321 0.0321
Echinococcus multilocularis g protein coupled receptor 0.1107 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0038 0.0188
Loa Loa (eye worm) esterase D 0.0035 0.0095 0.0095
Leishmania major cAMP-specific phosphodiesterase, putative 0.0036 0.0104 0.0513
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0154 0.0105
Echinococcus granulosus neuropeptide receptor 0.1107 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.1107 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0036 0.0104 0.0513
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0245 0.203 1
Loa Loa (eye worm) hypothetical protein 0.1107 1 1
Echinococcus granulosus g-protein coupled receptor 0.1107 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0701 0.3544
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0671 0.8709
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0701 0.3544
Echinococcus granulosus hypothetical protein 0.1107 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1107 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0127 0.0545

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.47 uM Inhibitory concentration against Phosphodiesterase type 5 ChEMBL. 16005625
IC50 (binding) = 5.47 uM Inhibitory concentration against Phosphodiesterase type 5 ChEMBL. 16005625
IC50 (binding) > 10 uM Inhibitory concentration against Phosphodiesterase type 1 ChEMBL. 16005625
IC50 (binding) > 10 uM Inhibitory concentration against Phosphodiesterase type 1 ChEMBL. 16005625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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