Detailed information for compound 331748

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.395 | Formula: C17H15F2N5O3S
  • H donors: 2 H acceptors: 5 LogP: 2.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(nn1C(=O)c1c(F)ccc(c1F)C)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C17H15F2N5O3S/c1-9-3-8-13(18)14(15(9)19)16(25)24-10(2)21-17(23-24)22-11-4-6-12(7-5-11)28(20,26)27/h3-8H,1-2H3,(H,22,23)(H2,20,26,27)
  • InChiKey: BHQZGGSZRHDQFZ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 4 References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin A2 References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin B1 References
Homo sapiens cyclin D1 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 alpha References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens fibroblast growth factor receptor 2 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 1 References
Homo sapiens insulin receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 3 357 aa 316 aa 34.5 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.4372 0.454
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0125 0.4458 0.464
Echinococcus granulosus twitchin 0.0022 0.014 0.014
Schistosoma mansoni g1/s-specific cyclin C 0.003 0.0455 0.0455
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0236 0.9082 1
Schistosoma mansoni cyclin k 0.003 0.0455 0.0455
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0118 0.4164 0.4164
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.003 0.0455 0.0455
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.6347 0.6173
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0118 0.4164 0.43
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1508 0.1221
Echinococcus granulosus protein kinase shaggy 0.0118 0.4164 0.4164
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0055 0.1508 0.1221
Loa Loa (eye worm) cyclin C 0.003 0.0455 0.0306
Brugia malayi Furin-like cysteine rich region family protein 0.0075 0.2337 0.1972
Echinococcus granulosus epidermal growth factor receptor 0.0075 0.2337 0.2337
Schistosoma mansoni tyrosine kinase 0.0075 0.2337 0.2337
Echinococcus granulosus cyclins 0.0123 0.4372 0.4372
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.4458 0.4458
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0125 0.4458 0.464
Echinococcus multilocularis cyclin G2 0.003 0.0455 0.0455
Echinococcus granulosus fibroblast growth factor receptor 4 0.0163 0.6026 0.6026
Echinococcus multilocularis cyclin 0.003 0.0455 0.0455
Brugia malayi Immunoglobulin I-set domain containing protein 0.0186 0.6983 0.6839
Echinococcus granulosus cyclin dependent kinase 0.0055 0.1508 0.1508
Loa Loa (eye worm) TK/EGFR protein kinase 0.0075 0.2337 0.2217
Onchocerca volvulus 0.0118 0.4164 0.43
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0118 0.4164 0.4164
Trichomonas vaginalis cyclin A, putative 0.0236 0.9082 1
Echinococcus granulosus cyclin G2 0.003 0.0455 0.0455
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.003 0.0455 0.0455
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0075 0.2337 0.2337
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0118 0.4164 0.4164
Schistosoma mansoni hypothetical protein 0.003 0.0455 0.0455
Loa Loa (eye worm) TK/INSR protein kinase 0.0161 0.5948 0.5885
Plasmodium falciparum glycogen synthase kinase 3 0.0118 0.4164 0.947
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.4164 0.43
Schistosoma mansoni tyrosine kinase 0.0071 0.2169 0.2169
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0118 0.4164 0.9267
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0258 1 1
Echinococcus granulosus oligomeric golgi complex subunit 3 0.003 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0112 0.3919 0.3824
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0163 0.6026 0.6026
Schistosoma mansoni cyclin B 0.0236 0.9082 0.9082
Brugia malayi Cyclin, N-terminal domain containing protein 0.0236 0.9082 0.9038
Echinococcus granulosus cyclin 0.003 0.0455 0.0455
Trichomonas vaginalis cyclin B, putative 0.0236 0.9082 1
Plasmodium falciparum protein kinase 5 0.0055 0.1508 0.269
Loa Loa (eye worm) hypothetical protein 0.0236 0.9082 0.9068
Trichomonas vaginalis cyclins, putative 0.0236 0.9082 1
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0455 0.0306
Echinococcus granulosus cyclins 0.0123 0.4372 0.4372
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.1508 0.1221
Giardia lamblia Kinase, CMGC GSK 0.0118 0.4164 0.43
Schistosoma mansoni hypothetical protein 0.003 0.0455 0.0455
Brugia malayi Cyclin, N-terminal domain containing protein 0.0236 0.9082 0.9038
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0055 0.1508 0.1508
Trichomonas vaginalis CMGC family protein kinase 0.0125 0.4458 0.464
Echinococcus granulosus cyclin G2 0.003 0.0455 0.0455
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.003 0.0455 0.0455
Trichomonas vaginalis CMGC family protein kinase 0.0125 0.4458 0.464
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0455 0.0306
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.1508 0.1376
Trypanosoma cruzi cyclin, putative 0.0236 0.9082 1
Trichomonas vaginalis cyclin B, putative 0.0123 0.4372 0.454
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Echinococcus multilocularis 0.0021 0.0074 0.0074
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.4164 0.43
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Trypanosoma brucei cdc2-related kinase 3 0.0055 0.1508 0.1221
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0455 0.0306
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.003 0.0455 0.0455
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0055 0.1508 0.1221
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.1508 0.1221
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0186 0.6983 0.6936
Loa Loa (eye worm) hypothetical protein 0.003 0.0455 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.4164 0.43
Echinococcus granulosus cyclin t1 0.003 0.0455 0.0455
Trypanosoma cruzi cyclin 6, putative 0.0236 0.9082 1
Echinococcus granulosus insulin receptor 0.0161 0.5948 0.5948
Echinococcus granulosus cyclin dependent kinase 1 0.0055 0.1508 0.1508
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0455 0.0306
Onchocerca volvulus Tyrosine kinase homolog 0.0178 0.6679 0.7215
Brugia malayi Protein kinase domain containing protein 0.009 0.2988 0.2654
Onchocerca volvulus 0.0167 0.6191 0.6649
Giardia lamblia G2/mitotic-specific cyclin B 0.0236 0.9082 1
Echinococcus multilocularis cyclin B 0.0236 0.9082 0.9082
Echinococcus granulosus cyclin A3 4 0.003 0.0455 0.0455
Entamoeba histolytica cyclin family protein 0.0123 0.4372 0.454
Echinococcus granulosus cyclins 0.0123 0.4372 0.4372
Giardia lamblia Cyclin A 0.0123 0.4372 0.454
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0125 0.4458 1
Echinococcus multilocularis epidermal growth factor receptor 0.0075 0.2337 0.2337
Echinococcus granulosus mitogen activated protein kinase 0.0125 0.4458 0.4458
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0118 0.4164 0.4073
Schistosoma mansoni tyrosine kinase 0.0075 0.2337 0.2337
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.1508 0.1508
Echinococcus multilocularis epidermal growth factor receptor 0.0075 0.2337 0.2337
Trichomonas vaginalis cyclin B, putative 0.0236 0.9082 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0163 0.6026 0.6026
Echinococcus multilocularis cyclin y 0.003 0.0455 0.0455
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.1508 0.1221
Echinococcus multilocularis cyclin k 0.003 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0236 0.9082 0.9068
Schistosoma mansoni cyclin d 0.003 0.0455 0.0455
Giardia lamblia Kinase, CMGC CDK 0.0055 0.1508 0.1221
Trichomonas vaginalis CMGC family protein kinase 0.0125 0.4458 0.464
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Trypanosoma brucei protein kinase, putative 0.0118 0.4164 0.43
Schistosoma mansoni tyrosine kinase 0.0075 0.2337 0.2337
Loa Loa (eye worm) cyclin domain-containing protein 0.0258 1 1
Giardia lamblia Kinase, CMGC CDK 0.0055 0.1508 0.1221
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0125 0.4458 0.464
Trypanosoma brucei cdc2-related kinase 1 0.0055 0.1508 0.1221
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1508 0.1508
Echinococcus multilocularis cyclin G2 0.003 0.0455 0.0455
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0125 0.4458 0.464
Trypanosoma brucei protein kinase, putative 0.0125 0.4458 0.464
Echinococcus multilocularis insulin receptor 0.0161 0.5948 0.5948
Echinococcus granulosus cyclins 0.0123 0.4372 0.4372
Entamoeba histolytica cyclin, putative 0.0123 0.4372 0.454
Trichomonas vaginalis cyclins, putative 0.0123 0.4372 0.454
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0125 0.4458 0.464
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0161 0.5948 0.5948
Plasmodium falciparum cyclin 0.0123 0.4372 1
Schistosoma mansoni cyclins 0.0123 0.4372 0.4372
Brugia malayi Protein kinase domain containing protein 0.0161 0.5948 0.5755
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0258 1 1
Echinococcus multilocularis Cyclin L1 0.003 0.0455 0.0455
Trypanosoma cruzi CYC2-like cyclin, putative 0.0236 0.9082 1
Leishmania major cyclin 0.0236 0.9082 1
Toxoplasma gondii hypothetical protein 0.0093 0.3126 0.6672
Brugia malayi Protein kinase domain containing protein 0.0055 0.1508 0.1104
Plasmodium vivax protein kinase Crk2 0.0055 0.1508 0.284
Trichomonas vaginalis cyclin B, putative 0.0236 0.9082 1
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Trichomonas vaginalis cyclins, putative 0.0142 0.5165 0.546
Loa Loa (eye worm) CYL-1 protein 0.003 0.0455 0.0306
Echinococcus multilocularis cyclin y 0.003 0.0455 0.0455
Schistosoma mansoni cyclin G 0.003 0.0455 0.0455
Echinococcus multilocularis cyclin dependent kinase 5 0.0055 0.1508 0.1508
Entamoeba histolytica protein kinase, putative 0.0118 0.4164 0.43
Echinococcus multilocularis cyclin A3 4 0.003 0.0455 0.0455
Schistosoma mansoni cyclin l 0.003 0.0455 0.0455
Echinococcus multilocularis protein kinase shaggy 0.0118 0.4164 0.4164
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.4164 0.43
Echinococcus granulosus G1:S specific cyclin D1 0.003 0.0455 0.0455
Giardia lamblia Hypothetical protein 0.0123 0.4372 0.454
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.1508 0.1376
Schistosoma mansoni tyrosine kinase 0.0071 0.2169 0.2169
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1508 0.1221
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0118 0.4164 0.4073
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.1508 0.1221
Trichomonas vaginalis cyclin D, putative 0.0123 0.4372 0.454
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0125 0.4458 0.464
Echinococcus granulosus cyclin B3 1 0.0123 0.4372 0.4372
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0055 0.1508 0.1376
Schistosoma mansoni tyrosine kinase 0.0163 0.6026 0.6026
Loa Loa (eye worm) hypothetical protein 0.0086 0.282 0.2708
Echinococcus granulosus roundabout 2 0.0023 0.0153 0.0153
Loa Loa (eye worm) TK protein kinase 0.017 0.6347 0.629
Trichomonas vaginalis cyclin D, putative 0.0123 0.4372 0.454
Giardia lamblia Kinase, CMGC GSK 0.0118 0.4164 0.43
Echinococcus granulosus cyclin b3 0.0123 0.4372 0.4372
Brugia malayi cell division control protein 2 homolog 0.0055 0.1508 0.1104
Loa Loa (eye worm) hypothetical protein 0.0052 0.1368 0.1234
Giardia lamblia Kinase, CMGC MAPK 0.0125 0.4458 0.464
Trichomonas vaginalis CMGC family protein kinase 0.0125 0.4458 0.464
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0455 0.0306
Echinococcus multilocularis mitogen activated protein kinase 0.0125 0.4458 0.4458
Trypanosoma cruzi cyclin, putative 0.0236 0.9082 1
Trichomonas vaginalis cyclins, putative 0.0236 0.9082 1
Echinococcus granulosus Cyclin L1 0.003 0.0455 0.0455
Echinococcus granulosus mitogen activated protein kinase 3 0.0125 0.4458 0.4458
Schistosoma mansoni cyclin B3 0.0258 1 1
Echinococcus multilocularis roundabout 2 0.0023 0.0153 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1508 0.1221
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.1508 0.1221
Schistosoma mansoni tyrosine kinase 0.0161 0.5948 0.5948
Echinococcus granulosus cyclin y 0.003 0.0455 0.0455
Echinococcus multilocularis cyclin b3 0.0123 0.4372 0.4372
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.1508 0.1508
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0455 0.0306
Schistosoma mansoni Cyclin fold protein 0.003 0.0455 0.0455
Echinococcus multilocularis cyclin dependent kinase 0.0055 0.1508 0.1508
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0125 0.4458 0.464
Schistosoma mansoni tyrosine kinase 0.0161 0.5948 0.5948
Schistosoma mansoni tyrosine kinase 0.0071 0.2169 0.2169
Echinococcus multilocularis G1:S specific cyclin D1 0.003 0.0455 0.0455
Echinococcus multilocularis cyclins 0.0123 0.4372 0.4372
Echinococcus granulosus cyclin B 0.0236 0.9082 0.9082
Trichomonas vaginalis cyclins, putative 0.0236 0.9082 1
Echinococcus multilocularis cyclin t1 0.003 0.0455 0.0455
Echinococcus granulosus cyclin dependent kinase 5 0.0055 0.1508 0.1508
Echinococcus granulosus cyclins 0.0123 0.4372 0.4372
Echinococcus multilocularis cyclin B3 1 0.0123 0.4372 0.4372
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.1508 0.1221
Onchocerca volvulus 0.0236 0.9082 1
Trichomonas vaginalis cyclin B, putative 0.0236 0.9082 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0125 0.4458 0.4371
Echinococcus granulosus cyclin y 0.003 0.0455 0.0455
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0055 0.1508 0.2632
Echinococcus granulosus cyclins 0.003 0.0455 0.0455
Brugia malayi intracellular kinase 0.0118 0.4164 0.3886
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0161 0.5948 0.5948
Loa Loa (eye worm) hypothetical protein 0.003 0.0455 0.0306
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0118 0.4164 0.43
Plasmodium vivax glycogen synthase kinase 3, putative 0.0118 0.4164 1
Entamoeba histolytica cyclin family protein 0.0123 0.4372 0.454
Trypanosoma brucei mitotic cyclin 6 0.0236 0.9082 1
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1508 0.1508
Echinococcus granulosus epidermal growth factor receptor 0.0075 0.2337 0.2337
Trichomonas vaginalis cyclins, putative 0.0236 0.9082 1
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.003 0.0455 0.0306
Echinococcus granulosus cyclin k 0.003 0.0455 0.0455
Brugia malayi MAP kinase sur-1 0.0125 0.4458 0.4194
Echinococcus multilocularis mitogen activated protein kinase 3 0.0125 0.4458 0.4458
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0163 0.6026 0.6026
Entamoeba histolytica cyclin, putative 0.0236 0.9082 1
Trichomonas vaginalis cyclin B3, putative 0.0123 0.4372 0.454
Schistosoma mansoni cyclin G2 0.003 0.0455 0.0455

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 0.27 uM.h Area under concentration time curve after 3 mg/kg of oral dose in nude mice ChEMBL. 15974571
AUC (ADMET) = 0.55 uM.h Area under concentration time curve after 30 mg/kg of oral dose in nude mice ChEMBL. 15974571
Cmax (ADMET) = 0.33 uM Maximum plasma concentration after intravenous administration of 3 mg/kg of the compound in nude mice ChEMBL. 15974571
Cmax (ADMET) = 0.43 uM Maximum plasma concentration after oral administration of 30 mg/kg of the compound in nude mice ChEMBL. 15974571
F (ADMET) = 20.6 % Bioavailability in mouse (nude) (dose 30 mg/kg p.o.) ChEMBL. 15974571
IC50 (binding) = 0.0003 uM Inhibition of Cyclin-dependent kinase 2-cyclin A ChEMBL. 15974571
IC50 (binding) = 0.0003 uM Inhibition of Cyclin-dependent kinase 2-cyclin A ChEMBL. 15974571
IC50 (binding) = 0.003 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (binding) = 0.003 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (binding) = 0.008 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (binding) = 0.008 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (binding) = 0.031 uM Inhibition of Glycogen synthase kinase-3 ChEMBL. 15974571
IC50 (binding) = 0.031 uM Inhibition of Glycogen synthase kinase-3 ChEMBL. 15974571
IC50 (functional) = 0.16 uM In vitro inhibitory concentration against cell proliferation in human PC-3 (prostate adenocarcinoma)tumor cells ChEMBL. 15974571
IC50 (functional) = 0.16 uM In vitro inhibitory concentration against cell proliferation in human PC-3 (prostate adenocarcinoma)tumor cells ChEMBL. 15974571
IC50 (binding) = 0.19 uM Inhibition of Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 15974571
IC50 (binding) = 0.19 uM Inhibition of Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 15974571
IC50 (functional) = 0.22 uM In vitro inhibitory concentration against cell proliferation in human SK-OV-3 (ovarian adenocarcinoma)tumor cells ChEMBL. 15974571
IC50 (functional) = 0.22 uM In vitro inhibitory concentration against cell proliferation in human SK-OV-3 (ovarian adenocarcinoma)tumor cells ChEMBL. 15974571
IC50 (binding) = 0.27 uM Inhibition of Fibroblast growth factor receptor 2 ChEMBL. 15974571
IC50 (binding) = 0.27 uM Inhibition of Fibroblast growth factor receptor 2 ChEMBL. 15974571
IC50 (functional) = 0.37 uM In vitro inhibitory concentrationagainst cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells ChEMBL. 15974571
IC50 (functional) = 0.37 uM In vitro inhibitory concentrationagainst cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells ChEMBL. 15974571
IC50 (binding) = 0.51 uM Inhibition of Vascular endothelial growth factor receptor 2 ChEMBL. 15974571
IC50 (binding) = 0.51 uM Inhibition of Vascular endothelial growth factor receptor 2 ChEMBL. 15974571
IC50 (functional) = 0.88 uM In vitro inhibitory concentration against cell proliferation in human HCT-116 (colon carcinoma) tumor cells ChEMBL. 15974571
IC50 (functional) = 0.88 uM In vitro inhibitory concentration against cell proliferation in human HCT-116 (colon carcinoma) tumor cells ChEMBL. 15974571
IC50 (binding) = 9.5 uM Inhibition of Mitogen-activated protein kinase 1 ChEMBL. 15974571
IC50 (binding) = 9.5 uM Inhibition of Mitogen-activated protein kinase 1 ChEMBL. 15974571
IC50 (binding) = 9.8 uM Inhibition of Insulin kinase-beta activity ChEMBL. 15974571
IC50 (binding) = 9.8 uM Inhibition of Insulin kinase-beta activity ChEMBL. 15974571
IC50 (binding) = 10.7 uM Inhibition of Platelet-derived growth factor receptor beta ChEMBL. 15974571
IC50 (binding) = 45.8 uM Inhibition of Epidermal growth factor receptor ChEMBL. 15974571
IC50 (binding) = 45.8 uM Inhibition of Epidermal growth factor receptor ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of Protein kinase A ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of human casein kinase-1 ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of Casein kinase-2 ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of Protein kinase-C alpha/gama ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of Protein kinase C- beta 2 ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of [Ca2+]/calmodulin dependent kinase ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of human casein kinase-1 ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of Casein kinase-2 ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of Protein kinase C- beta 2 ChEMBL. 15974571
IC50 (binding) > 100 uM Inhibition of [Ca2+]/calmodulin dependent kinase ChEMBL. 15974571
IC50 (functional) = 790 uM In vitro inhibitory concentration against cell proliferation in human A375 (malignant melanoma),tumor cells ChEMBL. 15974571
IC50 (functional) = 790 uM In vitro inhibitory concentration against cell proliferation in human A375 (malignant melanoma),tumor cells ChEMBL. 15974571
T1/2 (ADMET) = 1.94 hr Half life of the compound after intravenous administration of 3 mg/kg ChEMBL. 15974571
T1/2 (ADMET) = 2.29 hr Half life of the compound after oral administration of 30 mg/kg ChEMBL. 15974571

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15974571

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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