Detailed information for compound 331825

Basic information

Technical information
  • TDR Targets ID: 331825
  • Name: 4-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benz oic acid
  • MW: 314.333 | Formula: C18H18O5
  • H donors: 1 H acceptors: 2 LogP: 3.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/c2ccc(cc2)C(=O)O)cc(c1OC)OC
  • InChi: 1S/C18H18O5/c1-21-15-10-13(11-16(22-2)17(15)23-3)5-4-12-6-8-14(9-7-12)18(19)20/h4-11H,1-3H3,(H,19,20)/b5-4+
  • InChiKey: ZIEUMSNBDHAVCX-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.004 0.0588 0.0517
Echinococcus granulosus flap endonuclease 1 0.0027 0.0306 0.0233
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.3433 0.7267
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.02 0.4069 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0482 0.1021
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.2439 0.5162
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0041 0.0616 0.0546
Schistosoma mansoni flap endonuclease-1 0.0025 0.0249 0.0175
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0187 0.0113
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0306 0.4401
Echinococcus granulosus expressed protein 0.0255 0.5276 0.5241
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0482 0.041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0482 0.041
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0187 0.0395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Echinococcus granulosus geminin 0.0344 0.721 0.7189
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0588 0.0517
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0588 0.0517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0482 0.041
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0118 0.0044
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0482 0.041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0616 0.335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0766 0.0697
Brugia malayi hypothetical protein 0.0017 0.0075 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0766 0.0697
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0482 0.041
Brugia malayi conserved hypotetical protein 0.0017 0.0075 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0616 0.335
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0045 0.0695 0.0625
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0537 0.7442
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0482 0.041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0482 0.041
Schistosoma mansoni retinoic acid receptor RXR 0.0134 0.2641 0.2585
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0482 0.041
Brugia malayi nuclear hormone receptor 0.023 0.4724 1
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0187 0.0395
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0306 0.0233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0766 0.0697
Trypanosoma brucei glucosidase, putative 0.0038 0.0537 0.7724
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0045 0.0695 0.0625
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0537 0.7724
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0281 0.0208
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0537 0.0466
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.3433 0.7267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0482 0.1021
Brugia malayi nuclear hormone receptor 0.0035 0.0482 0.1021
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0482 0.1021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0616 0.335
Brugia malayi jmjC domain containing protein 0.004 0.0588 0.1245
Brugia malayi nuclear receptor NHR-88 0.0035 0.0482 0.1021
Onchocerca volvulus 0.0099 0.1864 0.3609
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0537 0.128
Onchocerca volvulus 0.0017 0.0075 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0766 0.0697
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0482 0.0906
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0019 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Brugia malayi hypothetical protein 0.0019 0.0118 0.0251
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0075 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0482 0.1021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0766 0.1622
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0482 0.041
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0482 0.041
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0537 0.128
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0019 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0482 0.1021
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0075 0.0158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Echinococcus multilocularis geminin 0.0344 0.721 0.7189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0251
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0537 0.128
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0075 0.0158
Brugia malayi ecdysone receptor 0.0017 0.0075 0.0158
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0281 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.2439 0.5162
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0482 0.041
Loa Loa (eye worm) DR-78 0.0017 0.0075 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0482 0.1021
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0098 0.184 1
Onchocerca volvulus 0.0035 0.0482 0.0906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0537 0.1137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0482 0.1021
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0098 0.184 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Giardia lamblia Fructose-bisphosphate aldolase 0.02 0.4069 1
Schistosoma mansoni alpha-glucosidase 0.0147 0.2915 0.2862
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0482 0.041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0482 0.1021
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0187 0.0113
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.004 0.0588 0.0517
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0482 0.041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0482 0.1021
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0306 0.0709
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0045 0.0695 1
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0019 0.0269
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0588 0.0517
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0537 0.7724
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0075 0.0158
Toxoplasma gondii aldehyde dehydrogenase 0.0041 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Brugia malayi N-terminal motif family protein 0.0177 0.3571 0.7558
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0766 0.1622
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0537 0.128
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0482 0.041
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0116 0.2233 0.2175
Echinococcus multilocularis expressed protein 0.0255 0.5276 0.5241
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.3433 0.3384
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0482 0.1021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0482 0.1021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0041 0.0616 0.0546
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0075 0.0158
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.3571 0.6947
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0588 0.1245
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0588 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0482 0.1021
Brugia malayi nuclear receptor NHR-88 0.0017 0.0075 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0251
Brugia malayi jmjC domain containing protein 0.004 0.0588 0.1245
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0045 0.0695 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0482 0.041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0306 0.4401
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0482 0.041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0482 0.041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0118 0.0044
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0187 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0616 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.023 0.4724 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0019 0.0269
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0075 0.0158
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0075 0.011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0041 0.0616 0.8865
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0766 0.0697
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0187 0.0113
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0482 0.041
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0482 0.041
Schistosoma mansoni alpha-glucosidase 0.0147 0.2915 0.2862
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0537 0.128
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0616 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0482 0.1021
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0482 0.1021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0766 0.0697
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0075 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0482 0.1021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Treponema pallidum fructose-bisphosphate aldolase 0.02 0.4069 0.5
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0537 0.128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0766 0.0697
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0482 0.1021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0482 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0251
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Schistosoma mansoni hypothetical protein 0.0344 0.721 0.7189
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0306 0.0648
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0118 0.0044
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0019 0.0269
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0075 0.0158
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0537 0.128
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.3433 0.3384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0482 0.041
Plasmodium falciparum flap endonuclease 1 0.0027 0.0306 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0134 0.2641 0.2585
Brugia malayi hypothetical protein 0.0017 0.0075 0.0158
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0045 0.0695 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0482 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0482 0.1021
Schistosoma mansoni jumonji domain containing protein 0.004 0.0588 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0482 0.1021
Brugia malayi Flap endonuclease-1 0.0027 0.0306 0.0648
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0537 0.128
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0118 0.0044
Schistosoma mansoni hypothetical protein 0.0344 0.721 0.7189
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0045 0.0695 0.1472
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0482 0.1021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0482 0.041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0306 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0471 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.1021
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0075 0.0158
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0537 0.1137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0482 0.1021
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0045 0.0695 1
Brugia malayi ecdysteroid receptor 0.0035 0.0482 0.1021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0482 0.041
Brugia malayi hypothetical protein 0.0019 0.0118 0.0251
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0118 0.0251
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0482 0.041
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0045 0.0695 0.0625
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0537 0.0466
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0482 0.041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0187 0.0113
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.02 0.4069 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0248 0.5131 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0537 0.128
Brugia malayi MH2 domain containing protein 0.0125 0.2439 0.5162
Loa Loa (eye worm) hypothetical protein 0.0177 0.3571 0.7558
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.3433 0.3384
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0251
Brugia malayi nuclear receptor RXR 0.0019 0.0118 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0482 0.1021
Loa Loa (eye worm) hypothetical protein 0.0213 0.436 0.923
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0098 0.184 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0482 0.041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0395
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0118 0.0251
Brugia malayi tailless protein 0.0017 0.0075 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0251
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0045 0.0695 0.1472
Brugia malayi steroid hormone receptor 0.0035 0.0482 0.1021
Brugia malayi nuclear receptor RXR 0.0017 0.0075 0.0158
Brugia malayi nuclear receptor NHR-67 0.0017 0.0075 0.0158
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0482 0.041
Schistosoma mansoni coup transcription factor 0.0035 0.0482 0.041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Schistosoma mansoni alpha glucosidase 0.0038 0.0537 0.0466
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0306 0.0709
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0158
Onchocerca volvulus 0.0017 0.0075 0.011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0482 0.041
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0537 0.7724
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0118 0.0251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0482 0.041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.02 0.4069 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0306 0.4401
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0537 0.128
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0482 0.0906
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.004
Schistosoma mansoni microtubule-associated protein tau 0.0471 1 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0045 0.0695 0.1671
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0187 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0482 0.1021
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0537 0.128

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 166 no. of living cells (10E3) /mL Effect of the compound (1 uM) on HL-60 cell growth cultured for 72 hours in nonsupplemented serum-free medium ChEMBL. 15974583
Activity (functional) = 166 no. of living cells (10E3) /mL Effect of the compound (1 uM) on HL-60 cell growth cultured for 72 hours in nonsupplemented serum-free medium ChEMBL. 15974583
Apoptosis (functional) = 36 % Effect of the compound (1 uM) on HL-60 cell apoptosis cultured for 72 hours in nonsupplemented serum-free medium ChEMBL. 15974583
Apoptosis (functional) = 36 % Effect of the compound (1 uM) on HL-60 cell apoptosis cultured for 72 hours in nonsupplemented serum-free medium ChEMBL. 15974583

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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