Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0878 | 0.1718 | 0.106 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3127 | 0.6515 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3127 | 0.6515 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4761 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0878 | 0.1718 | 0.1718 |
Brugia malayi | Dihydrofolate reductase | 0.4761 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4761 | 1 | 1 |
Onchocerca volvulus | 0.0878 | 0.1718 | 0.5 | |
Echinococcus multilocularis | thymidylate synthase | 0.0878 | 0.1718 | 0.1718 |
Schistosoma mansoni | dihydrofolate reductase | 0.4761 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0107 | 0.0073 | 0.0073 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3127 | 0.6515 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0878 | 0.1718 | 0.1718 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0099 | 0.0056 | 0.0056 |
Brugia malayi | hypothetical protein | 0.0418 | 0.0736 | 0.0724 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4761 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0107 | 0.0073 | 0.0073 |
Brugia malayi | thymidylate synthase | 0.0878 | 0.1718 | 0.1708 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0073 | 0.0043 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3127 | 0.6515 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4761 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0418 | 0.0736 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0878 | 0.1718 | 0.1693 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0087 | 0.003 | 0.0017 |
Echinococcus granulosus | dihydrofolate reductase | 0.4761 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4761 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3127 | 0.6515 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4761 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3127 | 0.6515 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.004 ug ml-1 | Minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 (erythromycin-susceptible strain) | ChEMBL. | 15863336 |
MIC (functional) | = 0.015 ug ml-1 | Minimum inhibitory concentration against Streptococcus pyogenes EES61 (erythromycin-susceptible strain) | ChEMBL. | 15863336 |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus 6538P (erythromycin-susceptiblestrain) | ChEMBL. | 15863336 |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus A5177 (erythromycin-resistant strain | ChEMBL. | 15863336 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration against Streptococcus pneumoniae 5649 strain | ChEMBL. | 15863336 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against Streptococcus pyogenes 930 (erythromycin-resistant strain) | ChEMBL. | 15863336 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against Streptococcus pneumoniae 5979 strain | ChEMBL. | 15863336 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against Haemophilus influenzae GYR1435 (erythromycin susceptible strain) | ChEMBL. | 15863336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.