TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 227.265 | Formula: C12H13N5
H donors: 1 H acceptors: 0 LogP: 0.29 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: NC1=NC=NC2C1C=NN2Cc1ccccc1
InChi: 1S/C12H13N5/c13-11-10-6-16-17(12(10)15-8-14-11)7-9-4-2-1-3-5-9/h1-6,8,10,12H,7H2,(H2,13,14,15)
InChiKey: ISAQPRABHCIIIX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Melatonin receptor type 1A	0.0049	0.1317	0.12
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.1317	0.1197
Loa Loa (eye worm)	oxidoreductase	0.0099	0.2782	0.2683
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0058	0.1592	0.4286
Brugia malayi	G-protein coupled receptor	0.0049	0.1317	0.12
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0049	0.1317	0.1242
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.1317	0.1242
Entamoeba histolytica	aldose reductase, putative	0.0099	0.2782	1
Echinococcus multilocularis	serotonin receptor	0.0049	0.1317	0.1242
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0058	0.1592	0.5616
Plasmodium falciparum	aldehyde reductase, putative	0.0029	0.0723	0.5
Echinococcus granulosus	g protein coupled receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.1317	0.1317
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	neuropeptide receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	neuropeptide FF receptor 2	0.0049	0.1317	0.1242
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0099	0.2782	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0049	0.1317	0.1242
Echinococcus granulosus	neuroligin	0.0058	0.1592	0.152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Onchocerca volvulus		0.0058	0.1592	0.4286
Echinococcus multilocularis	G protein coupled receptor 139	0.0049	0.1317	0.1242
Schistosoma mansoni	histamine h1 receptor	0.0049	0.1317	0.1317
Echinococcus multilocularis	neuroligin	0.0058	0.1592	0.152
Onchocerca volvulus		0.0049	0.1317	0.2963
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Brugia malayi	AKH receptor	0.0049	0.1317	0.12
Schistosoma mansoni	opsin-like receptor	0.0049	0.1317	0.1317
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0058	0.1592	0.5616
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Brugia malayi	Carboxylesterase family protein	0.0058	0.1592	0.148
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0049	0.1317	0.2963
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Brugia malayi	Carboxylesterase family protein	0.0344	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0344	1	1
Echinococcus multilocularis	aldo keto reductase	0.0099	0.2782	0.272
Onchocerca volvulus		0.0049	0.1317	0.2963
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.1317	0.1242
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0049	0.1317	0.12
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.1317	0.1242
Echinococcus granulosus	neuropeptide s receptor	0.0049	0.1317	0.1242
Onchocerca volvulus		0.0099	0.2782	1
Schistosoma mansoni	cpg binding protein	0.0028	0.07	0.07
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	carboxylesterase	0.0058	0.1592	0.1477
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.1317	0.1242
Brugia malayi	putative neuropeptide receptor	0.0049	0.1317	0.12
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2782	0.2683
Echinococcus granulosus	voltage gated potassium channel subunit	0.0029	0.0723	0.0642
Echinococcus granulosus	aldo keto reductase	0.0099	0.2782	0.272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0049	0.1317	0.1197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Schistosoma mansoni	aldo-keto reductase	0.0099	0.2782	0.2782
Echinococcus granulosus	hypothetical protein	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Brugia malayi	ORL1-like opioid receptor	0.0049	0.1317	0.12
Echinococcus granulosus	cpg binding protein	0.0029	0.0746	0.0666
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0049	0.1317	0.1197
Echinococcus multilocularis	dro:myosuppressin receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Onchocerca volvulus		0.0049	0.1317	0.2963
Brugia malayi	Dopamine receptor protein 2	0.0049	0.1317	0.12
Echinococcus multilocularis	para nitrobenzyl esterase	0.0058	0.1592	0.152
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.1317	0.1242
Giardia lamblia	Aldose reductase	0.0099	0.2782	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0049	0.1317	0.1317
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.1317	0.1317
Schistosoma mansoni	neuropeptide receptor	0.0049	0.1317	0.1317
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.1592	0.1592
Loa Loa (eye worm)	TYRA-2 protein	0.0049	0.1317	0.1197
Schistosoma mansoni	amine GPCR	0.0049	0.1317	0.1317
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0099	0.2782	1
Brugia malayi	Carboxylesterase family protein	0.0058	0.1592	0.148
Schistosoma mansoni	amine GPCR	0.0049	0.1317	0.1317
Schistosoma mansoni	acetylcholinesterase	0.0058	0.1592	0.1592
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0049	0.1317	0.1197
Loa Loa (eye worm)	carboxylesterase	0.0058	0.1592	0.1477
Schistosoma mansoni	BC026374 protein (S09 family)	0.0058	0.1592	0.1592
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0049	0.1317	0.1242
Brugia malayi	Dopamine receptor	0.0049	0.1317	0.12
Schistosoma mansoni	aldo-keto reductase	0.0099	0.2782	0.2782
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.1317	0.1242
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0058	0.1592	0.1592
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0136	0.005
Onchocerca volvulus		0.0099	0.2782	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0049	0.1317	0.1317
Schistosoma mansoni	opsin-like receptor	0.0049	0.1317	0.1317
Trichomonas vaginalis	aldo-keto reductase, putative	0.0029	0.0723	0.2412
Schistosoma mansoni	opsin-like receptor	0.0049	0.1317	0.1317
Entamoeba histolytica	aldose reductase, putative	0.0099	0.2782	1
Echinococcus granulosus	acetylcholinesterase	0.0344	1	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0099	0.2782	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1615	0.1615
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Entamoeba histolytica	aldose reductase, putative	0.0099	0.2782	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0099	0.2782	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.1317	0.1242
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.1317	0.1317
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0049	0.1317	0.1197
Brugia malayi	CXXC zinc finger family protein	0.0028	0.07	0.0575
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.1317	0.1242
Schistosoma mansoni	amine GPCR	0.0049	0.1317	0.1317
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.1317	0.1317
Echinococcus multilocularis	neuropeptide receptor A26	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	carboxylesterase 5A	0.0344	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Schistosoma mansoni	neuropeptide receptor	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0049	0.1317	0.2963
Brugia malayi	putative neuropeptide receptor NPR1	0.0049	0.1317	0.12
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.1317	0.1317
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0029	0.0723	0.0598
Schistosoma mansoni	hypothetical protein	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Plasmodium falciparum	aldo-keto reductase, putative	0.0029	0.0723	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0049	0.1317	0.12
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0049	0.1317	0.1317
Echinococcus granulosus	somatostatin receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.1317	0.1242
Schistosoma mansoni	pol-related	0.0099	0.2782	0.2782
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Trypanosoma brucei	prostaglandin f synthase	0.0099	0.2782	1
Schistosoma mansoni	potassium channel beta	0.0029	0.0723	0.0723
Brugia malayi	neuropeptide F receptor	0.0049	0.1317	0.12
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0049	0.1317	0.12
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0058	0.1592	0.4222
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.1592	0.1592
Schistosoma mansoni	gliotactin	0.0058	0.1592	0.1592
Schistosoma mansoni	cpg binding protein	0.0029	0.0746	0.0746
Onchocerca volvulus		0.0049	0.1317	0.2963
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Loa Loa (eye worm)	oxidoreductase	0.0099	0.2782	0.2683
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	acetylcholinesterase	0.0344	1	1
Onchocerca volvulus		0.0049	0.1317	0.2963
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus granulosus	neuropeptide receptor A26	0.0049	0.1317	0.1242
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0723	0.2412
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0086	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.1317	0.1242
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0099	0.2782	1
Brugia malayi	G-protein coupled receptor	0.0049	0.1317	0.12
Onchocerca volvulus		0.0099	0.2782	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0049	0.1317	0.1242
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0099	0.2782	0.2686
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.1317	0.1317
Echinococcus multilocularis	aldo keto reductase	0.0099	0.2782	0.272
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0029	0.0723	0.2412
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	neuropeptide s receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0049	0.1317	0.1317
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.1592	0.1592
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Toxoplasma gondii	aldose reductase, putative	0.0099	0.2782	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0058	0.1592	0.152
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Brugia malayi	NADH-dependent xylose reductase	0.0029	0.0723	0.0598
Echinococcus granulosus	serotonin receptor	0.0049	0.1317	0.1242
Onchocerca volvulus		0.0049	0.1317	0.2963
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Schistosoma mansoni	amine GPCR	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	carboxylesterase	0.0344	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.1317	0.1242
Brugia malayi	larval opioid receptor	0.0049	0.1317	0.12
Echinococcus granulosus	7tm_1 domain containing protein	0.0049	0.1317	0.1242
Onchocerca volvulus		0.0029	0.0723	0.0111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Brugia malayi	G protein-coupled receptor	0.0049	0.1317	0.12
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.1317	0.1242
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0058	0.1592	0.152
Brugia malayi	Serotonin receptor	0.0049	0.1317	0.12
Schistosoma mansoni	biogenic amine receptor	0.0049	0.1317	0.1317
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0058	0.1592	0.4222
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.143	0.3436
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0049	0.1317	0.1242
Brugia malayi	G protein-coupled receptor F59B2.13	0.0049	0.1317	0.12
Brugia malayi	Carboxylesterase family protein	0.0058	0.1592	0.148
Echinococcus multilocularis	orexin receptor type 2	0.0049	0.1317	0.1242
Loa Loa (eye worm)	oxidoreductase	0.0099	0.2782	0.2683
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0049	0.1317	0.12
Schistosoma mansoni	growth hormone secretagogue receptor	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus multilocularis	serotonin receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	7TM GPCR rhodopsin	0.0049	0.1317	0.1242
Schistosoma mansoni	amine GPCR	0.0049	0.1317	0.1317
Trichomonas vaginalis	aldo/keto reductase, putative	0.0099	0.2782	1
Onchocerca volvulus		0.0058	0.1592	0.4286
Loa Loa (eye worm)	oxidoreductase	0.0099	0.2782	0.2683
Echinococcus granulosus	g protein coupled receptor	0.0049	0.1317	0.1242
Brugia malayi	follicle stimulating hormone receptor	0.0049	0.1317	0.12
Leishmania major	aldo-keto reductase-like protein	0.0099	0.2782	1
Echinococcus granulosus	fmrfamide receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Schistosoma mansoni	myosin xvIII	0.0049	0.1317	0.1317
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0099	0.2782	0.2686
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.1317	0.1317
Mycobacterium tuberculosis	Probable oxidoreductase	0.0099	0.2782	1
Onchocerca volvulus		0.0099	0.2782	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0049	0.1317	0.12
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.1317	0.1242
Onchocerca volvulus		0.0058	0.1592	0.4286
Echinococcus granulosus	para nitrobenzyl esterase	0.0058	0.1592	0.152
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0099	0.2782	1
Brugia malayi	Carboxylesterase family protein	0.0058	0.1592	0.148
Echinococcus multilocularis	aldo keto reductase	0.0099	0.2782	0.272
Trichomonas vaginalis	aldo-keto reductase, putative	0.0029	0.0723	0.2412
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Mycobacterium ulcerans	carboxylesterase, LipT	0.0058	0.1592	0.4222
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.1317	0.1242
Mycobacterium ulcerans	oxidoreductase	0.0099	0.2782	1
Echinococcus granulosus	orexin receptor type 2	0.0049	0.1317	0.1242
Schistosoma mansoni	hypothetical protein	0.0049	0.1317	0.1317
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0029	0.0723	0.5
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0058	0.1592	0.152
Loa Loa (eye worm)	acetylcholinesterase 1	0.0344	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0049	0.1317	0.1242
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0049	0.1317	0.1242
Schistosoma mansoni	hypothetical protein	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0049	0.1317	0.1242
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Brugia malayi	hypothetical protein	0.0049	0.1317	0.12
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Brugia malayi	Serotonin receptor	0.0049	0.1317	0.12
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus multilocularis	g-protein coupled receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Leishmania major	prostaglandin f synthase, putative	0.0099	0.2782	1
Echinococcus granulosus	acetylcholinesterase	0.0344	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0049	0.1317	0.2963
Echinococcus multilocularis	aldo keto reductase	0.0099	0.2782	0.272
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0136	0.005
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	neuropeptide receptor	0.0049	0.1317	0.1242
Trypanosoma cruzi	aldo-keto reductase	0.0099	0.2782	1
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0344	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Onchocerca volvulus		0.0099	0.2782	1
Echinococcus granulosus	aldehyde reductase	0.007	0.1943	0.1873
Brugia malayi	GnHR receptor homolog	0.0049	0.1317	0.12
Schistosoma mansoni	neuropeptide receptor	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Schistosoma mansoni	adenoreceptor	0.0049	0.1317	0.1317
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0049	0.1317	0.1317
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0049	0.1317	0.1317
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0049	0.1317	0.12
Echinococcus multilocularis	sex peptide receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.1317	0.1242
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Trichomonas vaginalis	aldo-keto reductase, putative	0.0029	0.0723	0.2412
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0099	0.2782	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1477
Loa Loa (eye worm)	melatonin receptor type 1A	0.0049	0.1317	0.1197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.1317	0.1317
Onchocerca volvulus		0.0049	0.1317	0.2963
Echinococcus granulosus	aldo keto reductase	0.0099	0.2782	0.272
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.1317	0.1242
Brugia malayi	RE15519p	0.0049	0.1317	0.12
Mycobacterium leprae	Conserved hypothetical protein	0.007	0.1943	0.5922
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	cpg binding protein	0.0029	0.0746	0.0666
Echinococcus granulosus	aldo keto reductase	0.0099	0.2782	0.272
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.07	0.0572
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0029	0.0723	0.0642
Echinococcus multilocularis	acetylcholinesterase	0.0344	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.1317	0.1197
Brugia malayi	sulfakinin receptor protein	0.0049	0.1317	0.12
Schistosoma mansoni	hypothetical protein	0.0049	0.1317	0.1317
Echinococcus granulosus	hypothetical protein	0.0099	0.2782	0.272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0049	0.1317	0.1317
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.1317	0.1317
Echinococcus multilocularis	aldehyde reductase	0.007	0.1943	0.1873
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Echinococcus granulosus	g-protein coupled receptor	0.0049	0.1317	0.1242
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0049	0.1317	0.1317
Echinococcus granulosus	G protein coupled receptor 139	0.0049	0.1317	0.1242
Brugia malayi	neuropeptide F receptor	0.0049	0.1317	0.12
Loa Loa (eye worm)	oxidoreductase	0.0099	0.2782	0.2683
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0049	0.1317	0.1242
Brugia malayi	hypothetical protein	0.0058	0.1592	0.148
Schistosoma mansoni	biogenic amine receptor	0.0049	0.1317	0.1317
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0029	0.0723	0.0595
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Brugia malayi	Dopamine receptor protein 1	0.0049	0.1317	0.12
Echinococcus multilocularis	allatostatin A receptor	0.0049	0.1317	0.1242
Giardia lamblia	Aldose reductase	0.0099	0.2782	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Trichomonas vaginalis	aldo/keto reductase, putative	0.0099	0.2782	1
Onchocerca volvulus		0.0058	0.1592	0.4286
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0049	0.1317	0.1317
Echinococcus granulosus	dro:myosuppressin receptor	0.0049	0.1317	0.1242
Onchocerca volvulus		0.0049	0.1317	0.2963
Echinococcus granulosus	allatostatin A receptor	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Trichomonas vaginalis	aldo-keto reductase, putative	0.0099	0.2782	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.1317	0.1317
Echinococcus granulosus	g protein coupled receptor	0.0049	0.1317	0.1242
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0099	0.2782	0.2686
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0049	0.1317	0.1242
Schistosoma mansoni	cpg binding protein	0.0029	0.0746	0.0746
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.1317	0.1242
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0344	1	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0099	0.2782	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0099	0.2782	1
Echinococcus multilocularis	somatostatin receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.1317	0.1242
Plasmodium vivax	aldehyde reductase, putative	0.0029	0.0723	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0049	0.1317	0.1242
Onchocerca volvulus		0.0049	0.1317	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0049	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Schistosoma mansoni	biogenic amine receptor	0.0049	0.1317	0.1317
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0099	0.2782	1
Echinococcus granulosus	carboxylesterase 5A	0.0344	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0099	0.2782	0.2686
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.1317	0.1242
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0049	0.1317	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.1317	0.1242
Schistosoma mansoni	neuropeptide receptor	0.0049	0.1317	0.1317
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0029	0.0723	0.0642
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0099	0.2782	0.272
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1317	0.1197
Echinococcus granulosus	sex peptide receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.1317	0.1242
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.1317	0.1242
Echinococcus granulosus	BC026374 protein S09 family	0.0058	0.1592	0.152
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0049	0.1317	0.1242
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0099	0.2782	0.272
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0058	0.1592	0.4222

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	0 nM	Inhibitory constant against bovine spleen Adenosine deaminase at >10e-5; n.a.=not active	ChEMBL.	16078836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 332038