Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.1638 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.2798 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1638 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.2798 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.2798 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1638 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1638 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0626 | 0.2798 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1638 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1638 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.2798 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.2798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.1466 | 0.1466 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1638 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0283 | 0.0283 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1638 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1638 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration of the compound against methicillin-resistant Staphyloccocus epidermidis UC12084 | ChEMBL. | 16033280 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration of the compound against penicillin-susceptible Streptococcus pneumoniae UC9912 | ChEMBL. | 16033280 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration of the compound against methicillin, ciprofloxacin, rifampin, imipenem-resistant Staphyloccocus aureus UC12673; Range is 1-2 ug/mL | ChEMBL. | 16033280 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration of the compound against Enterococcus faecalis UC9217; Range is 1-2 ug/mL | ChEMBL. | 16033280 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration of the compound against methicillin-susceptible Staphyloccocus aureus UC9213; Range is 2-4 ug/mL | ChEMBL. | 16033280 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration of the compound against ampicillin-reisitant Haemophilus influenzae UC30063 | ChEMBL. | 16033280 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration of the compound against Escherichia coli UC6674 | ChEMBL. | 16033280 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration of the compound against Escherichia coli UC6674 | ChEMBL. | 16033280 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.