Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | Dehydrogenase:reductase SDR family | hydroxysteroid (17-beta) dehydrogenase 2 | 387 aa | 359 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.3467 | 0.6345 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.5464 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.3467 | 0.6345 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.3467 | 0.6345 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0034 | 0.5464 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.5464 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.3467 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0027 | 0.3467 | 0.6345 |
Toxoplasma gondii | NAC domain-containing protein | 0.0034 | 0.5464 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3331 | 0.6095 |
Schistosoma mansoni | transcription factor btf3 | 0.0034 | 0.5464 | 0.3057 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.5464 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.5464 | 0.5 |
Brugia malayi | beta-NAC-like protein | 0.0034 | 0.5464 | 1 |
Echinococcus granulosus | transcription factor btf3 | 0.0034 | 0.5464 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.5464 | 0.5 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0034 | 0.5464 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.5464 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.3467 | 0.5 | |
Loa Loa (eye worm) | ICD-1 protein | 0.0034 | 0.5464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3467 | 0.6345 |
Echinococcus multilocularis | transcription factor btf3 | 0.0034 | 0.5464 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0034 | 0.5464 | 0.5 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0034 | 0.5464 | 0.5 |
Leishmania major | basic transcription factor 3a, putative | 0.0034 | 0.5464 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.02 uM | Inhibitory concentration against 17 beta hydroxysteroid dehydrogenase type 2 (type II 17-beta-HSD II) | ChEMBL. | 15890515 |
IC50 (binding) | = 1.02 uM | Inhibitory concentration against 17 beta hydroxysteroid dehydrogenase type 2 (type II 17-beta-HSD II) | ChEMBL. | 15890515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.