Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0195 | 0.1786 | 0.6055 |
Plasmodium vivax | glutathione reductase, putative | 0.0262 | 0.2694 | 1 |
Brugia malayi | glutathione reductase | 0.0262 | 0.2694 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0262 | 0.2694 | 0.2694 |
Toxoplasma gondii | thioredoxin reductase | 0.0262 | 0.2694 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0262 | 0.2694 | 1 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0208 | 0.1967 | 0.1967 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0128 | 0.0888 | 0.216 |
Loa Loa (eye worm) | glutathione reductase | 0.0262 | 0.2694 | 1 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1453 | 0.3552 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0208 | 0.1967 | 0.4811 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0091 | 0.0391 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0091 | 0.0391 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0128 | 0.0888 | 0.216 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0091 | 0.0391 | 0.5 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0067 | 0.0066 | 0.0246 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0067 | 0.0066 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Brugia malayi | Sushi domain | 0.0208 | 0.1967 | 0.7301 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0208 | 0.1967 | 0.7301 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0091 | 0.0391 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0128 | 0.0888 | 0.216 |
Plasmodium falciparum | glutathione reductase | 0.0262 | 0.2694 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.1042 | 0.2548 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.1345 | 0.1345 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0253 | 0.2564 | 0.9516 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0162 | 0.1345 | 0.4992 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2281 | 0.8467 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0208 | 0.1967 | 0.7301 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0091 | 0.0391 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0091 | 0.0391 | 0.5 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0208 | 0.1967 | 0.6844 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.1042 | 0.2548 |
Leishmania major | trypanothione reductase | 0.0262 | 0.2694 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1453 | 0.3552 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0208 | 0.1967 | 0.6844 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0195 | 0.1786 | 0.6055 |
Plasmodium falciparum | apical sushi protein | 0.0208 | 0.1967 | 0.6844 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0162 | 0.1345 | 0.4992 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0091 | 0.0391 | 0.145 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0262 | 0.2694 | 1 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0208 | 0.1967 | 0.7301 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0091 | 0.0391 | 0.5 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Plasmodium vivax | apical sushi protein, putative | 0.0208 | 0.1967 | 0.6844 |
Echinococcus multilocularis | geminin | 0.017 | 0.1453 | 0.1453 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0262 | 0.2694 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0262 | 0.2694 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0208 | 0.1967 | 0.1967 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0091 | 0.0391 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0262 | 0.2694 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0262 | 0.2694 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0091 | 0.0391 | 0.145 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0091 | 0.0391 | 0.0955 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0162 | 0.1345 | 0.4992 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2564 | 0.9516 |
Treponema pallidum | NADH oxidase | 0.0091 | 0.0391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Echinococcus granulosus | geminin | 0.017 | 0.1453 | 0.5391 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.1345 | 0.1345 |
Plasmodium falciparum | thioredoxin reductase | 0.0262 | 0.2694 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0128 | 0.0888 | 0.216 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0091 | 0.0391 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Mycobacterium tuberculosis | Probable reductase | 0.0128 | 0.0888 | 0.216 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0195 | 0.1786 | 0.6055 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Echinococcus granulosus | c4b binding protein beta chain | 0.0208 | 0.1967 | 0.7301 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0195 | 0.1786 | 1 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0091 | 0.0391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Onchocerca volvulus | 0.0208 | 0.1967 | 1 | |
Trypanosoma brucei | trypanothione reductase | 0.0262 | 0.2694 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0128 | 0.0888 | 0.216 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Brugia malayi | hypothetical protein | 0.0208 | 0.1967 | 0.7301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.