Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.165847 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.165847 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.165847 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.111209 | 0.651905 | 0.651905 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0416368 | 0.208664 | 0.208664 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.165847 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.165847 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.165847 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.165847 | 1 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.111209 | 0.651905 | 0.651905 |
Echinococcus granulosus | dihydrofolate reductase | 0.165847 | 1 | 1 |
Echinococcus granulosus | Homeodomain | 0.021149 | 0.0781374 | 0.0781374 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.063412 | 0.347393 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.153705 | 0.922648 | 0.922648 |
Schistosoma mansoni | hypothetical protein | 0.021149 | 0.0781374 | 0.0781374 |
Schistosoma mansoni | integrin alpha-4 | 0.0447156 | 0.228279 | 0.228279 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.165847 | 1 | 1 |
Echinococcus multilocularis | Homeodomain | 0.021149 | 0.0781374 | 0.0781374 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.063412 | 0.347393 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0264635 | 0.111996 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.165847 | 1 | 1 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.153705 | 0.922648 | 0.922648 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | NA 0 | Cytotoxicity against human diploid embryonic lung cell line hMRC-5 was observed at conc. upto 32 uM ;(No cytotoxicity) | ChEMBL. | 15537352 |
IC50 (functional) | = 1 uM | Inhibitory concentration against Plasmodium falciparum FcBIR strain | ChEMBL. | 15537352 |
IC50 (functional) | = 1 uM | Inhibitory concentration against Plasmodium falciparum FcBIR strain | ChEMBL. | 15537352 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15537352 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.