Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.3777 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.3005 | 0.2916 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3495 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.212 | 0.6066 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.2837 | 0.2745 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1203 | 0.1091 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0321 | 0.0198 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0321 | 0.0198 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.2837 | 0.2745 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1359 | 0.2673 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.2837 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.2745 |
Echinococcus multilocularis | geminin | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.212 | 0.6066 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1203 | 0.1091 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0195 | 0.0071 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1081 | 0.0968 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2769 | 0.2677 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.212 | 0.4979 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0195 | 0.0559 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.212 | 0.4979 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1364 | 0.3902 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2769 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1646 | 0.4709 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1081 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1081 | 0.3093 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.152 | 0.4348 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0321 | 0.0198 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2837 | 0.2745 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Apoptotic Activity (functional) | = 39 % | Percent apoptotic activity of compound in chronic myelogenous leukaemia K562 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Apoptotic Activity (functional) | = 39 % | Percent apoptotic activity of compound in chronic myelogenous leukaemia K562 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Apoptotic Activity (functional) | = 40 % | Percent apoptotic activity of compound in human acute myelocytic leukemia HL-60 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Apoptotic Activity (functional) | = 40 % | Percent apoptotic activity of compound in human acute myelocytic leukemia HL-60 cells at 10 uM for 16 h | ChEMBL. | 15974589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.